Exhibit E

                             JOINT FILING STATEMENT

      The undersigned hereby agree as follows:

      (i) Each of them is individually eligible to use the Schedule 13D
Amendment to which this Exhibit is attached, and such Schedule 13D Amendment is
filed on behalf of each of them; and

      (ii) Each of them is responsible for the timely filing of such Schedule
13D and any amendments thereto, and for the completeness and accuracy of the
information concerning such person contained therein; but none of them is
responsible for the completeness or accuracy of the information concerning the
other persons making the filing, unless such person knows or has reason to
believe that such information is inaccurate.

Date: July 13, 2005

                              GREAT POINT PARTNERS LLC

                              Signature:      /s/ Dr. Jeffrey R. Jay, M.D.
                                           ----------------------------------
                                           By Dr. Jeffrey R. Jay, M.D.,
                                             as senior managing member

                              BIOMEDICAL VALUE FUND L.P.

                              Signature:      /s/ Dr. Jeffrey R. Jay, M.D.
                                           ----------------------------------
                                           By Great Point Partners, LLC,
                                             as investment manager,
                                           By Dr. Jeffrey R. Jay, M.D.,
                                             as senior managing member

                              BIOMEDICAL OFFSHORE VALUE FUND, LTD.

                              Signature:      /s/ Dr. Jeffrey R. Jay, M.D.
                                           ----------------------------------
                                           By Great Point Partners, LLC,
                                             as investment manager,
                                           By Dr. Jeffrey R. Jay, M.D.,
                                             as senior managing member

                              DR. JEFFREY R. JAY, M.D.

                              Signature:      /s/ Dr. Jeffrey R. Jay, M.D.
                                           ----------------------------------