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Note 5 - Summary of Significant Accounting Policies (Tables)
3 Months Ended
Mar. 31, 2020
Notes Tables  
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
   
March 31,
 
   
2020
   
2019
 
Employee and non-employee stock options
   
1,745,811
     
1,032,211
 
Estimated common shares issuable upon conversion of notes payable and accrued interest
   
-
     
636,234
 
Common stock issuable under common stock purchase warrants
   
3,497,099
     
2,509,477
 
     
5,242,910
     
4,177,922