EXHIBIT 1

Joint Filing Agreement

This Joint Filing Agreement is entered into as of August 21, 2013, by the undersigned, who hereby agree that the Statement on Amendment No. 1 to Schedule 13D in respect of the common shares ofTransition Therapeutics Inc. is, and any amendment subsequently signed by each of the undersigned shall be, filed on behalf of each of the undersigned pursuant to and in accordance with the provisions of Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended.

/S/ JACK W. SCHULER

Jack W. Schuler

/S/ RENATE SCHULER

Renate Schuler

Schuler Family Foundation
By	/S/ JACK W. SCHULER
	Jack W. Schuler, Director

Tanya Eva Schuler Trust
By	/S/ H. GEORGE SCHULER
	H. George Schuler, Trustee

Therese Heidi Schuler Trust
By	/S/ H. GEORGE SCHULER
	H. George Schuler, Trustee

Tino Hans Schuler Trust
By	/S/ H. GEORGE SCHULER
	H. George Schuler, Trustee