Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Mar. 31, 2019	Dec. 31, 2018
Current assets:
Cash and cash equivalents	$ 112,133	$ 49,348
Marketable securities available-for-sale	71,083	96,188
Accounts and other receivables, net	5,791	3,704
Inventories, net	27,569	19,022
Prepaid expenses and other current assets	5,948	6,102
Total current assets	222,524	174,364
Property and equipment, net	25,305	17,064
Intangible assets, net	9,445	11,717
Operating lease right-of-use assets	33,505
Goodwill	2,102	2,144
Restricted cash	615	619
Other assets	3,104	4,976
Total assets	296,600	210,884
Current liabilities:
Accounts payable	11,868	5,278
Accrued research and development	9,630	9,714
Accrued liabilities	12,384	16,041
Other current liabilities	8,369	7,000
Total current liabilities	42,251	38,033
Long-term debt, net	175,673	100,871
Long-term portion of lease liabilities	35,076
Other long-term liabilities	441	8,915
Total liabilities	253,441	147,819
Commitments and contingencies (Note 6)
Stockholders’ equity:
Preferred stock: $0.001 par value; 5,000 shares authorized at March 31, 2019 and December 31, 2018; no shares issued and outstanding at March 31, 2019 and December 31, 2018
Common stock: $0.001 par value; 139,000 shares authorized at March 31, 2019 and December 31, 2018; 65,020 and 62,862 shares issued and outstanding at March 31, 2019 and December 31, 2018, respectively	65	63
Additional paid-in capital	1,151,421	1,131,241
Accumulated other comprehensive loss	(2,431)	(2,015)
Accumulated deficit	(1,105,896)	(1,066,224)
Total stockholders’ equity	43,159	63,065
Total liabilities and stockholders’ equity	$ 296,600	$ 210,884