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Capital Stock (Authorized, Issued and Reserved shares of common stock) (Detail)
3 Months Ended
Mar. 31, 2017
$ / shares
shares
Reserved for issuance 201,841,145
Total common shares issued and outstanding at March 31, 2017 229,435,726
Total common shares outstanding and reserved for issuance at March 31, 2017 431,276,871
Warrants with common stock additional purchase rights associated with December 2014 private placement [Member]  
Reserved for issuance 50,189,431
Strike Price | $ / shares $ 0.1003
Expiry Dec. 23, 2021
Warrants to purchase common stock associated with September 2014 consulting agreement with Danforth Advisors [Member]  
Reserved for issuance 100,000
Strike Price | $ / shares $ 0.25
Expiry Sep. 08, 2024
Debt Restructuring 2016 [Member]  
Reserved for issuance 5,169,577
Strike Price | $ / shares $ 0.0994
Expiry Aug. 01, 2026
July 2016 Private Placement [Member]  
Reserved for issuance 56,262,571
Strike Price | $ / shares $ 0.0994
Expiry Jul. 29, 2023
Shares reserved under outstanding stock options and options available for grant [Member]  
Reserved for issuance 52,092,463
Shares reserved for future issuance under the Employee Stock Purchase Plan [Member]  
Reserved for issuance 15,455
Warrants to purchase common stock associated with December 2014 venture loan and security agreement [Member]  
Reserved for issuance 2,492,523
Strike Price | $ / shares $ 0.1003
Expiry Dec. 23, 2024
Outstanding warrants issued in June 2012 [Member]  
Reserved for issuance 437,158
Strike Price | $ / shares $ 0.2745
Expiry Jun. 29, 2017
Outstanding warrants issued in May 2013, vesting May 2013 [Member]  
Reserved for issuance 20,655,737
Strike Price | $ / shares $ 0.2745
Expiry May 17, 2020
Outstanding warrants issued in May 2013, vesting August 2013 [Member]  
Reserved for issuance 14,426,230
Strike Price | $ / shares $ 0.2745
Expiry Aug. 09, 2020