Exhibit 99.1

FORM 51-102F3

MATERIAL CHANGE REPORT

1.	Name and Address of Company
	Cardiome Pharma Corp.
	6190 Agronomy Rd, 6th Floor
	Vancouver, BC V6T 1Z3

2.   Date of Material Change

March 30, 2009

3.   News Release

March 30, 2009 - Vancouver, Canada

4.   Summary of Material Change

Cardiome Pharma Corp. today reported financial results for the year ended December 31, 2008.  Amounts, unless specified otherwise, are expressed in Canadian dollars and in accordance with Canadian Generally Accepted Accounting Principles (Canadian GAAP).  At close of business on December 31, 2008, the exchange rate was CAD$1.00=US$0.8210.

5.   Full Description of Material Change

See attached press release

6.   Reliance on Subsection 7.1(2) or (3) of National Instrument 51-102

Not Applicable.

7.   Omitted Information

Not Applicable.

8.   Executive Officer

Name:	Curtis Sikorsky
Title:	Chief Financial Officer
Phone No.:	604-677-6905

9.   Date of Report

March 30, 2009

Per:         “Curtis Sikorksy”            

Curtis Sikorksy,

Chief Financial Officer