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Note 9 - Stock-based Compensation (Tables)
9 Months Ended
Sep. 30, 2017
Notes Tables  
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]
   
Nine
months
Ended
 
   
September
30
, 2017
   
September
30
, 2016
 
Research and development
  $
229
    $
 
G
eneral and administrative
   
938
     
 
Total
share-based compensation
  $
1,167
    $
 
Share-based Compensation, Stock Options, Activity [Table Text Block]
   
Shares
Available for
Grant
   
Shares
Underlying
Options
   
Weighted
Average
Exercise Price
Per Share
   
Aggregate
Intrinsic
Value
 
Balances
at December 31, 2016
   
1,114,400
     
701,960
    $
9.50
    $
3,896,235
 
Granted
   
(4,000
)    
4,000
     
10.10
     
 
 
Exercised
   
     
(22,000
)    
1.25
     
 
 
Cancelled
   
     
     
     
 
 
Balances
at September 30, 2017
   
1,110,400
     
683,960
    $
9.77
    $
2,121,985
 
Schedule of Share-based Compensation, Shares Authorized under Stock Option Plans, by Exercise Price Range [Table Text Block]
   
 
 
 
Outstanding, Vested and Expected to Vest
   
Options Vested and Exercisable
 
   
 
 
 
 
 
 
 
Weighted Average
   
 
 
 
 
 
 
 
 
Weighted Average
 
   
 
 
 
 
 
 
 
Remaining
   
Weighted
   
 
 
 
 
Remaining
 
Per Share
   
 
 
 
 
Contractual
   
Average
   
Options
   
Contractual
 
Exercise Price
   
Shares
   
Life (Years)
   
Exercise Price
   
Exercisable
   
Life (Years)
 
$0.88
1.10
     
38,360
     
5.08
    $
1.00
     
38,360
     
5.08
 
2.28
2.50
     
42,000
     
6.37
     
2.47
     
42,000
     
6.37
 
 
3.18
 
     
214,000
     
7.42
     
3.18
     
214,000
     
7.42
 
 
10.10
 
     
4,000
     
4.28
     
10.10
     
     
 
 
15.10
 
     
385,600
     
8.76
     
15.10
     
196,050
     
9.11
 
 
 
 
     
683,960
     
7.96
    $
9.77
     
490,410
     
7.83
 
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
   
2017
   
2016
 
Common stock fair value
   
$10.00
$29.80
     
n/a
 
Risk-free interest rate
   
1.43%
1.93%
     
n/a
 
Expected dividend yield
   
 
0%
 
     
n/a
 
Expected option life (in years)
   
2.25
  5.0
     
n/a
 
Expected stock price volatility
   
75.0
78.0%
     
n/a