Revenue Recognition - Schedule of Revenues from Major Customers (Details) - Revenue Benchmark [Member] - Product Concentration Risk [Member]	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Largest Customer | HEPLISAV-B
Concentration Risk [Line Items]
Percentage of product revenue	21.00%	21.00%	22.00%
Second Largest Customer | HEPLISAV-B
Concentration Risk [Line Items]
Percentage of product revenue	19.00%	20.00%	21.00%
Third Largest Customer | HEPLISAV-B
Concentration Risk [Line Items]
Percentage of product revenue	19.00%	20.00%	19.00%
Largest Collaboration Partner | CpG 1018
Concentration Risk [Line Items]
Percentage of product revenue	49.00%	62.00%	0.00%
Second Largest Collaboration Partner | CpG 1018
Concentration Risk [Line Items]
Percentage of product revenue	24.00%	36.00%	0.00%
Third Largest Customer | CpG 1018
Concentration Risk [Line Items]
Percentage of product revenue	19.00%	2.00%	0.00%