10-Q

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549

FORM 10-Q

(Mark One)

x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934

For the quarterly period ended September 30, 2012

or

¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from                           to                          

Commission File No. 001-31326

SENESCO TECHNOLOGIES, INC.

(Exact name of registrant as specified in its charter)

Delaware	84-1368850
(State or other jurisdiction of incorporation or organization)	(IRS Employer Identification No.)

721 Route 202/206, Suite 130
Bridgewater, New Jersey 08807
(Address of principal executive offices)

(908) 864-4444
(Registrant’s telephone number, including area code)

Indicate by check mark whether the registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.

Yes: x No: ¨

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files).

Yes: x No: ¨

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer or a smaller reporting company. See definitions of “accelerated filer”, “large accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act.

Large accelerated filer ¨ Accelerated filer ¨

Non-accelerated filer ¨ Smaller reporting company x

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).

Yes: ¨ No: x

116,975,283 shares of the issuer’s common stock, par value $0.01 per share, were outstanding as of October 31, 2012.

SENESCO TECHNOLOGIES, INC. AND SUBSIDIARY

TABLE OF CONTENTS

		Page
PART I.	FINANCIAL INFORMATION
Item 1.	Financial Statements (Unaudited)	1
	CONDENSED CONSOLIDATED BALANCE SHEETS as of September 30, 2012 and June 30, 2012	2
	CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS For the Three Months Ended September 30, 2012 and 2011, and From Inception on July 1, 1998 through September 30, 2012	3
	CONDENSED CONSOLIDATED STATEMENT OF STOCKHOLDERS’
	EQUITY For the Three Months Ended September 30, 2012	4
	CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS For the Three Months Ended September 30, 2012 and 2011, and From Inception on July 1, 1998 through September 30, 2012	5
	NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS	6
Item 2.	Management’s Discussion and Analysis of Financial Condition and Results of Operations	16
	Overview	16
	Liquidity and Capital Resources	20
	Changes to Critical Accounting Policies and Estimates	20
	Results of Operations	21
	Off-Balance Sheet Arrangements	23
Item 3.	Quantitative and Qualitative Disclosures about Market Risk	24
Item 4.	Controls and Procedures	24
PART II.	OTHER INFORMATION
Item 1.	Legal Proceedings	25
Item 1A.	Risk Factors	25
Item 2.	Unregistered Sales of Equity Securities and Use of Proceeds	41
Item 3.	Defaults Upon Senior Securities	41
Item 4.	Mine Safety Disclosures	41
Item 5.	Other Information	41
Item 6.	Exhibits	41
SIGNATURES		42

PART I. FINANCIAL INFORMATION.

Item 1. Financial Statements (Unaudited).

Certain information and footnote disclosures required under United States generally accepted accounting principles have been condensed or omitted from the following consolidated financial statements pursuant to the rules and regulations of the Securities and Exchange Commission. However, Senesco Technologies, Inc., a Delaware corporation, and its wholly owned subsidiary, Senesco, Inc., a New Jersey corporation (collectively, “Senesco” or the “Company”), believe that the disclosures are adequate to assure that the information presented is not misleading in any material respect.

The results of operations for the interim periods presented herein are not necessarily indicative of the results to be expected for the entire fiscal year.

1

SENESCO TECHNOLOGIES, INC. AND SUBSIDIARY

(A DEVELOPMENT STAGE COMPANY)

 CONDENSED CONSOLIDATED BALANCE SHEETS

(unaudited)

	September 30,			June 30,
	2012			2012
ASSETS
CURRENT ASSETS:
Cash and cash equivalents	$	1,312,056		$	2,001,325
Prepaid research supplies and expenses		1,459,643			1,548,524
Total Current Assets		2,771,699			3,549,849
Equipment, furniture and fixtures,  net		6,491			5,857
Intangibles, net		3,476,784			3,393,992
Deferred income tax assets, net		-			-
Security deposit		5,171			5,171
TOTAL ASSETS	$	6,260,145		$	6,954,869
LIABILITIES AND STOCKHOLDERS' EQUITY
CURRENT LIABILITIES:
Accounts payable	$	932,167		$	594,514
Accrued expenses		304,986			369,695
Line of credit		2,199,108			2,199,108
Total Current Liabilities		3,436,261			3,163,317
Warrant liabilities		94,739			238,796
Grant payable		99,728			99,728
TOTAL LIABILITIES		3,630,728			3,501,841
STOCKHOLDERS' EQUITY:
Preferred stock, $0.01 par value, authorized 5,000,000 shares
Series A 10,297 shares issued and 995 and 3,379 shares outstanding, respectively		10			34
(liquidation preference of $1,044,750 and $3,463,475
at September 30, 2012 and June 30, 2012, respectively)
Series B 1,200 shares issued and 0 and 1,200 outstanding, respectively		-			12
(liquidation preference of $0 and $1,230,000
at September 30, 2012 and June 30, 2012, respectively)
Common stock, $0.01 par value, authorized 350,000,000 shares,
issued and outstanding 116,753,185 and 94,112,483, respectively		1,167,532			941,125
Capital in excess of par		71,611,793			69,952,152
Deficit accumulated during the development stage		(70,149,918	)		(67,440,295	)
Total Stockholders' Equity		2,629,417			3,453,028
TOTAL LIABILITIES AND STOCKHOLDERS'  EQUITY	$	6,260,145		$	6,954,869

 See Notes to Condensed Consolidated Financial Statements 

2

SENESCO TECHNOLOGIES, INC. AND SUBSIDIARY

(A DEVELOPMENT STAGE COMPANY)

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS

(unaudited)

							Cumulative
	Three months ended September 30,						Amounts from
	2012			2011			Inception
Revenue	$	-		$	-		$	1,790,000
Operating expenses:
General and administrative		732,720			645,959			32,347,397
Research and development		513,433			634,186			21,749,038
Total operating expenses		1,246,153			1,280,145			54,096,435
Loss from operations		(1,246,153	)		(1,280,145	)		(52,306,435	)
Other non-operating income (expense)
Grant income		-			-			244,479
Fair value – warrant liability		(20,148	)		271,703			8,309,982
Sale of state income tax loss – net		-			-			586,442
Other noncash (expense) income, net		-			-			205,390
Loss on extinguishment of debt		(785,171	)		-			(1,147,048	)
Write-off of patents abandoned		-			-			(1,909,224	)
Amortization of debt discount and financing costs		-			-			(11,227,870	)
Interest expense – convertible notes		-			-			(2,027,930	)
Interest (expense) income - net		(33,982	)		(30,541	)		250,006
Net loss		(2,085,454	)		(1,038,983	)		(59,022,208	)
Preferred dividends		(624,169	)		(908,846	)		(11,127,710	)
Loss applicable to common shares	$	(2,709,623	)	$	(1,947,829	)	$	(70,149,918	)
Basic and diluted net loss per common share	$	(0.03	)	$	(0.02	)
Basic and diluted weighted-average number
of common shares outstanding		107,449,311			79,289,756

See Notes to Condensed Consolidated Financial Statements

3

SENESCO TECHNOLOGIES, INC. AND SUBSIDIARY

(A DEVELOPMENT STAGE COMPANY)

CONDENSED STATEMENT OF STOCKHOLDERS' EQUITY

FOR THE THREE MONTHS ENDED SEPTEMBER 30, 2012

(unaudited)

												Capital in Excess			Deficit Accumulated During the Development			Stockholders' Equity
	Preferred Stock						Common Stock					of Par Value			Stage			(Deficiency)
	Shares			Amount			Shares			Amount
Balance at June 30, 2012		4,579		$	46			94,112,483		$	941,125	$	69,952,152		$	(67,440,295	)	$	3,453,028
Issuance of common stock at $0.26 per share		-			-			353,895			3,539		97,031			-			100,570
Commissions and other fees related to the issuance of common stock		-			-			-			-		(6,387	)		-			(6,387	)
Preferred stock converted into common stock		(3,584	)		(36	)		13,784,615			137,846		(137,810	)		-			-
Issuance of common stock in lieu of cash payment for dividends		-			-			1,600,000			16,000		432,000			(333,526	)		114,474
Issuance of common stock in exchange for warrants		-			-			6,902,192			69,022		(69,022	)		-			-
Deemed dividend - preferred stock		-			-			-			-		240,891			(240,891	)		-
Loss on extinguishment of debt		-			-			-			-		785,171			-			785,171
Reclassification of warrant liability		-			-				-		-		164,205			-			164,205
Fair market value of options and warrants vested		-			-			-			-		153,562			-			153,562
Dividends accrued and upaid at September 30, 2012		-			-			-			-		-			(49,752	)		(49,752	)
Net loss		-			-			-			-		-			(2,085,454	)		(2,085,454	)
Balance July 1, 1998 (inception) through September 30, 2012		995		$	10			116,753,185		$	1,167,532	$	71,611,793		$	(70,149,918	)	$	2,629,417

See Notes to Condensed Consolidated Financial Statements

4

SENESCO TECHNOLOGIES, INC. AND SUBSIDIARY

(A DEVELOPMENT STAGE COMPANY)

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS

(unaudited)

	Three months ended September 30,						Cumulative Amounts from
	2012			2011			Inception
Cash flows from operating activities:
Net loss	$	(2,085,454	)	$	(1,038,983	)	$	(59,022,208	)
Adjustments to reconcile net loss to net cash used in
operating activities:
Noncash capital contribution		-			-			85,179
Noncash conversion of accrued expenses into equity		-			-			131,250
Noncash loss (income) related to change in fair value
of warrant liability		20,148			(271,703	)		(8,631,241	)
Noncash charge for change in warrant terms		-			-			115,869
Issuance of common stock and warrants for interest		-			-			2,003,386
Issuance of common stock for services		-			-			53,800
Stock-based compensation expense		153,562			123,551			12,259,515
Depreciation and amortization		63,572			57,319			1,163,877
Write-off of intangibles								1,909,224
Amortization of convertible note discount		-			-			10,000,000
Amortization of deferred financing costs		-			-			1,227,869
Loss on extinguishment of debt		785,171			-			1,147,048
(Increase) decrease in operating assets:
Prepaid expenses and other current assets		88,881			(378,455	)		(1,459,643	)
Security deposit		-			7,187			(5,171	)
Increase (decrease) in operating liabilities:
Accounts payable		337,653			389,565			932,167
Accrued expenses		13			21,281			430,235
Net cash used in operating activities		(636,454	)		(1,090,238	)		(37,658,844	)
Cash flows from investing activities:
Patent costs		(145,717	)		(128,839	)		(6,370,429	)
Purchase of equipment, furniture and fixtures		(1,281	)		-			(185,947	)
Net cash (used in) provided by investing activities		(146,998	)		(128,839	)		(6,556,376	)
Cash flows from financing activities:
Proceeds from grant		-			-			99,728
Proceeds from draw-down on line of credit		-			-			2,199,108
Proceeds from issuance of bridge notes		-			-			525,000
Proceeds from issuance of preferred stock and warrants, net		-			-			10,754,841
Redemption of convertible notes and warrants		-			-			(2,160,986	)
Proceeds from issuance of convertible notes		-			-			9,340,000
Deferred financing costs		-			-			(651,781	)
Proceeds from issuance of common stock and
warrants, net and exercise of warrants and options		94,183			451,097			25,421,366
Net cash provided by financing activities		94,183			451,097			45,527,276
Net (decrease) increase in cash and cash equivalents		(689,269	)		(767,980	)		1,312,056
Cash and cash equivalents at beginning of period		2,001,325			3,609,954			-
Cash and cash equivalents at end of period	$	1,312,056		$	2,841,974		$	1,312,056
Supplemental disclosure of non-cash transactions:
Conversion of convertible note into common stock	$	-		$	-		$	10,000,000
Conversion of bridge notes into common stock		-			-			534,316
Conversion of preferred stock into common stock		137,810			1,555			356,924
Allocation of preferred stock proceeds to warrants
and beneficial conversion feature		-			-			8,526,135
Allocation of convertible debt proceeds to warrants
and beneficial conversion feature		-			-			9,340,000
Warrants issued for financing costs		-			-			690,984
Issuance of common stock for interest payments on
convertible notes		-			-			2,003,386
Issuance of common stock for dividend payments on
preferred stock		448,000			10,848			4,069,943
Issuance of common stock in settlement of accounts payable		-			-			175,000
Dividends accrued on preferred stock		(64,722	)		119,998			49,752
Supplemental disclosure of cash flow information:
Cash paid for interest		34,990			33,310			406,673

See Notes to Condensed Consolidated Financial Statements 

5

SENESCO TECHNOLOGIES, INC. AND SUBSIDIARY

(A DEVELOPMENT STAGE COMPANY)

NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS
(unaudited)

Note 1 - Basis of Presentation:

The financial statements included herein have been prepared by Senesco Technologies, Inc. (the “Company”), without audit, pursuant to the rules and regulations of the Securities and Exchange Commission. Certain information and footnote disclosures normally included in financial statements prepared in accordance with United States generally accepted accounting principles have been condensed or omitted pursuant to such rules and regulations. These unaudited condensed consolidated financial statements should be read in conjunction with the audited consolidated financial statements and notes thereto included in the Company’s Annual Report on Form 10-K for the fiscal year ended June 30, 2012, as amended.

In the opinion of the Company’s management, the accompanying unaudited condensed consolidated financial statements contain all adjustments, consisting solely of those which are of a normal recurring nature, necessary to present fairly its financial position as of September 30, 2012, the results of its operations and cash flows for the three months ended September 30, 2012 and 2011.

Interim results are not necessarily indicative of results for the full fiscal year.

Note 2 – Liquidity:

As shown in the accompanying condensed consolidated financial statements, the Company has a history of losses with a deficit accumulated during the development stage from July 1, 1998 (inception) through September 30, 2012 of $70,149,918. Additionally, the Company has generated minimal revenues by licensing its technology for certain crops to companies willing to share in its development costs. In addition, the Company’s technology may not be ready for commercialization for several years. The Company expects to continue to incur losses for the next several years because it anticipates that its expenditures on research and development and administrative activities will significantly exceed its revenues during that period. The Company cannot predict when, if ever, it will become profitable.

As of September 30, 2012, the Company had cash and cash equivalents in the amount of $1,312,056, which consisted of checking accounts and money market funds. The Company estimates that its cash and cash equivalents as of September 30, 2012 will cover its expenses through December 2012. The Company has the ability to draw down on its unused line of credit and delay certain costs, if necessary, which will provide the Company with enough cash to fund its operations at least through March 31, 2013. In order to provide the Company with the cash resources necessary to fund operations through at least September 30, 2013, the Company plans on raising additional capital through a private or public placement of its Common Stock in the near future.

The Company will need additional capital and plans to raise additional capital through the placement of debt instruments or equity or both. However, the Company may not be able to obtain adequate funds for its operations when needed or on acceptable terms. If the Company is unable to raise additional funds, it will need to do one or more of the following:

6

· delay, scale-back or eliminate some or all of its research and product development programs;

· license third parties to develop and commercialize products or technologies that it would otherwise seek to develop and commercialize itself;

· seek strategic alliances or business combinations;

· attempt to sell the Company;

· cease operations; or

· declare bankruptcy.

Note 3 – Intangible Assets:

The Company conducts research and development activities, the cost of which is expensed as incurred, in order to generate patents that can be licensed to third parties in exchange for license fees and royalties. Because the patents are the basis of the Company’s future revenue, the patent costs are capitalized. The capitalized patent costs represent the outside legal fees incurred by the Company to submit and undertake all necessary efforts to have such patent applications issued as patents.

The length of time that it takes for an initial patent application to be approved is generally between four to six years. However, due to the unique nature of each patent application, the actual length of time may vary. If a patent application is denied, the associated cost of that application would be written off. However, the Company has not had any patent applications denied as of September 30, 2012. Additionally, should a patent application become impaired during the application process, the Company would write down or write off the associated cost of that patent application.

Issued patents and agricultural patent applications pending are being amortized over a period of 17 years from inception, the expected economic life of the patent.

The Company assesses the impairment in value of intangible assets whenever events or circumstances indicate that their carrying value may not be recoverable. Factors the Company considers important which could trigger an impairment review include the following:

• significant negative industry trends;

• significant underutilization of the assets;

• significant changes in how the Company uses the assets or its plans for their use; and

• changes in technology and the appearance of competing technology.

If a triggering event occurs and the Company's review determines that the future undiscounted cash flows related to the groups, including these assets, will not be sufficient to recover their carrying value, the Company will reduce the carrying values of these assets down to its estimate of fair value and continue amortizing them over their remaining useful lives. To date, except for certain patents and patents pending that the Company abandoned during the fiscal years ended June 30, 2012 and 2011, the Company has not recorded any impairment of intangible assets.

Note 4 - Loss Per Share:

Basic earnings (loss) per share is computed by dividing net income (loss) available to common shareholders by the weighted average number of common shares assumed to be outstanding during the period of computation. Diluted earnings per share is computed similar to basic earnings per share except that the denominator is increased to include the number of additional common shares that would have been outstanding if the potential common shares had been issued and if the additional common shares were dilutive.

7

For all periods presented, basic and diluted loss per share are the same, as any additional Common Stock equivalents would be anti-dilutive. Potentially dilutive shares of Common Stock have been excluded from the calculation of the weighted average number of dilutive common shares.

As of September 30, 2012, there were 59,571,479 additional potentially dilutive shares of Common Stock. These additional shares include 3,826,923 shares issuable upon conversion of the Preferred Stock, and 55,744,556 shares issuable upon the exercise of outstanding options and warrants. As of September 30, 2011, there were 88,806,984 additional potentially dilutive shares of Common Stock. These additional shares included 17,944,444 shares issuable upon conversion of Preferred Stock and 70,862,540 shares issuable upon the exercise of outstanding options and warrants.

Note 5 – Stock-Based Transactions:

The terms and vesting schedules for share-based awards vary by type of grant and the employment status of the grantee. Generally, the awards vest based upon time-based conditions or achievement of specified goals and milestones.

The fair value of each stock option and warrant granted or vesting has been determined using the Black-Scholes model. The material factors incorporated in the Black-Scholes model in estimating the value of the options and warrants granted during the three months ended September 30, 2012 and 2011 include the following:

	Three Months Ended
	September 30,
	2012		2011
Warrants granted		None		None
Options granted		None		4,213,000
Estimated life in years  (1)		None		3.0-10.0
Risk-free interest rate (2)		None		1.0%-1.9%
Volatility		None		102-105%
Dividend paid		None		None

(1) Expected life for employee based stock options was estimated using the “simplified” method, as allowed under the provisions of the Securities and Exchange Commission Staff Accounting Bulletin No.110.

(2) Represents the interest rate on a U.S. Treasury security with a maturity date corresponding to that of the option or warrant term.

The economic values of the options will depend on the future price of the Company's Common Stock, which cannot be forecast with reasonable accuracy.

8

Stock option activity under the Company’s 2008 Plan and 1998 Plan for the three months ended September 30, 2012 is summarized as follows:

	Number of Options		Weighted-Average Exercise Price
Outstanding at July 1, 2012		15,647,742	$	0.50
Granted		--		--
Exercised		--		--
Expired		--		--
Outstanding at September 30, 2012		15,647,742	$	0.50
Exercisable at September 30, 2012		11,777,429	$	0.57
Not Exercisable at September 30, 2012		3,870,313	$	0.28

There were no options granted during the three months ended September 30, 2012. The weighted average grant date fair value of options granted during the three months ended September 30, 2011 was $0.18.

As of September 30, 2012, the aggregate intrinsic value of stock options outstanding was $6,473, with a weighted-average remaining term of 7.3 years. The aggregate intrinsic value of stock options exercisable at that same date was $6,473, with a weighted-average remaining term of 6.7 years. As of September 30, 2012, the Company has 11,588,876 shares available for future stock option grants.

Stock-based compensation expense for the three months ended September 30, 2012 and 2011 amounted to $153,391 and $123,551, respectively.

As of September 30, 2012, total stock-based compensation expense not yet recognized related to stock option grants amounted to approximately $864,000, which will be recognized over the next 36 months.

Note 6 –Line of Credit:

On February 17, 2010, the Company entered into a credit agreement with JMP Securities LLC. The agreement provides the Company with, subject to certain restrictions, including the existence of suitable collateral, up to a $3.0 million line of credit upon which the Company may draw at any time (the “Line of Credit”). Any draws upon the Line of Credit accrue at an annual interest rate of (i) the broker rate in effect at the interest date (which was 3.75% at September 30, 2012), plus (ii) 2.0%. There are no other conditions or fees associated with the Line of Credit. The Line of Credit is not secured by any assets of the Company, but it is secured by certain assets of a member of the Company’s Board of Directors, Harlan W. Waksal, M.D., which is currently held by JMP Securities. The balance outstanding as of September 30, 2012 and June 30, 2012 was $2,199,108. In April 2011, we were required to enter into a new demand note with the clearing agent for JMP Securities in connection with the Line of Credit.

Total interest expense recorded under the Line of Credit for the three months ended September 30, 2012 and 2011 amounted to $34,990 and $33,310, respectively.

Note 7 – Income Taxes:

No provision for income taxes has been made for the three months ended September 30, 2012 and 2011 given the Company’s losses in 2012 and 2011 and available net operating loss carryforwards. A benefit has not been recorded as the realization of the net operating losses is not assured and the timing in which the Company can utilize its net operating loss carryforwards in any year or in total may be limited by provisions of the Internal Revenue Code regarding changes in ownership of corporations.

9

Note 8 - Fair Value Measurements:

The following tables provide the assets and liabilities carried at fair value measured on a recurring basis as of September 30, 2012 and June 30, 2012:

			Fair Value Measurement at
	Carrying		September 30, 2012
	Value		Level 1		Level 2		Level 3
Assets:
Cash and cash equivalents	$	1,312,056	$	1,312,056	$	-	$	-
Liabilities:
Warrant Liabilities	$	94,739	$	-	$	-	$	94,739

			Fair Value Measurement at
	Carrying		June 30, 2012
	Value		Level 1		Level 2		Level 3
Assets:
Cash and cash equivalents	$	2,001,325	$	2,001,325	$	-	$	-
Liabilities:
Warrant Liabilities	$	238,796	$	-	$	-	$	238,796

The following table summarizes the changes in fair value of the Company’s Level 3 financial instruments:

	Three months ended September 30,
	2012			2011
Beginning Balance	$	238,796		$	711,259
Reclassification of warrant liabilities		(164,205	)		-
Loss (gain) due to change in fair value of warrant liabilities, net		20,148			(271,703	)
Ending Balance	$	94,739		$	439,556

Note 9 – Warrant Liabilities:

The warrant liabilities represent the fair value of Common Stock purchase warrants, which have exercise price reset features and cash settlement features.

The fair value of the warrants that have exercise price reset features is estimated using an adjusted Black-Scholes model. The Company computes valuations, each quarter, using the Black-Scholes model for such warrants to account for the various possibilities that could occur due to changes in the inputs to the Black-Scholes model as a result of contractually-obligated changes. The Company effectively weights each calculation based on the likelihood of occurrence to determine the value of the derivative at the reporting date. The Company has an unobservable input for the estimation of the likelihood of a reset occurring, which was estimated to be 75% made up of various reset amounts with probabilities ranging between 10% and 25% per occurrence. These estimates of the likelihood of completing an equity raise that would meet the criteria to trigger the reset provisions are based on numerous factors, including the remaining term of the financial instruments and the Company’s overall financial condition.

10

The fair value of the warrants that have cash settlement features is estimated using a probability –weighted Black-Scholes model. The unobservable input used by the Company on certain warrants was the estimation of the likelihood of a fundamental transaction, as defined in the related agreements, which was estimated to be 15% at September 30, 2012.

Changes in the unobservable input values would likely cause material changes in the fair value of the Company’s Level 3 financial instruments. The significant unobservable input used in the fair value measurement is the estimation of the likelihood of the occurrence of a change to the strike price of the warrants or the occurrence of a fundamental transaction. A significant increase (decrease) in the this likelihood would result in a higher (lower) fair value measurement.

During the three months ended September 30, 2012, the Company issued 3,390,625 shares of common stock in exchange for 9,687,500 warrants that were included in the computation of warrant liabilities. In connection with this exchange, the Company compared the value of the common stock issued with the Black-Scholes value of the warrants exchanged. The difference in these values resulted in a loss on the extinguishment of debt in the amount of $785,171. Additionally, the value of the warrants on the date of the exchange, in the amount of $164,205, were reclassified from warrant liabilities to additional paid in capital.

At ended September 30, 2012 and 2011, the Company revalued all of the remaining warrant liabilities, using the adjusted Black-Scholes and Black-Scholes models. A (loss) gain on the change in fair value of the warrant liabilities in the amount of $(20,148)and $271,703 was recorded in the Condensed Consolidated Statement of Operations for the three months ended September 30, 2012 and 2011, respectively.

At September 30, 2012 and 2011, there were an aggregate of 11,620,314 and 21,307,814 warrants included in the fair value of the warrant liabilities, which are valued at $94,739 and $439,556, respectively.

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The assumptions used to value the warrants were as follows:

	September 30, 2012		June 30, 2012
Warrants issued on December 20, 2007
Estimated life in years		0.25		0.50
Risk-free interest rate (1)		0.09%		0.15%
Volatility		72%		75%
Dividend paid		None		None
Range of estimated strike prices		$0.32-$0.35		$0.33-$0.36
Range of estimated probabilities		10% - 50%		10% - 50%
Warrants issued on June 30, 2008
Estimated life in years		0.75		1.00
Risk-free interest rate (1)		0.15%		0.21%
Volatility		72%		75%
Dividend paid		None		None
Range of estimated strike prices		$0.32-$0.35		$0.33-$0.36
Range of estimated probabilities		10% - 50%		10% - 50%
Warrants issued on April 1, 2010
Estimated life in years		2.5		2.75
Risk-free interest rate (1)		0.30%		0.39%
Volatility		75%		78%
Dividend paid		None		None
Estimated probability of a fundamental transaction		15%		15%

(1) Represents the interest rate on a U.S. Treasury security with a maturity date corresponding to that of the warrant term.

Note 10- At Market Issuance Sales Agreement

On December 22, 2010, the Company entered into an At Market Issuance Sales Agreement (the “ATM”) under which the Company, from time to time, was able to issue and sell shares of its Common Stock, par value $0.01 per share, with an aggregate offering price of up to $5,500,000.

During the three months ended September 30, 2012, the Company issued 353,895 shares of Common Stock under the ATM for gross proceeds in the amount of $100,570. From the inception of the ATM through September 30, 2012, the Company has issued 8,099,909 shares of Common Stock under the ATM for gross proceeds in the amount of $2,463,661.

As the Company expects that it will no longer be listed on the NYSE MKT exchange, the Company will no longer be able to issue and sell shares of its Common Stock under the ATM after the Company is delisted.

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Note 11 –Preferred Stock

During the three months ended September 30, 2012, 3,584 shares of Preferred Stock were converted into 13,784,615 shares of Common Stock. During the three months ended September 30, 2012, the Company issued an additional 1,600,000 shares of Common Stock for the payment of dividends in the amount of $448,000. Total dividends payable on the outstanding 995 shares of Preferred Stock at September 30, 2012 amounted to $49,752.

On August 8, 2012, the Company completed an exchange (the “Exchange”) of certain five-year warrants issued by the Company in 2010 (the “Warrants”) to purchase 17,262,500 shares of Common Stock (the “Warrant Shares”) for 6,902,192 shares of Common Stock, and 2,384 shares of the Company’s 10% Series A Convertible Preferred Stock, par value $0.01 per share (the “Series A Preferred Stock”) were converted into 9,169,231 shares of Common Stock, pursuant to warrant exchange agreements (the “Warrant Exchange Agreements”) by and between the Company and certain holders of the Warrants (the “Warrant Holders”). Following the Exchange, Warrants to purchase 19,745,313 Warrant Shares and 995 shares of Series A Preferred Stock remain outstanding.

Pursuant to the terms of the Warrant Exchange Agreements, the Company and each Warrant Holder agreed to exchange the Warrant held by such Warrant Holder for a number of shares of Common Stock equal to the product of (i) the number of Warrant Shares underlying the Warrant, multiplied by (ii) 0.35; provided, that if such Warrant Holder also owned shares of the Company’s Series A Preferred Stock, such Warrant Holder additionally converted such shares of Series A Preferred Stock into the number of shares of Common Stock as determined pursuant to the terms set forth in the Certificate of Designation of Preferences, Rights and Limitations of 10% Series A Convertible Preferred Stock and the Company exchanged the Warrant held by such Warrant Holder for a number of shares of Common Stock equal to the product of (i) the number of Warrant Shares underlying the Warrant, multiplied by (ii) 0.45.

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Additionally, certain members of the Company’s board of directors that owned shares of the Company’s 10% Series B Convertible Preferred Stock, par value $0.01 per share (the “Series B Preferred Stock”), agreed to convert 1,200 shares of Series B Preferred Stock into 4,615,385 shares of Common Stock, as determined pursuant to the terms set forth in the Certificate of Designation of Preferences, Rights and Limitations of 10% Series B Convertible Preferred Stock. Such conversions were not made pursuant to Warrant Exchange Agreements and therefore such directors did not receive any additional Common Stock. Following this conversion, no shares of Series B Preferred Stock remain outstanding.

In connection with the warrant exchange, a beneficial dividend in the amount of $240,891 was recorded on the conversion of the Convertible Preferred Stock.

Note 12 – Recent Accounting Pronouncements

In July 2012, the Financial Accounting Standards Board (“FASB”) issued Accounting Standards Update (“ASU”) No. 2012-02, “Intangibles-Goodwill and Other (Topic 350): Testing Indefinite-Lived Intangible Assets for Impairment” (“ASU 2012-02”).  This ASU states that an entity has the option first to assess qualitative factors to determine whether the existence of events and circumstances indicates that it is more likely than not that the indefinite-lived intangible asset is impaired. If, after assessing the totality of events and circumstances, an entity concludes that it is not more likely than not that the indefinite-lived intangible asset is impaired, then the entity is not required to take further action. However, if an entity concludes otherwise, then it is required to determine the fair value of the indefinite-lived intangible asset and perform the quantitative impairment test by comparing the fair value with the carrying amount in accordance with Codification Subtopic 350-30, Intangibles-Goodwill and Other, General Intangibles Other than Goodwill. Under the guidance in this ASU, an entity also has the option to bypass the qualitative assessment for any indefinite-lived intangible asset in any period and proceed directly to performing the quantitative impairment test. An entity will be able to resume performing the qualitative assessment in any subsequent period. The amendments in this ASU are effective for annual and interim impairment tests performed for fiscal years beginning after September 15, 2012. Early adoption is permitted, including for annual and interim impairment tests performed as of a date before July 27, 2012, if a public entity’s financial statements for the most recent annual or interim period have not yet been issued or, for nonpublic entities, have not yet been made available for issuance. The Company is evaluating the impact of this ASU and does not expect its adoption to have a significant impact on the Company’s consolidated financial statements.

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In June 2011, the FASB issued FASB ASU No. 2011-05, Comprehensive Income (Topic 220): Presentation of Comprehensive Income in U.S. GAAP and IFRS. This ASU provides companies the option to present the components of net income and other comprehensive income either as one continuous statement of comprehensive income or as two separate but consecutive statements. It eliminates the option to present components of other comprehensive income as part of the statement of changes in stockholders’ equity. The provisions of this new guidance are effective for fiscal years, and interim periods within those years, beginning after December 15, 2011. We adopted this disclosure standard in the first quarter of fiscal 2013 and it did not have a material impact on our results of operations.

Other recent accounting pronouncements issued by the FASB (including its Emerging Issues Task Force) and the SEC did not or are not believed by management to have a material impact on our present or future financial statements.

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Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations.

The following discussion and analysis should be read in conjunction with our condensed consolidated financial statements and the related notes thereto included in this Quarterly Report on Form 10-Q. The discussion and analysis may contain forward-looking statements that are based upon current expectations and entail various risks and uncertainties. Our actual results and the timing of events could differ materially from those anticipated in the forward-looking statements as a result of various factors, including those set forth under “Risk Factors” and elsewhere in this report.

Overview

Our Business

The primary business of Senesco Technologies, Inc., a Delaware corporation incorporated in 1999, and its wholly-owned subsidiary, Senesco, Inc., a New Jersey corporation incorporated in 1998, collectively referred to as “Senesco,” “we,” “us” or “our,” is to utilize our patented and patent-pending technology related to certain genes, primarily eukaryotic translation initiation Factor 5A, or Factor 5A, and deoxyhypusine synthase, or DHS, and related technologies for human therapeutic applications to develop novel approaches to treat cancer and inflammatory diseases.

For agricultural applications, we have licensed applications of the Factor 5A, DHS and Lipase platforms to enhance the quality, productivity and stress resistance of fruits, flowers, vegetables, agronomic and biofuel feedstock crops through the control of cell death, referred to herein as senescence, and growth in plants.

Human Therapeutic Applications

We believe that our Factor 5A gene regulatory technology could have broad applicability in the human therapeutic field, by either inducing or inhibiting programmed cell death, also known as apoptosis, which is the natural process the human body goes through in order to eliminate redundant or defective cells. Inducing apoptosis is useful in treating cancer where the defective cancer cells have failed to respond to the body’s natural apoptotic signals. Conversely, inhibiting apoptosis may be useful in preventing, ameliorating or treating an exaggerated, acute immune response in a wide range of inflammatory and ischemic diseases attributable to or aggravated by premature apoptosis.

SNS01-T for Multiple Myeloma

We have developed a therapeutic candidate, SNS01-T, an improved formulation of SNS01, for the potential treatment of multiple myeloma and non-Hodgkin B-cell lymplomas. SNS01-T utilizes our Factor 5A technology and comprises two active components: a DNA plasmid, or pDNA, expressing human eIF5A containing a lysine to arginine substitution at amino acid position 50, or eIF5AK50R, and a small inhibitory RNA, or siRNA. These two components are combined in a fixed ratio with a polymer, polyethyleneimine, or PEI, which enables self-assembly of the DNA and RNA into nanoparticles with demonstrated enhanced delivery to tissues and protection from degradation in the blood stream. Under the control of a B cell selective promoter, SNS01-T’s DNA plasmid up-regulates the apoptotic pathways within cancer cells by preferentially expressing the stable arginine form of the Factor 5A death message in target cells. The siRNA, by silencing the eIF5A gene, reduces expression of the hypusine form of Factor 5A that supports cell survival and proliferation. The silencing of the eIF5A gene by an eIF5A siRNA also down-regulates anti-apoptotic proteins, such as NFkB, ICAM and pro-inflammatory cytokines, which protect malignant cells from apoptosis and promote cell growth in multiple myeloma. The PEI, a cationic polymer, promotes auto-assembly of a nanoparticle with the other two components for intravenous delivery and protects the combination from degradation in the bloodstream until it is taken up by the tumor cell, where the siRNA and DNA plasmid are released.

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We have performed efficacy, toxicological and dose-finding studies in vitro in non-human and human cells and in vivo in mice with SNS01. Our efficacy studies in severe combined immune-deficient, or SCID, mice with subcutaneous human multiple myeloma tumors tested SNS01 dose ranging from 0.15 mg/kg to 1.5 mg/kg. In these studies, mice treated with a dose of either 0.75 mg/kg or 1.5 mg/kg both showed, compared to relevant controls, a 91% reduction in tumor volume and a decrease in tumor weight of 87% and 95%, respectively. For mice that received smaller doses of either 0.38 mg/kg or 0.15 mg/kg, there was also a reduction in tumor volume of 73% and 61%, respectively, and weight of 74% and 36%, respectively. All SNS01 treated mice survived. This therapeutic dose range study provided the basis for a non-good laboratory practices, or GLP, 8-day maximum tolerated dose study in which normal mice received two intravenous doses of increasing amounts of SNS01 (from 2.2 mg/kg). Body weight, organ weight and serum levels of liver enzymes were used as clinical indices to assess toxicity. A dose between 2.2 mg/kg and 2.9 mg/kg was well tolerated with respect to these clinical indices, and the survival rate at 2.9 mg/kg was 80%. Mice receiving above 2.9 mg/kg of SNS01 showed evidence of morbidity and up to 80% mortality. The 2.9 mg/kg threshold was therefore determined to be the maximum tolerated dose in mice in this study. We have also completed our pivotal GLP toxicology studies in mice and dogs, employing SNS01-T, an improved formulation of SNS01, and have an open investigational new drug application, or IND, with the United States Food and Drug Administration, or FDA. We have also been granted orphan drug status for SNS01-T by the FDA for the potential treatment of multiple myeloma, mantle cell lymphoma and diffuse large B-cell lymphoma.

We are conducting a Phase 1b/2a clinical study with SNS01-T in multiple myeloma, diffuse large B cell lymphoma (DLBCL) and mantle cell lymphoma (MCL) patients. The clinical study is an open-label, multiple-dose, dose-escalation study, which is evaluating the safety and tolerability of SNS01-T when administered by intravenous infusion to relapsed or refractory multiple myeloma patients. The study design calls for four cohorts of three to six patients each. Patients in each cohort will receive twice-weekly dosing for six weeks followed by up to a four-week safety data review period before escalating to a higher dose level in the next cohort. While the primary objective of the initial study is to evaluate safety and tolerability, the effect of SNS01-T on tumor response will also be evaluated using multiple, well-established criteria including measurement of the monoclonal protein, or M-protein. We have selected Mayo Clinic, University of Arkansas for Medical Sciences and the Randolph Cancer Center at West Virginia University as our clinical sites. The study is open and we have completed our first cohort. The results of the first cohort showed that SNS01-T was safe and well tolerated and met the criteria for Stable Disease in 2 of the 3 evaluable patients. We are now treating patients in the second cohort.

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We have demonstrated in human multiple myeloma cell lines that there may be an additional benefit to combining SNS01-T with other approved myeloma drugs, such as bortezomib and lenalidomide. We have shown, in vitro, that these drugs are up to forty (40) times more effective in inhibiting cell growth when used in combination with SNS01-T. These results further reinforce the significance of our target and will guide us in designing future clinical studies. We have demonstrated that a high level of tumor eradication in a mouse model of human multiple myeloma was achieved with a combination of SNS01-T and lenalidomide. While SNS01-T alone performed well by completely eliminating tumors in 40% of the animals, complete tumor eradication was achieved in five out of six or 83% of the treated animals that received SNS01-T combined with the optimal study dose of lenalidomide. This effect lasted throughout 6 weeks of observation after the end of treatment. Neither dose of lenalidomide used alone eliminated tumors in any of the treated mice. Most recently, we have demonstrated the benefits of combining SNS01-T with bortezomib. In a mouse model of human multiple myeloma, SNS01-T as a monotherapy achieved 59% tumor growth inhibition, which exceeded that of bortezomib alone at either the 0.2 mg/kg dose (22% inhibition) or at the 0.5 mg/kg dose (39% inhibition). However, the combination of SNS01-T with 0.5 mg/kg of bortezomib resulted in 89% tumor inhibition, which was significantly more effective than either SNS01-T or bortezomib alone.

SNS01-T for other B-cell cancers

We have demonstrated in mice that we can inhibit the growth of both human mantle cell and diffuse large B-cell lymphoma in a dose-dependent manner.

We have also demonstrated that the combination of lenalidomide and SNS01-T performs better than either treatment alone in mouse xenograft models of human mantle cell lymphoma. When SCID mice, implanted with an aggressive human mantle cell lymphoma cell line (JVM2), were treated with either 15 mg/kg lenalidomide (5 times weekly by intra-peritoneal injection) or 0.375 mg/kg SNS01-T (twice weekly by intravenous injection) there was a growth delay of 4 days and 14 days, respectively. Mice treated with a combination of both drugs using the same dose levels and dosing regimens exhibited a tumor growth delay of 27 days (p value = 0.0008).

The median survival of mice treated with control nanoparticles was 21 days. Mice treated with lenalidomide or SNS01-T had a median survival of 28 days (33 % increase) and 37 days (76 % increase), respectively. Mice treated with the drug combination had a median survival of 52 days, an increase in survival of 148 %. Survival analysis using the Kaplan-Meier method revealed that treatment of mice with the drug combination resulted in statistically significant increases in survival compared to both SNS01-T (p value = 0.002) and lenalidomide (p value = 0.007) alone. We believe that the results of these studies not only support moving forward in multiple myeloma, but also support extending our clinical evaluation of SNS01-T in other B-cell cancers.

We may consider other human diseases in order to determine the role of Factor 5A and SNS01-T.

We may further expand our research and development program beyond the initiatives listed above to include other diseases and research centers.

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Agricultural Applications

Our agricultural research focuses on the discovery and development of certain gene technologies, which are designed to confer positive traits on fruits, flowers, vegetables, forestry species and agronomic crops.

We have licensed this technology to various strategic partners. We may continue to license this technology, as opportunities present themselves, to additional strategic partners and/or enter into joint collaborations or ventures.

Our ongoing research and development initiatives for agriculture include assisting our license partners to:

· further develop and implement the DHS and Factor 5A gene technology in banana, canola, cotton, turfgrass, rice, alfalfa, corn, soybean and trees; and

· test the resultant crops for new beneficial traits such as increased yield, increased tolerance to environmental stress, disease resistance and more efficient use of fertilizer.

Agricultural Development and License Agreements

As of September 30, 2012, we have nine (9) active license agreements with established agricultural biotechnology companies.

Intellectual Property

We have twenty-seven (27) issued patents from the United States Patent and Trademark Office, or PTO, and sixty-six (66) issued patents from foreign countries. Of our ninety-three (93) domestic and foreign issued patents, fifty-six (56) are for the use of our technology in agricultural applications and thirty-seven (37) relate to human therapeutics applications.

In addition to our ninety-three (93) patents, we have a wide variety of patent applications, including divisional applications and continuations-in-part, in process with the PTO and internationally. We intend to continue our strategy of enhancing these new patent applications through the addition of data as it is collected.

Our agricultural patents are generally set to expire in 2019 in the United States and 2025 outside the United States. Our core human therapeutic technology patents are set to expire in 2021 in the United States and 2025 outside the United States, and our patents related to multiple myeloma are set to expire, both in and outside the United States in 2029.

During our 2012 and 2011 fiscal years, we reviewed our patent portfolio in order to determine if we could reduce our cost of patent prosecution and maintenance. We identified several patents and patents pending that we believe we no longer need to maintain without having a material impact on the portfolio. We determined that we would no longer incur the cost to prosecute or maintain those patents or patents pending.

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Liquidity and Capital Resources

Overview

For the three months ended September 30, 2012, net cash of $636,454 was used in operating activities primarily due to a net loss of $2,085,454, which was reduced by non-cash expenses, of $1,022,453. Cash used in operating activities was also reduced by changes in operating assets and liabilities in the amount of $426,547.

The $426,547 change in operating assets and liabilities was primarily the result of a decrease in prepaid expenses in the amount of $88,881 and an increase in accounts payable and accrued expenses in the amount of $337,666.

During the three months ended September 30, 2012, cash used for investing activities amounted to $146,998, which was primarily related to patent costs incurred.

Cash provided by financing activities during the three months ended September 30, 2012 amounted to $94,183 related to the placement of common stock through our $5,500,000 ATM facility.

As of September 30, 2012, our cash balance totaled $1,312,056, and we had working capital deficit of $664,562.

We expect our capital requirements to increase significantly over the next several years as we commence new research and development efforts, increase our business and administrative infrastructure and embark on developing in-house business capabilities and facilities. Our future liquidity and capital funding requirements will depend on numerous factors, including, but not limited to, the levels and costs of our research and development initiatives and the cost and timing of the expansion of our business development and administrative staff.

We anticipate that, based upon our cash balance as of September 30, 2012, we will be able to fund our operations through December 31, 2012. However, we have the ability to utilize our unused line of credit and, if necessary, delay certain costs. Over such period, we plan to fund our research and development and commercialization activities by:

· utilizing our current cash balance and investments;

· the placement of additional equity or debt instruments;

· achieving some of the milestones set forth in our current licensing agreements; and

· the possible execution of additional licensing agreements for our technology.

We cannot assure you that we will be able to raise money through any of the foregoing transactions on favorable terms, if at all.

Changes to Critical Accounting Policies and Estimates

There have been no changes to our critical accounting policies and estimates as set forth in our Annual Report on Form 10-K for the fiscal year ended June 30, 2012, as amended.

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Results of Operations

Three Months Ended September 30, 2012 andThree Months Ended September 30, 2011

The net loss for the three months ended September 30, 2012 was $2,085,454. The net loss for the three months ended September 30, 2011 was $1,038,983. Such a change represents an increase in net loss of $1,046,471, or 100.7%. This increase in net loss was the result of an increase in non-operating expenses and general and administrative expenses, which was partially offset by a decrease in research and development costs.

Revenue

There was no revenue during the three months ended September 30, 2012 and September 30, 2011.

We anticipate that we will receive future milestone payments in connection with our current agricultural development and license agreements. Additionally, we may receive future royalty payments from our license agreements when our partners commercialize their crops containing our technology. However, it is difficult for us to determine our future revenue expectations because our future milestone payments are primarily contingent on our partners successful implementation of their development plan, we have no history of receiving royalties and the timing and outcome of our experiments, the timing of signing new partner agreements and the timing of our partners moving through the development process into commercialization is difficult to accurately predict.

General and Administrative Expenses

	Three Months Ended September 30,
	2012		2011		Change			%
	(in thousands, except % values)
Payroll and benefits	$	141	$	137	$	4			2.9	%
Investor relations		40		46		(6	)		(13.0	)%
Professional fees		194		138		56			40.6	%
Director fees		64		50		14			28.0	%
Depreciation and amortization		64		57		7			12.3	%
Other general and administrative		101		102		(1)			(1.0	)%
Stock-based compensation		604 129		530 116		74 13			14.0 11.2	% %
Total general and administrative	$	733	$	646	$	87			13.5	%

· Payroll and benefits for the three months ended September 30, 2012 was higher than for the three months ended September 30, 2011, primarily as a result of salary increases.

· Investor relations fees for the three months ended September 30, 2012 was lower than for the three months ended September 30, 2011, primarily as a result of a reduction in investor relations consulting costs

· Professional fees for the three months ended September 30, 2012 was higher than for the three months ended September 30, 2011, primarily as a result of an increase in legal fees. Legal fees increased primarily due to fees incurred in connection with the exploration of additional technologies and financing options during the three months ended September 30, 2012 which were not incurred during the three months ended September 30, 2011.

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· Director fees for the three months ended September 30, 2012 was higher than for the three months ended September 30, 2011, primarily as a result of more meetings being held during the three months ended September 30, 2012.

· Depreciation and amortization for the three months ended September 30, 2012 was higher than for the three months ended September 30, 2011, primarily as a result of an increase in amortization of patent costs.

· Other general and administrative expenses for the three months ended September 30, 2012 was lower than for the three months ended September 30, 2011, primarily due to a decrease in office supplies and franchise taxes, which was partially offset by an increase in consulting and travel costs.

· Stock-based compensation for the three months ended September 30, 2012 was higher than for the three months ended September 30, 2011, primarily due to the Black-Scholes value on a greater number of options vesting during the three months ended September 30, 2012.

We expect cash-based general and administrative expenses to remain relatively unchanged over the next twelve months.

Research and Development Expenses

	Three Months Ended September 30,
	2012		2011		Change			%
	(in thousands, except % values)
Payroll	$	42	$	40	$	2			5.0	%
Research contract with the University of Waterloo		144		152		(8	)		(5.3	)%
Other research and development		302		434		(132	)		(30.4	)%
Stock-based compensation		488 25		626 8		(138 17	)		(22.0 212.5	)% %
Total research and development	$	513	$	634	$	(121	)		(27.9	)%

· Payroll for the three months ended September 30, 2012 was higher than for the three months ended September 30, 2011, primarily as a result of salary increases.

· The cost associated with the research contract with the University of Waterloo for the three months ended September 30, 2012 was lower than for the three months ended September 30 2011, primarily due to a reduction in amount being funded for agricultural research.

· Other research and development costs for the three months ended September 30, 2012 was lower than for the three months ended September 30, 2011, primarily due to a decrease in the costs in connection with agricultural research programs and formulation studies, which was partially offset by an increase in costs associated with the development of SNS01-T for multiple myeloma.

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· Stock-based compensation for the three months ended September 30, 2012 was higher than for the three months ended September 30, 2011, primarily due to the Black-Scholes value on a greater number of options vesting during the three months ended September 30, 2012.

The breakdown of our research and development expenses between our agricultural and human therapeutic research programs is as follows:

	Three Months Ended September 30,
	2012		%			2011		%
	(in thousands, except % values)
Agricultural	$	24		5	%	$	112		18	%
Human therapeutic		489		95	%		522		82	%
Total research and development	$	513		100	%	$	634		100	%

· Agricultural research expenses for the three months ended September 30, 2012 was lower than for the three months ended September 30, 2011, primarily due to a reduction in the funding for agricultural research at the University of Waterloo and the amendment to the Rahan Meristem agreement for the development of bananas. Effective January 1, 2012, we amended the agreement whereby we no longer incur costs related to such development.

· Human therapeutic research expenses for the three months ended September 30, 2012 was lower than for the three months ended September 30, 2011, primarily as a result of the timing of certain aspects of the development of our drug candidate, SNS01-T, for treating multiple myeloma. Specifically, during the three months ended September 30, 2011, we incurred costs related to the formulation of SNS01-T, which we did not incur during the three months ended September 30, 2012.

We expect our human therapeutic research program to increase as a percentage of the total research and development expenses as we continue our current research projects and begin new human therapeutic initiatives, in particular as they relate to the clinical development of our drug candidate, SNS01-T, for treating multiple myeloma and other cancers.

Other non-operating income and expense

Fair value – warrant liability

The amounts represent the change in the fair value of the warrant liability for the three months ended September 30, 2012 and 2011.

Off Balance-Sheet Arrangements

We do not have any off balance-sheet arrangements.

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Item 3. Quantitative and Qualitative Disclosures about Market Risk.

Foreign Currency Risk

Our financial statements are denominated in United States dollars and, except for our agreement with the University of Waterloo, which is denominated in Canadian dollars, all of our contracts are denominated in United States dollars. Therefore, we believe that fluctuations in foreign currency exchange rates will not result in any material adverse effect on our financial condition or results of operations. In the event we derive a greater portion of our revenues from international operations or in the event a greater portion of our expenses are incurred internationally and denominated in a foreign currency, then changes in foreign currency exchange rates could affect our results of operations and financial condition.

Interest Rate Risk

We invest in high-quality financial instruments, primarily money market funds, with an effective duration of the portfolio of less than one year, which we believe are subject to limited credit risk. We currently do not hedge our interest rate exposure. Due to the short-term nature of our investments, we do not believe that we have any material exposure to interest rate risk arising from our investments.

Item 4. Controls and Procedures.

(a) Evaluation of disclosure controls and procedures.

The principal executive officer and principal financial officer have evaluated our disclosure controls and procedures (as defined in Rules 13a-15(e) and 15d-15(e) under the Securities Exchange Act of 1934) as of September 30, 2012. Based on this evaluation, they have concluded that our disclosure controls and procedures were effective to ensure that the information required to be disclosed by us in reports that we file or submit under the Securities Exchange Act of 1934 is recorded, processed, summarized and reported within the time periods specified in the Securities and Exchange Commission’s rules and forms, and to ensure that information required to be disclosed by us in the reports that we file or submit under the Securities Exchange Act of 1934 is accumulated and communicated to our management, including our principal executive and principal financial officers, to allow timely decisions regarding required disclosure.

(b) Changes in internal controls.

No change in our internal controls over financial reporting (as defined in Rules 13a-15(f) and 15d-15(f) under the Securities Exchange Act of 1934) occurred during the three month period ended September 30, 2012 that has materially affected, or is reasonably likely to materially affect, our internal controls over financial reporting.

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PART II. OTHER INFORMATION.

Item 1. Legal Proceedings.

None

Item 1A. Risk Factors.

The more prominent risks and uncertainties inherent in our business are described below. However, additional risks and uncertainties may also impair our business operations. If any of the following risks actually occur, our business, financial condition or results of operations may suffer.

Risks Related to Our Business

Recurring losses and negative cash flows from operations raise substantial doubt about our ability to continue as a going concern and we may not be able to continue as a going concern.

Our recurring losses from operations and negative cash flows from operations raise substantial doubt about our ability to continue as a going concern and as a result, our independent registered public accounting firm included an explanatory paragraph in its report on our consolidated financial statements for the fiscal year ended June 30, 2012 and our unaudited consolidated financial statements for the fiscal quarter ended September 30, 2012 with respect to this uncertainty. Substantial doubt about our ability to continue as a going concern may create negative reactions to the price of the common shares of our stock and we may have a more difficult time obtaining financing.

We have prepared our financial statements on a going concern basis, which contemplates the realization of assets and the satisfaction of liabilities and commitments in the normal course of business. The financial statements do not include any adjustments relating to the recoverability and classification of recorded asset amounts or amounts of liabilities that might be necessary should we be unable to continue in existence.

We have a limited operating history and have incurred substantial losses and expect to incur future losses.

We are a development stage biotechnology company with a limited operating history and limited assets and capital. We have incurred losses each year since inception and had an accumulated deficit of $70,149,918 at September 30, 2012. We have generated minimal revenues by licensing our technology for certain crops to companies willing to share in our development costs. In addition, our technology may not be ready for commercialization for several years. We expect to continue to incur losses for the next several years because we anticipate that our expenditures on research and development and administrative activities will significantly exceed our revenues during that period. We cannot predict when, if ever, we will become profitable.

We will need additional capital to fund our operations until we are able to generate a profit.

Our operations to date have required significant cash expenditures. Our future capital requirements will depend on the results of our research and development activities, preclinical and clinical studies, and competitive and technological advances.

We will need to obtain more funding in the future through collaborations or other arrangements with research institutions and corporate partners, or public and private offerings of our securities, including debt or equity financing. We may not be able to obtain adequate funds for our operations from these sources when needed or on acceptable terms. Future collaborations or similar arrangements may require us to license valuable intellectual property to, or to share substantial economic benefits with, our collaborators. If we raise additional capital by issuing additional equity or securities convertible into equity, our stockholders may experience dilution and our share price may decline. Any debt financing may result in restrictions on our spending.

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If we are unable to raise additional funds, we will need to do one or more of the following:

· delay, scale-back or eliminate some or all of our research and product development programs;

· provide licenses to third parties to develop and commercialize products or technologies that we would otherwise seek to develop and commercialize ourselves;

· seek strategic alliances or business combinations;

· attempt to sell our company;

· cease operations; or

· declare bankruptcy.

We believe that at the projected rate of spending we should have sufficient cash to maintain our present operations through December 2012. However, we have the ability to utilize our unused line of credit and, if necessary, delay certain costs which would provide us with sufficient cash to maintain our present operations through March 2013.

We may be adversely affected by the current economic environment.

Our ability to obtain financing, invest in and grow our business, and meet our financial obligations depends on our operating and financial performance, which in turn is subject to numerous factors. In addition to factors specific to our business, prevailing economic conditions and financial, business and other factors beyond our control can also affect our business and ability to raise capital. We cannot anticipate all of the ways in which the current economic climate and financial market conditions could adversely impact our business.

Materials necessary to manufacture some of our compounds currently under development may not be available on commercially reasonable terms, or at all, which may delay our development and commercialization of these compounds.

Some of the materials necessary for the manufacture of our compounds under development may, from time to time, be available either in limited quantities, or from a limited number of manufacturers, or both. Our contract manufacturers need to obtain these materials for our clinical trials and, potentially, for commercial distribution when and if we obtain marketing approval for these compounds. Suppliers may not sell us these materials at the time we need them or on commercially reasonable terms. If we are unable to obtain the materials needed to conduct our clinical trials, product testing and potential regulatory approval could be delayed, adversely affecting our ability to develop the product candidates. Similarly, if we are unable to obtain critical manufacturing materials after regulatory approval has been obtained for a product candidate, the commercial launch of that product candidate could be delayed or there could be a shortage in supply, which could materially affect our ability to generate revenues from that product candidate. If suppliers increase the price of manufacturing materials, the price for one or more of our products may increase, which may make our products less competitive in the marketplace. If it becomes necessary to change suppliers for any of these materials or if any of our suppliers experience a shutdown or disruption at the facilities used to produce these materials, due to technical, regulatory or other reasons, it could harm our ability to manufacture our products.

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We depend on a single principal technology and, if our technology is not commercially successful, we will have no alternative source of revenue.

Our primary business is the development and licensing of technology to identify, isolate, characterize and promote or silence genes which control the death of cells in humans and plants. Our future revenue and profitability critically depend upon our ability, or our licensees’ ability, to successfully develop apoptosis and senescence gene technology and later license or market such technology. We have conducted experiments on certain crops with favorable results and have conducted certain preliminary cell-line and animal experiments, which have provided us with data upon which we have designed additional research programs. However, we cannot give any assurance that our technology will be commercially successful or economically viable for any crops or human therapeutic applications.

In addition, no assurance can be given that adverse consequences might not result from the use of our technology such as the development of negative effects on humans or plants or reduced benefits in terms of crop yield or protection. Our failure to obtain market acceptance of our technology or the failure of our current or potential licensees to successfully commercialize such technology would have a material adverse effect on our business.

We outsource all of our research and development activities and, if we are unsuccessful in maintaining our alliances with these third parties, our research and development efforts may be delayed or curtailed.

We rely on third parties to perform all of our research and development activities. Our research and development efforts take place at the University of Waterloo in Ontario, Canada, where our technology was discovered, at other commercial research facilities and with our commercial partners. At this time, we do not have the internal capabilities to perform our own research and development activities. Accordingly, the failure of third party research partners to perform under agreements entered into with us, or our failure to renew important research agreements with these third parties, may delay or curtail our research and development efforts.

We have significant future capital needs and may be unable to raise capital when needed, which could force us to delay or reduce our research and development efforts.

As of September 30, 2012, we had a cash balance of $1,312,056 and a working capital deficit of $664,562. Using our available reserves as of September 30, 2012, we believe that we can operate according to our current business plan through December 2012. However, we have the ability to utilize our unused line of credit and, if necessary, delay certain costs, which would provide us with sufficient cash to maintain our present operations through March 2013.

To date, we have generated minimal revenues and anticipate that our operating costs will exceed any revenues generated over the next several years. Therefore, we will be required to raise additional capital in the future in order to operate in accordance with our current business plan, and this funding may not be available on favorable terms, if at all. If we are unable to raise additional funds, we will need to do one or more of the following:

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· delay, scale back or eliminate some or all of our research and development programs;

· provide a license to third parties to develop and commercialize our technology that we would otherwise seek to develop and commercialize ourselves;

· seek strategic alliances or business combinations;

· attempt to sell our company;

· cease operations; or

· declare bankruptcy.

In addition, in connection with any funding, if we need to issue more equity securities than our certificate of incorporation currently authorizes, or more than 20% of the shares of our common stock outstanding, we may need stockholder approval. If stockholder approval is not obtained or if adequate funds are not available, we may be required to curtail operations significantly or to obtain funds through arrangements with collaborative partners or others that may require us to relinquish rights to certain of our technologies, product candidates, products or potential markets. Investors may experience dilution in their investment from future offerings of our common stock. For example, if we raise additional capital by issuing equity securities, such an issuance would reduce the percentage ownership of existing stockholders. In addition, assuming the exercise of all options and warrants outstanding and the conversion of the preferred stock into common stock, as of September 30, 2012, we had 154,447,092 shares of common stock authorized but unissued and unreserved, which may be issued from time to time by our board of directors. Furthermore, we may need to issue securities that have rights, preferences and privileges senior to our common stock. Failure to obtain financing on acceptable terms would have a material adverse effect on our liquidity.

Since our inception, we have financed all of our operations through equity and debt financings. Our future capital requirements depend on numerous factors, including:

· the scope of our research and development;

· our ability to attract business partners willing to share in our development costs;

· our ability to successfully commercialize our technology;

· competing technological and market developments;

· our ability to enter into collaborative arrangements for the development, regulatory approval and commercialization of other products; and

· the cost of filing, prosecuting, defending and enforcing patent claims and other intellectual property rights.

Our business depends upon our patents and proprietary rights and the enforcement of these rights. Our failure to obtain and maintain patent protection may increase competition and reduce demand for our technology.

As a result of the substantial length of time and expense associated with developing products and bringing them to the marketplace in the biotechnology and agricultural industries, obtaining and maintaining patent and trade secret protection for technologies, products and processes is of vital importance. Our success will depend in part on several factors, including, without limitation:

· our ability to obtain patent protection for our technologies and processes;

· our ability to preserve our trade secrets; and

· our ability to operate without infringing the proprietary rights of other parties both in the United States and in foreign countries.

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As of September 30, 2012, we have been issued twenty-seven (27) patents by the PTO and sixty-six (66) patents from foreign countries. We have also filed numerous patent applications for our technology in the United States and in several foreign countries, which technology is vital to our primary business, as well as several continuations in part on these patent applications. Our success depends in part upon the grant of patents from our pending patent applications.

Although we believe that our technology is unique and that it will not violate or infringe upon the proprietary rights of any third party, we cannot assure you that these claims will not be made or if made, could be successfully defended against. If we do not obtain and maintain patent protection, we may face increased competition in the United States and internationally, which would have a material adverse effect on our business.

Since patent applications in the United States are maintained in secrecy until patents are issued, and since publication of discoveries in the scientific and patent literature tend to lag behind actual discoveries by several months, we cannot be certain that we were the first creator of the inventions covered by our pending patent applications or that we were the first to file patent applications for these inventions.

In addition, among other things, we cannot assure you that:

· our patent applications will result in the issuance of patents;

· any patents issued or licensed to us will be free from challenge and if challenged, would be held to be valid;

· any patents issued or licensed to us will provide commercially significant protection for our technology, products and processes;

· other companies will not independently develop substantially equivalent proprietary information which is not covered by our patent rights;

· other companies will not obtain access to our know-how;

· other companies will not be granted patents that may prevent the commercialization of our technology; or

· we will not incur licensing fees and the payment of significant other fees or royalties to third parties for the use of their intellectual property in order to enable us to conduct our business.

Our competitors may allege that we are infringing upon their intellectual property rights, forcing us to incur substantial costs and expenses in resulting litigation, the outcome of which would be uncertain.

Patent law is still evolving relative to the scope and enforceability of claims in the fields in which we operate. We are like most biotechnology companies in that our patent protection is highly uncertain and involves complex legal and technical questions for which legal principles are not yet firmly established. In addition, if issued, our patents may not contain claims sufficiently broad to protect us against third parties with similar technologies or products, or provide us with any competitive advantage.

The PTO and the courts have not established a consistent policy regarding the breadth of claims allowed in biotechnology patents. The allowance of broader claims may increase the incidence and cost of patent interference proceedings and the risk of infringement litigation. On the other hand, the allowance of narrower claims may limit the scope and value of our proprietary rights.

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The laws of some foreign countries do not protect proprietary rights to the same extent as the laws of the United States, and many companies have encountered significant problems and costs in protecting their proprietary rights in these foreign countries.

We could become involved in infringement actions to enforce and/or protect our patents. Regardless of the outcome, patent litigation is expensive and time consuming and would distract our management from other activities. Some of our competitors may be able to sustain the costs of complex patent litigation more effectively than we could because they have substantially greater resources. Uncertainties resulting from the initiation and continuation of any patent litigation could limit our ability to continue our operations.

If our technology infringes the intellectual property of our competitors or other third parties, we may be required to pay license fees or damages.

The current patent landscape surrounding siRNA technology is unclear due to the recent proliferation of siRNA-related patent litigation and grants of third-party patents encompassing this technology. If any relevant claims of third party patents that are adverse to us are upheld as valid and enforceable, we could be prevented from commercializing our technology or could be required to obtain licenses from the owners of such patents. We cannot assure you that such licenses would be available or, if available, would be on acceptable terms. Some licenses may be non-exclusive and, therefore, our competitors may have access to the same technology licensed to us. In addition, if any parties successfully claim that the creation or use of our technology infringes upon their intellectual property rights, we may be forced to pay damages, including treble damages.

Our security measures may not adequately protect our unpatented technology and, if we are unable to protect the confidentiality of our proprietary information and know-how, the value of our technology may be adversely affected.

Our success depends upon know-how, unpatentable trade secrets, and the skills, knowledge and experience of our scientific and technical personnel. As a result, all employees agreed to a confidentiality provision in their employment agreement that prohibited the disclosure of confidential information to anyone outside of our company, during the term of employment and for five (5) years thereafter. The employment agreements have since been terminated, but the period of confidentiality is still in effect. We also require all employees to disclose and assign to us the rights to their ideas, developments, discoveries and inventions. We also attempt to enter into similar agreements with our consultants, advisors and research collaborators. We cannot assure you that adequate protection for our trade secrets, know-how or other proprietary information against unauthorized use or disclosure will be available.

We occasionally provide information to research collaborators in academic institutions and request that the collaborators conduct certain tests. We cannot assure you that the academic institutions will not assert intellectual property rights in the results of the tests conducted by the research collaborators, or that the academic institutions will grant licenses under such intellectual property rights to us on acceptable terms, if at all. If the assertion of intellectual property rights by an academic institution is substantiated, and the academic institution does not grant intellectual property rights to us, these events could limit our ability to commercialize our technology.

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As we evolve from a company primarily involved in the research and development of our technology into one that is also involved in the commercialization of our technology, we may have difficulty managing our growth and expanding our operations.

As our business grows, we may need to add employees and enhance our management, systems and procedures. We may need to successfully integrate our internal operations with the operations of our marketing partners, manufacturers, distributors and suppliers to produce and market commercially viable products. We may also need to manage additional relationships with various collaborative partners, suppliers and other organizations. Although we do not presently conduct research and development activities in-house, we may undertake those activities in the future. Expanding our business may place a significant burden on our management and operations. We may not be able to implement improvements to our management information and control systems in an efficient and timely manner and we may discover deficiencies in our existing systems and controls. Our failure to effectively respond to such changes may make it difficult for us to manage our growth and expand our operations.

We have no marketing or sales history and depend on third party marketing partners. Any failure of these parties to perform would delay or limit our commercialization efforts.

We have no history of marketing, distributing or selling biotechnology products, and we are relying on our ability to successfully establish marketing partners or other arrangements with third parties to market, distribute and sell a commercially viable product both here and abroad. Our business plan envisions creating strategic alliances to access needed commercialization and marketing expertise. We may not be able to attract qualified sub-licensees, distributors or marketing partners, and even if qualified, these marketing partners may not be able to successfully market agricultural products or human therapeutic applications developed with our technology. If our current or potential future marketing partners fail to provide adequate levels of sales, our commercialization efforts will be delayed or limited and we may not be able to generate revenue.

We will depend on joint ventures and strategic alliances to develop and market our technology and, if these arrangements are not successful, our technology may not be developed and the expenses to commercialize our technology will increase.

In its current state of development, our technology is not ready to be marketed to consumers. We intend to follow a multi-faceted commercialization strategy that involves the licensing of our technology to business partners for the purpose of further technological development, marketing and distribution. We have and are seeking business partners who will share the burden of our development costs while our technology is still being developed, and who will pay us royalties when they market and distribute products incorporating our technology upon commercialization. The establishment of joint ventures and strategic alliances may create future competitors, especially in certain regions abroad where we do not pursue patent protection. If we fail to establish beneficial business partners and strategic alliances, our growth will suffer and the continued development of our technology may be harmed.

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Competition in the human therapeutic and agricultural biotechnology industries is intense and technology is changing rapidly. If our competitors market their technology faster than we do, we may not be able to generate revenues from the commercialization of our technology.

Many human therapeutic and agricultural biotechnology companies are engaged in research and development activities relating to apoptosis and senescence. The market for plant protection and yield enhancement products is intensely competitive, rapidly changing and undergoing consolidation. We may be unable to compete successfully against our current and future competitors, which may result in price reductions, reduced margins and the inability to achieve market acceptance for products containing our technology. Our competitors in the field of plant senescence gene technology are companies that develop and produce transgenic plants and include major international agricultural companies, specialized biotechnology companies, research and academic institutions and, potentially, our joint venture and strategic alliance partners. These companies include: Mendel Biotechnology, Inc.; Ceres, Inc., Archer Daniels Midland and Syngenta International AG; among others. Some of our competitors that are involved in apoptosis research include: Celgene, Inc.; Takeda/Millennium; ONYX Pharmaceuticals, Inc.; Amgen Inc.; Janssen Biotech, Inc.; Novartis AG; andPharmacyclics, Inc. Many of these competitors have substantially greater financial, marketing, sales, distribution and technical resources than us and have more experience in research and development, clinical trials, regulatory matters, manufacturing and marketing. We anticipate increased competition in the future as new companies enter the market and new technologies become available. Our technology may be rendered obsolete or uneconomical by technological advances or entirely different approaches developed by one or more of our competitors, which will prevent or limit our ability to generate revenues from the commercialization of our technology.

Our business is subject to various government regulations and, if we or our licensees are unable to obtain regulatory approval, we may not be able to continue our operations.

At present, the U.S. federal government regulation of biotechnology is divided among three agencies:

· the United States Department of Agriculture, or USDA, regulates the import, field testing and interstate movement of specific types of genetic engineering that may be used in the creation of transgenic plants;

· the United States Environmental Protection Agency, or EPA, regulates activity related to the invention of plant pesticides and herbicides, which may include certain kinds of transgenic plants; and

· the FDA regulates foods derived from new plant varieties.

The FDA requires that transgenic plants meet the same standards for safety that are required for all other plants and foods in general. Except in the case of additives that significantly alter a food’s structure, the FDA does not require any additional standards or specific approval for genetically engineered foods, but expects transgenic plant developers to consult the FDA before introducing a new food into the marketplace.

Use of our technology, if developed for human therapeutic applications, is also subject to FDA regulation. The FDA must approve any drug or biologic product before it can be marketed in the United States. In addition, prior to being sold outside of the United States, any products resulting from the application of our human therapeutic technology must be approved by the regulatory agencies of foreign governments. Prior to filing a new drug application or biologics license application with the FDA, we would have to perform extensive clinical trials, and prior to beginning any clinical trial, we would need to perform extensive preclinical testing which could take several years and may require substantial expenditures.

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We believe that our current agricultural activities, which to date have been confined to research and development efforts, do not require licensing or approval by any governmental regulatory agency. However, we are performing clinical trials in connection with our human therapeutic applications, which is subject to FDA approval. Additionally, federal, state and foreign regulations relating to crop protection products and human therapeutic applications developed through biotechnology are subject to public concerns and political circumstances, and, as a result, regulations have changed and may change substantially in the future. Accordingly, we may become subject to governmental regulations or approvals or become subject to licensing requirements in connection with our research and development efforts. We may also be required to obtain such licensing or approval from the governmental regulatory agencies described above, or from state agencies, prior to the commercialization of our genetically transformed plants and human therapeutic technology. In addition, our marketing partners who utilize our technology or sell products grown with our technology may be subject to government regulations. If unfavorable governmental regulations are imposed on our technology or if we fail to obtain licenses or approvals in a timely manner, we may not be able to continue our operations.

Preclinical studies of our human therapeutic applications may be unsuccessful, which could delay or prevent regulatory approval.

Preclinical studies may reveal that our human therapeutic technology is ineffective or harmful, and/or may be unsuccessful in demonstrating efficacy and safety of our human therapeutic technology, which would significantly limit the possibility of obtaining regulatory approval for any drug or biologic product manufactured with our technology. The FDA requires submission of extensive preclinical, clinical and manufacturing data to assess the efficacy and safety of potential products. Any delay in receiving approval for any applicable IND from the FDA would result in a delay in the commencement of the related clinical trial. Additionally, we could be required to perform additional preclinical studies prior to the FDA approving any applicable IND. Furthermore, the success of preliminary studies does not ensure commercial success, and later-stage clinical trials may fail to confirm the results of the preliminary studies.

Our success will depend on the success of our clinical trials of our human therapeutic applications.

It may take several years to complete the clinical trials of a product, and failure of one or more of our clinical trials can occur at any stage of testing. We believe that the development of our product candidate involves significant risks at each stage of testing. If clinical trial difficulties and failures arise, our product candidate may never be approved for sale or become commercially viable.

There are a number of difficulties and risks associated with clinical trials. These difficulties and risks may result in the failure to receive regulatory approval to sell our product candidate or the inability to commercialize our product candidate. The possibility exists that:

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· we may discover that the product candidate does not exhibit the expected therapeutic results in humans, may cause harmful side effects or have other unexpected characteristics that may delay or preclude regulatory approval or limit commercial use if approved;

· the results from early clinical trials may not be statistically significant or predictive of results that will be obtained from expanded advanced clinical trials;

· institutional review boards or regulators, including the FDA, may hold, suspend or terminate our clinical research or the clinical trials of our product candidate for various reasons, including noncompliance with regulatory requirements or if, in their opinion, the participating subjects are being exposed to unacceptable health risks;

· subjects may drop out of our clinical trials;

· our preclinical studies or clinical trials may produce negative, inconsistent or inconclusive results, and we may decide, or regulators may require us, to conduct additional preclinical studies or clinical trials; and

· the cost of our clinical trials may be greater than we currently anticipate.

Clinical trials for our human therapeutic technology will be lengthy and expensive and their outcome is uncertain.

Before obtaining regulatory approval for the commercial sales of any product containing our technology, we must demonstrate through clinical testing that our technology and any product containing our technology is safe and effective for use in humans. Conducting clinical trials is a time-consuming, expensive and uncertain process and typically requires years to complete. In our industry, the results from preclinical studies and early clinical trials often are not predictive of results obtained in later-stage clinical trials. Some products and technologies that have shown promising results in preclinical studies or early clinical trials subsequently fail to establish sufficient safety and efficacy data necessary to obtain regulatory approval. At any time during clinical trials, we or the FDA might delay or halt any clinical trial for various reasons, including:

· occurrence of unacceptable toxicities or side effects;

· ineffectiveness of the product candidate;

· negative or inconclusive results from the clinical trials, or results that necessitate additional studies or clinical trials;

· delays in obtaining or maintaining required approvals from institutions, review boards or other reviewing entities at clinical sites;

· delays in patient enrollment; or

· insufficient funding or a reprioritization of financial or other resources.

Any failure or substantial delay in successfully completing clinical trials and obtaining regulatory approval for our product candidates could severely harm our business.

If our clinical trials for our product candidates are delayed, we would be unable to commercialize our product candidates on a timely basis, which would materially harm our business.

Planned clinical trials may not begin on time or may need to be restructured after they have begun. Clinical trials can be delayed for a variety of reasons, including delays related to:

· obtaining an effective IND or regulatory approval to commence a clinical trial;

· negotiating acceptable clinical trial agreement terms with prospective trial sites;

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· obtaining institutional review board approval to conduct a clinical trial at a prospective site;

· recruiting qualified subjects to participate in clinical trials;

· competition in recruiting clinical investigators;

· shortage or lack of availability of supplies of drugs for clinical trials;

· the need to repeat clinical trials as a result of inconclusive results or poorly executed testing;

· the placement of a clinical hold on a study;

· the failure of third parties conducting and overseeing the operations of our clinical trials to perform their contractual or regulatory obligations in a timely fashion; and

· exposure of clinical trial subjects to unexpected and unacceptable health risks or noncompliance with regulatory requirements, which may result in suspension of the trial

We believe that our product candidate has significant milestones to reach, including the successful completion of clinical trials, before commercialization. If we have significant delays in or termination of clinical trials, our financial results and the commercial prospects for our product candidates or any other products that we may develop will be adversely impacted. In addition, our product development costs would increase and our ability to generate revenue could be impaired.

Any inability to license from third parties their proprietary technologies or processes which we use in connection with the development of our technology may impair our business.

Other companies, universities and research institutions have or may obtain patents that could limit our ability to use our technology in a product candidate or impair our competitive position. As a result, we would have to obtain licenses from other parties before we could continue using our technology in a product candidate. Any necessary licenses may not be available on commercially acceptable terms, if at all. If we do not obtain required licenses, we may not be able to develop our technology into a product candidate or we may encounter significant delays in development while we redesign methods that are found to infringe on the patents held by others.

Even if we receive regulatory approval, consumers may not accept products containing our technology, which will prevent us from being profitable since we have no other source of revenue.

We cannot guarantee that consumers will accept products containing our technology. Recently, there has been consumer concern and consumer advocate activism with respect to genetically-engineered agricultural consumer products. The adverse consequences from heightened consumer concern in this regard could affect the markets for agricultural products developed with our technology and could also result in increased government regulation in response to that concern. If the public or potential customers perceive our technology to be genetic modification or genetic engineering, agricultural products grown with our technology may not gain market acceptance.

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We face potential product liability exposure far in excess of our limited insurance coverage.

We may be held liable if any product we or our collaborators develop causes injury or is found otherwise unsuitable during product testing, manufacturing, marketing or sale. Regardless of merit or eventual outcome, product liability claims could result in decreased demand for our product candidates, injury to our reputation, withdrawal of patients from our clinical trials, substantial monetary awards to trial participants and the inability to commercialize any products that we may develop. These claims might be made directly by consumers, health care providers, pharmaceutical companies or others selling or testing our products. We have obtained limited product liability insurance coverage for our clinical trials; however, our insurance may not reimburse us or may not be sufficient to reimburse us for expenses or losses we may suffer. Moreover, if insurance coverage becomes more expensive, we may not be able to maintain insurance coverage at a reasonable cost or in sufficient amounts to protect us against losses due to liability. If we obtain marketing approval for any of our product candidates, we intend to expand our insurance coverage to include the sale of commercial products, but we may be unable to obtain commercially reasonable product liability insurance for any products approved for marketing. On occasion, juries have awarded large judgments in class action lawsuits for claims based on drugs that had unanticipated side effects. In addition, the pharmaceutical and biotechnology industries, in general, have been subject to significant medical malpractice litigation. A successful product liability claim or series of claims brought against us could harm our reputation and business and would decrease our cash reserves.

We depend on our key personnel and, if we are not able to attract and retain qualified scientific and business personnel, we may not be able to grow our business or develop and commercialize our technology.

We are highly dependent on our scientific advisors, consultants and third-party research partners. Our success will also depend in part on the continued service of our key employees and our ability to identify, hire and retain additional qualified personnel in an intensely competitive market. Although we have a research agreement with Dr. John Thompson, this agreement may be terminated upon short or no notice. Additionally, we do not have employment agreements with our key employees. We do not maintain key person life insurance on any member of management. The failure to attract and retain key personnel could limit our growth and hinder our research and development efforts.

Certain provisions of our charter, by-laws, Delaware law and stock plans could make a takeover difficult.

Certain provisions of our certificate of incorporation and by-laws could make it more difficult for a third party to acquire control of us, even if the change in control would be beneficial to stockholders. Our certificate of incorporation authorizes our board of directors to issue, without stockholder approval, 5,000,000 shares of preferred stock with voting, conversion and other rights and preferences that could adversely affect the voting power or other rights of the holders of our common stock.

In addition, we are subject to the Business Combination Act of the Delaware General Corporation Law which, subject to certain exceptions, restricts certain transactions and business combinations between a corporation and a stockholder owning 15% or more of the corporation’s outstanding voting stock for a period of three years from the date such stockholder becomes a 15% owner. These provisions may have the effect of delaying or preventing a change of control of us without action by our stockholders and, therefore, could adversely affect the value of our common stock.

Furthermore, in the event of our merger or consolidation with or into another corporation, or the sale of all or substantially all of our assets in which the successor corporation does not assume our outstanding equity awards or issue equivalent equity awards, our current equity plans require the accelerated vesting of such outstanding equity awards.

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Risks Related to Our Common Stock

We no longer meet the NYSE MKT continued listing standards and therefore we expect to be delisted from the NYSE MKT. We may not be able to list on any other stock exchange in the future.

The NYSE MKT requires companies listed on its exchange to meet minimum financial requirements in order to maintain our listing. While we were listed on the NYSE MKT, we received a notice of noncompliance from the NYSE MKT on October 20, 2011 that we did not meet the $6,000,000 minimum net worth continued listing requirement of the NYSE MKT. We submitted a plan of compliance on November 17, 2011 to the NYSE MKT discussing how we intended to regain compliance with the continued listing requirements. The NYSE MKT accepted our plan and granted us an extension until July 20, 2012 to regain compliance with the NYSE MKT’s continued listing standards. On July 20, 2012, we were still not in compliance with the NYSE MKT’s continued listing standards and we requested an extension of time to regain compliance. On August 22, 2012, we received a notice from NYSE Regulation, Inc. on behalf of NYSE MKT providing notification that NYSE MKT has determined not to grant us an extension of time to cure the non-compliance and that, therefore, the NYSE MKT intended to file a delisting application with the Securities and Exchange Commission striking our common stock from the NYSE MKT. We requested an appeal of the NYSE MKT’s determination and we were granted a hearing with a committee of NYSE MKT in accordance with our rights as set forth in Sections 1203 and 1009(d) of the NYSE MKT Company Guide. The appeal hearing was held on October 24, 2012 and the NYSE MKT granted us an extension through November 5, 2012, which was subsequently extended through November 12, 2012 due to the effects of Hurricane Sandy, within which to regain compliance. As a result of our inability to regain compliance during the extension period, we expect to be delisted from the NYSE MKT and our common stock will be considered a “penny stock” following such delisting.

We intend to make every possible effort to have our common stock quoted on the Over the Counter Bulletin Board, or the OTC Bulletin Board, or an equivalent quotation system. If our common stock was to be quoted on the OTC Bulletin Board, the Securities Exchange Act of 1934, as amended, and related SEC rules would impose additional sales practice requirements on broker-dealers that sell our securities. These rules may adversely affect the ability of stockholders to sell our common stock and otherwise negatively affect the liquidity, trading market and price of our common stock.

We believe that the listing of our common stock on a recognized national trading market, such as the NYSE MKT, is an important part of our business and strategy and we intend to pursue such a listing again in the future. Such a listing would help our stockholders by providing a readily available trading market with current quotations. Without that, stockholders may have a difficult time getting a quote for the sale or purchase of our stock, the sale or purchase of our stock would likely be made more difficult and the trading volume and liquidity of our stock would likely decline. Further, we are not able to file shelf registration statements. The absence of such a listing may adversely affect the acceptance of our common stock as currency or the value accorded it by other parties. In that regard, the absence of a listing on a recognized national trading market also affects our ability to benefit from the use of our operations and expansion plans, including for use in licensing agreements, joint ventures, the development of strategic relationships and acquisitions, which are critical to our business and strategy and none of which is currently the subject of any agreement, arrangement or understanding, with respect to any future financing or strategic relationship we may undertake.

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Penny stock regulations may impose certain restrictions on marketability of our securities.

The SEC has adopted regulations which generally define a “penny stock” to be any equity security that has a market price of less than $5.00 per share or an exercise price of less than $5.00 per share, subject to certain exceptions. As a result, our common stock is subject to rules that impose additional sales practice requirements on broker dealers who sell such securities to persons other than established customers and accredited investors (generally those with assets in excess of $1,000,000 or annual income exceeding $200,000, or $300,000 together with their spouse). For transactions covered by such rules, the broker dealer must make a special suitability determination for the purchase of such securities and have received the purchaser’s written consent to the transaction prior to the purchase. Additionally, for any transaction involving a penny stock, unless exempt, the rules require the delivery, prior to the transaction, of a risk disclosure document mandated by the SEC relating to the penny stock market. The broker dealer must also disclose the commission payable to both the broker dealer and the registered representative, current quotations for the securities and, if the broker dealer is the sole market maker, the broker dealer must disclose this fact and the broker dealer’s presumed control over the market.

Finally, monthly statements must be sent disclosing recent price information for the penny stock held in the account and information on the limited market in penny stocks. Broker-dealers must wait two business days after providing buyers with disclosure materials regarding a security before effecting a transaction in such security. Consequently, the “penny stock” rules restrict the ability of broker dealers to sell our securities and affect the ability of investors to sell our securities in the secondary market and the price at which such purchasers can sell any such securities, thereby affecting the liquidity of the market for our common stock.

Stockholders should be aware that, according to the SEC, the market for penny stocks has suffered in recent years from patterns of fraud and abuse. Such patterns include:

· control of the market for the security by one or more broker-dealers that are often related to the promoter or issuer;

· manipulation of prices through prearranged matching of purchases and sales and false and misleading press releases;

· “boiler room” practices involving high pressure sales tactics and unrealistic price projections by inexperienced sales persons;

· excessive and undisclosed bid-ask differentials and markups by selling broker-dealers; and

· the wholesale dumping of the same securities by promoters and broker-dealers after prices have been manipulated to a desired level, along with the inevitable collapse of those prices with consequent investor losses.

Our management is aware of the abuses that have occurred historically in the penny stock market.

38

Our management and other affiliates have significant control of our common stock and could significantly influence our actions in a manner that conflicts with our interests and the interests of other stockholders.

As of September 30, 2012, our executive officers and directors together beneficially own approximately 28% of the outstanding shares of our common stock, assuming the conversion of preferred stock and exercise of options and warrants which are currently exercisable or will become exercisable within 60 days of September 30, 2012, held by these stockholders. As a result, these stockholders, acting together, will be able to exercise significant influence over matters requiring approval by our stockholders, including the election of directors, and may not always act in the best interests of other stockholders. Such a concentration of ownership may have the effect of delaying or preventing a change in control of us, including transactions in which our stockholders might otherwise receive a premium for their shares over then-current market prices.

A significant portion of our total outstanding shares of common stock may be sold in the market in the near future, which could cause the market price of our common stock to drop significantly.

As of September 30 2012, we had 116,753,185 shares of our common stock issued and outstanding and 995 shares of convertible preferred stock outstanding which can convert into 3,826,923 shares of common stock. Approximately 34,164,431 of such shares are registered pursuant to registration statements on Form S-3 and 86,415,677 of which are either eligible to be sold under SEC Rule 144 or are in the public float. In addition, we have registered 35,890,007 shares of our common stock underlying warrants previously issued on Form S-3 registration statements and we registered 25,215,260 shares of our common stock underlying options granted or to be granted under our stock option plan. Consequently, sales of substantial amounts of our common stock in the public market, or the perception that such sales could occur, may have a material adverse effect on our stock price.

Our common stock has a limited trading market, which could limit your ability to resell your shares of common stock at or above your purchase price.

Our common stock is currently listed on the NYSE MKT, however we expect to be delisted from the NYSE MKT and we intend to apply for quotation on an over-the-counter securities market, and our common stock currently has a limited trading market. We cannot assure you that an active trading market will develop or, if developed, will be maintained. As a result, our stockholders may find it difficult to dispose of shares of our common stock and, as a result, may suffer a loss of all or a substantial portion of their investment.

The market price of our common stock may fluctuate and may drop below the price you paid.

We cannot assure you that you will be able to resell the shares of our common stock at or above your purchase price. The market price of our common stock may fluctuate significantly in response to a number of factors, some of which are beyond our control. These factors include:

· quarterly variations in operating results;

· the progress or perceived progress of our research and development efforts;

· changes in accounting treatments or principles;

· announcements by us or our competitors of new technology, product and service offerings, significant contracts, acquisitions or strategic relationships;

· additions or departures of key personnel;

· future offerings or resales of our common stock or other securities;

· stock market price and volume fluctuations of publicly-traded companies in general and development companies in particular; and

· general political, economic and market conditions.

39

For example, during the quarter ended September 30, 2012, our common stock traded between $0.17 and $0.32 per share.

Because we do not intend to pay, and have not paid, any cash dividends on our shares of common stock, our stockholders will not be able to receive a return on their shares unless the value of our common stock appreciates and they sell their shares.

We have never paid or declared any cash dividends on our common stock, and we intend to retain any future earnings to finance the development and expansion of our business. We do not anticipate paying any cash dividends on our common stock in the foreseeable future. Therefore, our stockholders will not be able to receive a return on their investment unless the value of our common stock appreciates and they sell their shares.

Our stockholders may experience substantial dilution as a result of the conversion of convertible preferred stock, the exercise of options and warrants to purchase our common stock, or due to anti-dilution provisions relating to any on the foregoing.

As of September 30, 2012, we have outstanding 995 shares of convertible preferred stock which may convert into 3,826,923 shares of our common stock and warrants to purchase 40,096,814 shares of our common stock.  In addition, as of September 30, 2012, we have reserved 25,215,260 shares of our common stock for issuance upon the exercise of options granted or available to be granted pursuant to our stock option plan, all of which may be granted in the future.  Furthermore, in connection with the preferred stock agreements, we are required to reserve an additional 7,204,930 shares of common stock. The conversion of the convertible preferred stock and the exercise of these options and warrants will result in dilution to our existing stockholders and could have a material adverse effect on our stock price. The conversion price of the convertible preferred stock and certain warrants are also subject to certain anti-dilution adjustments.

40

Item 2. Unregistered Sales of Equity Securities and Use of Proceeds.

              None

Item 3. Defaults Upon Senior Securities.

              None

Item 4. Mine Safety Disclosures.

              None

Item 5. Other Information.

              None

Item 6. Exhibits.

Exhibits.

Exhibit No.	Description
10.1	Form of Warrant Exchange Agreement (Incorporated by reference to Exhibit 10.1 of Senesco Technologies, Inc. current report on Form 8-K filed on August 10, 2012.)
31.1	Certification of principal executive officer pursuant to Section 302 of the Sarbanes-Oxley Act of 2002. (filed herewith).
31.2	Certification of principal financial and accounting officer pursuant to Section 302 of the Sarbanes-Oxley Act of 2002. (filed herewith).
32.1	Certification of principal executive officer pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, 18 U.S.C. 1350. (furnished herewith).
32.2	Certification of principal financial and accounting officer pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, 18 U.S.C. 1350. (furnished herewith).
101.1	Financial Statements from the Quarterly Report on Form 10-Q of Senesco Technologies, Inc. for the quarter ended September 30, 2012, filed on November 14, 2012, formatted in XBRL: (i) the Condensed Consolidated Balance Sheets; (ii) the Condensed Consolidated Statements of Operations; (iii) the Condensed Consolidated Statements of Stockholder’s Equity; (iv) the Condensed Consolidated Statements of Cash Flows and (v) the Notes to Condensed Consolidated Financial Statements. (filed herewith).

41

SIGNATURES

In accordance with the requirements of the Securities Exchange Act of 1934, the registrant caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

	SENESCO TECHNOLOGIES, INC.
DATE: November 14, 2012	By:	/s/ Leslie J. Browne
		Leslie J. Browne, Ph.D., President and Chief Executive Officer (Principal Executive Officer)

DATE: November 14, 2012	By:	/s/ Joel Brooks
		Joel Brooks, Chief Financial Officer, Secretary and Treasurer (Principal Financial and Accounting Officer)

42

EX-31.1

CERTIFICATION PURSUANT TO SECTION 302
OF THE SARBANES-OXLEY ACT OF 2002

I, Leslie J. Browne, Ph.D., certify that:

1. I have reviewed this Quarterly Report on Form 10-Q of Senesco Technologies, Inc.;

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4. The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

c) Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

d) Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

5. The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

Date: November 14, 2012	By:	/s/ Leslie J. Browne
		Leslie J. Browne, Ph.D. President and Chief Executive Officer (Principal Executive Officer)

EX-31.2

CERTIFICATION PURSUANT TO SECTION 302
OF THE SARBANES-OXLEY ACT OF 2002

I, Joel Brooks, certify that:

1. I have reviewed this Quarterly Report on Form 10-Q of Senesco Technologies, Inc.;

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4. The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

c) Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

d) Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

5. The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

Date: November 14, 2012	By:	/s/ Joel Brooks
		Joel Brooks Chief Financial Officer, Secretary and Treasurer (Principal Financial and Accounting Officer)

EX-32.1

CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350, 

AS ADOPTED PURSUANT TO 

SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the Quarterly Report on Form 10-Q of Senesco Technologies, Inc. for the period ended September 30, 2012 as filed with the Securities and Exchange Commission on the date hereof, the undersigned, Leslie J. Browne, Ph.D., President and Chief Executive Officer, hereby certifies, pursuant to 18 U.S.C. Section 1350, that:

(1) The Quarterly Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

(2) The information contained in the Quarterly Report fairly presents, in all material respects, the financial condition and results of operations of Senesco Technologies, Inc.

Dated: November 14, 2012	By:	/s/ Leslie J. Browne *
		Leslie J. Browne, Ph.D. President and Chief Executive Officer (Principal Executive Officer)

* A signed original of this written statement required by Section 906 has been provided to us and will be retained by us and furnished to the Securities and Exchange Commission or its staff upon request.

EX-32.2

CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350, 

AS ADOPTED PURSUANT TO 

SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the Quarterly Report on Form 10-Q of Senesco Technologies, Inc. for the period ended September 30, 2012 as filed with the Securities and Exchange Commission on the date hereof, the undersigned, Joel Brooks, Chief Financial Officer, Secretary and Treasurer, hereby certifies, pursuant to 18 U.S.C. Section 1350, that:

(1) The Quarterly Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

(2) The information contained in the Quarterly Report fairly presents, in all material respects, the financial condition and results of operations of Senesco Technologies, Inc.

Dated: November 14, 2012	By:	/s/ Joel Brooks *
		Joel Brooks Chief Financial Officer, Secretary and Treasurer (Principal Financial and Accounting Officer)

* A signed original of this written statement required by Section 906 has been provided to us and will be retained by us and furnished to the Securities and Exchange Commission or its staff upon request.

XML

Assumptions used to Value Warrants (Detail) (USD $)	3 Months Ended
	Sep. 30, 2012 Y		Jun. 30, 2012 Y
Warrants issued on December 20, 2007
Class of Warrant or Right [Line Items]
Estimated life in years	0.25		0.50
Risk-free interest rate	0.09%	[1]	0.15%	[1]
Volatility	72.00%		75.00%
Dividend paid
Warrants issued on December 20, 2007 | Minimum
Class of Warrant or Right [Line Items]
Estimated probabilities	10.00%		10.00%
Estimated strike prices	$ 0.32		$ 0.33
Warrants issued on December 20, 2007 | Maximum
Class of Warrant or Right [Line Items]
Estimated probabilities	50.00%		50.00%
Estimated strike prices	$ 0.35		$ 0.36
Warrants issued on June 30, 2008
Class of Warrant or Right [Line Items]
Estimated life in years	0.75		1.00
Risk-free interest rate	0.15%	[1]	0.21%	[1]
Volatility	72.00%		75.00%
Dividend paid
Warrants issued on June 30, 2008 | Minimum
Class of Warrant or Right [Line Items]
Estimated probabilities	10.00%		10.00%
Estimated strike prices	$ 0.32		$ 0.33
Warrants issued on June 30, 2008 | Maximum
Class of Warrant or Right [Line Items]
Estimated probabilities	50.00%		50.00%
Estimated strike prices	$ 0.35		$ 0.36
Warrants issued on April 1, 2010
Class of Warrant or Right [Line Items]
Estimated life in years	2.50		2.75
Risk-free interest rate	0.30%	[1]	0.39%	[1]
Volatility	75.00%		78.00%
Dividend paid
Estimated probabilities	15.00%		15.00%

[1] Represents the interest rate on a U.S. Treasury security with a maturity date corresponding to that of the warrant term.

XML

Loss Per Share - Additional Information (Detail)	3 Months Ended
	Sep. 30, 2012	Sep. 30, 2011
Earnings Per Share Disclosure [Line Items]
Potentially dilutive shares of common Stock	59,571,479	88,806,984
Convertible Preferred Stock
Earnings Per Share Disclosure [Line Items]
Potentially dilutive shares of common Stock	3,826,923	17,944,444
Stock Options and Warrants
Earnings Per Share Disclosure [Line Items]
Potentially dilutive shares of common Stock	55,744,556	70,862,540

XML

Liquidity:

3 Months Ended

Sep. 30, 2012

Liquidity:

Note 2 – Liquidity:

As shown in the accompanying condensed consolidated financial statements, the Company has a history of losses with a deficit accumulated during the development stage from July 1, 1998 (inception) through September 30, 2012 of $70,149,918. Additionally, the Company has generated minimal revenues by licensing its technology for certain crops to companies willing to share in its development costs. In addition, the Company’s technology may not be ready for commercialization for several years. The Company expects to continue to incur losses for the next several years because it anticipates that its expenditures on research and development and administrative activities will significantly exceed its revenues during that period. The Company cannot predict when, if ever, it will become profitable.

As of September 30, 2012, the Company had cash and cash equivalents in the amount of $1,312,056, which consisted of checking accounts and money market funds. The Company estimates that its cash and cash equivalents as of September 30, 2012 will cover its expenses through December 2012. The Company has the ability to draw down on its unused line of credit and delay certain costs, if necessary, which will provide the Company with enough cash to fund its operations at least through March 31, 2013. In order to provide the Company with the cash resources necessary to fund operations through at least September 30, 2013, the Company plans on raising additional capital through a private or public placement of its Common Stock in the near future.

The Company will need additional capital and plans to raise additional capital through the placement of debt instruments or equity or both. However, the Company may not be able to obtain adequate funds for its operations when needed or on acceptable terms. If the Company is unable to raise additional funds, it will need to do one or more of the following:

· delay, scale-back or eliminate some or all of its research and product development programs;

· license third parties to develop and commercialize products or technologies that it would otherwise seek to develop and commercialize itself;

· seek strategic alliances or business combinations;

· attempt to sell the Company;

· cease operations; or

· declare bankruptcy.

XML

Line of Credit - Additional Information (Detail) (USD $)	1 Months Ended	3 Months Ended
	Feb. 17, 2010	Sep. 30, 2012	Sep. 30, 2011	Jun. 30, 2012
Line of Credit Facility [Line Items]
Line of credit facility, maximum borrowing capacity	$ 3,000,000
Line of credit facility, interest rate	3.75%
Line of credit facility, spread over base rate	2.00%
Line of credit facility, interest rate description	Line of Credit accrue at an annual interest rate of (i) the broker rate in effect at the interest date (which was 3.75% at September 30, 2012), plus (ii) 2.0%. There are no other conditions or fees associated with the Line of Credit.
Line of credit, outstanding amount		2,199,108		2,199,108
Interest expense under Line of Credit		$ 34,990	$ 33,310

XML

Stock-Based Transactions - Additional Information (Detail) (USD $)	3 Months Ended		171 Months Ended
	Sep. 30, 2012	Sep. 30, 2011	Sep. 30, 2012
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Weighted average grant date fair value of options		$ 0.18
Stock option outstanding intrinsic value	$ 6,473		$ 6,473
Option outstanding weighted average remaining term	7 years 3 months 18 days
Exercisable aggregate intrinsic value	6,473		6,473
Weighted average option exercisable remaining life	6 years 8 months 12 days
Shares available for future stock option grant	11,588,876		11,588,876
Stock based compensation expense	153,562	123,551	12,259,515
Stock based compensation expense related to stock options, not yet recognized	$ 864,000		$ 864,000
Stock based compensation expense related to stock options, not yet recognized, period of recognition	36 months

XML

Assets and Liabilities at Fair Value Measured on Recurring Basis (Detail) (USD $)	Sep. 30, 2012	Jun. 30, 2012	Sep. 30, 2011	Jun. 30, 2011
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Cash and cash equivalents	$ 1,312,056	$ 2,001,325	$ 2,841,974	$ 3,609,954
Warrant Liabilities	94,739	238,796	439,556
Level 1 | Fair Value Measurements Recurring Basis
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Cash and cash equivalents, fair value	1,312,056	2,001,325
Level 3 | Fair Value Measurements Recurring Basis
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Warrant Liabilities, fair value	$ 94,739	$ 238,796

XML

Changes in Fair Value of Level Three Financial Instruments (Detail) (USD $)	3 Months Ended
	Sep. 30, 2012	Sep. 30, 2011
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
Beginning Balance	$ 238,796	$ 711,259
Reclassification of warrant liabilities	(164,205)
Loss (gain) due to change in fair value of warrant liabilities, net	20,148	(271,703)
Ending Balance	$ 94,739	$ 439,556

XML

Basis of Presentation

3 Months Ended

Sep. 30, 2012

Basis of Presentation

Note 1 - Basis of Presentation:

The financial statements included herein have been prepared by Senesco Technologies, Inc. (the “Company”), without audit, pursuant to the rules and regulations of the Securities and Exchange Commission. Certain information and footnote disclosures normally included in financial statements prepared in accordance with United States generally accepted accounting principles have been condensed or omitted pursuant to such rules and regulations. These unaudited condensed consolidated financial statements should be read in conjunction with the audited consolidated financial statements and notes thereto included in the Company’s Annual Report on Form 10-K for the fiscal year ended June 30, 2012, as amended.

In the opinion of the Company’s management, the accompanying unaudited condensed consolidated financial statements contain all adjustments, consisting solely of those which are of a normal recurring nature, necessary to present fairly its financial position as of September 30, 2012, the results of its operations and cash flows for the three months ended September 30, 2012 and 2011.

Interim results are not necessarily indicative of results for the full fiscal year.

XML

Warrant Liabilities - Additional Information (Detail) (USD $)	3 Months Ended		171 Months Ended
	Sep. 30, 2012	Sep. 30, 2011	Sep. 30, 2012	Jun. 30, 2012
Class of Warrant or Right [Line Items]
Unobservable input likelihood of reset occurring	75.00%
Shares of common stock issued in exchange for warrants	3,390,625		3,390,625
Number of warrants exchanged	9,687,500
Loss on extinguishment of debt	$ (785,171)		$ (1,147,048)
Reclassification of warrant liability	164,205
Fair value - warrant liability	(20,148)	271,703	8,309,982
Aggregate warrant included in fair value of warrant liability, shares	11,620,314	21,307,814	11,620,314
Warrant Liabilities	94,739	439,556	94,739	238,796
Capital in Excess of Par Value
Class of Warrant or Right [Line Items]
Loss on extinguishment of debt	(785,171)
Reclassification of warrant liability	$ 164,205
Per Occurrence | Minimum
Class of Warrant or Right [Line Items]
Unobservable input likelihood of reset occurring	10.00%
Per Occurrence | Maximum
Class of Warrant or Right [Line Items]
Unobservable input likelihood of reset occurring	25.00%
Black Scholes Option Pricing Model
Class of Warrant or Right [Line Items]
Weighted average probability of exercisability of warrants	15.00%		15.00%

XML

CONDENSED CONSOLIDATED BALANCE SHEETS (USD $)	Sep. 30, 2012	Jun. 30, 2012
CURRENT ASSETS:
Cash and cash equivalents	$ 1,312,056	$ 2,001,325
Prepaid research supplies and expenses	1,459,643	1,548,524
Total Current Assets	2,771,699	3,549,849
Equipment, furniture and fixtures, net	6,491	5,857
Intangibles, net	3,476,784	3,393,992
Deferred income tax assets, net
Security deposit	5,171	5,171
TOTAL ASSETS	6,260,145	6,954,869
CURRENT LIABILITIES:
Accounts payable	932,167	594,514
Accrued expenses	304,986	369,695
Line of credit	2,199,108	2,199,108
Total Current Liabilities	3,436,261	3,163,317
Warrant Liabilities	94,739	238,796
Grant payable	99,728	99,728
TOTAL LIABILITIES	3,630,728	3,501,841
Preferred stock, $0.01 par value, authorized 5,000,000 shares
Common stock, $0.01 par value, authorized 350,000,000 shares, issued and outstanding 116,753,185 and 94,112,483, respectively	1,167,532	941,125
Capital in excess of par	71,611,793	69,952,152
Deficit accumulated during the development stage	(70,149,918)	(67,440,295)
Total Stockholders' Equity	2,629,417	3,453,028
TOTAL LIABILITIES AND STOCKHOLDERS' EQUITY	6,260,145	6,954,869
Series A Preferred stock
Preferred stock, $0.01 par value, authorized 5,000,000 shares
Preferred stock	10	34
Series B Preferred stock
Preferred stock, $0.01 par value, authorized 5,000,000 shares
Preferred stock		$ 12

XML

CONDENSED STATEMENT OF STOCKHOLDERS' EQUITY (Parenthetical) (USD $)	3 Months Ended
	Sep. 30, 2012
Issuance of common stock, price per share	$ 0.26

XML

Preferred Stock - Additional Information (Detail) (USD $)	3 Months Ended		171 Months Ended		1 Months Ended	3 Months Ended			3 Months Ended	1 Months Ended	3 Months Ended			1 Months Ended		3 Months Ended
	Sep. 30, 2012	Sep. 30, 2011	Sep. 30, 2012	Jun. 30, 2012	Aug. 08, 2012 Warrant Exchange Agreements	Sep. 30, 2012 Warrant Exchange Agreements	Sep. 30, 2012 Preferred Stock	Jun. 30, 2012 Preferred Stock	Sep. 30, 2012 Common Stock	Aug. 08, 2012 Common Stock Warrant Exchange Agreements	Sep. 30, 2012 Common Stock Warrant Exchange Agreements	Sep. 30, 2012 Common Stock Including Additional Paid in Capital	Sep. 30, 2012 Series A Preferred stock	Aug. 08, 2012 Series A Preferred stock Warrant Exchange Agreements	Sep. 30, 2012 Series A Preferred stock Warrant Exchange Agreements	Sep. 30, 2012 Series B Preferred stock Warrant Exchange Agreements
Class of Stock [Line Items]
Common stock issued at conversion of preferred stock, shares							(3,584)		13,784,615	9,169,231	4,615,385			2,384		1,200
Issuance of common stock in lieu of cash payment for dividends, shares									1,600,000
Issuance of common stock in lieu of cash payment for dividends	$ 114,474								$ 16,000			$ 448,000
Preferred stock, shares outstanding							995	4,579					995		995
Dividends accrued on preferred stock	(64,722)	119,998	49,752
Number of warrants exchanged	9,687,500				17,262,500
Shares of common stock issued for warrant	3,390,625		3,390,625		6,902,192
Warrants term					5 years
Preferred stock, dividend rate														10.00%		10.00%
Preferred stock, par value	$ 0.01		$ 0.01	$ 0.01										$ 0.01		$ 0.01
Warrants outstanding	11,620,314	21,307,814	11,620,314			19,745,313
Warrants exchange description						Pursuant to the terms of the Warrant Exchange Agreements, the Company and each Warrant Holder agreed to exchange the Warrant held by such Warrant Holder for a number of shares of Common Stock equal to the product of (i) the number of Warrant Shares underlying the Warrant, multiplied by (ii) 0.35; provided, that if such Warrant Holder also owned shares of the Company's Series A Preferred Stock, such Warrant Holder additionally converted such shares of Series A Preferred Stock into the number of shares of Common Stock as determined pursuant to the terms set forth in the Certificate of Designation of Preferences, Righs and Limitations of 10% Series A Convertible Preferred Stock and the Company exchanged the Warrant held by such Warrant Holder for a number of shares of Common Stock equal to the product of (i) the number of Warrant Shares underlying the Warrant, multiplied by (ii) 0.45.
Deemed dividend - preferred stock	$ 240,891

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Warrant Liabilities: (Tables)

3 Months Ended

Sep. 30, 2012

Assumption Used to Value Warrants

The assumptions used to value the warrants were as follows:

	September 30, 2012		June 30, 2012
Warrants issued on December 20, 2007
Estimated life in years		0.25		0.50
Risk-free interest rate (1)		0.09%		0.15%
Volatility		72%		75%
Dividend paid		None		None
Range of estimated strike prices		$0.32-$0.35		$0.33-$0.36
Range of estimated probabilities		10% - 50%		10% - 50%
Warrants issued on June 30, 2008
Estimated life in years		0.75		1.00
Risk-free interest rate (1)		0.15%		0.21%
Volatility		72%		75%
Dividend paid		None		None
Range of estimated strike prices		$0.32-$0.35		$0.33-$0.36
Range of estimated probabilities		10% - 50%		10% - 50%
Warrants issued on April 1, 2010
Estimated life in years		2.5		2.75
Risk-free interest rate (1)		0.30%		0.39%
Volatility		75%		78%
Dividend paid		None		None
Estimated probability of a fundamental transaction		15%		15%

(1) Represents the interest rate on a U.S. Treasury security with a maturity date corresponding to that of the warrant term.

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Intangible Assets - Additional Information (Detail)	3 Months Ended
	Sep. 30, 2012
Finite-Lived Intangible Assets [Line Items]
Issued patents and agricultural patent applications pending amortization period	17 years

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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (USD $)	3 Months Ended		171 Months Ended
	Sep. 30, 2012	Sep. 30, 2011	Sep. 30, 2012
Cash flows from operating activities:
Net loss	$ (2,085,454)	$ (1,038,983)	$ (59,022,208)
Adjustments to reconcile net loss to net cash used in operating activities:
Noncash capital contribution			85,179
Noncash conversion of accrued expenses into equity			131,250
Noncash loss (income) related to change in fair value of warrant liability	20,148	(271,703)	(8,631,241)
Noncash charge for change in warrant terms			115,869
Issuance of common stock and warrants for interest			2,003,386
Issuance of common stock for services			53,800
Stock-based compensation expense	153,562	123,551	12,259,515
Depreciation and amortization	63,572	57,319	1,163,877
Write-off of intangibles			1,909,224
Amortization of convertible note discount			10,000,000
Amortization of deferred financing costs			1,227,869
Loss on extinguishment of debt	785,171		1,147,048
(Increase) decrease in operating assets:
Prepaid expenses and other current assets	88,881	(378,455)	(1,459,643)
Security deposit		7,187	(5,171)
Increase (decrease) in operating liabilities:
Accounts payable	337,653	389,565	932,167
Accrued expenses	13	21,281	430,235
Net cash used in operating activities	(636,454)	(1,090,238)	(37,658,844)
Cash flows from investing activities:
Patent costs	(145,717)	(128,839)	(6,370,429)
Purchase of equipment, furniture and fixtures	(1,281)		(185,947)
Net cash (used in) provided by investing activities	(146,998)	(128,839)	(6,556,376)
Cash flows from financing activities:
Proceeds from grant			99,728
Proceeds from draw-down on line of credit			2,199,108
Proceeds from issuance of preferred stock and warrants, net			10,754,841
Redemption of convertible notes and warrants			(2,160,986)
Deferred financing costs			(651,781)
Proceeds from issuance of common stock and warrants, net and exercise of warrants and options	94,183	451,097	25,421,366
Net cash provided by financing activities	94,183	451,097	45,527,276
Net (decrease) increase in cash and cash equivalents	(689,269)	(767,980)	1,312,056
Cash and cash equivalents at beginning of period	2,001,325	3,609,954
Cash and cash equivalents at end of period	1,312,056	2,841,974	1,312,056
Supplemental disclosure of non-cash transactions:
Conversion of preferred stock into common stock	137,810	1,555	356,924
Warrants issued for financing costs			690,984
Dividends accrued on preferred stock	(64,722)	119,998	49,752
Supplemental disclosure of cash flow information:
Cash paid for interest	34,990	33,310	406,673
Bridge notes
Cash flows from financing activities:
Proceeds from issuance of notes			525,000
Supplemental disclosure of non-cash transactions:
Conversion of notes payable into common stock			534,316
Convertible notes
Cash flows from financing activities:
Proceeds from issuance of notes			9,340,000
Supplemental disclosure of non-cash transactions:
Conversion of notes payable into common stock			10,000,000
Preferred Stock
Supplemental disclosure of non-cash transactions:
Allocation of Proceeds to warrants and beneficial conversion feature			8,526,135
Convertible Debt
Supplemental disclosure of non-cash transactions:
Allocation of Proceeds to warrants and beneficial conversion feature			9,340,000
Interest expense
Supplemental disclosure of non-cash transactions:
Issuance of common stock			2,003,386
Preferred stock dividends
Supplemental disclosure of non-cash transactions:
Issuance of common stock	448,000	10,848	4,069,943
Accounts payable
Supplemental disclosure of non-cash transactions:
Issuance of common stock			$ 175,000

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CONDENSED CONSOLIDATED BALANCE SHEETS (Parenthetical) (USD $)	Sep. 30, 2012	Jun. 30, 2012
Preferred stock, par value	$ 0.01	$ 0.01
Preferred stock, authorized	5,000,000	5,000,000
Common stock, par value	$ 0.01	$ 0.01
Common stock, authorized	350,000,000	350,000,000
Common stock, issued	116,753,185	94,112,483
Common stock, outstanding	116,753,185	94,112,483
Series A Preferred stock
Preferred stock, shares issued	10,297	10,297
Preferred stock, shares outstanding	995	3,379
Preferred stock, liquidation preference	$ 1,044,750	$ 3,463,475
Series B Preferred stock
Preferred stock, shares issued	1,200	1,200
Preferred stock, shares outstanding	0	1,200
Preferred stock, liquidation preference	$ 0	$ 1,230,000

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At Market Issuance Sales Agreement

3 Months Ended

Sep. 30, 2012

At Market Issuance Sales Agreement

Note 10- At Market Issuance Sales Agreement

On December 22, 2010, the Company entered into an At Market Issuance Sales Agreement (the “ATM”) under which the Company, from time to time, was able to issue and sell shares of its Common Stock, par value $0.01 per share, with an aggregate offering price of up to $5,500,000.

During the three months ended September 30, 2012, the Company issued 353,895 shares of Common Stock under the ATM for gross proceeds in the amount of $100,570. From the inception of the ATM through September 30, 2012, the Company has issued 8,099,909 shares of Common Stock under the ATM for gross proceeds in the amount of $2,463,661.

As the Company expects that it will no longer be listed on the NYSE MKT exchange, the Company will no longer be able to issue and sell shares of its Common Stock under the ATM after the Company is delisted.

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Document and Entity Information	3 Months Ended
	Sep. 30, 2012	Oct. 31, 2012
Document Information [Line Items]
Document Type	10-Q
Amendment Flag	false
Document Period End Date	Sep. 30, 2012
Document Fiscal Year Focus	2013
Document Fiscal Period Focus	Q1
Trading Symbol	SNT
Entity Registrant Name	SENESCO TECHNOLOGIES INC
Entity Central Index Key	0001035354
Current Fiscal Year End Date	--06-30
Entity Filer Category	Smaller Reporting Company
Entity Common Stock, Shares Outstanding		116,975,283

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Preferred Stock

3 Months Ended

Sep. 30, 2012

Preferred Stock

Note 11 –Preferred Stock

During the three months ended September 30, 2012, 3,584 shares of Preferred Stock were converted into 13,784,615 shares of Common Stock. During the three months ended September 30, 2012, the Company issued an additional 1,600,000 shares of Common Stock for the payment of dividends in the amount of $448,000. Total dividends payable on the outstanding 995 shares of Preferred Stock at September 30, 2012 amounted to $49,752.

On August 8, 2012, the Company completed an exchange (the “Exchange”) of certain five-year warrants issued by the Company in 2010 (the “Warrants”) to purchase 17,262,500 shares of Common Stock (the “Warrant Shares”) for 6,902,192 shares of Common Stock, and 2,384 shares of the Company’s 10% Series A Convertible Preferred Stock, par value $0.01 per share (the “Series A Preferred Stock”) were converted into 9,169,231 shares of Common Stock, pursuant to warrant exchange agreements (the “Warrant Exchange Agreements”) by and between the Company and certain holders of the Warrants (the “Warrant Holders”). Following the Exchange, Warrants to purchase 19,745,313 Warrant Shares and 995 shares of Series A Preferred Stock remain outstanding.

Pursuant to the terms of the Warrant Exchange Agreements, the Company and each Warrant Holder agreed to exchange the Warrant held by such Warrant Holder for a number of shares of Common Stock equal to the product of (i) the number of Warrant Shares underlying the Warrant, multiplied by (ii) 0.35; provided, that if such Warrant Holder also owned shares of the Company’s Series A Preferred Stock, such Warrant Holder additionally converted such shares of Series A Preferred Stock into the number of shares of Common Stock as determined pursuant to the terms set forth in the Certificate of Designation of Preferences, Rights and Limitations of 10% Series A Convertible Preferred Stock and the Company exchanged the Warrant held by such Warrant Holder for a number of shares of Common Stock equal to the product of (i) the number of Warrant Shares underlying the Warrant, multiplied by (ii) 0.45.

Additionally, certain members of the Company’s board of directors that owned shares of the Company’s 10% Series B Convertible Preferred Stock, par value $0.01 per share (the “Series B Preferred Stock”), agreed to convert 1,200 shares of Series B Preferred Stock into 4,615,385 shares of Common Stock, as determined pursuant to the terms set forth in the Certificate of Designation of Preferences, Rights and Limitations of 10% Series B Convertible Preferred Stock. Such conversions were not made pursuant to Warrant Exchange Agreements and therefore such directors did not receive any additional Common Stock. Following this conversion, no shares of Series B Preferred Stock remain outstanding.

In connection with the warrant exchange, a beneficial dividend in the amount of $240,891 was recorded on the conversion of the Convertible Preferred Stock.

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CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS (USD $)	3 Months Ended		171 Months Ended
	Sep. 30, 2012	Sep. 30, 2011	Sep. 30, 2012
Revenue			$ 1,790,000
Operating expenses:
General and administrative	732,720	645,959	32,347,397
Research and development	513,433	634,186	21,749,038
Total operating expenses	1,246,153	1,280,145	54,096,435
Loss from operations	(1,246,153)	(1,280,145)	(52,306,435)
Other non-operating income (expense)
Grant income			244,479
Fair value - warrant liability	(20,148)	271,703	8,309,982
Sale of state income tax loss - net			586,442
Other noncash (expense) income, net			205,390
Loss on extinguishment of debt	(785,171)		(1,147,048)
Write-off of patents abandoned			(1,909,224)
Amortization of debt discount and financing costs			(11,227,870)
Interest expense - convertible notes			(2,027,930)
Interest (expense) income - net	(33,982)	(30,541)	250,006
Net loss	(2,085,454)	(1,038,983)	(59,022,208)
Preferred dividends	(624,169)	(908,846)	(11,127,710)
Loss applicable to common shares	$ (2,709,623)	$ (1,947,829)	$ (70,149,918)
Basic and diluted net loss per common share	$ (0.03)	$ (0.02)
Basic and diluted weighted-average number of common shares outstanding	107,449,311	79,289,756

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Stock-Based Transactions

3 Months Ended

Sep. 30, 2012

Stock-Based Transactions

Note 5 – Stock-Based Transactions:

The terms and vesting schedules for share-based awards vary by type of grant and the employment status of the grantee. Generally, the awards vest based upon time-based conditions or achievement of specified goals and milestones.

The fair value of each stock option and warrant granted or vesting has been determined using the Black-Scholes model. The material factors incorporated in the Black-Scholes model in estimating the value of the options and warrants granted during the three months ended September 30, 2012 and 2011 include the following:

	Three Months Ended
	September 30,
	2012		2011
Warrants granted		None		None
Options granted		None		4,213,000
Estimated life in years  (1)		None		3.0-10.0
Risk-free interest rate (2)		None		1.0%-1.9%
Volatility		None		102-105%
Dividend paid		None		None

(1) Expected life for employee based stock options was estimated using the “simplified” method, as allowed under the provisions of the Securities and Exchange Commission Staff Accounting Bulletin No.110.

(2) Represents the interest rate on a U.S. Treasury security with a maturity date corresponding to that of the option or warrant term.

The economic values of the options will depend on the future price of the Company's Common Stock, which cannot be forecast with reasonable accuracy.

Stock option activity under the Company’s 2008 Plan and 1998 Plan for the three months ended September 30, 2012 is summarized as follows:

	Number of Options		Weighted-Average Exercise Price
Outstanding at July 1, 2012		15,647,742	$	0.50
Granted		--		--
Exercised		--		--
Expired		--		--
Outstanding at September 30, 2012		15,647,742	$	0.50
Exercisable at September 30, 2012		11,777,429	$	0.57
Not Exercisable at September 30, 2012		3,870,313	$	0.28

There were no options granted during the three months ended September 30, 2012. The weighted average grant date fair value of options granted during the three months ended September 30, 2011 was $0.18.

As of September 30, 2012, the aggregate intrinsic value of stock options outstanding was $6,473, with a weighted-average remaining term of 7.3 years. The aggregate intrinsic value of stock options exercisable at that same date was $6,473, with a weighted-average remaining term of 6.7 years. As of September 30, 2012, the Company has 11,588,876 shares available for future stock option grants.

Stock-based compensation expense for the three months ended September 30, 2012 and 2011 amounted to $153,391and $123,551, respectively.

As of September 30, 2012, total stock-based compensation expense not yet recognized related to stock option grants amounted to approximately $864,000, which will be recognized over the next 36 months.

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Loss Per Share

3 Months Ended

Sep. 30, 2012

Loss Per Share

Note 4 - Loss Per Share:

Basic earnings (loss) per share is computed by dividing net income (loss) available to common shareholders by the weighted average number of common shares assumed to be outstanding during the period of computation. Diluted earnings per share is computed similar to basic earnings per share except that the denominator is increased to include the number of additional common shares that would have been outstanding if the potential common shares had been issued and if the additional common shares were dilutive.

For all periods presented, basic and diluted loss per share are the same, as any additional Common Stock equivalents would be anti-dilutive. Potentially dilutive shares of Common Stock have been excluded from the calculation of the weighted average number of dilutive common shares.

As of September 30, 2012, there were 59,571,479 additional potentially dilutive shares of Common Stock. These additional shares include 3,826,923 shares issuable upon conversion of the Preferred Stock, and 55,744,556 shares issuable upon the exercise of outstanding options and warrants. As of September 30, 2011, there were 88,806,984 additional potentially dilutive shares of Common Stock. These additional shares included 17,944,444 shares issuable upon conversion of Preferred Stock and 70,862,540 shares issuable upon the exercise of outstanding options and warrants.

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Liquidity - Additional Information (Detail) (USD $)	Sep. 30, 2012	Jun. 30, 2012	Sep. 30, 2011	Jun. 30, 2011
Stockholders Equity Note [Line Items]
Deficit accumulated during the development stage	$ 70,149,918	$ 67,440,295
Cash and cash equivalents	$ 1,312,056	$ 2,001,325	$ 2,841,974	$ 3,609,954

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Recent Accounting Pronouncements

3 Months Ended

Sep. 30, 2012

Recent Accounting Pronouncements

Note 12 – Recent Accounting Pronouncements

In July 2012, the Financial Accounting Standards Board (“FASB”) issued Accounting Standards Update (“ASU”) No. 2012-02, “Intangibles-Goodwill and Other (Topic 350): Testing Indefinite-Lived Intangible Assets for Impairment” (“ASU 2012-02”).  This ASU states that an entity has the option first to assess qualitative factors to determine whether the existence of events and circumstances indicates that it is more likely than not that the indefinite-lived intangible asset is impaired. If, after assessing the totality of events and circumstances, an entity concludes that it is not more likely than not that the indefinite-lived intangible asset is impaired, then the entity is not required to take further action. However, if an entity concludes otherwise, then it is required to determine the fair value of the indefinite-lived intangible asset and perform the quantitative impairment test by comparing the fair value with the carrying amount in accordance with Codification Subtopic 350-30, Intangibles-Goodwill and Other, General Intangibles Other than Goodwill. Under the guidance in this ASU, an entity also has the option to bypass the qualitative assessment for any indefinite-lived intangible asset in any period and proceed directly to performing the quantitative impairment test. An entity will be able to resume performing the qualitative assessment in any subsequent period. The amendments in this ASU are effective for annual and interim impairment tests performed for fiscal years beginning after September 15, 2012. Early adoption is permitted, including for annual and interim impairment tests performed as of a date before July 27, 2012, if a public entity’s financial statements for the most recent annual or interim period have not yet been issued or, for nonpublic entities, have not yet been made available for issuance. The Company is evaluating the impact of this ASU and does not expect its adoption to have a significant impact on the Company’s consolidated financial statements.

In June 2011, the FASB issued FASB ASU No. 2011-05, Comprehensive Income (Topic 220): Presentation of Comprehensive Income in U.S. GAAP and IFRS. This ASU provides companies the option to present the components of net income and other comprehensive income either as one continuous statement of comprehensive income or as two separate but consecutive statements. It eliminates the option to present components of other comprehensive income as part of the statement of changes in stockholders’ equity. The provisions of this new guidance are effective for fiscal years, and interim periods within those years, beginning after December 15, 2011. We adopted this disclosure standard in the first quarter of fiscal 2013 and it did not have a material impact on our results of operations.

Other recent accounting pronouncements issued by the FASB (including its Emerging Issues Task Force) and the SEC did not or are not believed by management to have a material impact on our present or future financial statements.

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Fair Value Measurements

3 Months Ended

Sep. 30, 2012

Fair Value Measurements

Note 8 - Fair Value Measurements:

The following tables provide the assets and liabilities carried at fair value measured on a recurring basis as of September 30, 2012 and June 30, 2012:

			Fair Value Measurement at
	Carrying		September 30, 2012
	Value		Level 1		Level 2		Level 3
Assets:
Cash and cash equivalents	$	1,312,056	$	1,312,056	$	-	$	-
Liabilities:
Warrant Liabilities	$	94,739	$	-	$	-	$	94,739

			Fair Value Measurement at
	Carrying		June 30, 2012
	Value		Level 1		Level 2		Level 3
Assets:
Cash and cash equivalents	$	2,001,325	$	2,001,325	$	-	$	-
Liabilities:
Warrant Liabilities	$	238,796	$	-	$	-	$	238,796

The following table summarizes the changes in fair value of the Company’s Level 3 financial instruments:

	Three months ended September 30,
	2012			2011
Beginning Balance	$	238,796		$	711,259
Reclassification of warrant liabilities		(164,205	)		-
Loss (gain) due to change in fair value of warrant liabilities, net		20,148			(271,703	)
Ending Balance	$	94,739		$	439,556

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Line of Credit

3 Months Ended

Sep. 30, 2012

Line of Credit

Note 6 –Line of Credit:

On February 17, 2010, the Company entered into a credit agreement with JMP Securities LLC. The agreement provides the Company with, subject to certain restrictions, including the existence of suitable collateral, up to a $3.0 million line of credit upon which the Company may draw at any time (the “Line of Credit”). Any draws upon the Line of Credit accrue at an annual interest rate of (i) the broker rate in effect at the interest date (which was 3.75% at September 30, 2012), plus (ii) 2.0%. There are no other conditions or fees associated with the Line of Credit. The Line of Credit is not secured by any assets of the Company, but it is secured by certain assets of a member of the Company’s Board of Directors, Harlan W. Waksal, M.D., which is currently held by JMP Securities. The balance outstanding as of September 30, 2012 and June 30, 2012 was $2,199,108. In April 2011, we were required to enter into a new demand note with the clearing agent for JMP Securities in connection with the Line of Credit.

Total interest expense recorded under the Line of Credit for the three months ended September 30, 2012 and 2011 amounted to $34,990 and $33,310, respectively.

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Income Taxes

3 Months Ended

Sep. 30, 2012

Income Taxes

Note 7 – Income Taxes:

No provision for income taxes has been made for the three months ended September 30, 2012 and 2011 given the Company’s losses in 2012 and 2011 and available net operating loss carryforwards. A benefit has not been recorded as the realization of the net operating losses is not assured and the timing in which the Company can utilize its net operating loss carryforwards in any year or in total may be limited by provisions of the Internal Revenue Code regarding changes in ownership of corporations.

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Warrant Liabilities:

3 Months Ended

Sep. 30, 2012

Warrant Liabilities:

Note 9 – Warrant Liabilities:

The warrant liabilities represent the fair value of Common Stock purchase warrants, which have exercise price reset features and cash settlement features.

The fair value of the warrants that have exercise price reset features is estimated using an adjusted Black-Scholes model. The Company computes valuations, each quarter, using the Black-Scholes model for such warrants to account for the various possibilities that could occur due to changes in the inputs to the Black-Scholes model as a result of contractually-obligated changes. The Company effectively weights each calculation based on the likelihood of occurrence to determine the value of the derivative at the reporting date. The Company has an unobservable input for the estimation of the likelihood of a reset occurring, which was estimated to be 75% made up of various reset amounts with probabilities ranging between 10% and 25% per occurrence. These estimates of the likelihood of completing an equity raise that would meet the criteria to trigger the reset provisions are based on numerous factors, including the remaining term of the financial instruments and the Company’s overall financial condition.

The fair value of the warrants that have cash settlement features is estimated using a probability –weighted Black-Scholes model. The unobservable input used by the Company on certain warrants was the estimation of the likelihood of a fundamental transaction, as defined in the related agreements, which was estimated to be 15% at September 30, 2012.

Changes in the unobservable input values would likely cause material changes in the fair value of the Company’s Level 3 financial instruments. The significant unobservable input used in the fair value measurement is the estimation of the likelihood of the occurrence of a change to the strike price of the warrants or the occurrence of a fundamental transaction. A significant increase (decrease) in the this likelihood would result in a higher (lower) fair value measurement.

During the three months ended September 30, 2012, the Company issued 3,390,625 shares of common stock in exchange for 9,687,500 warrants that were included in the computation of warrant liabilities. In connection with this exchange, the Company compared the value of the common stock issued with the Black-Scholes value of the warrants exchanged. The difference in these values resulted in a loss on the extinguishment of debt in the amount of $785,171. Additionally, the value of the warrants on the date of the exchange, in the amount of $164,205, were reclassified from warrant liabilities to additional paid in capital.

At ended September 30, 2012 and 2011, the Company revalued all of the remaining warrant liabilities, using the adjusted Black-Scholes and Black-Scholes models. A (loss) gain on the change in fair value of the warrant liabilities in the amount of $(20,148)and $271,703 was recorded in the Condensed Consolidated Statement of Operations for the three months ended September 30, 2012 and 2011, respectively.

At September 30, 2012 and 2011, there were an aggregate of 11,620,314 and 21,307,814 warrants included in the fair value of the warrant liabilities, which are valued at $94,739 and $439,556, respectively.

The assumptions used to value the warrants were as follows:

	September 30, 2012		June 30, 2012
Warrants issued on December 20, 2007
Estimated life in years		0.25		0.50
Risk-free interest rate (1)		0.09%		0.15%
Volatility		72%		75%
Dividend paid		None		None
Range of estimated strike prices		$0.32-$0.35		$0.33-$0.36
Range of estimated probabilities		10% - 50%		10% - 50%
Warrants issued on June 30, 2008
Estimated life in years		0.75		1.00
Risk-free interest rate (1)		0.15%		0.21%
Volatility		72%		75%
Dividend paid		None		None
Range of estimated strike prices		$0.32-$0.35		$0.33-$0.36
Range of estimated probabilities		10% - 50%		10% - 50%
Warrants issued on April 1, 2010
Estimated life in years		2.5		2.75
Risk-free interest rate (1)		0.30%		0.39%
Volatility		75%		78%
Dividend paid		None		None
Estimated probability of a fundamental transaction		15%		15%

(1) Represents the interest rate on a U.S. Treasury security with a maturity date corresponding to that of the warrant term.

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At Market Issuance Sales Agreement - Additional Information (Detail) (USD $)	3 Months Ended		3 Months Ended	21 Months Ended		1 Months Ended
	Sep. 30, 2012	Jun. 30, 2012	Sep. 30, 2012 At Market Issuance Sales Agreement	Sep. 30, 2012 At Market Issuance Sales Agreement	Dec. 22, 2010 At Market Issuance Sales Agreement	Dec. 22, 2010 At Market Issuance Sales Agreement Maximum
Stockholders Equity Note [Line Items]
Common stock, par value	$ 0.01	$ 0.01			$ 0.01
Common stock issued	$ 100,570					$ 5,500,000
Stock issued during period, shares			353,895	8,099,909
Proceeds from issuance of common stock, gross			$ 100,570	$ 2,463,661

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Fair Value Measurements (Tables)

3 Months Ended

Sep. 30, 2012

Assets and Liabilities Carried at Fair Value Measured on Recurring Basis

The following tables provide the assets and liabilities carried at fair value measured on a recurring basis as of September 30, 2012 and June 30, 2012:

			Fair Value Measurement at
	Carrying		September 30, 2012
	Value		Level 1		Level 2		Level 3
Assets:
Cash and cash equivalents	$	1,312,056	$	1,312,056	$	-	$	-
Liabilities:
Warrant Liabilities	$	94,739	$	-	$	-	$	94,739

			Fair Value Measurement at
	Carrying		June 30, 2012
	Value		Level 1		Level 2		Level 3
Assets:
Cash and cash equivalents	$	2,001,325	$	2,001,325	$	-	$	-
Liabilities:
Warrant Liabilities	$	238,796	$	-	$	-	$	238,796

Changes in Fair Value of Level Three Financial Instruments

The following table summarizes the changes in fair value of the Company’s Level 3 financial instruments:

	Three months ended September 30,
	2012			2011
Beginning Balance	$	238,796		$	711,259
Reclassification of warrant liabilities		(164,205	)		-
Loss (gain) due to change in fair value of warrant liabilities, net		20,148			(271,703	)
Ending Balance	$	94,739		$	439,556

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Material Factors Incorporated in Black-Scholes Model in Estimating Value of Options and Warrants (Detail) (USD $)	3 Months Ended
	Sep. 30, 2012		Sep. 30, 2011
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Warrants granted
Options granted			4,213,000
Estimated life in years	0 years	[1]
Risk-free interest rate		[2]		[2]
Risk-free interest rate, minimum			1.00%	[2]
Risk-free interest rate, maximum			1.90%	[2]
Expected Volatility
Expected Volatility, minimum			102.00%
Expected Volatility, maximum			105.00%
Dividend paid
Minimum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Estimated life in years			3 years	[1]
Maximum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Estimated life in years			10 years	[1]

[1] Expected life for employee based stock options was estimated using the "simplified" method, as allowed under the provisions of the Securities and Exchange Commission Staff Accounting Bulletin No.110.

[2] Represents the interest rate on a U.S. Treasury security with a maturity date corresponding to that of the option or warrant term.

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CONDENSED STATEMENT OF STOCKHOLDERS' EQUITY (USD $)	Total	Preferred Stock	Common Stock	Capital in Excess of Par Value	Deficit Accumulated During the Development Stage
Beginning Balance at Jun. 30, 2012	$ 3,453,028	$ 46	$ 941,125	$ 69,952,152	$ (67,440,295)
Beginning Balance at Jun. 30, 2012		4,579
Beginning Balance (in shares) at Jun. 30, 2012	94,112,483		94,112,483
Issuance of common stock at $0.26 per share (in shares)			353,895
Issuance of common stock at $0.26 per share	100,570		3,539	97,031
Commissions and other fees related to the issuance of common stock	(6,387)			(6,387)
Preferred stock converted into common stock (in shares)		(3,584)	13,784,615
Preferred stock converted into common stock		(36)	137,846	(137,810)
Issuance of common stock in lieu of cash payment for dividends (in shares)			1,600,000
Issuance of common stock in lieu of cash payment for dividends	114,474		16,000	432,000	(333,526)
Issuance of common stock in exchange for warrants (in shares)			6,902,192
Issuance of common stock in exchange for warrants			69,022	(69,022)
Deemed dividend - preferred stock	(240,891)			240,891	(240,891)
Loss on extinguishment of debt	785,171			785,171
Reclassification of warrant liability	164,205			164,205
Fair market value of options and warrants vested	153,562			153,562
Dividends accrued and unpaid at September 30, 2012	(49,752)				(49,752)
Net loss	(2,085,454)				(2,085,454)
Ending Balance at Sep. 30, 2012	$ 2,629,417	$ 10	$ 1,167,532	$ 71,611,793	$ (70,149,918)
Ending Balance at Sep. 30, 2012		995
Ending Balance (in shares) at Sep. 30, 2012	116,753,185		116,753,185

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Intangible Assets

3 Months Ended

Sep. 30, 2012

Intangible Assets

Note 3 – Intangible Assets:

The Company conducts research and development activities, the cost of which is expensed as incurred, in order to generate patents that can be licensed to third parties in exchange for license fees and royalties. Because the patents are the basis of the Company’s future revenue, the patent costs are capitalized. The capitalized patent costs represent the outside legal fees incurred by the Company to submit and undertake all necessary efforts to have such patent applications issued as patents.

The length of time that it takes for an initial patent application to be approved is generally between four to six years. However, due to the unique nature of each patent application, the actual length of time may vary. If a patent application is denied, the associated cost of that application would be written off. However, the Company has not had any patent applications denied as of September 30, 2012. Additionally, should a patent application become impaired during the application process, the Company would write down or write off the associated cost of that patent application.

Issued patents and agricultural patent applications pending are being amortized over a period of 17 years from inception, the expected economic life of the patent.

The Company assesses the impairment in value of intangible assets whenever events or circumstances indicate that their carrying value may not be recoverable. Factors the Company considers important which could trigger an impairment review include the following:

• significant negative industry trends;

• significant underutilization of the assets;

• significant changes in how the Company uses the assets or its plans for their use; and

• changes in technology and the appearance of competing technology.

If a triggering event occurs and the Company's review determines that the future undiscounted cash flows related to the groups, including these assets, will not be sufficient to recover their carrying value, the Company will reduce the carrying values of these assets down to its estimate of fair value and continue amortizing them over their remaining useful lives. To date, except for certain patents and patents pending that the Company abandoned during the fiscal years ended June 30, 2012 and 2011, the Company has not recorded any impairment of intangible assets.

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Stock Option Activity (Detail) (USD $)	3 Months Ended
	Sep. 30, 2012	Sep. 30, 2011
Number of Options
Beginning Balance	15,647,742
Granted		4,213,000
Exercised
Expired
Ending Balance	15,647,742
Exercisable at end of Period	11,777,429
Not Exercisable at end of Period	3,870,313
Weighted Average Exercise Price
Beginning Balance	$ 0.50
Granted
Exercised
Expired
Ending Balance	$ 0.50
Exercisable at end of Period	$ 0.57
Not Exercisable end of Period	$ 0.28

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Stock-Based Transactions (Tables)

3 Months Ended

Sep. 30, 2012

Material Factors Incorporated in Black Scholes Model in Estimating Value of Options and Warrants

The fair value of each stock option and warrant granted or vesting has been determined using the Black-Scholes model. The material factors incorporated in the Black-Scholes model in estimating the value of the options and warrants granted during the three months ended September 30, 2012 and 2011 include the following:

	Three Months Ended
	September 30,
	2012		2011
Warrants granted		None		None
Options granted		None		4,213,000
Estimated life in years  (1)		None		3.0-10.0
Risk-free interest rate (2)		None		1.0%-1.9%
Volatility		None		102-105%
Dividend paid		None		None

(1) Expected life for employee based stock options was estimated using the “simplified” method, as allowed under the provisions of the Securities and Exchange Commission Staff Accounting Bulletin No.110.

(2) Represents the interest rate on a U.S. Treasury security with a maturity date corresponding to that of the option or warrant term.

Stock Option Activity

Stock option activity under the Company’s 2008 Plan and 1998 Plan for the three months ended September 30, 2012 is summarized as follows:

	Number of Options		Weighted-Average Exercise Price
Outstanding at July 1, 2012		15,647,742	$	0.50
Granted		--		--
Exercised		--		--
Expired		--		--
Outstanding at September 30, 2012		15,647,742	$	0.50
Exercisable at September 30, 2012		11,777,429	$	0.57
Not Exercisable at September 30, 2012		3,870,313	$	0.28