Exhibit 12.1

CURAGEN CORPORATION AND SUBSIDIARY

RATIO OF EARNINGS TO FIXED CHARGES

(in thousands, except ratio data)

	Year Ended December 31,
	2008		2007			2006			2005			2004
Loss:
Income (loss) from continuing operations before income tax benefit	$	25,103	$	(50,148	)	$	(57,540	)	$	(69,571	)	$	(80,770	)
Add: Fixed charges		1,935		5,617			9,778			12,396			13,653
Total income (loss)	$	27,038	$	(44,531	)	$	(47,762	)	$	(57,175	)	$	(67,117	)
Fixed charges:
Interest expense on indebtedness (including amortization of financing costs)	$	1,687	$	5,167		$	9,351		$	11,701		$	12,941
Estimated interest portion of rental expense		248		450			427			695			712
Total fixed charges	$	1,935	$	5,617		$	9,778		$	12,396		$	13,653
Ratio of Earnings to Fixed Charges		13.97		(7.93	)		(4.88	)		(4.61	)		(4.92	)
Earnings (Deficiency) of Earnings Available to Cover Fixed Charges	$	25,103	$	(50,148	)	$	(57,540	)	$	(69,571	)	$	(80,770	)