CONSOLIDATED STATEMENTS OF CHANGES IN STOCKHOLDERS’ EQUITY (USD $)	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Beginning balance, Value	$ 10,230,606	$ 16,968,589	$ 8,702,284
Exercise of warrants, Value		212,018	4,919,345
Exercise of stock options, Value		195,259	136,790
Proceeds from issuance of Common Stock, net, Value	21,964,570	3,272,202
Series B Preferred Stock dividend paid-in-kind
Series B Preferred Stock redeemed for Series C Preferred Stock in warrant exercise, Value
Common Stock subscription			6,667
Share-based payments - restricted stock, net of forfeitures, Value
Share-based payments - options, net of forfeitures			836,866
Issuance of Common Stock, net of cash issuance costs of $188,333 and non-cash costs of $468,741, Value			6,154,489
Issuance of Series D Preferred Stock and warrants, net of cash issuance costs of $21,299, Value			3,484,702
Fair value of Common Stock and warrants issued for services, Value	96,375	153,464	448,940
Proceeds from issuance of Common Stock, Series E Preferred Stock and warrants, net of cash issuance cost, Value	4,900,000
Fair value of derivative warrant liabilities reclassified to additional paid-in capital		61,520	2,272,597
Common Stock issued in preferred stock conversion, Value
Common Stock and warrants issued to settle short-term note, Value			35,500
Share-based compensation, Value	1,244,342	1,699,562
Net Loss	(19,067,397)	(12,332,008)	(10,029,591)
Preferred Stock
Beginning balance, Value	30,160	30,160	51
Beginning balance, Shares	3,015,974	3,015,974	5,072
Exercise of warrants, Value			32
Exercise of warrants, Shares			3,225
Exercise of stock options, Value
Exercise of stock options, Shares
Proceeds from issuance of Common Stock, net, Value
Proceeds from issuance of Common Stock, net, Shares
Series B Preferred Stock dividend paid-in-kind			16
Series B Preferred Stock redeemed for Series C Preferred Stock in warrant exercise, Value			17
Series B Preferred Stock redeemed for Series C Preferred Stock in warrant exercise, Shares			1,661
Common Stock subscription
Share-based payments - restricted stock, net of forfeitures, Value
Share-based payments - restricted stock, net of forfeitures, Shares
Share-based payments - options, net of forfeitures
Issuance of Common Stock, net of cash issuance costs of $188,333 and non-cash costs of $468,741, Value
Issuance of Common Stock, net of cash issuance costs of $188,333 and non-cash costs of $468,741, Shares
Issuance of Series D Preferred Stock and warrants, net of cash issuance costs of $21,299, Value			35,060
Issuance of Series D Preferred Stock and warrants, net of cash issuance costs of $21,299, Shares			3,506,000
Fair value of Common Stock and warrants issued for services, Value
Fair value of Common Stock and warrants issued for services, Shares
Proceeds from issuance of Common Stock, Series E Preferred Stock and warrants, net of cash issuance cost, Value	17,486
Proceeds from issuance of Common Stock, Series E Preferred Stock and warrants, net of cash issuance cost, Shares	1,748,613
Fair value of derivative warrant liabilities reclassified to additional paid-in capital
Common Stock issued in preferred stock conversion, Value	(20,150)		(5,000)
Common Stock issued in preferred stock conversion, Shares	(2,014,974)		(500,000)
Common Stock and warrants issued to settle short-term note, Value
Common Stock and warrants issued to settle short-term note, Shares
Share-based compensation, Value
Share-based compensation, Shares
Net Loss
Common Stock
Beginning balance, Value	44,374	38,544	31,126
Beginning balance, Shares	4,437,346	3,854,400	3,112,625
Exercise of warrants, Value		166	2,304
Exercise of warrants, Shares		16,545	230,346
Exercise of stock options, Value		225	706
Exercise of stock options, Shares		22,453	70,584
Proceeds from issuance of Common Stock, net, Value	61,963	4,080
Proceeds from issuance of Common Stock, net, Shares	6,196,605	408,000
Series B Preferred Stock dividend paid-in-kind
Series B Preferred Stock redeemed for Series C Preferred Stock in warrant exercise, Value
Series B Preferred Stock redeemed for Series C Preferred Stock in warrant exercise, Shares
Common Stock subscription
Share-based payments - restricted stock, net of forfeitures, Value			190
Share-based payments - restricted stock, net of forfeitures, Shares			19,000
Share-based payments - options, net of forfeitures
Issuance of Common Stock, net of cash issuance costs of $188,333 and non-cash costs of $468,741, Value			3,550
Issuance of Common Stock, net of cash issuance costs of $188,333 and non-cash costs of $468,741, Shares			355,045
Issuance of Series D Preferred Stock and warrants, net of cash issuance costs of $21,299, Value
Issuance of Series D Preferred Stock and warrants, net of cash issuance costs of $21,299, Shares
Fair value of Common Stock and warrants issued for services, Value	92	95	138
Fair value of Common Stock and warrants issued for services, Shares	9,122	9,533	13,800
Proceeds from issuance of Common Stock, Series E Preferred Stock and warrants, net of cash issuance cost, Value	969
Proceeds from issuance of Common Stock, Series E Preferred Stock and warrants, net of cash issuance cost, Shares	69,569
Fair value of derivative warrant liabilities reclassified to additional paid-in capital
Common Stock issued in preferred stock conversion, Value	10,980		500
Common Stock issued in preferred stock conversion, Shares	1,098,019		50,000
Common Stock and warrants issued to settle short-term note, Value			30
Common Stock and warrants issued to settle short-term note, Shares			3,000
Share-based compensation, Value	(341)	1,264
Share-based compensation, Shares	(34,083)	126,415
Net Loss
Additional Paid-In Capital
Beginning balance, Value	104,058,087	98,463,225	79,926,523
Exercise of warrants, Value		211,852	4,917,009
Exercise of stock options, Value		195,034	136,084
Proceeds from issuance of Common Stock, net, Value	21,902,607	3,268,122
Series B Preferred Stock dividend paid-in-kind
Series B Preferred Stock redeemed for Series C Preferred Stock in warrant exercise, Value			(17)
Common Stock subscription		6,667
Share-based payments - restricted stock, net of forfeitures, Value			(190)
Share-based payments - options, net of forfeitures			836,866
Issuance of Common Stock, net of cash issuance costs of $188,333 and non-cash costs of $468,741, Value			6,435,939
Issuance of Series D Preferred Stock and warrants, net of cash issuance costs of $21,299, Value			3,449,642
Fair value of Common Stock and warrants issued for services, Value	96,283	153,369	448,802
Proceeds from issuance of Common Stock, Series E Preferred Stock and warrants, net of cash issuance cost, Value	4,881,818
Fair value of derivative warrant liabilities reclassified to additional paid-in capital		61,520	2,272,597
Common Stock issued in preferred stock conversion, Value	9,170		4,500
Common Stock and warrants issued to settle short-term note, Value			35,470
Share-based compensation, Value	1,244,683	1,698,298
Net Loss
Common Stock Subscribed
Beginning balance, Value		6,667	285,000
Exercise of warrants, Value
Exercise of stock options, Value
Proceeds from issuance of Common Stock, net, Value
Series B Preferred Stock dividend paid-in-kind
Series B Preferred Stock redeemed for Series C Preferred Stock in warrant exercise, Value
Common Stock subscription		(6,667)	6,667
Share-based payments - restricted stock, net of forfeitures, Value
Share-based payments - options, net of forfeitures
Issuance of Common Stock, net of cash issuance costs of $188,333 and non-cash costs of $468,741, Value			(285,000)
Issuance of Series D Preferred Stock and warrants, net of cash issuance costs of $21,299, Value
Fair value of Common Stock and warrants issued for services, Value
Proceeds from issuance of Common Stock, Series E Preferred Stock and warrants, net of cash issuance cost, Value
Fair value of derivative warrant liabilities reclassified to additional paid-in capital
Common Stock issued in preferred stock conversion, Value
Common Stock and warrants issued to settle short-term note, Value
Share-based compensation, Value
Net Loss
Accumulated Deficit
Beginning balance, Value	(93,902,015)	(81,570,007)	(71,540,416)
Exercise of warrants, Value
Exercise of stock options, Value
Proceeds from issuance of Common Stock, net, Value
Series B Preferred Stock dividend paid-in-kind
Series B Preferred Stock redeemed for Series C Preferred Stock in warrant exercise, Value
Common Stock subscription
Share-based payments - restricted stock, net of forfeitures, Value
Share-based payments - options, net of forfeitures
Issuance of Common Stock, net of cash issuance costs of $188,333 and non-cash costs of $468,741, Value
Issuance of Series D Preferred Stock and warrants, net of cash issuance costs of $21,299, Value
Fair value of Common Stock and warrants issued for services, Value
Proceeds from issuance of Common Stock, Series E Preferred Stock and warrants, net of cash issuance cost, Value
Fair value of derivative warrant liabilities reclassified to additional paid-in capital
Common Stock issued in preferred stock conversion, Value
Common Stock and warrants issued to settle short-term note, Value
Share-based compensation, Value
Net Loss	$ (19,067,397)	$ (12,332,008)	$ (10,029,591)