Exhibit 99.1

Form 51-102F3

MATERIAL CHANGE REPORT

Item 1.	Name and Address of Reporting Issuer
	Cardiome Pharma Corp. (“Cardiome” or the “Corporation”)
	1441 Creekside Drive, 6th floor
	Vancouver, BC V6J 4S7
Item 2.	Date of Material Change
	May 12, 2017
Item 3.	News Release
	May 15, 2017 – Vancouver, Canada.
Item 4.	Summary of Material Change
	Cardiome amended its term loan agreement with CRG-managed funds (the “Amended Agreement”) that was originally entered into on June 13, 2016. The Amended Agreement provides Cardiome with up to $50 million of available borrowing capacity.
Item 5.	5.1 - Full Description of Material Change
	Cardiome amended its term loan agreement with CRG-managed funds that was originally entered into on June 13, 2016. The Amended Agreement provides Cardiome with up to $50 million of available borrowing capacity.
	Under the terms of the original term loan agreement, CRG provided $20 million to the Company for general working capital purposes and to retire existing debt at the time. On May 12, 2017 under the terms of the Amended Agreement, CRG provided an additional $10 million to the Company.  Two additional tranches of $10 million each are available to the Company subject to certain conditions. The loan matures on March 31, 2022.
	The Amended Agreement bears interest at 13% per annum. Interest payments may be split, at the Company’s option, between 9% per annum in cash interest and 4% per annum in paid in-kind interest in the form of additional term loans until March 31, 2020.  In consideration for entering into the Amended Agreement, CRG received 700,000 transferrable warrants with an exercise price of $4.00 USD (the “Warrants”).  The Warrants are subject to a four-month hold period and are exercisable until May 11, 2022.
	5.2 – Disclosure for Restructuring Transactions
	Not applicable.
Item 6.	Reliance on subsection 7.1(2) of National Instrument 51-102
	Not applicable.

Item 7.	Omitted Information
	Not applicable.
Item 8.	Executive Officer
	Justin Renz, Chief Financial Officer
	Telephone: 604-677-6905.
Item 9.	Date of Report
	This Material Change Report is dated May 19, 2017.

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