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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 Nki4EUWiasEB31TagYdPhuHJXrvurXMPR5POnHuxZf4TuCGL4h2XljYEQjz54uHS
 rNqUvzyXnoW9o8whkVnjtA==

<SEC-DOCUMENT>0001104659-08-020224.txt : 20080327
<SEC-HEADER>0001104659-08-020224.hdr.sgml : 20080327
<ACCEPTANCE-DATETIME>20080327125829
ACCESSION NUMBER:		0001104659-08-020224
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20080310
FILED AS OF DATE:		20080327
DATE AS OF CHANGE:		20080327

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			O'Leary George
		CENTRAL INDEX KEY:			0001430860

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-21607
		FILM NUMBER:		08714268

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		303-279-7900

	MAIL ADDRESS:	
		STREET 1:		C/O ISONICS CORPORATION
		STREET 2:		5906 MCINTYRE STREET
		CITY:			GOLDEN
		STATE:			CO
		ZIP:			80403

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ISONICS CORP
		CENTRAL INDEX KEY:			0001023966
		STANDARD INDUSTRIAL CLASSIFICATION:	CHEMICALS & ALLIED PRODUCTS [2800]
		IRS NUMBER:				770338561
		STATE OF INCORPORATION:			CA
		FISCAL YEAR END:			0430

	BUSINESS ADDRESS:	
		STREET 1:		5906 MCINTYRE STREET
		CITY:			GOLDEN
		STATE:			CO
		ZIP:			80403
		BUSINESS PHONE:		3032797900

	MAIL ADDRESS:	
		STREET 1:		5906 MCINTYRE STREET
		CITY:			GOLDEN
		STATE:			CO
		ZIP:			80403
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>a3.xml
<DESCRIPTION>3
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2008-03-10</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001023966</issuerCik>
        <issuerName>ISONICS CORP</issuerName>
        <issuerTradingSymbol>ISON</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001430860</rptOwnerCik>
            <rptOwnerName>O'Leary George</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>5906 MCINTYRE STREET</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>GOLDEN</rptOwnerCity>
            <rptOwnerState>CO</rptOwnerState>
            <rptOwnerZipCode>80403</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <remarks>Mr. O'Leary does not directly or indirectly beneficially own any Isonics securities.  This Form 3 is being filed as required by Section 16 of the 1934 Securities Exchange Act.</remarks>

    <ownerSignature>
        <signatureName>/s/ George O'Leary</signatureName>
        <signatureDate>2008-03-26</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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