CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018
Operating activities
Net loss	$ (54,321)	$ (41,359)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	1,781	1,109
Stock-based compensation	9,612	7,579
Non-cash lease expense	1,224
Non-cash interest expense	343	892
Loss on disposal of property and equipment	14	5
Changes in operating assets and liabilities:
Accounts receivable	(5,750)	1,939
Inventories	(7,459)	1,043
Other assets	1,876	(2,724)
Accounts payable	3,005	3,020
Accrued liabilities and other non-current liabilities	(1,377)	4,459
Manufacturing and development obligations	(6,288)	(187)
Deferred product revenue	63	73
Net cash used in operating activities	(57,277)	(24,151)
Investing activities
Capital expenditures	(8,460)	(624)
Purchases of investments	(34,756)	(80,453)
Proceeds from maturities and sale of investments	62,000	30,002
Net cash provided by (used in) investing activities	18,784	(51,075)
Financing activities
Net proceeds from equity incentives	2,854	7,150
Net proceeds from public offering	17,803	79,301
Net proceeds from revolving line of credit	4,993
Proceeds from loans	39,433
Repayment of debt	(31,080)	(99)
Net cash provided by financing activities	34,003	86,352
Net (decrease) increase in cash, cash equivalents and restricted cash	(4,490)	11,126
Cash, cash equivalents and restricted cash, beginning of period	31,587	13,930
Cash, cash equivalents and restricted cash, end of period	$ 27,097	$ 25,056