Exhibit 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We consent to the incorporation by reference in the following registration statements of American Equity Investment Life Holding Company and in the related prospectuses listed below:

(1)Registration Statement (Form S-3 No.333-268611) of American Equity Investment Life Holding Company

(2)Registration Statement (Form S-3 No. 333-267065) of American Equity Investment Life Holding Company

(3)Registration Statement (Form S-3 No. 333-233544) of American Equity Investment Life Holding Company

(4)Registration Statement (Form S-8 No. 333-238940) pertaining to the American Equity Investment Life Holding Company Amended and Restated Equity Incentive Plan

(5)Registration Statement (Form S-8 No. 333-214885) pertaining to the American Equity Investment Life Holding Company 2013 Director Equity and Incentive Plan

(6)Registration Statement (Form S-8 No. 333-213545) pertaining to the American Equity Investment Life Holding Company 2016 Employee Incentive Plan

(7)Registration Statement (Form S-8 No. 333-175355) pertaining to the American Equity Investment Life Holding Company 2011 Director Stock Option Plan

(8)Registration Statement (Form S-8 No. 333-167755) pertaining to the American Equity Investment Life Holding Company 2009 Employee Incentive Plan, and

(9)Registration Statement (Form S-8 No. 333-127001) pertaining to the 1996 Stock Option Plan, 2000 Employee Stock Option Plan, 2000 Director Stock Option Plan, 1997 Management Subscription Rights Plan, and Restated and Amended Stock Option and Warrant Agreement with David J. Noble of American Equity Investment Life Holding Company

of our report dated February 28, 2023 (except for the adoption of ASU No. 2018-12 disclosed in Note 1 as to which the date is August 9, 2023), with respect to the consolidated financial statements and financial statement schedules of American Equity Investment Life Holding Company included in its Current Report on Form 8-K dated August 9, 2023.

/s/ Ernst & Young LLP

Des Moines, Iowa

August 9, 2023