-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 Afgt0Edk0XejLhw9tYTbPOsHoL+43aBL6E0r4fzFYJjPiqO3CGqdhOUXzVLLDW7/
 XKu+maBsF1Aqny/YhfKZRw==

<SEC-DOCUMENT>0001179110-03-012571.txt : 20031215
<SEC-HEADER>0001179110-03-012571.hdr.sgml : 20031215
<ACCEPTANCE-DATETIME>20031215155541
ACCESSION NUMBER:		0001179110-03-012571
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20031211
FILED AS OF DATE:		20031215

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			REILLY PHILIP R
		CENTRAL INDEX KEY:			0001237194

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-23413
		FILM NUMBER:		031054647

	MAIL ADDRESS:	
		STREET 1:		C/O INTERLEUKIN GENETICS INC
		STREET 2:		135 BEAVER STREET
		CITY:			WALTHAM
		STATE:			MA
		ZIP:			02452

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			INTERLEUKIN GENETICS INC
		CENTRAL INDEX KEY:			0001037649
		STANDARD INDUSTRIAL CLASSIFICATION:	IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES [2835]
		IRS NUMBER:				943123681
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		135 BEAVER ST
		CITY:			WATHAM
		STATE:			MA
		ZIP:			02452
		BUSINESS PHONE:		1-781-398-0700

	MAIL ADDRESS:	
		STREET 1:		135 BEAVER ST
		CITY:			WATHAM
		STATE:			MA
		ZIP:			02452

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	MEDICAL SCIENCE SYSTEMS INC
		DATE OF NAME CHANGE:	19971003
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>edgar.xml
<DESCRIPTION>FORM 4 -
<TEXT>
<XML>
<ownershipDocument>
    <schemaVersion>X0201</schemaVersion>

    <documentType>4</documentType>
<periodOfReport>2003-12-11</periodOfReport>
<notSubjectToSection16>0</notSubjectToSection16>
    <issuer>
        <issuerCik>0001037649</issuerCik>
        <issuerName>INTERLEUKIN GENETICS INC</issuerName>
        <issuerTradingSymbol>ILGN</issuerTradingSymbol>
</issuer>
<reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001237194</rptOwnerCik>
            <rptOwnerName>REILLY PHILIP R</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>135 BEAVER STREET</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>WALTHAM</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02452</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
            <reportingOwnerRelationship>
<isDirector>1</isDirector>
<isOfficer>1</isOfficer>
<isTenPercentOwner>0</isTenPercentOwner>
<isOther>0</isOther>
<officerTitle>Chief Executive Officer</officerTitle>
<otherText></otherText>
</reportingOwnerRelationship>
</reportingOwner>
<nonDerivativeTable></nonDerivativeTable>
<derivativeTable><derivativeTransaction><securityTitle><value>Options to Buy</value>
</securityTitle>
<conversionOrExercisePrice><value>4.70</value>
</conversionOrExercisePrice>
<transactionDate><value>2003-12-11</value>
</transactionDate>
<transactionCoding><transactionFormType>4</transactionFormType>
<transactionCode>A</transactionCode>
<equitySwapInvolved>0</equitySwapInvolved>
</transactionCoding>
<transactionAmounts><transactionShares><value>150000</value>
</transactionShares>
<transactionPricePerShare><value>0</value>
</transactionPricePerShare>
<transactionAcquiredDisposedCode><value>A</value>
</transactionAcquiredDisposedCode>
</transactionAmounts>
<exerciseDate><footnoteId id="F1"></footnoteId>
</exerciseDate>
<expirationDate><value>2013-12-11</value>
</expirationDate>
<underlyingSecurity><underlyingSecurityTitle><value>Common Stock</value>
</underlyingSecurityTitle>
<underlyingSecurityShares><value>150000</value>
</underlyingSecurityShares>
</underlyingSecurity>
<postTransactionAmounts><sharesOwnedFollowingTransaction><value>150000</value>
</sharesOwnedFollowingTransaction>
</postTransactionAmounts>
<ownershipNature><directOrIndirectOwnership><value>D</value>
</directOrIndirectOwnership>
</ownershipNature>
</derivativeTransaction>
<derivativeTransaction><securityTitle><value>Option to Buy</value>
</securityTitle>
<conversionOrExercisePrice><value>4.70</value>
</conversionOrExercisePrice>
<transactionDate><value>2003-12-11</value>
</transactionDate>
<transactionCoding><transactionFormType>4</transactionFormType>
<transactionCode>A</transactionCode>
<equitySwapInvolved>0</equitySwapInvolved>
</transactionCoding>
<transactionAmounts><transactionShares><value>30000</value>
</transactionShares>
<transactionPricePerShare><value>0</value>
</transactionPricePerShare>
<transactionAcquiredDisposedCode><value>A</value>
</transactionAcquiredDisposedCode>
</transactionAmounts>
<exerciseDate><value>2003-12-11</value>
</exerciseDate>
<expirationDate><value>2013-12-11</value>
</expirationDate>
<underlyingSecurity><underlyingSecurityTitle><value>Common Stock</value>
</underlyingSecurityTitle>
<underlyingSecurityShares><value>30000</value>
</underlyingSecurityShares>
</underlyingSecurity>
<postTransactionAmounts><sharesOwnedFollowingTransaction><value>30000</value>
</sharesOwnedFollowingTransaction>
</postTransactionAmounts>
<ownershipNature><directOrIndirectOwnership><value>D</value>
</directOrIndirectOwnership>
</ownershipNature>
</derivativeTransaction>
</derivativeTable>
<footnotes><footnote id="F1">Options to buy 150,000 shares of Common Stock were granted on 12/11/03 pursuant to a stock option agreement between the Company and the reporting person.  Options are exercisable as follows:  2500 shares per month for the first 24 months and 7500 shares per month for the last 12 months.</footnote>
</footnotes>
<ownerSignature><signatureName>Philip R. Reilly</signatureName>
<signatureDate>2003-12-15</signatureDate>
</ownerSignature>
</ownershipDocument>

</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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