Summary of Significant Accounting Policies - Additional Information (Detail) $ in Thousands	12 Months Ended
	Dec. 31, 2022 USD ($) Segment	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)	May 31, 2021 USD ($)
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]
Number of operating segment | Segment	1
Long-term debt, net of debt discount	$ 3,922	$ 5,010
Net income (loss)	293,156	76,713	$ (75,240)
Unrealized foreign currency translation (loss) gain	(1,800)	(2,500)	2,700
Currency transaction gain (loss)	$ 100	$ 900	(800)
Percentage of long lived assets	34.00%	43.00%
Inventory write-off	$ 34,288	$ 2,588	$ 0
Inventory write-offs recognized	34,300	$ 0
Goodwill impairment	0
2.50% Convertible Senior Notes Due 2026
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]
Principal amount	$ 225,500			$ 200,000
Debt interest rate	2.50%			2.50%
Long-term debt, net of debt discount	$ 3,900
Debt maturity date	May 15, 2026
Product | Credit Concentration Risk
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]
Concentration risk, customer	one
Product | Trade Receivable | Credit Concentration Risk
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]
Concentration risk, customer		one
Product | Trade Receivable | Customer Concentration Risk
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]
Concentration risk, percentage	100.00%	94.00%
HEPLISAV-B
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]
Inventory write-off	$ 0	$ 2,600
HEPLISAV-B | Credit Concentration Risk
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]
Concentration risk, customer	three	three
HEPLISAV-B | Trade Receivable | Credit Concentration Risk
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]
Concentration risk, percentage	78.00%	76.00%
Maximum
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]
Cash equivalents original maturity period	3 months
Percentage of long lived assets	10.00%	10.00%
Expected period of payment to be received	1 year
Dynavax GmbH
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]
Cumulative translation adjustment	$ (4,000)	$ (2,300)