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Note 11 - Income Taxes - Income Tax Reconciliation (Details)
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Statutory rate 21.00% 34.00%
Permanent differences 0.10% (13.50%)
Change in effective tax rate 0.60% (17.20%)
Valuation allowance (22.60%) (6.60%)
Foreign research incentives 5.70% 3.80%
Deferred true-up 3.00%
Other 0.90% 0.30%
Effective rate 5.70% 3.80%