-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 P7NBEfUUrScYc4PhlFb68VSIKoVJqpvHMghP+JR87/p3VWjMY80V3bY1AqrKPfQ+
 P0LdfePNbZRxOrkiftY20A==

<SEC-DOCUMENT>0001104659-05-008212.txt : 20050224
<SEC-HEADER>0001104659-05-008212.hdr.sgml : 20050224
<ACCEPTANCE-DATETIME>20050224210435
ACCESSION NUMBER:		0001104659-05-008212
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20050222
FILED AS OF DATE:		20050224
DATE AS OF CHANGE:		20050224

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			GRADY DANIEL J
		CENTRAL INDEX KEY:			0001197756

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-12531
		FILM NUMBER:		05638750

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		3032797900

	MAIL ADDRESS:	
		STREET 1:		ISONICS CORP
		STREET 2:		5906 MCINTYRE STREET
		CITY:			GOLDEN
		STATE:			CO
		ZIP:			80403

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ISONICS CORP
		CENTRAL INDEX KEY:			0001023966
		STANDARD INDUSTRIAL CLASSIFICATION:	CHEMICALS & ALLIED PRODUCTS [2800]
		IRS NUMBER:				770338561
		STATE OF INCORPORATION:			CA
		FISCAL YEAR END:			0430

	BUSINESS ADDRESS:	
		STREET 1:		5906 MCINTYRE STREET
		CITY:			GOLDEN
		STATE:			CO
		ZIP:			80403
		BUSINESS PHONE:		3032797900

	MAIL ADDRESS:	
		STREET 1:		5906 MCINTYRE STREET
		CITY:			GOLDEN
		STATE:			CO
		ZIP:			80403
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>a4.xml
<DESCRIPTION>4
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2005-02-22</periodOfReport>

    <notSubjectToSection16>1</notSubjectToSection16>

    <issuer>
        <issuerCik>0001023966</issuerCik>
        <issuerName>ISONICS CORP</issuerName>
        <issuerTradingSymbol>ISON</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001197756</rptOwnerCik>
            <rptOwnerName>GRADY DANIEL J</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>ISONICS CORPORATION 5906 MCINTYRE STREET</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>GOLDEN</rptOwnerCity>
            <rptOwnerState>CO</rptOwnerState>
            <rptOwnerZipCode>80403</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>See Remarks</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
                <footnoteId id="F7"/>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>55154</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Stock Option</value>
                <footnoteId id="F1"/>
                <footnoteId id="F2"/>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>0.58</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>1996-01-02</value>
            </exerciseDate>
            <expirationDate>
                <value>2006-01-02</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>207340</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>207340</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Stock Option</value>
                <footnoteId id="F3"/>
                <footnoteId id="F4"/>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>1.06</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2001-11-13</value>
            </exerciseDate>
            <expirationDate>
                <value>2001-11-13</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>100000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>100000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Stock Option</value>
                <footnoteId id="F3"/>
                <footnoteId id="F5"/>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>1.13</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2002-03-28</value>
            </exerciseDate>
            <expirationDate>
                <value>2007-03-28</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>6375</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>6375</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Stock Option</value>
                <footnoteId id="F3"/>
                <footnoteId id="F6"/>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>1.20</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2003-12-16</value>
            </exerciseDate>
            <expirationDate>
                <value>2003-12-16</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>50000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>50000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Issuer's right to repurchase these options as disclosed on Form 3 dated 9/22/97 expired on 10/1/98.</footnote>
        <footnote id="F2">The number of shares and convertible/exercise price reflects a 3-for-1 stock split effected by the issuer following the effectiveness of its Registration Statement on Form SB-2 for its initial public offering of its securities.</footnote>
        <footnote id="F3">This transaction is exempt from Section 16 pursuant to Rule 16b-3(d).</footnote>
        <footnote id="F4">20,000 shares vest on November 13, 2001 and 20,000 shares vest on November 13th of each of the years 2002, 2003, 2004 and 2005.  The grant of options was subject to acceptance by the reporting person.  The reporting person accepted the options on December 19, 2001.</footnote>
        <footnote id="F5">Options granted by resolution of the Compensation Committee of the Board of Directors as consideration for salary deferral.  The grant of the options is subject to acceptance by the reporting person by no later than April 30, 2002, which acceptance was received.</footnote>
        <footnote id="F6">Options granted by resolution of the Board of Directors pursuant to the 1996 Executives' Equity Incentive Plan.  The grant of the options is subject to acceptance by the reporting person, which acceptance was received on December 16, 2003.</footnote>
        <footnote id="F7">A portion of these Shares were acquired pursuant to an Employee Stock Purchase Plan.  The transaction is therefore exempt from Section 16(a) reporting requirements by reason of Rule 16a-3(f)(i)(B) and is exempt from Section 16(b) by reason of Rules 16b-3(c) and 16(b)-3(d).</footnote>
    </footnotes>

    <remarks>Effective as of February 22, 2005, Daniel J. Grady is no longer an officer, as that term is defined in Rule 16a-1(f).</remarks>

    <ownerSignature>
        <signatureName>/s/ Daniel J. Grady</signatureName>
        <signatureDate>2005-02-23</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----