Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Cash Flows from Operating Activities
Net income (loss)	$ (122,210)	$ (31,978)	$ (66,940)
Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities:
Depreciation and amortization	32,650	39,850	24,573
Deferred income taxes	940	2,648	(11,330)
Share-based compensation expense	15,741	17,986	18,813
Asset impairment	69,520	126	58,170
Gain on sale of lab tools		(1,261)	(1,549)
Provision (recovery) for bad debts	171	43	(1,814)
Gain on cumulative translation adjustment	(430)		(3,142)
Changes in contingent consideration			(29,368)
Changes in operating assets and liabilities:
Accounts receivable	(8,667)	10,715	(25,390)
Inventories and deferred cost of sales	(5,389)	(12,312)	6,513
Prepaid expenses and other current assets	6,726	(39)	(2,245)
Accounts payable and accrued expenses	(24,202)	9,470	(5,534)
Customer deposits and deferred revenue	8,807	(20,738)	55,536
Income taxes receivable and payable, net	547	759	20,279
Other, net	1,952	520	5,497
Net cash provided by (used in) operating activities	(23,844)	15,789	42,069
Cash Flows from Investing Activities
Acquisitions of businesses, net of cash acquired		(68)	(144,069)
Capital expenditures	(11,479)	(13,887)	(15,588)
Proceeds from the sale of investments	152,301	88,647	318,276
Payments for purchases of investments	(103,394)	(84,244)	(157,737)
Payments for purchase of cost method investment		(1,594)	(2,388)
Proceeds from sale of property, plant, and equipment	9,512
Proceeds from sale of lab tools		3,068	9,259
Other	(230)	1,000	350
Net cash provided by (used in) investing activities	46,710	(7,078)	8,103
Cash Flows from Financing Activities
Proceeds from stock option exercises and employee stock purchase plan	1,656	2,233	12,056
Restricted stock tax withholdings	(2,601)	(3,215)	(2,075)
Purchases of common stock	(13,349)	(8,907)
Repayments of long-term debt	(340)	(314)	(290)
Net cash provided by (used) in financing activities	(14,634)	(10,203)	9,691
Effect of exchange rate changes on cash and cash equivalents	(20)	(87)	149
Net increase in cash and cash equivalents	8,212	(1,579)	60,012
Cash and cash equivalents - beginning of period	269,232	270,811	210,799
Cash and cash equivalents - end of period	277,444	269,232	270,811
Supplemental Disclosure of Cash Flow Information
Interest paid	225	485	159
Income taxes paid	1,699	$ 7,091	$ 3,320
Non-cash operating and financing activities
Net transfer of inventory to property, plant and equipment	$ 1,827