-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0001031927-09-000002.txt : 20090728
<SEC-HEADER>0001031927-09-000002.hdr.sgml : 20090728
<ACCEPTANCE-DATETIME>20090728144709
ACCESSION NUMBER:		0001031927-09-000002
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20090728
DATE AS OF CHANGE:		20090728
EFFECTIVENESS DATE:		20090728

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Echo Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001031927
		STANDARD INDUSTRIAL CLASSIFICATION:	ELECTROMEDICAL & ELECTROTHERAPEUTIC APPARATUS [3845]
		IRS NUMBER:				411649949
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-59012
		FILM NUMBER:		09966962

	BUSINESS ADDRESS:	
		STREET 1:		10 FORGE PARKWAY
		CITY:			FRANKLIN
		STATE:			MA
		ZIP:			02038
		BUSINESS PHONE:		508 553-8850

	MAIL ADDRESS:	
		STREET 1:		10 FORGE PARKWAY
		CITY:			FRANKLIN
		STATE:			MA
		ZIP:			02038

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	SONTRA MEDICAL CORP
		DATE OF NAME CHANGE:	20020702

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	CHOICETEL COMMUNICATIONS INC/MN/
		DATE OF NAME CHANGE:	20020701

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	SONTRA MEDICAL CORP
		DATE OF NAME CHANGE:	20020701
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0502</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001031927</cik>
        <entityName>Echo Therapeutics, Inc.</entityName>
        <issuerAddress>
            <street1>10 FORGE PARKWAY</street1>
            <street2></street2>
            <city>FRANKLIN</city>
            <stateOrCountry>MA</stateOrCountry>
            <zipCode>02038</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>508 553-8850</issuerPhoneNumber>
        <issuerPreviousNameList>
            <previousName>SONTRA MEDICAL CORP</previousName>
            <previousName>CHOICETEL COMMUNICATIONS INC/MN/</previousName>
            <previousName>SONTRA MEDICAL CORP</previousName>
        </issuerPreviousNameList>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>PATRICK</firstName>
                <middleName></middleName>
                <lastName>MOONEY</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>625 CLINTON AVENUE</street1>
                <street2></street2>
                <city>HADDONFIELD</city>
                <stateOrCountry>NJ</stateOrCountry>
                <zipCode>08033</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>VINCENT</firstName>
                <middleName></middleName>
                <lastName>ENRIGHT</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>10 FORGE PARKWAY</street1>
                <street2></street2>
                <city>FRANKLIN</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02038</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>ROBERT</firstName>
                <middleName></middleName>
                <lastName>LANGER</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>77 MASSACHUSETTS AVENUE</street1>
                <street2>ROOM E25-342</street2>
                <city>CAMBRIDGE</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02139</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>SHAWN</firstName>
                <middleName></middleName>
                <lastName>SINGH</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>1737 ELIZABETH STREET</street1>
                <street2></street2>
                <city>SAN CARLOS</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94070</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>WALTER</firstName>
                <middleName></middleName>
                <lastName>WITOSHKIN</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>QUANTRX BIOMEDICAL COMPANY</street1>
                <street2>100 S. MAIN STREET, SUITE 300</street2>
                <city>DOYLESTOWN</city>
                <stateOrCountry>PA</stateOrCountry>
                <zipCode>18901</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>HARRY</firstName>
                <middleName></middleName>
                <lastName>MITCHELL</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>10 FORGE PARKWAY</street1>
                <street2></street2>
                <city>FRANKLIN</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02038</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>KIMBERLY</firstName>
                <middleName></middleName>
                <lastName>BURKE</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>1540 HERMITAGE COURT</street1>
                <street2></street2>
                <city>DURHAM</city>
                <stateOrCountry>NC</stateOrCountry>
                <zipCode>27707</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Other Health Care</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>$1,000,001 - $5,000,000</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-07-07</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>2000000</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>BURNHAM HILL PARTNERS</recipientName>
                <recipientCRDNumber>148000</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>590 MADISON AVENUE</street1>
                    <street2>5TH FLOOR</street2>
                    <city>NEW YORK</city>
                    <stateOrCountry>NY</stateOrCountry>
                    <zipCode>10022</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>NY</state>
                </statesOfSolicitationList>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>2006031</totalOfferingAmount>
            <totalAmountSold>2006031</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>1</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>200000</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Echo Therapeutics, Inc.</issuerName>
                <signatureName>HARRY G. MITCHELL</signatureName>
                <nameOfSigner>HARRY G. MITCHELL</nameOfSigner>
                <signatureTitle>CFO</signatureTitle>
                <signatureDate>2009-07-28</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----