Shareholders Equity (USD $)	Preferred Stock	Common Stock	Additional Paid-In Capital	Common Stock Subscribed	Accumulated Deficit	Total
Beginning balance, Value at Dec. 31, 2009	$ 51	$ 270,459	$ 74,155,716		$ (67,393,620)	$ 7,032,606
Beginning balance, Shares at Dec. 31, 2009	5,059	27,045,792
Exercise of warrants, Value		357	(357)
Exercise of warrants, Shares		35,714
Share-based payments - restricted stock, net of forfeitures, Value		3,630	389,619			393,249
Share-based payments - restricted stock, net of forfeitures, Shares		363,000
Share-based payments - options, net of forfeitures			164,810			164,810
Fair value of warrants issued for services			616,634			616,634
Fair value of options issued for services			59,471			59,471
Common Stock issued to charitable organization, Value		600	112,800			113,400
Common Stock issued to charitable organization, Shares		60,000
Issuance of Common Stock, net of cash issuance costs of $188,333 and non-cash costs of $468,741, Value		33,568	3,484,485			3,518,053
Issuance of Common Stock, net of cash issuance costs of $188,333 and non-cash costs of $468,741, Shares		3,356,739
Fair value of fully vested Common Stock issued for services, Value		2,650	462,850			465,500
Fair value of fully vested Common Stock issued for services, Shares		265,000
Fair value of derivative warrant liabilities reclassified to additional paid-in capital			200,357			200,357
Common Stock subscription, 285,000 shares				285,000		285,000
Dividends on Series B Preferred Stock, Value
Dividends on Series B Preferred Stock, Shares	13
Net Loss					(4,146,796)	(4,146,796)
Ending balance, Value at Dec. 31, 2010	51	311,264	79,646,385	285,000	(71,540,416)	8,702,284
Ending balance, Shares at Dec. 31, 2010	5,072	31,126,245
Exercise of warrants, Value	32	23,035	4,896,278			4,919,345
Exercise of warrants, Shares	3,225	2,303,456
Share-based payments - restricted stock, net of forfeitures, Value		1,900	(1,900)
Share-based payments - restricted stock, net of forfeitures, Shares		190,000
Share-based payments - options, net of forfeitures			836,866			836,866
Fair value of fully vested Common Stock issued for services, Value		1,380	447,560			448,940
Fair value of fully vested Common Stock issued for services, Shares		138,000
Fair value of derivative warrant liabilities reclassified to additional paid-in capital			2,272,597			2,272,597
Series B Preferred Stock redeemed for Series C Preferred Stock in warrant exercise, Value	17		(17)
Series B Preferred Stock redeemed for Series C Preferred Stock in warrant exercise, Shares	1,661
Series B Preferred Stock dividend paid-in-kind, Value
Series B Preferred Stock dividend paid-in-kind, Shares	16
Common Stock subscription, 33,333 shares				6,667		6,667
Issuance of Common Stock and warrants, net of cash issuance costs of $109,636 and non-cash costs of $41,363, Value		35,505	6,403,984	(285,000)		6,154,489
Issuance of Common Stock and warrants, net of cash issuance costs of $109,636 and non-cash costs of $41,363, Shares		3,550,449
Issuance of Series D Preferred Stock and warrants, net of cash issuance costs of $21,299, Value	35,060		3,449,642			3,484,702
Issuance of Series D Preferred Stock and warrants, net of cash issuance costs of $21,299, Shares	3,506,000
Common Stock issued in Series D Preferred Stock conversion, Value	(5,000)	5,000
Common Stock issued in Series D Preferred Stock conversion, Shares	(500,000)	500,000
Common Stock and warrants issued to settle short-term note, Value		300	35,200			35,500
Common Stock and warrants issued to settle short-term note, Shares		30,000
Exercise of stock options, Value		7,058	129,732			136,790
Exercise of stock options, Shares		705,844
Net Loss					(10,029,591)	(10,029,591)
Ending balance, Value at Dec. 31, 2011	30,160	385,442	98,116,327	6,667	(81,570,007)	16,968,589
Ending balance, Shares at Dec. 31, 2011	3,015,974	38,543,994
Exercise of warrants, Value		1,655	210,363			212,018
Exercise of warrants, Shares		165,451
Fair value of derivative warrant liabilities reclassified to additional paid-in capital			61,520			61,520
Exercise of stock options, Value		2,245	193,014			195,259
Exercise of stock options, Shares		224,528
Proceeds from issuance of Common Stock, net, Value		40,800	3,231,402			3,272,202
Proceeds from issuance of Common Stock, net, Shares		4,080,000
Issuance of Common Stock subscribed			6,667	(6,667)
Fair value of Common Stock and warrants issued for services, Value		953	152,511			153,464
Fair value of Common Stock and warrants issued for services, Shares		95,332
Share-based compensation, Value		12,642	1,686,920			1,699,562
Share-based compensation, Shares		1,264,156
Net Loss					(12,332,008)	(12,332,008)
Ending balance, Value at Dec. 31, 2012	$ 30,160	$ 443,737	$ 103,658,724		$ (93,902,015)	$ 10,230,606
Ending balance, Shares at Dec. 31, 2012	3,015,974	44,373,461