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Note 7 - Commitments and Contingencies (Details Textual)
12 Months Ended
Dec. 22, 2011
USD ($)
Dec. 31, 2017
USD ($)
Dec. 31, 2016
USD ($)
Accounts Payable, Current   $ 1,196,000 $ 1,245,000
SBP - 101 [Member]      
Number of Patients Enrolled   29  
Expected Cost of Approval   $ 200,000,000  
Indemnification Agreement [Member]      
Loss Contingency Accrual   $ 0 0
Minimum [Member] | SBP - 101 [Member]      
Estimated Time for Approval   5 years  
Maximum [Member] | SBP - 101 [Member]      
Estimated Time for Approval   6 years  
Licensing Agreement with University of Florida Research Foundation [Member]      
Royalty Term 10 years    
Minimum Annual Royalties, Due 270 Days After First Commercial Sale $ 50,000    
Minimum Annual Royalties, Due on the First Anniversary Date of the First Payment 100,000    
Minimum Annual Royalties, Due on the Second Anniversary Date of the First Payment 100,000    
Minimum Annual Royalties, Due on the Third Anniversary Date and Subsequent Anniversary Dates of the First Payment 300,000    
Annual License Maintenance Fee 10,000    
Accounts Payable, Current     50,000
Licensing Agreement with University of Florida Research Foundation [Member] | License Maintenance Fee [Member]      
Royalty Expense   $ 10,000 $ 10,000
Licensing Agreement with University of Florida Research Foundation [Member] | Milestone Payment Due Upon Enrollment of the First Subject in Phase II Clinical Trial [Member]      
Milestone Payments 300,000    
Licensing Agreement with University of Florida Research Foundation [Member] | Milestone Payments Due Upon Approval of a New Drug Application [Member]      
Milestone Payments 3,000,000    
Licensing Agreement with University of Florida Research Foundation [Member] | Milestone Payments Due Upon Approval to Manufacture and Market in Either European Union or Japan [Member]      
Milestone Payments 2,000,000    
Licensing Agreement with University of Florida Research Foundation [Member] | Milestone Payments Due Upon First Time Annual Net Sales of Licensed Products Reach 100,000,000 [Member]      
Milestone Payments 1,000,000    
Net Sales Required before Milestone Payments 100,000,000    
Licensing Agreement with University of Florida Research Foundation [Member] | Milestone Payments Due Upon the First Time Annual Net Sales of Licensed Product Reaches 500,000,000 [Member]      
Milestone Payments 3,000,000    
Net Sales Required before Milestone Payments $ 500,000,000    
Licensing Agreement with University of Florida Research Foundation [Member] | Minimum [Member]      
Royalty Fee Percentage of Net Sales 2.50%    
Licensing Agreement with University of Florida Research Foundation [Member] | Maximum [Member]      
Royalty Fee Percentage of Net Sales 5.00%