ECHO THERAPEUTICS, INC.

99 Wood Avenue South, Suite 302

Iselin, New Jersey 08830

              June 23, 2016

VIA EDGAR

Securities and Exchange Commission

100 F Street, N.E.

Washington, D.C.  20549

Mail Stop 3030

Attn:  Amanda Ravitz, Assistant Director

Re: Echo Therapeutics, Inc. Registration Statement on Form S-3 Filed June 10, 2016 File No. 333-211975 Request for Acceleration of Effectiveness

Dear Ms. Ravitz:

Pursuant to Rule 461(a) promulgated under the Securities Act of 1933, as amended, Echo Therapeutics, Inc. (the “Company”) respectfully requests that the Securities and Exchange Commission (the “Commission”) accelerate the effective date of the Company’s referenced Registration Statement on Form S-3 (the “Registration Statement”) to Friday, June 24, 2016, at 10:00 a.m., New York City time, or as soon as practicable thereafter.  The Company hereby acknowledges that:

· should the Commission or the staff, acting pursuant to delegated authority, declare the filing effective, it does not foreclose the Commission from taking any action with respect to the filing;

· the action of the Commission or the staff, acting pursuant to delegated authority, in declaring the filing effective, does not relieve the Company from its full responsibility for the adequacy and accuracy of the disclosure in the filing; and

· the Company may not assert staff comments and the declaration of effectiveness as a defense in any proceeding initiated by the Commission or any person under the federal securities laws of the United States.

The Company would appreciate telephone notice of effectiveness of the Registration Statement to the Company’s counsel, Kevin W. Waite, Esq. at (516) 937-5900.

Very truly yours,

ECHO THERAPEUTICS, INC.

By: /s/ Alan W. Schoenbart

Name: Alan W. Schoenbart

Title: Chief Financial Officer

cc:           Tom Jones

Kevin W. Waite, Esq.