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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0001415889-11-000081.txt : 20110218
<SEC-HEADER>0001415889-11-000081.hdr.sgml : 20110218
<ACCEPTANCE-DATETIME>20110218172751
ACCESSION NUMBER:		0001415889-11-000081
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20110216
FILED AS OF DATE:		20110218
DATE AS OF CHANGE:		20110218

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			SMITH JAMES FRANCIS
		CENTRAL INDEX KEY:			0001278350

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-23017
		FILM NUMBER:		11625568

	MAIL ADDRESS:	
		STREET 1:		80 SW 8TH ST
		CITY:			MIAMI
		STATE:			FL
		ZIP:			33130

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Echo Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001031927
		STANDARD INDUSTRIAL CLASSIFICATION:	ELECTROMEDICAL & ELECTROTHERAPEUTIC APPARATUS [3845]
		IRS NUMBER:				411649949
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			0208

	BUSINESS ADDRESS:	
		STREET 1:		10 FORGE PARKWAY
		CITY:			FRANKLIN
		STATE:			MA
		ZIP:			02038
		BUSINESS PHONE:		508 553-8850

	MAIL ADDRESS:	
		STREET 1:		10 FORGE PARKWAY
		CITY:			FRANKLIN
		STATE:			MA
		ZIP:			02038

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	SONTRA MEDICAL CORP
		DATE OF NAME CHANGE:	20020702

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	CHOICETEL COMMUNICATIONS INC/MN/
		DATE OF NAME CHANGE:	20020701

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	SONTRA MEDICAL CORP
		DATE OF NAME CHANGE:	20020701
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>form4-02182011_020239.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2011-02-16</periodOfReport>

    <issuer>
        <issuerCik>0001031927</issuerCik>
        <issuerName>Echo Therapeutics, Inc.</issuerName>
        <issuerTradingSymbol>ECTE</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001278350</rptOwnerCik>
            <rptOwnerName>SMITH JAMES FRANCIS</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>10 FORGE PARKWAY</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>FRANKLIN</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02038</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
            <isOfficer>false</isOfficer>
            <isTenPercentOwner>false</isTenPercentOwner>
            <isOther>false</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2011-02-16</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>20000</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0.00</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>27000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value></value>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">In accordance with a Restricted Stock Agreement dated as of February 16, 2011, 5,000 shares will vest on each of February 16, 2012, February 16, 2013, February 16, 2014 and February 16, 2015.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>Kimberly A. Burke, Attorney-in-Fact</signatureName>
        <signatureDate>2011-02-18</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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