Summary of Significant Accounting Policies (Tables)

12 Months Ended

Dec. 31, 2020

Summary of Product Revenue by Geographical Locations of Customers

Product revenue by geographical locations of customers during the years ended December 31, 2020, 2019 and 2018, were as follows (in thousands):


	Year Ended December 31,
	2020		2019		2018
Product revenue:
Europe, Middle East and Africa	$	57,427	$	52,499	$	46,974
North America		32,380		20,936		12,696
Other		2,113		1,214		1,238
Total product revenue	$	91,920	$	74,649	$	60,908

Computation of Basic and Diluted Net Loss per Share

The following table sets forth the reconciliation of the numerator and denominator used in the computation of basic and diluted net loss per share for the years ended December 31, 2020, 2019 and 2018 (in thousands, except per share amounts):

	Year Ended December 31,
	2020			2019			2018
Numerator for Basic and Diluted:
Net loss used for basic calculation	$	(59,857	)	$	(71,244	)	$	(57,564	)
Denominator:
Basic weighted average number of shares outstanding		163,949			139,831			131,663
Effect of dilutive potential shares		—			—			—
Diluted weighted average number of shares outstanding		163,949			139,831			131,663
Net loss per share:
Basic and diluted	$	(0.37	)	$	(0.51	)	$	(0.44	)

Anti-Dilutive Effect of Common Shares

The table below presents potential shares that were excluded from the calculation of the weighted average number of shares outstanding used for the calculation of diluted net loss per share. These are excluded from the calculation due to their anti-dilutive effect for the years ended December 31, 2020, 2019 and 2018 (shares in thousands):


	Year Ended December 31,
	2020		2019		2018
Weighted average number of anti-dilutive potential shares:
Stock options		17,692		17,401		18,031
Restricted stock units		5,485		3,361		1,902
Employee stock purchase plan rights		32		72		20
Total		23,209		20,834		19,953