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Stock-Based Compensation Expense (Detail) (USD $)
In Thousands, unless otherwise specified
3 Months Ended 6 Months Ended
Jun. 30, 2013
Jun. 30, 2012
Jun. 30, 2013
Jun. 30, 2012
Deferred Compensation Arrangement with Individual, Share-based Payments [Line Items]        
Share Based Compensation $ 3,736 $ 2,069 $ 8,002 $ 4,391
Research and Development Expense
       
Deferred Compensation Arrangement with Individual, Share-based Payments [Line Items]        
Share Based Compensation 1,027 938 2,350 1,741
General and Administrative Expense
       
Deferred Compensation Arrangement with Individual, Share-based Payments [Line Items]        
Share Based Compensation $ 2,709 $ 1,131 $ 5,652 $ 2,650