Exhibit 12.1

CURAGEN CORPORATION AND SUBSIDIARY

RATIO OF EARNINGS TO FIXED CHARGES

(in thousands, except ratio data)

	Year Ended December 31,
	2006			2005			2004			2003			2002
Loss:
Loss before income tax benefit and minority interest in subsidiary loss	$	(61,303	)	$	(75,605	)	$	(97,231	)	$	(80,634	)	$	(95,793	)
Add: Fixed charges		9,919			12,481			13,706			10,623			10,909
Total loss	$	(51,384	)	$	(63,124	)	$	(83,525	)	$	(70,011	)	$	(84,884	)
Fixed charges:
Interest expense on indebtedness (including amortization of financing costs)	$	9,352		$	11,701		$	12,941		$	9,845		$	10,176
Estimated interest portion of rental expense		567			780			765			778			733
Total fixed charges	$	9,919		$	12,481		$	13,706		$	10,623		$	10,909
Ratio of Earnings to Fixed Charges		(5.18	)		(5.06	)		(6.09	)		(6.59	)		(7.78	)
Deficiency of Earnings Available to Cover Fixed Charges	$	(61,303	)	$	(75,605	)	$	(97,231	)	$	(80,634	)	$	(95,793	)