Exhibit 99.1

Form 51-102F3

MATERIAL CHANGE REPORT 

Item 1.	Name and Address of Reporting Issuer
	Cardiome Pharma Corp. (“Cardiome” or the “Corporation”)
	1441 Creekside Drive, 6th floor
	Vancouver, BC V6J 4S7
Item 2.	Date of Material Change
	March 10, 2016
Item 3.	News Release
	March 10, 2016 – Vancouver, Canada.
Item 4.	Summary of Material Change
	Cardiome reported financial results for its fourth quarter and year ended December 31, 2015. Amounts, unless specified otherwise, are expressed in U.S. dollars and in accordance with generally accepted accounting principles used in the United States of America (U.S. GAAP).
Item 5.	5.1 - Full Description of Material Change
	See attached press release.
	5.2 – Disclosure for Restructuring Transactions
	Not applicable.
Item 6.	Reliance on subsection 7.1(2) of National Instrument 51-102
	Not applicable.
Item 7.	Omitted Information
	Not applicable.
Item 8.	Executive Officer
	Jennifer Archibald, Chief Financial Officer
	Telephone: 604-677-6905.
Item 9.	Date of Report
	This Material Change Report is dated March 10, 2016.