UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 14A

Proxy Statement Pursuant to Section 14(a)

of the Securities Exchange Act of 1934

(Amendment No.     )

Filed by the Registrant x                             Filed by a Party other than the Registrant ¨

Check the appropriate box:

¨ Preliminary Proxy Statement

¨ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))

¨ Definitive Proxy Statement

x Definitive Additional Materials

¨ Soliciting Material Pursuant to Rule 14a-12

ECHO THERAPEUTICS, INC.

(Name of the Registrant as Specified In Its Charter)

(Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):

x No fee required.

¨ Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.

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¨ Fee paid previously with preliminary materials.

¨ Check box if any part of the fee is offset as provided by Exchange Act Rule 0-11(a)(2) and identify the filing for which the offsetting fee was paid previously.  Identify the previous filing by registration statement number, or the Form or Schedule and the date of its filing.

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May 10, 2013

Dear Shareholder,

Material was recently mailed to you with regard to the upcoming annual shareholders meeting, scheduled to be held on Wednesday, May 22, 2013.  According to the records at your broker, you have not yet voted your shares.

Your vote is very important, and cannot be voted on certain proposals unless you specifically provide your instructions.  Please see the enclosures that will provide you with easy and immediate methods to vote at the meeting.

If you have any questions or would like additional copies of the materials, please call our proxy solicitation agents, The Laurel Hill Advisory Group, LLC, toll-free at (888) 742-1305.

Thank you for your vote!

/s/ Kimberly A. Burke

Kimberly A. Burke

Sr. Vice President, General Counsel and Secretary