EXHIBIT 99.1


SIMULATIONS PLUS
Integrating Science and Software
For Further Information:
SIMULATIONS PLUS, INC.
1220 W. Avenue J
Lancaster, CA 93534-2902
661.723.7723
www.simulations-plus.com

CONTACT:
Investor Relations
Ms. Renee Bouche
Simulations Plus, Inc.
661.723.7723
info@simulations-plus.com

For Immediate Release:

November 28, 2005

             SIMULATIONS PLUS ANNOUNCES CHANGE IN INVESTOR RELATIONS

         FUNCTION TO BE MOVED IN-HOUSE FOR GREATER OPERATING EFFICIENCY

     LANCASTER, CA, NOVEMBER 28, 2005 --Simulations Plus, Inc. (AMEX: SLP), the
leading provider of ADMET absorption simulation and structure-to-property
prediction software for pharmaceutical discovery and development, announced
today that it has terminated its former investor relations agreement with
Cameron and Associates and will move this function in-house.

     Walt Woltosz, chairman and chief executive officer of Simulations Plus,
said, "As the company has grown and we have learned more about how to handle
investor relations issues, we have decided to do as many other companies have
done and bring this function in-house. We believe that this will provide greater
shareholder value through both a significant cost savings, as well as allowing a
greater number of person-hours to be applied to this function to provide a more
active IR program."

ABOUT SIMULATIONS PLUS, INC.

Simulations Plus, Inc., is a premier developer of groundbreaking drug discovery
and development simulation software, which is licensed to and used in the
conduct of drug research by major pharmaceutical and biotechnology companies
worldwide. The Company has two other businesses, Words+, Inc. and FutureLab(TM),
which are based on its proprietary software technologies. Simulations Plus,
Inc., is headquartered in Southern California. For more information, visit our
Web site at www.simulations-plus.com.

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