POWER OF ATTORNEY
EX-24

 I, Jeffrey E. Jacob hereby authorize and designate each of Jennifer K.
 Simpson, Susan Horvath, W. Morgan Burns, Joshua L. Colburn, Vilena Nicolet, and
 Amra Hoso signing singly, as my true and lawful attorney-in-fact to:

 (1)	execute for and on my behalf, in my capacity as an officer and/or
 director of Panbela Therapeutics, Inc. (the "Company"), Form ID or Forms 3, 4
 and 5 in accordance with Section 16(a) of the Securities Exchange Act of 1934
 (the "Exchange Act") and the rules and regulations promulgated thereunder and
 other forms or reports on my behalf as may be required to be filed in
 connection with my ownership, acquisition, or disposition of securities
 of the Company, including Form 144 and Schedule 13D or Schedule 13G;

 (2)	do and perform any and all acts for and on my behalf, which may be
 necessary or desirable to complete and execute any such Form ID, Forms 3, 4 or
 5, Form 144, Schedule 13D or Schedule 13G and timely file such form with the
 Securities and Exchange Commission and any stock exchange or similar authority;
 and

 (3)	take any other action of any type whatsoever in connection with the
 foregoing which, in the opinion of such attorney-in-fact, may be to my benefit,
 in my best interest, or legally required of me, it being understood that the
 statements executed by such attorney-in-fact on my behalf pursuant to this
 Power of Attorney shall be in such form and shall contain such terms
 and conditions as such attorney-in-fact may approve in such
 attorney-in-fact's discretion.

 I hereby further grant to each such attorney-in-fact full power and
 authority to do and perform any and every act and thing whatsoever requisite,
 necessary, or proper to be done in the exercise of any of the rights and
 powers herein granted, as fully to all intents and purposes as I might or
 could do if personally present, with full power of substitution or
 revocation, hereby ratifying and confirming all that such
 attorney-in-fact, or such attorney-in-fact's substitute or substitutes,
 shall lawfully do or cause to be done by virtue of this Power of
 Attorney and the rights and powers herein granted. I herebyz
 acknowledge that the foregoing attorneys-in-fact, in serving in such
 capacity at my request, are not assuming, nor is the Company assuming,
 any of my responsibilities to comply with Section 16 of the Exchange Act.

 This Power of Attorney shall remain in full force and effect until I am no
 longer required to file Form ID or Forms 3, 4 and 5 with respect to my
 holdings of and transactions in securities issued by the Company, unless
 earlier revoked by me in a signed writing delivered to the foregoing
 attorneys-in-fact.  Notwithstanding the foregoing, if any such
 attorney-in-fact hereafter ceases to be at least one of the following:
  (i) a partner of Faegre Drinker Biddle & Reath LLP or
 (ii) an employee of Faegre Drinker Biddle & Reath LLP, then this
 Power of Attorney shall be automatically revoked solely as to
 such individual, immediately upon such cessation, without
 any further action on my part.

 I hereby revoke all previous Powers of Attorney that have been granted
 by me in connection with my reporting obligations under Section 16 of
 the Exchange Act with respect to my holdings of and transactions
 in securities issued by the Company.

 IN WITNESS WHEREOF, I have caused this Power of Attorney to be duly
 executed as of this 15th day of June 2022.

/s/ Jeffrey E. Jacob