UNITED STATES
                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C. 20549

                                  Form 13F

                             Form 13F COVER PAGE


Report for the Calendar Year or Quarter Ended: December 31, 2005

Check here if Amendment [ ]; Amendment No.:
This Amendment (Check only one.): [ ] is a restatement.
                                  [ ] adds new holdings entries.

Institutional Investment Manager Filing this Report:

Name:    Rho Capital Partners, Inc.
Address: 152 West 57th Street
         23rd Floor
         New York, New York 10019

13F File Number:  28-5883

The institutional investment manager filing this report and the person by whom
it is signed hereby represent that the person signing the report is authorized
to submit it, that all information contained herein is true, correct and
complete, and that it is understood that all required items, statements,
schedules, lists, and tables, are considered integral parts of this form.

Person Signing this Report on Behalf of Reporting Manager:

Name:   Peter E. Kalkanis

Title:  Chief Financial Officer

Phone:  212-751-6677


/s/ Peter E. Kalkanis     New York, New York   Dated: February 14, 2006.



Report Type (Check only one.):

[X] 13F HOLDINGS REPORT.

[ ] 13F NOTICE.

[ ] 13F COMBINATION REPORT.


I AM SIGNING THIS REPORT AS REQUIRED BY THE SECURITIES EXCHANGE ACT OF 1934.





                            FORM 13F SUMMARY PAGE


Report Summary:


Number of Other Included Managers:          0

Form 13F Information Table Entry Total:     16

Form 13F Information Table Value Total:     $201,689
                                           (thousands)



List of Other Included Managers:


Provide a numbered list of the name(s) and Form 13F file number(s) of all
institutional investment managers with respect to which this report is filed,
other than the manager filing this report.



       NONE







                                                  FORM 13F INFORMATION TABLE

                                             Value      Shares/  Sh/  Put/ Invstmt Other   Voting Authority
  Name of Issuer   Title of Class   CUSIP    (x$1000)   PrnAmt   Prn  Call Discret Mngrs   Sole Shared None

                                                                      

ACTIVE POWER INC          COM      00504W100     4,459  1,158,269   SH         Sole      1,158,269
ADVANCIS PHARMA          COM       00764L109     5,314  3,850,476   SH         Sole      3,850,476
AVANT IMMUNOTHRPTCS      COM       053491106       844    449,155   SH         Sole        449,155
CAPSTONE TURBINE          COM      14067D102    13,005  4,349,417   SH         Sole      4,349,417
CISCO SYS INC            COM       17275R102       831     48,534   SH         Sole         48,534
CYBERONICS INC            COM      23251P102    31,523    975,953   SH         Sole        975,953
DIVERSA CORP              COM      255064107     7,887  1,643,075   SH         Sole      1,643,075
GENVEC INC                COM      37246C109     4,276  2,591,790   SH         Sole      2,591,790
INPHONIC INC              COM      45772G105     1,645    189,265   SH         Sole        189,265
IVILLAGE INC              COM      46588H105    13,477  1,680,386   SH         Sole      1,680,386
MOBILE TELESYS         SPONS ADR   607409109     2,070     59,140   SH         Sole         59,140
NETLOGIC MICROSYS        COM       64118B100     1,381     50,656   SH         Sole         50,656
NITROMED INC              COM      654798503    76,297  5,469,333   SH         Sole      5,469,333
ROSTELECOM OPEN       SPONS ADR    778529107     1,457    106,723   SH         Sole        106,723
SENOMYX INC              COM       81724Q107    15,591  1,286,388   SH         Sole      1,286,388
TERCICA INC              COM       88078L105    21,632  3,016,987   SH         Sole      3,016,987