0001571049-16-017032.txt : 20160803 0001571049-16-017032.hdr.sgml : 20160803 20160803101816 ACCESSION NUMBER: 0001571049-16-017032 CONFORMED SUBMISSION TYPE: 10-Q PUBLIC DOCUMENT COUNT: 49 CONFORMED PERIOD OF REPORT: 20160630 FILED AS OF DATE: 20160803 DATE AS OF CHANGE: 20160803 FILER: COMPANY DATA: COMPANY CONFORMED NAME: ARQULE INC CENTRAL INDEX KEY: 0001019695 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] IRS NUMBER: 043221586 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 10-Q SEC ACT: 1934 Act SEC FILE NUMBER: 000-21429 FILM NUMBER: 161802528 BUSINESS ADDRESS: STREET 1: ONE WALL STREET CITY: BURLINGTON STATE: MA ZIP: 01803 BUSINESS PHONE: 781-994-0300 MAIL ADDRESS: STREET 1: ONE WALL STREET CITY: BURLINGTON STATE: MA ZIP: 01803 10-Q 1 t1600465_10q.htm FORM 10-Q

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, DC 20549

FORM 10-Q

Quarterly report pursuant to Section 13 or 15(d)

of the Securities Exchange Act of 1934

For the Quarter Ended June 30, 2016

Commission File No. 000-21429

ArQule, Inc.

(Exact Name of Registrant as Specified in its Charter)

Delaware	04-3221586
(State of Incorporation)	(I.R.S. Employer Identification Number)

One Wall Street, Burlington, Massachusetts 01803

(Address of Principal Executive Offices)

(781) 994-0300

(Registrant’s Telephone Number, including Area Code)

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes x No ¨

Indicate by check mark whether the registrant has submitted electronically and posted on its Web site, if any, every Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T (§ 232.405) of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files). Yes x No ¨

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See definitions of “large accelerated filer,” “accelerated filer,” and “smaller reporting company” in Rule 12b-2 of the Exchange Act. (Check one):

Large accelerated filer ¨		Accelerated filer x

Non-accelerated filer ¨		Smaller reporting company ¨
(Do not check if a smaller reporting company)

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ¨ No x

Number of shares outstanding of the registrant’s Common Stock as of July 20, 2016:

Common Stock, par value $.01

71,106,954 shares outstanding

ARQULE, INC.

QUARTER ENDED JUNE 30, 2016

TABLE OF CONTENTS

PART I - FINANCIAL INFORMATION

Item 1. — Unaudited Condensed Financial Statements

	Condensed Balance Sheets (Unaudited) June 30, 2016 and December 31, 2015	3

	Condensed Statements of Operations and Comprehensive Loss (Unaudited) three and six months ended June 30, 2016 and 2015	4

	Condensed Statements of Cash Flows (Unaudited) six months ended June 30, 2016 and 2015	5

	Notes to Unaudited Condensed Financial Statements	6

Item 2. — Management’s Discussion and Analysis of Financial Condition and Results of Operations		14

Item 3. — Quantitative and Qualitative Disclosures about Market Risk		23

Item 4. — Controls and Procedures		23

PART II - OTHER INFORMATION

Item 1. — Legal Proceedings		24

Item 1A. — Risk Factors		24

Item 2. — Unregistered Sales of Equity Securities and Use Of Proceeds		24

Item 3. — Defaults Upon Senior Securities		24

Item 4. — Mine Safety Disclosures		24

Item 5. — Other Information		24

Item 6. — Exhibits		24

SIGNATURES		25

ARQULE, INC.

CONDENSED BALANCE SHEETS (Unaudited)

	June 30, 2016			December 31, 2015
	(IN THOUSANDS, EXCEPT SHARE AND PER SHARE DATA)
ASSETS
Current assets:
Cash and cash equivalents	$	17,454		$	13,983
Marketable securities-short term		25,661			24,789
Prepaid expenses and other current assets		420			714
Total current assets		43,535			39,486
Property and equipment, net		228			266
Other assets		252			252
Total assets	$	44,015		$	40,004

LIABILITIES AND STOCKHOLDERS’ EQUITY
Current liabilities:

Accounts payable and accrued expenses	$	6,235		$	6,234
Deferred revenue		2,301			4,591
Total current liabilities		8,536			10,825

Commitments and contingencies

Stockholders’ equity:
Preferred stock, $0.01 par value; 1,000,000 shares authorized; no shares issued or outstanding		—			—
Common stock, $0.01 par value; 100,000,000 shares authorized; 71,106,224 and 62,939,780 shares issued and outstanding at June 30, 2016 and December 31, 2015, respectively		711			629
Additional paid-in capital		526,934			510,664
Accumulated other comprehensive income		32			3
Accumulated deficit		(492,198	)		(482,117	)
Total stockholders’ equity		35,479			29,179
Total liabilities and stockholders’ equity	$	44,015		$	40,004

The accompanying notes are an integral part of these interim unaudited financial statements.

ARQULE, INC.

CONDENSED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS (Unaudited)

	THREE MONTHS ENDED June 30,						SIX MONTHS ENDED June 30,
	2016			2015			2016			2015
	(IN THOUSANDS, EXCEPT PER SHARE DATA)

Research and development revenue	$	1,072		$	3,004		$	2,299		$	5,789

Costs and expenses:
Research and development		4,337			4,327			8,535			8,740
General and administrative		1,887			2,776			3,931			5,963
Total costs and expenses		6,224			7,103			12,466			14,703

Loss from operations		(5,152	)		(4,099	)		(10,167	)		(8,914	)

Interest income		52			28			86			64
Other income		—			54			—			282

Net loss		(5,100	)		(4,017	)		(10,081	)		(8,568	)

Unrealized gain (loss) on marketable securities		—			(8	)		29			3
Comprehensive loss	$	(5,100	)	$	(4,025	)	$	(10,052	)	$	(8,565	)

Basic and diluted net loss per share:
Net loss per share	$	(0.07	)	$	(0.06	)	$	(0.15	)	$	(0.14	)

Weighted average basic and diluted common shares outstanding		71,062			62,754			68,275			62,747

The accompanying notes are an integral part of these interim unaudited financial statements

ARQULE, INC.

CONDENSED STATEMENTS OF CASH FLOWS (Unaudited)

	SIX MONTHS ENDED JUNE 30,
	2016			2015
	(IN THOUSANDS)
Cash flows from operating activities:
Net loss	$	(10,081	)	$	(8,568	)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization		53			91
Amortization of premium on marketable securities		40			322
Amortization of deferred gain on sale leaseback		—			(232	)
Non-cash stock compensation		1,015			1,240
Gain on sale of property and equipment		—			(282	)
Changes in operating assets and liabilities:
Prepaid expenses and other assets		294			1,196
Accounts payable and accrued expenses		1			(1,210	)
Deferred revenue		(2,290	)		(5,513	)
Net cash used in operating activities		(10,968	)		(12,956	)
Cash flows from investing activities:
Purchases of marketable securities		(21,648	)		(11,807	)
Proceeds from sale or maturity of marketable securities		20,765			26,339
Additions to property and equipment		(15	)		(280	)
Proceeds from sale of property and equipment		—			228
Net cash provided by (used in) investing activities		(898	)		14,480
Cash flows from financing activities:
Proceeds from stock offering, net		15,174			—
Proceeds from employee stock option exercises and employee stock purchase plan purchases		163			62
Net cash provided by financing activities		15,337			62
Net increase in cash and cash equivalents		3,471			1,586
Cash and cash equivalents, beginning of period		13,983			12,525
Cash and cash equivalents, end of period	$	17,454		$	14,111

The accompanying notes are an integral part of these interim unaudited financial statements.

ARQULE, INC.

NOTES TO UNAUDITED CONDENSED FINANCIAL STATEMENTS

(IN THOUSANDS, EXCEPT SHARE AND PER SHARE DATA)

1. NATURE OF OPERATIONS AND BASIS OF PRESENTATION

We are a biopharmaceutical company engaged in the research and development of innovative therapeutics to treat cancers and rare diseases. Our mission is to discover, develop and commercialize novel small molecule drugs in areas of high unmet need that will dramatically extend and improve the lives of our patients. These drugs target biological pathways implicated in a wide range of cancers and certain non-oncology indications. Our discovery and development efforts are guided, when possible, by an understanding of the role of biomarkers, which are indicators of a particular biological condition or process and may predict the clinical benefit of our compounds in defined patient populations. Our clinical-stage pipeline consists of five drug candidates, all of which are in targeted patient populations, making ArQule a leader among companies our size in precision medicine.

Our lead product candidate is tivantinib (ARQ 197), an orally administered, small molecule inhibitor of the c-Met receptor tyrosine kinase (“MET”) and its biological pathway. MET is a promising target for cancer therapy, based on its multiple roles in cancerous cell proliferation, tumor spread, new blood vessel formation and resistance to certain drug therapies. We and our partners, Daiichi Sankyo Co., Ltd. (“Daiichi Sankyo”) and Kyowa Hakko Kirin Co., Ltd. (“Kyowa Hakko Kirin”), are implementing a worldwide clinical development program with tivantinib. Our strategy is to focus on the most promising indications within our clinical programs based upon continually generated and updated clinical and pre-clinical data. Our lead indication is liver cancer (“hepatocellular carcinoma” or “HCC”), and we are currently conducting two Phase 3 trials with our partners. We have also completed earlier-stage single agent and combination therapy trials and pre-clinical experiments with tivantinib and other anti-cancer agents that may provide data to support trials in additional indications.

On March 22, 2016, we and Daiichi Sankyo announced that the independent data monitoring committee (“DMC”) of the METIV-HCC study conducted the planned interim assessment, and it was determined the trial will continue to its final analysis. Accordingly, we reviewed the estimated development period and extended it to December 2016 for both the METIV-HCC trial and the JET-HCC trial.

We have licensed commercial rights to tivantinib for human cancer indications to Daiichi Sankyo in the U.S., Europe, South America and the rest of the world, excluding Japan and certain other Asian countries, where we have licensed commercial rights to Kyowa Hakko Kirin. Our agreements with these partners provide for possible future milestone payments, royalties on product sales, and development funding, in addition to significant payments that we have already received. To date we have received $100 million in upfront and milestone payments from Daiichi Sankyo, $15 million of which was related to the first patient enrolled in the METIV-HCC trial. That milestone was netted against our cumulative share of Phase 3 collaboration costs in 2013, and consequently we did not receive any cash proceeds from this milestone. To date, we have received $48 million in upfront and milestone payments from Kyowa Hakko Kirin.

Our proprietary pipeline of product candidates is directed toward molecular targets and biological processes with demonstrated roles in the development of both human cancers and rare, non-oncology diseases. Our clinical-stage candidates include: ARQ 087, a multi-kinase inhibitor designed to preferentially inhibit the fibroblast growth factor receptor (“FGFR”) family; ARQ 092, a selective inhibitor of the AKT serine/threonine kinase; ARQ 751, a next generation AKT inhibitor; and ARQ 761, a Beta lapachone analog being evaluated in investigator-sponsored testing as a promoter of NQO1-mediated programmed cancer cell necrosis. Specific tumor types and biomarkers have been identified to guide our clinical testing, based on analyses of Phase 1a anti-cancer activity in humans, preclinical findings and scientific literature. In addition, we have advanced ARQ 531, an investigational, orally bioavailable, potent and reversible inhibitor of both wild type and C481S-mutant BTK, into toxicology testing and plan to file an Investigational New Drug Application in early 2017.

Our uses of cash for operating activities have primarily consisted of salaries and wages for our employees, facility and facility-related costs for our offices and laboratories, fees paid in connection with preclinical and clinical studies, laboratory supplies and materials, and professional fees. The sources of our cash flow from operating activities have consisted primarily of payments received from our collaborators for services performed or upfront payments for future services. For the six months ended June 30, 2016 and 2015, our net use of cash was primarily driven by payments for operating expenses which resulted in net cash outflows of $11.0 million and $13.0 million, respectively.

Our cash requirements may vary materially from those now planned depending upon the results of our drug discovery and development strategies, our ability to enter into additional corporate collaborations and the terms of such collaborations, results of research and development, unanticipated required capital expenditures, competitive and technological advances, acquisitions and other factors. We cannot guarantee that we will be able to develop any of our drug candidates into a commercial product. It is likely we will need to raise additional capital or incur indebtedness to continue to fund our operations in the future. Our ability to raise additional funds will depend on financial, economic and market conditions, and due to global capital and credit market conditions or for other reasons, we may be unable to raise capital when needed, or on terms favorable to us. If necessary funds are not available, we may have to delay, reduce the scope of, or eliminate some of our development programs, potentially delaying the time to market for any of our product candidates.

We have prepared the accompanying condensed financial statements pursuant to the rules and regulations of the U.S. Securities and Exchange Commission (“SEC”). Certain information and footnote disclosures normally included in financial statements prepared in accordance with generally accepted accounting principles have been condensed or omitted pursuant to these rules and regulations. These condensed financial statements should be read in conjunction with our audited financial statements and footnotes related thereto for the year ended December 31, 2015 included in our annual report on Form 10-K filed with the SEC on February 29, 2016.

In the opinion of the Company, the accompanying unaudited condensed financial statements contain all adjustments, consisting only of normal recurring adjustments, necessary for a fair statement of its financial position as of June 30, 2016, its results of operations for the three and six months ended June 30, 2016 and June 30, 2015, and its cash flows for the six months ended June 30, 2016 and June 30, 2015. The results of operations for such interim periods are not necessarily indicative of the results to be achieved for the full year. The condensed balance sheet at December 31, 2015 was derived from audited annual financial statements, but does not contain all of the footnote disclosures from the annual financial statements.

2. COLLABORATIONS AND ALLIANCES

Daiichi Sankyo Tivantinib Agreement

On December 18, 2008, we entered into a license, co-development and co-commercialization agreement with Daiichi Sankyo to conduct research, clinical trials and the commercialization of tivantinib in human cancer indications in the U.S., Europe, South America and the rest of the world, excluding Japan, China (including Hong Kong), South Korea and Taiwan, where Kyowa Hakko Kirin has exclusive rights for development and commercialization.

The agreement provides for a $60 million cash upfront licensing payment from Daiichi Sankyo to us, which we received in December 2008, and an additional $560 million in potential development and sales milestone payments offset by our share of Phase 3 costs. On November 3, 2015, the Company announced that it had exercised its option with Daiichi Sankyo to co-commercialize tivantinib in the United States (the “Co-Commercialization Option”), pursuant to the agreement. Subject to the receipt of regulatory approvals, the first commercial indication for tivantinib under the Co-Commercialization Option is anticipated to be second line HCC. The parties have a prescribed period to conclude a co-commercialization agreement in accordance with the terms of the agreement which is expected to occur in 2016. If the METIV-HCC trial is successful, and tivantinib is approved in second line HCC, the agreement provides that the Company will receive a total of $55 million in milestone payments for the official acceptance of drug approval applications by FDA and the European Medicines Agency (“EMA”) in this first indication, plus an additional $100 million in combined milestones tied to receipt of commercialization regulatory approval by the FDA and the first commercial sale in the UK, Germany, France, Italy or Spain. These milestones, totaling $155 million, will be partially offset by Phase 3 costs owed to Daiichi Sankyo by the Company at the time of approval in the US or EU. At June 30, 2016, the Company’s share of these Phase 3 costs totaled $64.7 million. The agreement also provides that the Company will receive tiered double digit royalties on net sales of tivantinib throughout the territory. Given the anticipated commercial market for second line HCC, the Company expects to earn royalties on net sales for this indication at the baseline contractual rate of 20 percent.

We and Daiichi Sankyo will share equally the costs of Phase 2 and Phase 3 clinical studies, with our share of Phase 3 costs payable solely from milestone and royalty payments by Daiichi Sankyo. Under the terms of our tivantinib collaboration agreement with Daiichi Sankyo we share development costs equally with our share of Phase 3 costs funded solely from milestones and royalties. In each quarter the tivantinib collaboration costs we incur are compared with those of Daiichi Sankyo. If our costs for the quarter exceed Daiichi Sankyo’s, we recognize revenue on the amounts due to us under the contingency adjusted performance model. Revenue is calculated on a pro-rata basis using the time elapsed from inception of the agreement over the estimated duration of the development period under the agreement. If our costs for the quarter are less than those of Daiichi Sankyo’s, we report the amount due to Daiichi Sankyo as contra-revenue in that quarter. To the extent that our share of Phase 3 collaboration costs exceeds the amount of milestones and royalties received, that excess is netted against future milestones and royalties if and when earned and is not reported as contra-revenue.

Our cumulative share of the Daiichi Sankyo Phase 3 costs through June 30, 2016 totaled $104.7 million. We received a milestone of $25 million in February 2011 upon enrolling the first patient in the MARQUEE trial, the cash proceeds of which were subsequently applied to our share of Phase 3 collaboration costs. On January 31, 2013, we announced that the first patient had been enrolled in the pivotal Phase 3 METIV trial of tivantinib, entitling us to a $15 million milestone. That $15 million milestone was also netted against our cumulative share of Phase 3 collaboration costs in 2013, and consequently we did not receive any cash proceeds from this milestone. Our cumulative share of Phase 3 collaboration costs has exceeded the amount of milestones received through June 30, 2016 by $64.7 million which will be netted against future milestones and royalties, if any, when earned and has not been reported as contra-revenue.

For the quarter ended June 30, 2016, our non-Phase 3 tivantinib collaboration costs incurred were less than those of Daiichi Sankyo’s and $78 was recognized as research and development contra-revenue. For the six months ended June 30, 2016, no research and development revenue was recognized related to our non-Phase 3 tivantinib collaboration as our costs incurred were offset by an equal amount of contra-revenue.

For the quarter ended June 30, 2015, our non-Phase 3 tivantinib collaboration costs incurred exceeded those of Daiichi Sankyo’s and $229 was recognized as tivantinib Daiichi Sankyo research and development revenue. For the six months ended June 30, 2015, our non-Phase 3 tivantinib collaboration costs incurred exceeded those of Daiichi Sankyo’s and $240 was recognized as tivantinib Daiichi Sankyo research and development revenue.

The duration and termination of the agreement are tied to future events. Unless earlier terminated due to breach, insolvency or upon 90 days’ notice if prior to Phase 3 clinical trials or 180 days’ notice if on or after the beginning of Phase 3 clinical trials by Daiichi Sankyo, the agreement shall continue until the later of (i) such time as Daiichi Sankyo is no longer developing at least one licensed product or (ii) if Daiichi Sankyo has commercialized a licensed product or products, such time as all royalty terms for all licensed products have ended. The royalty term, on a country-by-country basis for a product, ends as of the later of (i) the expiration of the last valid claim under a patent covering the manufacture, use, or sale of a licensed product or (ii) a certain number of years from the date of the commercial sale of the licensed product in such country.

Revenue for this agreement is recognized using the contingency-adjusted performance model. Through September 30, 2012, revenue was recognized based upon an estimated development period through December 2013. As a result of the October 2012 decision to discontinue the MARQUEE trial, the development period as of October 1, 2012 was extended to June 2015. Commencing with the fourth quarter of 2012 and through the third quarter of 2013 revenue was recognized over that development period. In the fourth quarter of 2013, following a recommendation by the DMC that the METIV-HCC trial continue with patients receiving a lower dose of tivantinib than the dose originally employed in the trial, we reviewed the estimated development period and extended it to June 2016. On March 22, 2016, we and Daiichi Sankyo announced that the DMC of the METIV-HCC study conducted the planned interim assessment, and it was determined the trial will continue to its final analysis. Accordingly, we reviewed the estimated development period and extended it to December 2016.

For the three months and six months ended June 30, 2016, $0.6 million and $1.4 million, respectively, were recognized as net revenue. For the three months and six months ended June 30, 2015, $1.6 million and $2.9 million, respectively, were recognized as net revenue. At June 30, 2016, $1.4 million remains in deferred revenue.

Kyowa Hakko Kirin Licensing Agreement

On April 27, 2007, we entered into an exclusive license agreement with Kyowa Hakko Kirin to develop and commercialize tivantinib in Japan and parts of Asia. A $3 million portion of an upfront licensing fee was received by the Company under this agreement in the first quarter of 2007, and an additional $27 million in upfront licensing fees was received on May 7, 2007. The agreement includes $123 million in upfront and potential development milestone payments from Kyowa Hakko Kirin to ArQule, including the $30 million cash upfront licensing payments. In February 2008, we received a $3 million milestone payment from Kyowa Hakko Kirin. Upon commercialization, ArQule will receive tiered royalties in the mid-teen to low-twenty percent range from Kyowa Hakko Kirin on net sales of tivantinib. Kyowa Hakko Kirin will be responsible for all clinical development costs and commercialization of the compound in certain Asian countries, consisting of Japan, China (including Hong Kong), South Korea and Taiwan. In July 2010, we announced the initiation of a Phase 2 trial with tivantinib by Kyowa Hakko Kirin in gastric cancer, for which we received a $5 million milestone payment in September 2010.

In August 2011, Kyowa Hakko Kirin announced the initiation of the Phase 3 ATTENTION trial. Dosing of the first patient in this trial triggered a $10 million milestone payment, which we received in August 2011. The milestone payment was recorded as deferred revenue and is being recognized as revenue using the contingency-adjusted performance model. On February 4, 2014, Kyowa Hakko Kirin announced the initiation of the Phase 3 JET-HCC trial. There were no milestone payments associated with the initiation of this trial.

In addition to the upfront and possible regulatory milestone payments totaling $123 million, the Company will be eligible for future milestone payments based on the achievement of certain levels of net sales. The Company will recognize the payments, if any, as revenue in accordance with the contingency-adjusted performance model. As of June 30, 2016, the Company had not recognized any revenue from these sales milestone payments, and there can be no assurance that it will do so in the future.

The duration and termination of the agreement are tied to future events. Unless earlier terminated due to breach, insolvency or upon 90 days’ notice by Kyowa Hakko Kirin, the agreement terminates on the date that the last royalty term expires in all countries in the territory. The royalty term ends as of the later of (i) the expiration of the last pending patent application or expiration of the patent in the country covering the manufacture, use, or sale of a licensed product or (ii) a certain number of years from the date of the commercial launch in such country of such license product.

Through December 2015, revenue for this agreement was recognized using the contingency-adjusted performance model with an estimated development period through April 2016. As noted for the Daiichi Sankyo tivantinib program, the estimated development period for the METIV-HCC study was reviewed and extended to December 2016 in the first quarter of 2016. Similarly, the estimated development period for the Kyowa Hakko Kirin Phase 3 JET-HCC trial was reviewed and also extended to December 2016.

For the three months and six months ended June 30, 2016, $0.5 million and $0.9 million, respectively, were recognized as revenue. For the three months and six months ended June 30, 2015, $1.4 million and $2.8 million, respectively, were recognized as revenue. At June 30, 2016, $0.9 million remains in deferred revenue.

Beryllium Discovery Corp. Agreement

In May 2015, we entered into a collaborative research and development agreement with Beryllium Discovery Corp. (“Beryllium”). Pursuant to the agreement, we will jointly focus on the identification and preclinical development of inhibitors of PD-1 and PDL-1. We and Beryllium will each be responsible for our respective internal and outsourcing costs during pre-clinical development. Following lead optimization of any potential drug candidates, we and Beryllium will jointly decide whether to advance compounds into GLP/toxicology and clinical testing, initially on a shared cost basis, provided that we will have the right to advance compounds on our own should Beryllium vote against such advancement. The agreement also provides that we will be responsible for clinical development and commercialization of product candidates that are not out-licensed. Beryllium will have the right to participate financially throughout the program but will also have the option to opt out at certain times and receive a royalty. The agreement will terminate after the last payment obligation is satisfied, or prior to that upon 60-days’ notice by either party.

3. MARKETABLE SECURITIES AND FAIR VALUE MEASUREMENTS

We generally classify our marketable securities as available-for-sale at the time of purchase and re-evaluate such designation as of each balance sheet date. Since we generally intend to convert them into cash as necessary to meet our liquidity requirements our marketable securities are classified as cash equivalents if the original maturity, from the date of purchase, is ninety days or less and as short-term investments if the original maturity, from the date of purchase, is in excess of ninety days but less than one year. Our marketable securities are classified as long-term investments if the maturity date is in excess of one year of the balance sheet date.

We report available-for-sale investments at fair value as of each balance sheet date and include any unrealized gains and, to the extent deemed temporary, unrealized losses in stockholders’ equity. Realized gains and losses are determined using the specific identification method and are included in other income (expense) in the statement of operations and comprehensive loss.

We conduct quarterly reviews to determine the fair value of our investment portfolio and to identify and evaluate each investment that has an unrealized loss, in accordance with the meaning of other-than-temporary impairment and its application to certain investments. An unrealized loss exists when the current fair value of an individual security is less than its amortized cost basis. In the event that the cost basis of a security exceeds its fair value, we evaluate, among other factors, the duration of the period that, and extent to which, the fair value is less than cost basis, the financial health of and business outlook for the issuer, including industry and sector performance, and operational and financing cash flow factors, overall market conditions and trends, our intent to sell the investment and if it is more likely than not that we would be required to sell the investment before its anticipated recovery. Unrealized losses on available-for-sale securities that are determined to be temporary, and not related to credit loss, are recorded in accumulated other comprehensive income (loss).

For available-for-sale debt securities with unrealized losses, we perform an analysis to assess whether we intend to sell or whether we would more likely than not be required to sell the security before the expected recovery of the amortized cost basis. Where we intend to sell a security, or may be required to do so, the security’s decline in fair value is deemed to be other-than-temporary and the full amount of the unrealized loss is reflected in the statement of operations and comprehensive loss as an impairment loss.

Regardless of our intent to sell a security, we perform additional analysis on all securities with unrealized losses to evaluate losses associated with the creditworthiness of the security. Credit losses are identified where we do not expect to receive cash flows sufficient to recover the amortized cost basis of a security.

The following is a summary of the fair value of available-for-sale marketable securities we held at June 30, 2016 and December 31, 2015:

June 30, 2016	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Fair Value
Security type
Corporate debt securities-short term	$	25,629	$	34	$	(2	)	$	25,661
Total available-for-sale marketable securities	$	25,629	$	34	$	(2	)	$	25,661

December 31, 2015	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Fair Value
Security type
Corporate debt securities-short term	$	24,786	$	13	$	(10	)	$	24,789
Total available-for-sale marketable securities	$	24,786	$	13	$	(10	)	$	24,789

Our available-for-sale marketable securities in a loss position at June 30, 2016, and December 31, 2015 were in a continuous unrealized loss position for less than 12 months.

The following tables present information about our assets that are measured at fair value on a recurring basis for the periods presented and indicates the fair value hierarchy of the valuation techniques we utilized to determine such fair value. In general, fair values determined by Level 1 inputs utilize quoted prices (unadjusted) in active markets for identical assets or liabilities. Fair values determined by Level 2 inputs utilize data points that are observable such as quoted prices, interest rates and yield curves. We value our level 2 investments using quoted prices for identical assets in the markets where they are traded, although such trades may not occur daily. These quoted prices are based on observable inputs, primarily interest rates. Fair values determined by Level 3 inputs are unobservable data points for the asset or liability, and include situations where there is little, if any, market activity for the asset or liability. There were no transfers in or out of Level 1 or Level 2 measurements for the periods presented:

	June 30, 2016		Quoted Prices in Active Markets (Level 1)		Significant Other Observable Inputs (Level 2)		Significant Unobservable Inputs (Level 3)
Cash equivalents	$	15,051	$	15,051	$	—	$	—
Corporate debt securities-short term		25,661		—		25,661		—
Total	$	40,712	$	15,051	$	25,661	$	—

	December 31, 2015		Quoted Prices in Active Markets (Level 1)		Significant Other Observable Inputs (Level 2)		Significant Unobservable Inputs (Level 3)
Cash equivalents	$	11,800	$	11,800	$	—	$	—
Corporate debt securities-short term		24,789		—		24,789		—
Total	$	36,589	$	11,800	$	24,789	$	—

4. ACCOUNTS PAYABLE AND ACCRUED EXPENSES

Accounts payable and accrued expenses include the following at June 30, 2016 and December 31, 2015:

	June 30, 2016		December 31, 2015
Accounts payable	$	313	$	186
Accrued payroll		1,288		1,956
Accrued outsourced pre-clinical and clinical fees		4,098		3,273
Accrued professional fees		307		516
Other accrued expenses		229		303
	$	6,235	$	6,234

5. NET LOSS PER SHARE

Net loss per share is computed using the weighted average number of common shares outstanding. Basic and diluted net loss per share amounts are equivalent for the periods presented as the inclusion of potential common shares in the number of shares used for the diluted computation would be anti-dilutive to loss per share. Potential common shares, for the three and six months ended June 30, 2016, include 9,189,198 shares that would be issued upon the exercise of outstanding employee stock options and 3,567,956 shares that would be issued upon exercise of the stock options issued in our February 26, 2016 stock offering. Potential common shares, for the three months and six months ended June 30, 2015, include 8,791,732 shares that would be issued upon the exercise of outstanding employee stock options.

6. STOCK-BASED COMPENSATION AND STOCK PLANS

Our stock-based compensation cost is measured at the grant date, based on the calculated fair value of the award, and is recognized as an expense over the employees’ requisite service period (generally the vesting period of the equity grant). We estimate the fair value of stock options using the Black-Scholes valuation model. Key input assumptions used to estimate the fair value of stock options include the exercise price of the award, expected option term, expected volatility of our stock over the option’s expected term, risk-free interest rate over the option’s expected term, and the expected annual dividend yield. We believe that the valuation technique and approach utilized to develop the underlying assumptions are appropriate in calculating the fair values of our stock options granted in the six months ended June 30, 2016 and 2015.

The following table presents stock-based compensation expense included in our Condensed Statements of Operations and Comprehensive Loss:

	Three Months Ended June 30,				Six Months Ended June 30,
	2016		2015		2016		2015
Research and development	$	109	$	124	$	299	$	396
General and administrative		312		298		716		844
Total stock-based compensation expense	$	421	$	422	$	1,015	$	1,240

In the three and six months ended June 30, 2016 and 2015, no stock-based compensation expense was capitalized and there were no recognized tax benefits associated with the stock-based compensation expense.

Option activity under our stock plans for the six months ended June 30, 2016 was as follows:

Stock Options	Number of Shares			Weighted Average Exercise Price
Outstanding as of December 31, 2015		8,305,950		$	4.24
Granted		1,609,000			1.78
Exercised		(97,498	)		1.16
Cancelled		(628,254	)		5.31
Outstanding as of June 30, 2016		9,189,198		$	3.77

Exercisable as of June 30, 2016		6,103,542		$	4.78

The aggregate intrinsic value of options outstanding at June 30, 2016 was $1,023 including $203 related to exercisable options. The weighted average grant date fair value of options granted in the six months ended June 30, 2016 and 2015 was $1.10 and $0.77 per share, respectively. The intrinsic value of options exercised in the six months ended June 30, 2016 was $60.

Shares vested, expected to vest and exercisable at June 30, 2016 are as follows:

Weighted-Average

Exercise Price

Weighted-Average

Remaining

Contractual

Term (in years)

Aggregate

Intrinsic

Value

Vested and unvested expected to vest at June 30, 2016

9,020,805

3.77

5.8

979

Exercisable at June 30, 2016

6,103,542

4.78

4.2

203

The total compensation cost not yet recognized as of June 30, 2016 related to non-vested option awards was $3.4 million, which will be recognized over a weighted-average period of 2.7 years. During the six months ended June 30, 2016, 551,036 shares expired and 2,218 shares were forfeited. The weighted average remaining contractual life for options exercisable at June 30, 2016 was 4.2 years.

In 2013, we granted 242,697 shares of restricted stock to employees, vesting annually over a four year period. The weighted average fair value of the restricted stock at the time of grant in 2013 was $2.51 per share, and is being expensed ratably over the vesting period. Through June 30, 2016, 82,617 shares have been forfeited, and 130,804 shares have vested. We recognized share-based compensation expense related to restricted stock of $39 and $42 for the six months ended June 30, 2016 and 2015, respectively.

Restricted stock activity under the Plan for the six months ended June 30, 2016 was as follows:

Restricted Stock	Number of Shares			Weighted Average Grant Date Fair Value
Unvested as of December 31, 2015		58,635		$	2.51
Vested		(29,306	)		2.51
Cancelled		(53	)		2.51
Unvested as of June 30, 2016		29,276		$	2.51

The fair value of restricted stock vested in the six months ended June 30, 2016 and 2015 was $56 and $58, respectively.

In July 2010, the Company amended its chief executive officer’s (the “CEO’s”) employment agreement to grant the CEO 100,000 stock options, of which 25% vested upon grant and 25% vest annually over the next three years, and a maximum of 390,000 performance-based stock units that vest upon the achievement of certain performance and market based targets. In March 2013, the Company amended its CEO’s employment agreement to modify the performance and market based targets.

In February 2012, the Company amended its chief medical officer’s (the “CMO’s”) employment agreement to grant the CMO 50,000 performance-based stock units that vest upon the achievement of certain performance based targets.

In March 2013, the Company amended its chief operating officer’s (the “COO’s”) employment agreement to grant the COO 125,000 performance-based stock units that vest upon the achievement of certain performance based targets. In March 2013, the Company amended its CMO’s employment agreement to grant the CMO 120,000 performance-based stock units that vest upon the achievement of certain performance based targets.

Through June 30, 2016, no expense has been recorded for any performance-based stock units granted to the CEO, COO, or CMO.

7. STOCK OFFERING

On February 26, 2016 the Company entered into definitive stock purchase agreements with certain institutional and accredited investors. In conjunction with this stock offering we issued 8,027,900 shares of our common stock and non-transferable options for 3,567,956 shares of our common stock for aggregate net proceeds of $15.2 million. Each option is exercisable for $2.50 per share and expires on March 22, 2017. If all options were to be exercised it would result in additional proceeds of approximately $8.9 million.

8. RECENT ACCOUNTING PRONOUNCEMENTS

From time to time, new accounting pronouncements are issued by the Financial Accounting Standards Board (“FASB”) or other standard setting bodies that are adopted by the Company as of the specified effective date. Unless otherwise discussed, we believe that the impact of recently issued standards that are not yet effective will not have a material impact on our financial position or results of operations upon adoption.

In March 2016, the FASB issued ASU No. 2016-09, Compensation - Stock Compensation (Topic 718): Improvements to Employee Share-Based Payment Accounting. The new standard involves several aspects of the accounting for share-based payment transactions, including the income tax consequences, classification of awards as either equity or liabilities and classification on the statement of cash flows. The new standard will be effective for us on January 1, 2017. We are currently evaluating the potential impact that this standard may have on our financial position, results of operations and statement of cash flows.

In February 2016, the FASB issued ASU No. 2016-02, Leases (Topic 842). The new standard requires that all lessees recognize the assets and liabilities that arise from leases on the balance sheet and disclose qualitative and quantitative information about its leasing arrangements. The new standard will be effective for us on January 1, 2019. We are currently evaluating the potential impact that this standard may have on our financial position and results of operations.

In August 2014, the FASB issued Accounting Standard Update (“ASU”) 2014-15, Presentation of Financial Statements—Going Concern (Subtopic 205-40): Disclosure of Uncertainties about an Entity’s Ability to Continue as a Going Concern. Under the new guidance, management will be required to assess an entity’s ability to continue as a going concern, and to provide related footnote disclosures in certain circumstances. The provisions of this ASU are effective for annual periods ending after December 15, 2016, and for annual and interim periods thereafter. We are currently evaluating the potential impact that this ASU may have on our disclosures.

In June 2014, the FASB issued ASU No. 2014-12, “Accounting for Share-Based Payments When the Terms of an Award Provide That a Performance Target Could Be Achieved after the Requisite Service Period.” This ASU requires a reporting entity to treat a performance target that affects vesting and that could be achieved after the requisite service period as a performance condition, and apply existing guidance under the Stock Compensation Topic of the ASC as it relates to awards with performance conditions that affect vesting to account for such awards. The provisions of this ASU are effective for interim and annual periods beginning after December 15, 2015. We evaluated this ASU and determined that it did not have a material impact on our financial position or results of operations.

During the quarter ended June 30, 2014, the FASB issued ASU No. 2014-09, “Revenue from Contracts with Customers” (Topic 606), which supersedes all existing revenue recognition requirements, including most industry-specific guidance. The new standard requires a company to recognize revenue when it transfers goods or services to customers in an amount that reflects the consideration that the company expects to receive for those goods or services. In August 2015, the FASB issued ASU No. 2015-14, Revenue from Contracts with Customers (Topic 606): Deferral of the Effective Date, which delayed the effective date of the new standard from January 1, 2017 to January 1, 2018. The FASB also agreed to allow entities to choose to adopt the standard as of the original effective date. We are currently evaluating the method of adoption and the potential impact that Topic 606 may have on our financial position and results of operations.

9. INCOME TAXES

As of December 31, 2015, we had federal NOL, state NOL, and research and development credit carryforwards of approximately $357,122, $176,712 and $27,750 respectively, which expire at various dates through 2035. Approximately $15,020 of our federal NOL and $868 of our state NOL were generated from excess tax deductions from share-based awards, the tax benefit of which will be credited to additional paid-in-capital when the deductions reduce current taxes payable.

At June 30, 2016 and December 31, 2015, we had no unrecognized tax benefits. We do not expect that the total amount of unrecognized tax benefits will significantly increase in the next twelve months. Our policy is to recognize interest and penalties related to uncertain tax positions in income tax expense. As of December 31, 2015 and 2014, we had no accrued interest or penalties related to uncertain tax positions. Our U.S. federal tax returns for the tax years 2012 through 2015 and our state tax returns for the tax years 2012 through 2015 remain open to examination. Prior tax years remain open to the extent of net operating loss and tax credit carryforwards.

Utilization of NOL and research and development credit carryforwards may be subject to a substantial annual limitation in the event of an ownership change that has occurred previously or could occur in the future pursuant to Section 382 and 383 of the Internal Revenue Code of 1986, as amended, as well as similar state provisions. An ownership change may limit the amount of NOL and research and development credit carryforwards that can be utilized annually to offset future taxable income, and may, in turn, result in the expiration of a portion of those carryforwards before utilization. In general, an ownership change, as defined by Section 382, results from transactions that increase the ownership of certain stockholders or public groups in the stock of a corporation by more than 50 percentage points over a three year period. We undertook a detailed study of our NOL and research and development credit carryforwards through January 31, 2016, to determine whether such amounts are likely to be limited by Sections 382 or 383. As a result of this analysis, we currently do not believe any Sections 382 or 383 limitations will significantly impact our ability to offset income with available NOL and research and development credit carryforwards. However, future ownership changes under Section 382 may limit our ability to fully utilize these tax benefits.

ITEM 2. MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

The following discussion should be read in conjunction with our condensed financial statements and accompanying notes contained in this quarterly report on Form 10-Q and our audited financial statements and related notes included in our Annual Report on Form 10-K for the year ended December 31, 2015.

ArQule has a long history of kinase drug discovery and development, having discovered and introduced nine kinase inhibitors into human clinical trials. Our drug discovery efforts have been informed by our historical expertise in chemistry, our work in rational drug design and by our insight into kinase binding and regulation. We have applied this knowledge to produce significant chemical matter for a number of kinase targets and to build an extensive library of proprietary compounds with the potential to target multiple kinases in oncology and other therapeutic areas, such as rare diseases. We expect to bring further preclinical programs forward either directly or with collaborators and to interrogate our library against new targets beyond kinases.

Our most advanced ongoing clinical trial, the METIV-HCC trial, is a pivotal Phase 3 randomized, double-blind, controlled study of tivantinib as single agent therapy in previously treated patients with MET diagnostic-high, inoperable HCC conducted by Daiichi Sankyo and us. The primary endpoint is overall survival (“OS”) in the intent-to-treat (“ITT”) population, and the secondary endpoint is progression-free survival (“PFS”) in the same population.

We completed patient accrual in the METIV-HCC trial in December 2015 and have randomized over 300 patients at more than 100 clinical sites worldwide. On March 22, 2016, we and Daiichi Sankyo announced that the independent data monitoring committee (“DMC”) of the METIV-HCC study conducted the planned interim assessment, and it was determined that the trial will continue to its final analysis. The interim assessment was triggered when at least 60 percent of the target number of events occurred. The final analysis will take place when 100 percent of the target number of events occurs, which we currently expect to be in late 2016 or early 2017. The METIV-HCC trial is being conducted under a Special Protocol Assessment (“SPA”) agreement with the U.S. Food and Drug Administration (“FDA”).

In addition to METIV-HCC, a second Phase 3 clinical trial in HCC with tivantinib known as JET-HCC is ongoing in Japan. On February 4, 2014, Kyowa Hakko Kirin announced the initiation of this trial in Japanese patients with MET diagnostic-high, inoperable HCC previously treated with sorafenib. The trial is a randomized, double-blind placebo-controlled study to compare PFS in patients treated with tivantinib with those treated with placebo. Kyowa Hakko Kirin plans to enroll approximately 160 patients in this study.

We have collaborated with the National Cancer Institute (“NCI”) through its Cancer Therapy Evaluation Program (“CTEP”) to explore the clinical potential of tivantinib in a variety of tumor indications while we focus our internal efforts on the two Phase 3 programs in HCC. These CTEP-sponsored trials included Phase 2 single agent trials in prostate cancer (randomized), multiple myeloma, breast cancer and malignant mesothelioma, and Phase 2 combination therapy trials in kidney cancer (with or without erlotinib, randomized) and head and neck cancer (with or without cetuximab, randomized).

Under our agreement with the National Human Genome Research Institute of the NIH, a Phase 1 clinical trial investigating ARQ 092 as a potential treatment for Proteus syndrome, a rare overgrowth disorder caused by a mutation in the AKT 1 gene, began enrolling patients in November 2015. A Phase 1b clinical trial for ARQ 092 has completed enrollment in lymphoma, endometrial cancers and in cancers harboring AKT 1 and PI3K mutations. Thus far in this enriched cohort of the trial, we have observed five patients with confirmed responses, three of which had the same AKT 1 mutation that occurs in Proteus syndrome and one of which had a PI3k mutation. Clinical development of ARQ 087 has advanced into Phase 2 for intrahepatic cholangiocarcinoma (“iCCA”) following the observation of two confirmed partial responses in this patient population in the Phase 1 portion of the trial. Additional testing is on-going in solid tumors as part of a Phase 1b expansion cohort of this trial. ARQ 761 is currently in a Phase 1b clinical trial for solid tumors and Phase 1b/2 for pancreatic cancer.

We have incurred a cumulative deficit of approximately $492 million from inception through June 30, 2016. We recorded a net loss for 2014 and 2015 and expect a net loss for 2016.

Our revenue consists primarily of development funding from our alliances with Daiichi Sankyo and Kyowa Hakko Kirin. Revenue and expenses fluctuate from quarter to quarter based upon a number of factors, notably the timing and extent of our cancer-related research and development activities together with the length and outcome of our clinical trials.

In May 2015, we entered into a Collaborative Research and Development Agreement with Beryllium Discovery Corp. (“Beryllium”). Pursuant to the agreement, we will jointly focus on the identification and preclinical development of inhibitors of PD-1 and PDL-1. We and Beryllium will each be responsible for our respective internal and outsourcing costs during pre-clinical development. Following lead optimization of any potential drug candidates, we and Beryllium will jointly decide whether to advance compounds into GLP/toxicology and clinical testing, initially on a shared cost basis, provided that we will have the right to advance compounds on our own should Beryllium vote against such advancement. The agreement also provides that we will be responsible for clinical development and commercialization of product candidates that are not out-licensed. Beryllium will have the right to participate financially throughout the program but will also have the option to opt out at certain times and receive a royalty. The agreement will terminate after the last payment obligation is satisfied, or prior to that upon 60-days’ notice by either party.

On December 18, 2008, we entered into a license, co-development and co-commercialization agreement with Daiichi Sankyo to conduct research, clinical trials and commercialization of tivantinib in human cancer indications. The agreement provides for a $60 million cash upfront licensing payment from Daiichi Sankyo to us, which we received in December 2008, and an additional $560 million in potential development and sales milestone payments offset by our share of the Phase 3 costs. Upon commercialization, we will receive tiered, double-digit royalties from Daiichi Sankyo on net sales of tivantinib commensurate with the magnitude of the transaction. On November 3, 2015, the Company announced that it had exercised its option with Daiichi Sankyo to co-commercialize tivantinib in the United States (the “Co-Commercialization Option”), pursuant to the Agreement. Subject to the receipt of regulatory approvals, the first commercial indication for tivantinib under the Co-Commercialization Option is anticipated to be second line HCC. The parties have a prescribed period to conclude a co-commercialization agreement in accordance with the terms of the Agreement which is expected to occur in 2016. If the METIV-HCC trial is successful, and tivantinib is approved in second line HCC, the Agreement provides that the Company will receive a total of $55 million in milestone payments for the official acceptance of drug approval applications by FDA and the European Medicines Agency (“EMA”) in this first indication, plus an additional $100 million in combined milestones tied to receipt of commercialization regulatory approval by the FDA and the first commercial sale in the UK, Germany, France, Italy or Spain. These milestones, totaling $155 million, will be partially offset by Phase 3 costs owed to Daiichi Sankyo by the Company which the Company expects to total approximately $75 million to $85 million at the time of approval in the US or EU. The Agreement also provides that the Company will receive tiered double digit royalties on net sales of tivantinib throughout the territory. Given the anticipated commercial market for second line HCC, the Company expects to earn royalties on net sales for this indication at the baseline contractual rate of 20 percent.

We and Daiichi Sankyo will share equally the costs of Phase 2 and Phase 3 clinical studies, with our share of Phase 3 costs payable solely from milestone and royalty payments by Daiichi Sankyo.

The dosing of the first patient in the Phase 3 MARQUEE clinical trial of tivantinib in NSCLC, announced in January 2011, triggered the payment of a $25 million development milestone from Daiichi Sankyo that was received in February 2011. Revenue for this agreement is recognized using the contingency-adjusted performance model. Through September 30, 2012, revenue was recognized based upon an estimated development period through December 2013. As a result of the October 2012 decision to discontinue the MARQUEE trial, the development period as of October 1, 2012 was extended to June 2015. Commencing with the fourth quarter of 2012 and through the third quarter of 2013 revenue was recognized over that development period. In the fourth quarter of 2013, following a recommendation by the independent data monitoring committee that the METIV-HCC trial continue with patients receiving a lower dose of tivantinib than the dose originally employed in the trial, we reviewed the estimated development period and extended it to June 2016. On March 22, 2016, we and Daiichi Sankyo announced that the independent data monitoring committee (“DMC”) of the METIV-HCC study conducted the planned interim assessment, and it was determined the trial will continue to its final analysis. Accordingly, we reviewed the estimated development period and extended it to December 2016.

Under the terms of our tivantinib collaboration agreement with Daiichi Sankyo we share development costs equally with our share of Phase 3 costs funded solely from milestones and royalties. In each quarter the tivantinib collaboration costs we incur are compared with those of Daiichi Sankyo. If our costs for the quarter exceed Daiichi Sankyo’s, we recognize revenue on the amounts due to us under the contingency adjusted performance model. Revenue is calculated on a pro-rata basis using the time elapsed from inception of the agreement over the estimated duration of the development period under the agreement. If our costs for the quarter are less than those of Daiichi Sankyo, we report the amount due to Daiichi Sankyo as contra-revenue in that quarter. To the extent that our share of Phase 3 collaboration costs exceeds the amount of milestones and royalties received, that excess is netted against future milestones and royalties if and when earned and is not reported as contra-revenue.

For the quarter ended June 30, 2016, our non-Phase 3 tivantinib collaboration costs incurred were less than those of Daiichi Sankyo’s and $78 thousand was recognized as research and development contra-revenue. For the six months ended June 30, 2016, no research and development revenue was recognized related to our non-Phase 3 tivantinib collaboration as our costs incurred were offset by an equal amount of contra-revenue.

For the quarter ended June 30, 2015, our non-Phase 3 tivantinib collaboration costs incurred exceeded those of Daiichi Sankyo’s and $229 thousand was recognized as tivantinib Daiichi Sankyo research and development revenue. For the six months ended June 30, 2015, our non-Phase 3 tivantinib collaboration costs incurred exceeded those of Daiichi Sankyo’s and $240 thousand was recognized as tivantinib Daiichi Sankyo research and development revenue.

On April 27, 2007, we entered into an exclusive license agreement with Kyowa Hakko Kirin to develop and commercialize tivantinib in Japan and parts of Asia. The agreement includes $123 million in upfront and potential development milestone payments from Kyowa Hakko Kirin to ArQule, including $30 million cash upfront licensing payments that we received in 2007. In addition to the upfront and possible development milestone payments totaling $123 million, the Company will be eligible for future milestone payments based on the achievement of certain levels of net sales. To date, we have received $48 million in upfront and milestones payments.

The Company will recognize the payments, if any, as revenue in accordance with its revenue recognition policies. As of June 30, 2016, the Company has not recognized any revenue from these potential sales milestone payments, and there can be no assurance that it will do so in the future.

Upon commercialization, ArQule will receive tiered royalties in the mid-teen to low-twenty percent range from Kyowa Hakko Kirin on net sales of tivantinib. Kyowa Hakko Kirin will be responsible for all clinical development costs and commercialization of the compound in certain Asian countries, consisting of Japan, China (including Hong Kong), South Korea and Taiwan.

LIQUIDITY AND CAPITAL RESOURCES

	June 30,		December 31,		Increase (decrease)
	2016		2015		$		%
	(in millions)
Cash, cash equivalents and marketable securities-short term	$	43.1	$	38.8	$	4.3		11	%
Working capital		35.2		28.7		6.5		23	%

	Six Months Ended
	June 30, 2016			June 30, 2015			Increase (decrease)
	(in millions)
Cash flow from:
Operating activities	$	(11.0	)	$	(13.0	)	$	2.0
Investing activities		(0.9	)		14.5			(15.4	)
Financing activities		15.3			0.1			15.2

Cash flow from operating activities. Our uses of cash for operating activities have primarily consisted of salaries and wages for our employees, facility and facility-related costs for our offices and laboratories, fees paid in connection with preclinical and clinical studies, laboratory supplies and materials, and professional fees. The sources of our cash flow from operating activities have consisted primarily of payments received from our collaborators for services performed or upfront payments for future services. For the six months ended June 30, 2016 and 2015, our net use of cash was primarily driven by payments for operating expenses which resulted in net cash outflows of $11.0 million and $13.0 million, respectively.

Cash flow from investing activities. Our net cash used by investing activities of $0.9 million for the six months ended June 30, 2016, was comprised primarily of net purchases of marketable securities. Our net cash provided by investing activities of $14.5 million for the six months ended June 30, 2015 was comprised primarily of net sales of marketable securities. The composition and mix of cash, cash equivalents and marketable securities may change frequently as a result of the Company’s constant evaluation of conditions in financial markets, the maturity of specific investments, and our near term liquidity needs.

Cash flow from financing activities. Our net cash provided by financing activities of $15.3 million for the six months ended June 30, 2016, was comprised of net proceeds from our February 26, 2016 stock offering of $15.2 million and $0.1 million from stock option exercises and employee stock plan purchases. Our net cash provided by financing activities of $0.1 million for the six months ended June 30, 2015, was from employee stock plan purchases.

Our cash equivalents and marketable securities typically include U.S. Treasury bill funds, money market funds, commercial paper, and U.S. federal and state agency backed certificates that have investment grade ratings. Our cash equivalents and our portfolio of marketable securities are subject to market risk due to changes in interest rates. Fixed rate interest securities may have their market value adversely impacted due to a rise in interest rates, while floating rate securities may produce less income than expected if interest rates fall. Due in part to these factors, our future investment income may fall short of expectation due to changes in interest rates or we may suffer losses in principal if we are forced to sell securities that decline in market value due to changes in interest rates.

In light of the $15.2 million we received from the February 26, 2016 stock purchase agreements, we anticipate that our cash, cash equivalents and marketable securities on hand at June 30, 2016, and financial support from our collaboration agreements will be sufficient to finance our working capital and capital requirements into 2018.

Our contractual obligations were comprised of the following as of June 30, 2016 (in thousands):

	Payment due by period
Contractual Obligations	Total		Less than 1 year		1 - 3 years		3 - 5 years		More than 5 years
Operating lease obligations	$	2,035	$	518	$	1,475	$	42	$	—
Purchase obligations		4,098		4,098		—		—		—
Total	$	6,133	$	4,616	$	1,475	$	42	$	—

In January 2015, we entered into a lease agreement for a new headquarters facility. The lease commenced on May 1, 2015 for a term of five years and three months with an average annual rental rate of $455 thousand. The obligations for this new facility are included in the table above.

Purchase obligations are comprised primarily of outsourced preclinical and clinical trial expenses and payments to license certain intellectual property to support the Company’s research efforts. Under our tivantinib collaboration with Daiichi Sankyo, our share of Phase 3 costs are payable solely from future milestones and royalties. As of June 30, 2016 our portion of these costs was $64.7 million and is excluded from the table above. These costs are netted against any future milestones and royalties due to us. Daiichi Sankyo has the right to offset future milestone and royalty payments by this amount.

CRITICAL ACCOUNTING POLICIES AND ESTIMATES

A “critical accounting policy” is one which is both important to the portrayal of the Company’s financial condition and results and requires management’s most difficult, subjective or complex judgments, often as a result of the need to make estimates about the effect of matters that are inherently uncertain. For additional information, please see the discussion of our significant accounting policies in Note 2 to the Financial Statements included in our Annual Report for the fiscal year ended December 31, 2015 on Form 10-K filed with the SEC on February 29, 2016.

RESULTS OF OPERATIONS

The following are the results of operations for the three and six months ended June 30, 2016 and 2015:

Revenue

					Increase (decrease)
	2016		2015		$			%
	(in millions)
For the three months ended June 30:
Research and development revenue	$	1.1	$	3.0	$	(1.9	)		(64	)%

For the six months ended June 30:
Research and development revenue	$	2.3	$	5.8	$	(3.5	)		(60	)%

Research and development revenue in the three and six months ended June 30, 2016 and 2015 is comprised of revenue from the Daiichi Sankyo tivantinib development agreement and the Kyowa Hakko Kirin exclusive license agreement. The revenue decreases in the quarter ended June 30, 2016 of $1.0 million from our Daiichi Sankyo METIV-HCC trial and $0.9 million from our Kyowa Hakko Kirin JET-HCC trial were principally due to the March 2016 extension of the development period through December 31, 2016 for both programs. The revenue decreases in the six months ended June 30, 2016 of $1.6 million from our Daiichi Sankyo METIV-HCC trial and $1.9 million from our Kyowa Hakko Kirin JET-HCC trial were also principally due to the extension of the development period through December 31, 2016.

Under the terms of our tivantinib collaboration agreement with Daiichi Sankyo we share development costs equally with our share of Phase 3 costs funded solely from milestones and royalties. In each quarter the tivantinib collaboration costs that we incur are compared with those of Daiichi Sankyo. If our costs for the quarter exceed Daiichi Sankyo’s, we recognize revenue on the amounts due to us under the contingency adjusted performance model. Revenue is calculated on a pro-rata basis using the time elapsed from inception of the agreement over the estimated duration of the development period under the agreement. If our costs for the quarter are less than those of Daiichi Sankyo’s, we report the amount due to Daiichi Sankyo as contra-revenue in that quarter. To the extent that our share of Phase 3 collaboration costs exceeds the amount of milestones and royalties received, that excess is netted against future milestones and royalties if and when earned and is not reported as contra-revenue.

Research and development

					Increase (decrease)
	2016		2015		$			%
	(in millions)
For the three months ended June 30:
Research and development	$	4.3	$	4.3	$	—			—	%

For the six months ended June 30:
Research and development	$	8.5	$	8.7	$	(0.2	)		(2	)%

Research and development expense remained constant in the quarters ended June 30, 2016 and 2015. The increase in outsourced clinical and product development costs of $0.4 million were offset by lower labor and related costs of $0.3 million and facility costs reductions of $0.1 million.

Research and development expense in the six months ended June 30, 2016 decreased by $0.2 million. Decreased labor and related costs of $0.5 million and facility costs of $0.5 million were partially offset by increased outsourced clinical and product development costs of $0.8 million.

At June 30, 2016 and 2015 we had 21 employees dedicated to our research and development program.

Overview

Our research and development expense consists primarily of salaries and related expenses for personnel, costs of contract manufacturing services, costs of facilities and equipment, fees paid to professional service providers in conjunction with our clinical trials, fees paid to research organizations in conjunction with pre-clinical animal studies, costs of materials used in research and development, consulting, license, and sponsored research fees paid to third parties and depreciation of associated laboratory equipment. We expect that our research and development expense will remain significant as we continue to develop our portfolio of oncology programs.

We have not accumulated and tracked our internal historical research and development costs or our personnel and personnel-related costs on a program-by-program basis. Our employee and infrastructure resources are allocated across several projects, and many of our costs are directed to broadly applicable research endeavors. As a result, we cannot state the costs incurred for each of our oncology programs on a program-by-program basis.

The expenses incurred by us to third parties for pre-clinical and clinical trials in the current year and since inception of our lead clinical stage program were as follows (in millions):

Oncology program

Current status

Six Months

Ended

June 30, 2016

Program-to-

date

Met program—Tivantinib

Phase 3

(0.1

)

84.8

Under the terms of our tivantinib collaboration agreement with Daiichi Sankyo we share development costs equally with our share of Phase 3 costs funded solely from milestones and royalties. Our cumulative share of Phase 3 collaboration costs has exceeded the amount of milestones received through June 30, 2016 by $64.7 million and is not reflected in the above table.

Our future research and development expenses in support of our current and future oncology programs will be subject to numerous uncertainties in timing and cost to completion. We test potential products in numerous pre-clinical studies for safety, toxicology, and efficacy. We may conduct multiple clinical trials for each product. As we obtain results from trials, we may elect to discontinue or delay clinical trials for certain products in order to focus our resources on more promising products. Completion of clinical trials may take several years or more, and the length of time generally varies substantially according to the type, complexity, novelty, and intended use of a product. It is not unusual for the pre-clinical and clinical development of each of these types of products to take nine years or more, and for total development costs to exceed $500 million for each product.

We estimate that clinical trials of the type generally needed to secure new drug approval are typically completed over the following timelines:

Clinical Phase		Estimated Completion Period
Phase 1		1 – 2 years
Phase 2		2 – 3 years
Phase 3		2 – 4 years

The duration and the cost of clinical trials may vary significantly over the life of a project as a result of differences arising during clinical development, including, among others, the following:

●

the number of clinical sites included in the trials;

●

the length of time required to enroll suitable patients;

●

the number of patients that ultimately participate in the trials;

●

the duration of patient follow-up to ensure the absence of long-term product-related adverse events; and

●

the efficacy and safety profile of the product.

An element of our business strategy is to pursue the research and development of a broad pipeline of products. This is intended to allow us to diversify the risks associated with our research and development expenditures. As a result, we believe our future capital requirements and future financial success do not substantially depend on any one product. To the extent we are unable to build and maintain a broad pipeline of products, our dependence on the success of one or a few products increases.

Our strategy includes entering into alliance arrangements with third parties to participate in the development and commercialization of our products, such as our collaboration agreements with Daiichi Sankyo and Kyowa Hakko Kirin. In the event that third parties have control over the clinical trial process for a product, the estimated completion date would be under control of that third party rather than under our control. We cannot forecast with any degree of certainty whether our products will be subject to future collaborative arrangements or how such arrangements would affect our development plans or capital requirements.

As a result of the uncertainties discussed above, we make significant estimates in determining the duration and completion costs of our oncology programs or when and to what extent we will receive cash inflows from the commercialization and sale of a product. Our inability to complete our oncology programs in a timely manner or our failure to enter into appropriate collaborative agreements could significantly increase our capital requirements and could adversely impact our liquidity. These uncertainties could force us to seek additional, external sources of financing from time-to-time in order to continue with our product development strategy. Our inability to raise additional capital, or to do so on terms reasonably acceptable to us, would jeopardize the future success of our business.

General and administrative

					Increase (decrease)
	2016		2015		$			%
	(in millions)

For the three months ended June 30:
General and administrative	$	1.9	$	2.8	$	(0.9	)		(32	)%

For the six months ended June 30:
General and administrative	$	3.9	$	6.0	$	(2.1	)		(34	)%

General and administrative expense decreased in the quarter ended June 30, 2016 principally due to lower facility costs of $0.7 million and professional fees of $0.2 million.

General and administrative expense decreased in the six months ended June 30, 2016 principally due to lower facility costs of $1.6 million, labor related costs of $0.2 million and professional fees of $0.2 million.

General and administrative headcount was 14 at June 30, 2016, compared to 15 at June 30, 2015.

Interest income, interest expense and other income (expense)

					Increase (decrease)
	2016		2015		$			%
	(in thousands)
For the three months ended June 30:
Interest income	$	52	$	28	$	24			86	%
Other income		—		54		(54	)		(100	)%

For the six months ended June 30:
Interest income	$	86	$	64	$	22			34	%
Other income		—		282		(282	)		(100	)%

Interest income is derived from our portfolio of cash, cash equivalents and investments and increased in the three and six month periods ended June 30, 2016 primarily due to an increase in our portfolio balance resulting from our $15.2 million stock offering on February 26, 2016. Other income in the three and six month periods ended June 30, 2015 includes gains of $54 thousand and $282 thousand, respectively, from the sale of property and equipment.

RECENT ACCOUNTING PRONOUNCEMENTS

For a discussion of new accounting pronouncements please read Note 8, Recent Accounting Pronouncements to our financial statements included in this report.

FORWARD LOOKING STATEMENTS

In addition to historical information, this report contains forward-looking statements. You can identify these forward-looking statements by their use of words such as “anticipate,” “assume,” “believe,” “estimate,” “expect,” “forecast,” “intend,” “may,” “plan,” “project,” “target,” “will” and other words and terms of similar meaning. You also can identify them by the fact that they do not relate strictly to historical or current facts. All statements which address operating performance, events or developments that the Company expects or anticipates will occur in the future, such as projections about its future results of operations, its financial condition, research, development and commercialization of its products and anticipated trends in its business are forward-looking statements.

In this report we make forward-looking statements regarding our drug development pipeline and our clinical trials involving tivantinib. Additional forward-looking statements relate to our agreements with Kyowa Hakko Kirin and Daiichi Sankyo, including potential future milestones and royalty payments that could result from the future development of tivantinib.

Drug development involves a high degree of risk. Only a small number of research and development programs result in the commercialization of a product. For example, pre-clinical efforts associated with our product pipeline may fail or prove disappointing because our technology platform did not produce candidates with the desired characteristics. Animal xenograft pre-clinical studies may be unpredictive of human response. Positive information about early stage clinical trial results will not ensure that later stage or larger scale clinical trials will be successful.

Furthermore, our drugs may not demonstrate promising therapeutic effects; in addition, they may not demonstrate appropriate safety profiles in ongoing or later stage or larger scale clinical trials as a result of known or as yet unidentified side effects. The results achieved in later stage trials may not be sufficient to meet applicable regulatory standards. Problems or delays may arise during clinical trials or in the course of developing, testing or manufacturing our drugs that could lead us or our partner to discontinue development.

Even if later stage clinical trials are successful, the risk exists that unexpected concerns may arise from analysis of data or from additional data or that obstacles may arise or issues be identified in connection with review of clinical data with regulatory authorities or that regulatory authorities may disagree with the Company’s view of the data or require additional data or information or additional studies. Also, the planned timing of initiation of clinical trials and the duration and conclusion of such trials for our drugs are subject to the ability of the company to enroll patients, enter into agreements with clinical trial sites and investigators, and other technical hurdles and issues that may not be resolved.

We also make forward-looking statements regarding the adequacy of our financial resources. Our capital resources may not be adequate because our cash requirements may vary materially from those now planned depending upon the results of our drug discovery and development strategies, the outcomes of our clinical trials, our ability to enter into additional corporate collaborations in the future and the terms of such collaborations, results of research and development, the need for currently unanticipated capital expenditures, competitive and technological advances, acquisitions, financial market conditions and other factors. Additionally, our corporate collaborators may terminate their agreements with us, thereby eliminating that source of funding, because we may fail to satisfy the prescribed terms of the collaborations or for other reasons.

We cannot guarantee that we will be able to develop any of our drug candidates into a commercial product generating revenues. If we experience increased losses, we may have to seek additional financing from public and private sales of our securities, including equity securities. There can be no assurance that additional funding will be available when needed or on acceptable terms.

The factors, risks and uncertainties referred to above and others are more fully described under the heading “Risk Factors” in our Annual Report on Form 10-K for the fiscal year ended December 31, 2015 filed with the SEC on February 29, 2016, as updated from time to time in our subsequent Quarterly Reports on Form 10-Q and Current Reports on Form 8-K. The forward-looking statements contained herein represent the judgment of the Company as of the date of this report. We are not under any obligation, and we expressly disclaim any obligation, to update or alter any forward-looking statements, whether as a result of new information, future events or otherwise, except to the extent required by law.

ITEM 3. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

We own financial instruments that are sensitive to market risk as part of our investment portfolio. We have implemented policies regarding the amount and credit ratings of investments. Our investment portfolio is used to preserve our capital until it is used to fund operations, including our research and development activities. Our investments are evaluated quarterly to determine the fair value of the portfolio.

Our cash equivalents and marketable securities typically include commercial paper, money market funds, and U.S. Treasury bill funds that have investment grade ratings.

Our cash equivalents and our portfolio of marketable securities are subject to market risk due to changes in interest rates. Fixed rate interest securities may have their market value adversely impacted due to a rise in interest rates, while floating rate securities may produce less income than expected if interest rates fall. Due in part to these factors, our future investment income may fall short of expectation due to changes in interest rates or we may suffer losses in principal if we are forced to sell securities that decline in market value due to changes in interest rates. Based on the type of securities we hold, we do not believe a change in interest rates would have a material impact on our financial statements. If interest rates were to increase or decrease by 1%, this would not result in a material change in the fair value of our investment portfolio.

ITEM 4. CONTROLS AND PROCEDURES

Our management, with the participation of our Chief Executive Officer (Principal Executive Officer) and President and Chief Operating Officer (Principal Financial Officer), evaluated the effectiveness of our disclosure controls and procedures as of June 30, 2016. The term “disclosure controls and procedures,” as defined in Rules 13a-15(e) and 15d-15(e) under the Securities Exchange Act of 1934, as amended (“Exchange Act”), means controls and other procedures of a company that are designed to ensure that information required to be disclosed by a company in the reports that it files or submits under the Exchange Act is recorded, processed, summarized and reported, within the time periods specified in the SEC’s rules and forms. Disclosure controls and procedures include, without limitation, controls and procedures designed to ensure that information required to be disclosed by a company in the reports that it files or submits under the Exchange Act is accumulated and communicated to the company’s management, including its principal executive and financial officer, as appropriate to allow timely decisions regarding required disclosure. Our management recognizes that any controls and procedures, no matter how well designed and operated, can provide only reasonable assurance of achieving their objectives and our management necessarily applies its judgment in evaluating the cost-benefit relationship of possible controls and procedures. Based on the evaluation of our disclosure controls and procedures as of June 30, 2016, our Chief Executive Officer (Principal Executive Officer) and President and Chief Operating Officer (Principal Financial Officer) concluded that, as of such date, our disclosure controls and procedures were effective at the reasonable assurance level.

There have been no changes in the Company’s internal control over financial reporting during the most recently completed fiscal quarter that have materially affected, or are reasonably likely to materially affect, the Company’s internal control over financial reporting.

PART II - OTHER INFORMATION

ITEM 1. — LEGAL PROCEEDINGS. None.

ITEM 1A. — RISK FACTORS. For information regarding factors that could affect the Company’s results of operations, financial condition and liquidity, see the risk factors discussion provided under “Risk Factors” in Item 1A of ArQule’s Annual Report on Form 10-K for the year ended December 31, 2015 filed with the SEC on February 29, 2016, as updated from time to time in our subsequent Quarterly Reports on Form 10-Q and Current Reports on Form 8-K. See also, “Forward-Looking Statements” included in this Quarterly Report on Form 10-Q.

ITEM 2. — UNREGISTERED SALES OF EQUITY SECURITIES AND USE OF PROCEEDS. None.

ITEM 3. — DEFAULTS UPON SENIOR SECURITIES. None.

ITEM 4. — MINE SAFETY DISCLOSURES. Not applicable.

ITEM 5. — OTHERS INFORMATION. None.

ITEM 6. — EXHIBITS.

EXHIBIT NO.		DESCRIPTION

10.1		Third Amendment to Employment Agreement dated as of April 14, 2016, by and between ArQule, Inc. and Paolo Pucci, Filed as Exhibit 10.1 to the Company’s Current Report on Form 8-K filed on April 14, 2016 (File No. 000-21429) and incorporated herein by reference.

10.2		Fourth Amendment to Employment Agreement dated as of April 14, 2016, by and between ArQule, Inc. and Peter S. Lawrence. Filed as Exhibit 10.2 to the Company’s Current Report on Form 8-K filed on April 14, 2016 (File No. 000-21429) and incorporated herein by reference.

10.3		Third Amendment to Employment Agreement dated as of April 14, 2016, by and between ArQule, Inc. and Brian Schwartz. Filed as Exhibit 10.3 to the Company’s Current Report on Form 8-K filed on April 14, 2016 (File No. 000-21429) and incorporated herein by reference.

31.1		Rule 13a-14(a) Certificate of Chief Executive Officer, filed herewith.

31.2		Rule 13a-14(a) Certificate of Principal Financial Officer, filed herewith.

32		Rule 13a-14(b) Certificate of Chief Executive Officer and Chief Financial Officer, filed herewith.

101		Interactive Data File

ARQULE, INC.

SIGNATURES

Pursuant to the requirements of the Securities Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

	ArQule, Inc.

Date: August 3, 2016	/s/ PETER S. LAWRENCE
	Peter S. Lawrence
	President and Chief Operating Officer
	(Principal Financial Officer)

	/s/ ROBERT J. WEISKOPF
	Robert J. Weiskopf
	Chief Financial Officer and Treasurer
	(Principal Accounting Officer)

EX-31.1 2 t1600465_ex31-1.htm EXHIBIT 31.1

Exhibit 31.1

CERTIFICATE OF THE CHIEF EXECUTIVE OFFICER

I, Paolo Pucci, certify that:

I have reviewed this quarterly report on Form 10-Q of ArQule, Inc.;

Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

Based on my knowledge, the financial statements, and other financial information included in this report fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures as of the end of the period covered by this report based on such evaluation; and

Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

Date: August 3, 2016

	/s/ PAOLO PUCCI
	Paolo Pucci
	Chief Executive Officer
	(Principal Executive Officer)

EX-31.2 3 t1600465_ex31-2.htm EXHIBIT 31.2

Exhibit 31.2

CERTIFICATE OF THE PRINCIPAL FINANCIAL OFFICER

I, Peter S. Lawrence, certify that:

I have reviewed this quarterly report on Form 10-Q of ArQule, Inc.;

Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

Date: August 3, 2016

	/s/ PETER S. LAWRENCE
	Peter S. Lawrence
	President and Chief Operating Officer
	(Principal Financial Officer)

EX-32 4 t1600465_ex32.htm EXHIBIT 32

Exhibit 32

ARQULE, INC.

CERTIFICATE OF THE CHIEF EXECUTIVE OFFICER AND

PRINCIPAL FINANCIAL OFFICER

The undersigned, Paolo Pucci Chief Executive Officer (Principal Executive Officer) of ArQule, Inc. (the “Company”) and Peter S. Lawrence President and Chief Operating Officer (Principal Financial Officer), of the Company, both duly elected and currently serving, hereby certify that, to the best of his or her knowledge:

the quarterly report on Form 10-Q for the period ending June 30, 2016, filed on behalf of the Company pursuant to the Securities Exchange Act of 1934 (the “Exchange Act”) and containing the financial statements of the Company, fully complies with the requirements of section 13(a) of the Exchange Act; and

the information contained in such quarterly report fairly presents, in all material respects, the financial condition and results of operations of the Company for the dates and periods covered by such quarterly report.

This certification accompanies the Company’s Quarterly Report on Form 10-Q for the period ended June 30, 2016, pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 (the “2002 Act”) and shall not be deemed filed by the Company for purposes of Section 18 of the Exchange Act.

This certification is being made for the exclusive purpose of compliance by the Principal Executive Officer and Principal Financial Officer of the Company with the requirements of Section 906 of the 2002 Act, and may not be disclosed, distributed or used by any person for any reason other than as specifically required by law.

IN WITNESS WHEREOF, the undersigned have executed this Certificate as of the 3rd day of August 2016.

/s/ PAOLO PUCCI
Name:	Paolo Pucci
Title:	Chief Executive Officer
	(Principal Executive Officer)

/s/ PETER S. LAWRENCE
Name:	Peter S. Lawrence
Title:	President and Chief Operating Officer
	(Principal Financial Officer)

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163000

62000

15337000

1586000

3471000

3. MARKETABLE SECURITIES AND FAIR VALUE MEASUREMENTS   We generally classify our marketable securities as available-for-sale at the time of purchase and re-evaluate such designation as of each balance sheet date. Since we generally intend to convert them into cash as necessary to meet our liquidity requirements our marketable securities are classified as cash equivalents if the original maturity, from the date of purchase, is ninety days or less and as short-term investments if the original maturity, from the date of purchase, is in excess of ninety days but less than one year. Our marketable securities are classified as long-term investments if the maturity date is in excess of one year of the balance sheet date.   We report available-for-sale investments at fair value as of each balance sheet date and include any unrealized gains and, to the extent deemed temporary, unrealized losses in stockholders’ equity. Realized gains and losses are determined using the specific identification method and are included in other income (expense) in the statement of operations and comprehensive loss.   We conduct quarterly reviews to determine the fair value of our investment portfolio and to identify and evaluate each investment that has an unrealized loss, in accordance with the meaning of other-than-temporary impairment and its application to certain investments. An unrealized loss exists when the current fair value of an individual security is less than its amortized cost basis. In the event that the cost basis of a security exceeds its fair value, we evaluate, among other factors, the duration of the period that, and extent to which, the fair value is less than cost basis, the financial health of and business outlook for the issuer, including industry and sector performance, and operational and financing cash flow factors, overall market conditions and trends, our intent to sell the investment and if it is more likely than not that we would be required to sell the investment before its anticipated recovery. Unrealized losses on available-for-sale securities that are determined to be temporary, and not related to credit loss, are recorded in accumulated other comprehensive income (loss).   For available-for-sale debt securities with unrealized losses, we perform an analysis to assess whether we intend to sell or whether we would more likely than not be required to sell the security before the expected recovery of the amortized cost basis. Where we intend to sell a security, or may be required to do so, the security’s decline in fair value is deemed to be other-than-temporary and the full amount of the unrealized loss is reflected in the statement of operations and comprehensive loss as an impairment loss.   Regardless of our intent to sell a security, we perform additional analysis on all securities with unrealized losses to evaluate losses associated with the creditworthiness of the security. Credit losses are identified where we do not expect to receive cash flows sufficient to recover the amortized cost basis of a security.    The following is a summary of the fair value of available-for-sale marketable securities we held at June 30, 2016 and December 31, 2015:   <table align="center" style="font: 10pt/normal 'times new roman', times, serif; width: 100%; border-collapse: collapse; font-size-adjust: none; font-stretch: normal;" border="0" cellspacing="0" cellpadding="0"> <tr style="vertical-align: bottom;"> <td style="font-weight: bold; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" nowrap="nowrap">June 30, 2016</td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> Amortized Cost </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> Gross Unrealized Gains </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> Gross Unrealized Losses </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> Fair Value </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="text-align: left; font-style: italic;">Security type</td> <td> </td> <td style="text-align: left;"> </td> <td style="text-align: right;"> </td> <td style="text-align: left;"> </td> <td> </td> <td style="text-align: left;"> </td> <td style="text-align: right;"> </td> <td style="text-align: left;"> </td> <td> </td> <td style="text-align: left;"> </td> <td style="text-align: right;"> </td> <td style="text-align: left;"> </td> <td> </td> <td style="text-align: left;"> </td> <td style="text-align: right;"> </td> <td style="text-align: left;"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="width: 660.58px; text-align: left; text-indent: -8.65pt; padding-bottom: 2px; padding-left: 17.3pt;">Corporate debt securities-short term</td> <td style="width: 14.54px; padding-bottom: 2px;"> </td> <td style="width: 14.54px; text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">$</td> <td style="width: 142.72px; text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">25,629</td> <td style="width: 14.54px; text-align: left; padding-bottom: 2px;"> </td> <td style="width: 14.54px; padding-bottom: 2px;"> </td> <td style="width: 14.54px; text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">$</td> <td style="width: 142.72px; text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">34</td> <td style="width: 14.54px; text-align: left; padding-bottom: 2px;"> </td> <td style="width: 14.54px; padding-bottom: 2px;"> </td> <td style="width: 13.63px; text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">$</td> <td style="width: 141.81px; text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">(2</td> <td style="width: 13.63px; text-align: left; padding-bottom: 2px;">)</td> <td style="width: 13.63px; padding-bottom: 2px;"> </td> <td style="width: 13.63px; text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">$</td> <td style="width: 141.81px; text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">25,661</td> <td style="width: 13.63px; text-align: left; padding-bottom: 2px;"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="text-align: left; padding-bottom: 4px;">Total available-for-sale marketable securities</td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">$</td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">25,629</td> <td style="text-align: left; padding-bottom: 4px;"> </td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">$</td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">34</td> <td style="text-align: left; padding-bottom: 4px;"> </td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">$</td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">(2</td> <td style="text-align: left; padding-bottom: 4px;">)</td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">$</td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">25,661</td> <td style="text-align: left; padding-bottom: 4px;"> </td> </tr> </table>   <table align="center" style="font: 10pt/normal 'times new roman', times, serif; width: 100%; border-collapse: collapse; font-size-adjust: none; font-stretch: normal;" border="0" cellspacing="0" cellpadding="0"> <tr style="vertical-align: bottom;"> <td style="font-weight: bold; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" nowrap="nowrap">December 31, 2015</td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> Amortized Cost </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> Gross Unrealized Gains </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> Gross Unrealized Losses </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> Fair Value </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="text-align: left; font-style: italic;">Security type</td> <td> </td> <td style="text-align: left;"> </td> <td style="text-align: right;"> </td> <td style="text-align: left;"> </td> <td> </td> <td style="text-align: left;"> </td> <td style="text-align: right;"> </td> <td style="text-align: left;"> </td> <td> </td> <td style="text-align: left;"> </td> <td style="text-align: right;"> </td> <td style="text-align: left;"> </td> <td> </td> <td style="text-align: left;"> </td> <td style="text-align: right;"> </td> <td style="text-align: left;"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="width: 660.58px; text-align: left; text-indent: -8.65pt; padding-bottom: 2px; padding-left: 17.3pt;">Corporate debt securities-short term</td> <td style="width: 14.54px; padding-bottom: 2px;"> </td> <td style="width: 14.54px; text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">$</td> <td style="width: 142.72px; text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">24,786</td> <td style="width: 14.54px; text-align: left; padding-bottom: 2px;"> </td> <td style="width: 14.54px; padding-bottom: 2px;"> </td> <td style="width: 14.54px; text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">$</td> <td style="width: 142.72px; text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">13</td> <td style="width: 14.54px; text-align: left; padding-bottom: 2px;"> </td> <td style="width: 14.54px; padding-bottom: 2px;"> </td> <td style="width: 13.63px; text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">$</td> <td style="width: 141.81px; text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">(10</td> <td style="width: 13.63px; text-align: left; padding-bottom: 2px;">)</td> <td style="width: 13.63px; padding-bottom: 2px;"> </td> <td style="width: 13.63px; text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">$</td> <td style="width: 141.81px; text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">24,789</td> <td style="width: 13.63px; text-align: left; padding-bottom: 2px;"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="text-align: left; padding-bottom: 4px;">Total available-for-sale marketable securities</td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">$</td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">24,786</td> <td style="text-align: left; padding-bottom: 4px;"> </td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">$</td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">13</td> <td style="text-align: left; padding-bottom: 4px;"> </td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">$</td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">(10</td> <td style="text-align: left; padding-bottom: 4px;">)</td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">$</td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">24,789</td> <td style="text-align: left; padding-bottom: 4px;"> </td> </tr> </table>   Our available-for-sale marketable securities in a loss position at June 30, 2016, and December 31, 2015 were in a continuous unrealized loss position for less than 12 months.   The following tables present information about our assets that are measured at fair value on a recurring basis for the periods presented and indicates the fair value hierarchy of the valuation techniques we utilized to determine such fair value. In general, fair values determined by Level 1 inputs utilize quoted prices (unadjusted) in active markets for identical assets or liabilities. Fair values determined by Level 2 inputs utilize data points that are observable such as quoted prices, interest rates and yield curves. We value our level 2 investments using quoted prices for identical assets in the markets where they are traded, although such trades may not occur daily. These quoted prices are based on observable inputs, primarily interest rates. Fair values determined by Level 3 inputs are unobservable data points for the asset or liability, and include situations where there is little, if any, market activity for the asset or liability. There were no transfers in or out of Level 1 or Level 2 measurements for the periods presented:   <table align="center" style="font: 10pt/normal 'times new roman', times, serif; width: 100%; border-collapse: collapse; font-size-adjust: none; font-stretch: normal;" border="0" cellspacing="0" cellpadding="0"> <tr style="vertical-align: bottom;"> <td nowrap="nowrap"> </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> June 30, 2016 </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> Quoted Prices in Active Markets (Level 1) </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> Significant Other Observable Inputs (Level 2) </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> Significant Unobservable Inputs (Level 3) </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="width: 683.63px; text-align: left;">Cash equivalents</td> <td style="width: 14.54px;"> </td> <td style="width: 14.54px; text-align: left;">$</td> <td style="width: 142.72px; text-align: right;">15,051</td> <td style="width: 14.54px; text-align: left;"> </td> <td style="width: 14.54px;"> </td> <td style="width: 14.54px; text-align: left;">$</td> <td style="width: 142.72px; text-align: right;">15,051</td> <td style="width: 14.54px; text-align: left;"> </td> <td style="width: 14.54px;"> </td> <td style="width: 13.63px; text-align: left;">$</td> <td style="width: 141.81px; text-align: right;">—</td> <td style="width: 13.63px; text-align: left;"> </td> <td style="width: 13.63px;"> </td> <td style="width: 13.63px; text-align: left;">$</td> <td style="width: 141.81px; text-align: right;">—</td> <td style="width: 13.63px; text-align: left;"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="text-align: left; padding-bottom: 2px;">Corporate debt securities-short term</td> <td style="padding-bottom: 2px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;"> </td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">25,661</td> <td style="text-align: left; padding-bottom: 2px;"> </td> <td style="padding-bottom: 2px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;"> </td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">—</td> <td style="text-align: left; padding-bottom: 2px;"> </td> <td style="padding-bottom: 2px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;"> </td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">25,661</td> <td style="text-align: left; padding-bottom: 2px;"> </td> <td style="padding-bottom: 2px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;"> </td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">—</td> <td style="text-align: left; padding-bottom: 2px;"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="text-indent: -8.65pt; padding-bottom: 4px; padding-left: 34.55pt;">Total</td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">$</td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">40,712</td> <td style="text-align: left; padding-bottom: 4px;"> </td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">$</td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">15,051</td> <td style="text-align: left; padding-bottom: 4px;"> </td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">$</td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">25,661</td> <td style="text-align: left; padding-bottom: 4px;"> </td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">$</td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">—</td> <td style="text-align: left; padding-bottom: 4px;"> </td> </tr> </table>   <table align="center" style="font: 10pt/normal 'times new roman', times, serif; width: 100%; border-collapse: collapse; font-size-adjust: none; font-stretch: normal;" border="0" cellspacing="0" cellpadding="0"> <tr style="vertical-align: bottom;"> <td nowrap="nowrap"> </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> December 31, 2015 </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> Quoted Prices in Active Markets (Level 1) </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> Significant Other Observable Inputs (Level 2) </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> Significant Unobservable Inputs (Level 3) </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="width: 683.63px; text-align: left;">Cash equivalents</td> <td style="width: 14.54px;"> </td> <td style="width: 14.54px; text-align: left;">$</td> <td style="width: 142.72px; text-align: right;">11,800</td> <td style="width: 14.54px; text-align: left;"> </td> <td style="width: 14.54px;"> </td> <td style="width: 14.54px; text-align: left;">$</td> <td style="width: 142.72px; text-align: right;">11,800</td> <td style="width: 14.54px; text-align: left;"> </td> <td style="width: 14.54px;"> </td> <td style="width: 13.63px; text-align: left;">$</td> <td style="width: 141.81px; text-align: right;">—</td> <td style="width: 13.63px; text-align: left;"> </td> <td style="width: 13.63px;"> </td> <td style="width: 13.63px; text-align: left;">$</td> <td style="width: 141.81px; text-align: right;">—</td> <td style="width: 13.63px; text-align: left;"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="text-align: left; padding-bottom: 2px;">Corporate debt securities-short term</td> <td style="padding-bottom: 2px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;"> </td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">24,789</td> <td style="text-align: left; padding-bottom: 2px;"> </td> <td style="padding-bottom: 2px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;"> </td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">—</td> <td style="text-align: left; padding-bottom: 2px;"> </td> <td style="padding-bottom: 2px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;"> </td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">24,789</td> <td style="text-align: left; padding-bottom: 2px;"> </td> <td style="padding-bottom: 2px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;"> </td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">—</td> <td style="text-align: left; padding-bottom: 2px;"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="font: 13.33px/normal 'times new roman', times, serif; color: #000000; text-transform: none; text-indent: -8.65pt; letter-spacing: normal; padding-bottom: 4px; padding-left: 34.55pt; word-spacing: 0px; white-space: normal; widows: 1; -webkit-text-stroke-width: 0px;">Total</td> <td style="font: 13.33px/normal 'times new roman', times, serif; color: #000000; text-transform: none; text-indent: 0px; letter-spacing: normal; padding-bottom: 4px; word-spacing: 0px; white-space: normal; widows: 1; -webkit-text-stroke-width: 0px;"> </td> <td style="font: 13.33px/normal 'times new roman', times, serif; text-align: left; color: #000000; text-transform: none; text-indent: 0px; letter-spacing: normal; word-spacing: 0px; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double; white-space: normal; widows: 1; -webkit-text-stroke-width: 0px;">$</td> <td style="font: 13.33px/normal 'times new roman', times, serif; text-align: right; color: #000000; text-transform: none; text-indent: 0px; letter-spacing: normal; word-spacing: 0px; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double; white-space: normal; widows: 1; -webkit-text-stroke-width: 0px;">36,589</td> <td style="font: 13.33px/normal 'times new roman', times, serif; text-align: left; color: #000000; text-transform: none; text-indent: 0px; letter-spacing: normal; padding-bottom: 4px; word-spacing: 0px; white-space: normal; widows: 1; -webkit-text-stroke-width: 0px;"> </td> <td style="font: 13.33px/normal 'times new roman', times, serif; color: #000000; text-transform: none; text-indent: 0px; letter-spacing: normal; padding-bottom: 4px; word-spacing: 0px; white-space: normal; widows: 1; -webkit-text-stroke-width: 0px;"> </td> <td style="font: 13.33px/normal 'times new roman', times, serif; text-align: left; color: #000000; text-transform: none; text-indent: 0px; letter-spacing: normal; word-spacing: 0px; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double; white-space: normal; widows: 1; -webkit-text-stroke-width: 0px;">$</td> <td style="font: 13.33px/normal 'times new roman', times, serif; text-align: right; color: #000000; text-transform: none; text-indent: 0px; letter-spacing: normal; word-spacing: 0px; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double; white-space: normal; widows: 1; -webkit-text-stroke-width: 0px;">11,800</td> <td style="font: 13.33px/normal 'times new roman', times, serif; text-align: left; color: #000000; text-transform: none; text-indent: 0px; letter-spacing: normal; padding-bottom: 4px; word-spacing: 0px; white-space: normal; widows: 1; -webkit-text-stroke-width: 0px;"> </td> <td style="font: 13.33px/normal 'times new roman', times, serif; color: #000000; text-transform: none; text-indent: 0px; letter-spacing: normal; padding-bottom: 4px; word-spacing: 0px; white-space: normal; widows: 1; -webkit-text-stroke-width: 0px;"> </td> <td style="font: 13.33px/normal 'times new roman', times, serif; text-align: left; color: #000000; text-transform: none; text-indent: 0px; letter-spacing: normal; word-spacing: 0px; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double; white-space: normal; widows: 1; -webkit-text-stroke-width: 0px;">$</td> <td style="font: 13.33px/normal 'times new roman', times, serif; text-align: right; color: #000000; text-transform: none; text-indent: 0px; letter-spacing: normal; word-spacing: 0px; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double; white-space: normal; widows: 1; -webkit-text-stroke-width: 0px;">24,789</td> <td style="font: 13.33px/normal 'times new roman', times, serif; text-align: left; color: #000000; text-transform: none; text-indent: 0px; letter-spacing: normal; padding-bottom: 4px; word-spacing: 0px; white-space: normal; widows: 1; -webkit-text-stroke-width: 0px;"> </td> <td style="font: 13.33px/normal 'times new roman', times, serif; color: #000000; text-transform: none; text-indent: 0px; letter-spacing: normal; padding-bottom: 4px; word-spacing: 0px; white-space: normal; widows: 1; -webkit-text-stroke-width: 0px;"> </td> <td style="font: 13.33px/normal 'times new roman', times, serif; text-align: left; color: #000000; text-transform: none; text-indent: 0px; letter-spacing: normal; word-spacing: 0px; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double; white-space: normal; widows: 1; -webkit-text-stroke-width: 0px;">$</td> <td style="font: 13.33px/normal 'times new roman', times, serif; text-align: right; color: #000000; text-transform: none; text-indent: 0px; letter-spacing: normal; word-spacing: 0px; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double; white-space: normal; widows: 1; -webkit-text-stroke-width: 0px;">—</td> </tr> </table>

<p style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px; color: #000000; text-transform: none; text-indent: 0px; letter-spacing: normal; word-spacing: 0px; white-space: normal; widows: 1; font-stretch: normal; -webkit-text-stroke-width: 0px;">6. STOCK-BASED COMPENSATION AND STOCK PLANS <p style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px; color: #000000; text-transform: none; text-indent: 0.5in; letter-spacing: normal; word-spacing: 0px; white-space: normal; widows: 1; font-stretch: normal; -webkit-text-stroke-width: 0px;">  <p style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px; color: #000000; text-transform: none; text-indent: 0.5in; letter-spacing: normal; word-spacing: 0px; white-space: normal; widows: 1; font-stretch: normal; -webkit-text-stroke-width: 0px;">Our stock-based compensation cost is measured at the grant date, based on the calculated fair value of the award, and is recognized as an expense over the employees’ requisite service period (generally the vesting period of the equity grant). We estimate the fair value of stock options using the Black-Scholes valuation model. Key input assumptions used to estimate the fair value of stock options include the exercise price of the award, expected option term, expected volatility of our stock over the option’s expected term, risk-free interest rate over the option’s expected term, and the expected annual dividend yield. We believe that the valuation technique and approach utilized to develop the underlying assumptions are appropriate in calculating the fair values of our stock options granted in the six months ended June 30, 2016 and 2015. <p style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px; color: #000000; text-transform: none; text-indent: 0.5in; letter-spacing: normal; word-spacing: 0px; white-space: normal; widows: 1; font-stretch: normal; -webkit-text-stroke-width: 0px;">  <p style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px; color: #000000; text-transform: none; text-indent: 0.5in; letter-spacing: normal; word-spacing: 0px; white-space: normal; widows: 1; font-stretch: normal; -webkit-text-stroke-width: 0px;">The following table presents stock-based compensation expense included in our Condensed Statements of Operations and Comprehensive Loss: <p style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px; color: #000000; text-transform: none; text-indent: 0.5in; letter-spacing: normal; word-spacing: 0px; white-space: normal; widows: 1; font-stretch: normal; -webkit-text-stroke-width: 0px;">  <table align="center" style="font: 10pt/normal 'times new roman', times, serif; width: 100%; text-transform: none; text-indent: 0px; letter-spacing: normal; word-spacing: 0px; border-collapse: collapse; widows: 1; font-size-adjust: none; font-stretch: normal; -webkit-text-stroke-width: 0px;" border="0" cellspacing="0" cellpadding="0"> <tr style="vertical-align: bottom;"> <td nowrap="nowrap"> </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="6" nowrap="nowrap"> Three Months Ended June 30, </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="6" nowrap="nowrap"> Six Months Ended June 30, </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> </tr> <tr style="vertical-align: bottom;"> <td> </td> <td style="padding-bottom: 2px; font-weight: bold;"> </td> <td style="text-align: center; font-weight: bold; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2">2016</td> <td style="padding-bottom: 2px; font-weight: bold;"> </td> <td style="padding-bottom: 2px; font-weight: bold;"> </td> <td style="text-align: center; font-weight: bold; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2">2015</td> <td style="padding-bottom: 2px; font-weight: bold;"> </td> <td style="padding-bottom: 2px; font-weight: bold;"> </td> <td style="text-align: center; font-weight: bold; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2">2016</td> <td style="padding-bottom: 2px; font-weight: bold;"> </td> <td style="padding-bottom: 2px; font-weight: bold;"> </td> <td style="text-align: center; font-weight: bold; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2">2015</td> <td style="padding-bottom: 2px; font-weight: bold;"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="width: 546.36px; text-align: left;">Research and development</td> <td style="width: 11.81px;"> </td> <td style="width: 11.81px; text-align: left;">$</td> <td style="width: 114.54px; text-align: right;">109</td> <td style="width: 11.81px; text-align: left;"> </td> <td style="width: 11.81px;"> </td> <td style="width: 11.81px; text-align: left;">$</td> <td style="width: 114.54px; text-align: right;">124</td> <td style="width: 10.9px; text-align: left;"> </td> <td style="width: 10.9px;"> </td> <td style="width: 10.9px; text-align: left;">$</td> <td style="width: 113.63px; text-align: right;">299</td> <td style="width: 10.9px; text-align: left;"> </td> <td style="width: 10.9px;"> </td> <td style="width: 10.9px; text-align: left;">$</td> <td style="width: 113.63px; text-align: right;">396</td> <td style="width: 10.9px; text-align: left;"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="text-align: left; padding-bottom: 2px;">General and administrative</td> <td style="padding-bottom: 2px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;"> </td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">312</td> <td style="text-align: left; padding-bottom: 2px;"> </td> <td style="padding-bottom: 2px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;"> </td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">298</td> <td style="text-align: left; padding-bottom: 2px;"> </td> <td style="padding-bottom: 2px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;"> </td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">716</td> <td style="text-align: left; padding-bottom: 2px;"> </td> <td style="padding-bottom: 2px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;"> </td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">844</td> <td style="text-align: left; padding-bottom: 2px;"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="text-align: left; text-indent: -8.65pt; padding-bottom: 4px; padding-left: 25.95pt;">Total stock-based compensation expense</td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">$</td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">421</td> <td style="text-align: left; padding-bottom: 4px;"> </td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">$</td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">422</td> <td style="text-align: left; padding-bottom: 4px;"> </td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">$</td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">1,015</td> <td style="text-align: left; padding-bottom: 4px;"> </td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">$</td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">1,240</td> <td style="text-align: left; padding-bottom: 4px;"> </td> </tr> </table> <p style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px; color: #000000; text-transform: none; text-indent: 0.5in; letter-spacing: normal; word-spacing: 0px; white-space: normal; widows: 1; font-stretch: normal; -webkit-text-stroke-width: 0px;">  <p style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px; color: #000000; text-transform: none; text-indent: 0.5in; letter-spacing: normal; word-spacing: 0px; white-space: normal; widows: 1; font-stretch: normal; -webkit-text-stroke-width: 0px;">In the three and six months ended June 30, 2016 and 2015, no stock-based compensation expense was capitalized and there were no recognized tax benefits associated with the stock-based compensation expense. <p style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px 0pt 0.5in; color: #000000; text-transform: none; text-indent: 0px; letter-spacing: normal; word-spacing: 0px; white-space: normal; widows: 1; font-stretch: normal; -webkit-text-stroke-width: 0px;">  <p style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px 0pt 0.5in; color: #000000; text-transform: none; text-indent: 0px; letter-spacing: normal; word-spacing: 0px; white-space: normal; widows: 1; font-stretch: normal; -webkit-text-stroke-width: 0px;">Option activity under our stock plans for the six months ended June 30, 2016 was as follows: <p style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px 0pt 0.5in; color: #000000; text-transform: none; text-indent: 0px; letter-spacing: normal; word-spacing: 0px; white-space: normal; widows: 1; font-stretch: normal; -webkit-text-stroke-width: 0px;">  <table align="center" style="font: 10pt/normal 'times new roman', times, serif; width: 100%; text-transform: none; text-indent: 0px; letter-spacing: normal; margin-left: 0in; word-spacing: 0px; border-collapse: collapse; widows: 1; font-size-adjust: none; font-stretch: normal; -webkit-text-stroke-width: 0px;" border="0" cellspacing="0" cellpadding="0"> <tr style="vertical-align: bottom;"> <td style="font-weight: bold; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" nowrap="nowrap">Stock Options</td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> Number of Shares </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> Weighted Average Exercise Price </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="width: 797.27px;">Outstanding as of December 31, 2015</td> <td style="width: 11.81px;"> </td> <td style="width: 11.81px; text-align: left;"> </td> <td style="width: 137.27px; text-align: right;">8,305,950</td> <td style="width: 10.9px; text-align: left;"> </td> <td style="width: 10.9px;"> </td> <td style="width: 10.9px; text-align: left;">$</td> <td style="width: 136.36px; text-align: right;">4.24</td> <td style="width: 10.9px; text-align: left;"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td>Granted</td> <td> </td> <td style="text-align: left;"> </td> <td style="text-align: right;">1,609,000</td> <td style="text-align: left;"> </td> <td> </td> <td style="text-align: left;"> </td> <td style="text-align: right;">1.78</td> <td style="text-align: left;"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td>Exercised</td> <td> </td> <td style="text-align: left;"> </td> <td style="text-align: right;">(97,498</td> <td style="text-align: left;">)</td> <td> </td> <td style="text-align: left;"> </td> <td style="text-align: right;">1.16</td> <td style="text-align: left;"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="padding-bottom: 2px;">Cancelled</td> <td style="padding-bottom: 2px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;"> </td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">(628,254</td> <td style="text-align: left; padding-bottom: 2px;">)</td> <td style="padding-bottom: 2px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;"> </td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">5.31</td> <td style="text-align: left; padding-bottom: 2px;"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="padding-bottom: 4px;">Outstanding as of June 30, 2016</td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;"> </td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">9,189,198</td> <td style="text-align: left; padding-bottom: 4px;"> </td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">$</td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">3.77</td> <td style="text-align: left; padding-bottom: 4px;"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="padding-bottom: 2px;"> </td> <td style="padding-bottom: 2px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;"> </td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;"> </td> <td style="text-align: left; padding-bottom: 2px;"> </td> <td style="padding-bottom: 2px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;"> </td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;"> </td> <td style="text-align: left; padding-bottom: 2px;"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="padding-bottom: 4px;">Exercisable as of June 30, 2016</td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;"> </td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">6,103,542</td> <td style="text-align: left; padding-bottom: 4px;"> </td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">$</td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">4.78</td> <td style="text-align: left; padding-bottom: 4px;"> </td> </tr> </table> <p style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px; color: #000000; text-transform: none; text-indent: 0.5in; letter-spacing: normal; word-spacing: 0px; white-space: normal; widows: 1; font-stretch: normal; -webkit-text-stroke-width: 0px;">  <p style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px; color: #000000; text-transform: none; text-indent: 0.5in; letter-spacing: normal; word-spacing: 0px; white-space: normal; widows: 1; font-stretch: normal; -webkit-text-stroke-width: 0px;">The aggregate intrinsic value of options outstanding at June 30, 2016 was $1,023 including $203 related to exercisable options. The weighted average grant date fair value of options granted in the six months ended June 30, 2016 and 2015 was $1.10 and $0.77 per share, respectively. The intrinsic value of options exercised in the six months ended June 30, 2016 was $60. <p style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px; color: #000000; text-transform: none; text-indent: 0.5in; letter-spacing: normal; word-spacing: 0px; white-space: normal; widows: 1; font-stretch: normal; -webkit-text-stroke-width: 0px;">  <p style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px; color: #000000; text-transform: none; text-indent: 0.5in; letter-spacing: normal; word-spacing: 0px; white-space: normal; widows: 1; font-stretch: normal; -webkit-text-stroke-width: 0px;">Shares vested, expected to vest and exercisable at June 30, 2016 are as follows: <p style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px; color: #000000; text-transform: none; text-indent: 0.5in; letter-spacing: normal; word-spacing: 0px; white-space: normal; widows: 1; font-stretch: normal; -webkit-text-stroke-width: 0px;">  <table align="center" style="font: 10pt/normal 'times new roman', times, serif; width: 100%; text-transform: none; text-indent: 0px; letter-spacing: normal; word-spacing: 0px; border-collapse: collapse; widows: 1; font-size-adjust: none; font-stretch: normal; -webkit-text-stroke-width: 0px;" border="0" cellspacing="0" cellpadding="0"> <tr style="vertical-align: bottom;"> <td nowrap="nowrap"> </td> <td style="padding-bottom: 2px; font-weight: bold;" nowrap="nowrap"> </td> <td style="text-align: center; font-weight: bold; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap">Shares</td> <td style="padding-bottom: 2px; font-weight: bold;" nowrap="nowrap"> </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> Weighted-Average Exercise Price </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> Weighted-Average Remaining Contractual Term (in years) </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> Aggregate Intrinsic Value </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="width: 672.11px; text-align: left; text-indent: -8.65pt; padding-left: 8.65pt;">Vested and unvested expected to vest at June 30, 2016</td> <td style="width: 14.54px;"> </td> <td style="width: 14.54px; text-align: left;"> </td> <td style="width: 142.72px; text-align: right;">9,020,805</td> <td style="width: 14.54px; text-align: left;"> </td> <td style="width: 14.54px;"> </td> <td style="width: 14.54px; text-align: left;">$</td> <td style="width: 142.72px; text-align: right;">3.77</td> <td style="width: 14.54px; text-align: left;"> </td> <td style="width: 14.54px;"> </td> <td style="width: 13.63px; text-align: left;"> </td> <td style="width: 141.81px; text-align: right;">5.8</td> <td style="width: 13.63px; text-align: left;"> </td> <td style="width: 13.63px;"> </td> <td style="width: 13.63px; text-align: left;">$</td> <td style="width: 141.81px; text-align: right;">979</td> <td style="width: 13.63px; text-align: left;"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td>Exercisable at June 30, 2016</td> <td> </td> <td style="text-align: left;"> </td> <td style="text-align: right;">6,103,542</td> <td style="text-align: left;"> </td> <td> </td> <td style="text-align: left;">$</td> <td style="text-align: right;">4.78</td> <td style="text-align: left;"> </td> <td> </td> <td style="text-align: left;"> </td> <td style="text-align: right;">4.2</td> <td style="text-align: left;"> </td> <td> </td> <td style="text-align: left;">$</td> <td style="text-align: right;">203</td> <td style="text-align: left;"> </td> </tr> </table> <p style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px; color: #000000; text-transform: none; text-indent: 0.5in; letter-spacing: normal; word-spacing: 0px; white-space: normal; widows: 1; font-stretch: normal; -webkit-text-stroke-width: 0px;">  <p style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px; color: #000000; text-transform: none; text-indent: 0.5in; letter-spacing: normal; word-spacing: 0px; white-space: normal; widows: 1; font-stretch: normal; -webkit-text-stroke-width: 0px;">The total compensation cost not yet recognized as of June 30, 2016 related to non-vested option awards was $3.4 million, which will be recognized over a weighted-average period of 2.7 years. During the six months ended June 30, 2016, 551,036 shares expired and 2,218 shares were forfeited. The weighted average remaining contractual life for options exercisable at June 30, 2016 was 4.2 years. <p style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px; color: #000000; text-transform: none; text-indent: 0.5in; letter-spacing: normal; word-spacing: 0px; white-space: normal; widows: 1; font-stretch: normal; -webkit-text-stroke-width: 0px;">  <p style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px; color: #000000; text-transform: none; text-indent: 0.5in; letter-spacing: normal; word-spacing: 0px; white-space: normal; widows: 1; font-stretch: normal; -webkit-text-stroke-width: 0px;">In 2013, we granted 242,697 shares of restricted stock to employees, vesting annually over a four year period. The weighted average fair value of the restricted stock at the time of grant in 2013 was $2.51 per share, and is being expensed ratably over the vesting period. Through June 30, 2016, 82,617 shares have been forfeited, and 130,804 shares have vested. We recognized share-based compensation expense related to restricted stock of $39 and $42 for the six months ended June 30, 2016 and 2015, respectively. <p style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px; color: #000000; text-transform: none; text-indent: 0.5in; letter-spacing: normal; word-spacing: 0px; white-space: normal; widows: 1; font-stretch: normal; -webkit-text-stroke-width: 0px;">  <p style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px; color: #000000; text-transform: none; text-indent: 0.5in; letter-spacing: normal; word-spacing: 0px; white-space: normal; widows: 1; font-stretch: normal; -webkit-text-stroke-width: 0px;">Restricted stock activity under the Plan for the six months ended June 30, 2016 was as follows: <p style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px; color: #000000; text-transform: none; text-indent: 0.5in; letter-spacing: normal; word-spacing: 0px; white-space: normal; widows: 1; font-stretch: normal; -webkit-text-stroke-width: 0px;">  <table align="center" style="font: 10pt/normal 'times new roman', times, serif; width: 100%; text-transform: none; text-indent: 0px; letter-spacing: normal; word-spacing: 0px; border-collapse: collapse; widows: 1; font-size-adjust: none; font-stretch: normal; -webkit-text-stroke-width: 0px;" border="0" cellspacing="0" cellpadding="0"> <tr style="vertical-align: bottom;"> <td style="font-weight: bold; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" nowrap="nowrap">Restricted Stock</td> <td style="padding-bottom: 2px; font-weight: bold;" nowrap="nowrap"> </td> <td style="text-align: center; font-weight: bold; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap">Number of Shares</td> <td style="padding-bottom: 2px; font-weight: bold;" nowrap="nowrap"> </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> Weighted Average Grant Date Fair Value </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="width: 842.72px;">Unvested as of December 31, 2015</td> <td style="width: 11.81px;"> </td> <td style="width: 11.81px; text-align: left;"> </td> <td style="width: 114.54px; text-align: right;">58,635</td> <td style="width: 10.9px; text-align: left;"> </td> <td style="width: 10.9px;"> </td> <td style="width: 10.9px; text-align: left;">$</td> <td style="width: 113.63px; text-align: right;">2.51</td> <td style="width: 10.9px; text-align: left;"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="text-indent: -8.65pt; padding-left: 17.3pt;">Vested</td> <td> </td> <td style="text-align: left;"> </td> <td style="text-align: right;">(29,306</td> <td style="text-align: left;">)</td> <td> </td> <td style="text-align: left;"> </td> <td style="text-align: right;">2.51</td> <td style="text-align: left;"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="text-indent: -8.65pt; padding-bottom: 2px; padding-left: 17.3pt;">Cancelled</td> <td style="padding-bottom: 2px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;"> </td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">(53</td> <td style="text-align: left; padding-bottom: 2px;">)</td> <td style="padding-bottom: 2px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;"> </td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">2.51</td> <td style="text-align: left; padding-bottom: 2px;"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="padding-bottom: 4px;">Unvested as of June 30, 2016</td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;"> </td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">29,276</td> <td style="text-align: left; padding-bottom: 4px;"> </td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">$</td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">2.51</td> <td style="text-align: left; padding-bottom: 4px;"> </td> </tr> </table> <p style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px; color: #000000; text-transform: none; text-indent: 0.5in; letter-spacing: normal; word-spacing: 0px; white-space: normal; widows: 1; font-stretch: normal; -webkit-text-stroke-width: 0px;">  <p style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px; color: #000000; text-transform: none; text-indent: 0.5in; letter-spacing: normal; word-spacing: 0px; white-space: normal; widows: 1; font-stretch: normal; -webkit-text-stroke-width: 0px;">The fair value of restricted stock vested in the six months ended June 30, 2016 and 2015 was $56 and $58, respectively. <p style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px; color: #000000; text-transform: none; text-indent: 0.5in; letter-spacing: normal; word-spacing: 0px; white-space: normal; widows: 1; font-stretch: normal; -webkit-text-stroke-width: 0px;">  <p style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px; color: #000000; text-transform: none; text-indent: 0.5in; letter-spacing: normal; word-spacing: 0px; white-space: normal; widows: 1; font-stretch: normal; -webkit-text-stroke-width: 0px;">In July 2010, the Company amended its chief executive officer’s (the “CEO’s”) employment agreement to grant the CEO 100,000 stock options, of which 25% vested upon grant and 25% vest annually over the next three years, and a maximum of 390,000 performance-based stock units that vest upon the achievement of certain performance and market based targets. In March 2013, the Company amended its CEO’s employment agreement to modify the performance and market based targets. <p style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px; color: #000000; text-transform: none; text-indent: 0.5in; letter-spacing: normal; word-spacing: 0px; white-space: normal; widows: 1; font-stretch: normal; -webkit-text-stroke-width: 0px;">  <p style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px; color: #000000; text-transform: none; text-indent: 0.5in; letter-spacing: normal; word-spacing: 0px; white-space: normal; widows: 1; font-stretch: normal; -webkit-text-stroke-width: 0px;">In February 2012, the Company amended its chief medical officer’s (the “CMO’s”) employment agreement to grant the CMO 50,000 performance-based stock units that vest upon the achievement of certain performance based targets. <p style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px; color: #000000; text-transform: none; text-indent: 0.5in; letter-spacing: normal; word-spacing: 0px; white-space: normal; widows: 1; font-stretch: normal; -webkit-text-stroke-width: 0px;">  <p style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px; color: #000000; text-transform: none; text-indent: 0.5in; letter-spacing: normal; word-spacing: 0px; white-space: normal; widows: 1; font-stretch: normal; -webkit-text-stroke-width: 0px;">In March 2013, the Company amended its chief operating officer’s (the “COO’s”) employment agreement to grant the COO 125,000 performance-based stock units that vest upon the achievement of certain performance based targets. In March 2013, the Company amended its CMO’s employment agreement to grant the CMO 120,000 performance-based stock units that vest upon the achievement of certain performance based targets. <p style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px; color: #000000; text-transform: none; text-indent: 0.5in; letter-spacing: normal; word-spacing: 0px; white-space: normal; widows: 1; font-stretch: normal; -webkit-text-stroke-width: 0px;">  <p style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px; color: #000000; text-transform: none; text-indent: 0.5in; letter-spacing: normal; word-spacing: 0px; white-space: normal; widows: 1; font-stretch: normal; -webkit-text-stroke-width: 0px;">Through June 30, 2016, no expense has been recorded for any performance-based stock units granted to the CEO, COO, or CMO.

<p style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px; color: #000000; text-transform: none; text-indent: 0.5in; letter-spacing: normal; word-spacing: 0px; white-space: normal; widows: 1; font-stretch: normal; -webkit-text-stroke-width: 0px;">We have prepared the accompanying condensed financial statements pursuant to the rules and regulations of the U.S. Securities and Exchange Commission (“SEC”). Certain information and footnote disclosures normally included in financial statements prepared in accordance with generally accepted accounting principles have been condensed or omitted pursuant to these rules and regulations. These condensed financial statements should be read in conjunction with our audited financial statements and footnotes related thereto for the year ended December 31, 2015 included in our annual report on Form 10-K filed with the SEC on February 29, 2016. <p style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px; color: #000000; text-transform: none; text-indent: 0.5in; letter-spacing: normal; word-spacing: 0px; white-space: normal; widows: 1; font-stretch: normal; -webkit-text-stroke-width: 0px;">  <p style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px; color: #000000; text-transform: none; text-indent: 0.5in; letter-spacing: normal; word-spacing: 0px; white-space: normal; widows: 1; font-stretch: normal; -webkit-text-stroke-width: 0px;">In the opinion of the Company, the accompanying unaudited condensed financial statements contain all adjustments, consisting only of normal recurring adjustments, necessary for a fair statement of its financial position as of June 30, 2016, its results of operations for the three and six months ended June 30, 2016 and June 30, 2015, and its cash flows for the six months ended June 30, 2016 and June 30, 2015. The results of operations for such interim periods are not necessarily indicative of the results to be achieved for the full year. The condensed balance sheet at December 31, 2015 was derived from audited annual financial statements, but does not contain all of the footnote disclosures from the annual financial statements.

<table align="center" style="font: 10pt/normal 'times new roman', times, serif; width: 100%; text-transform: none; text-indent: 0px; letter-spacing: normal; word-spacing: 0px; border-collapse: collapse; widows: 1; font-size-adjust: none; font-stretch: normal; -webkit-text-stroke-width: 0px;" border="0" cellspacing="0" cellpadding="0"> <tr style="vertical-align: bottom;"> <td style="font-weight: bold; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" nowrap="nowrap">June 30, 2016</td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> Amortized Cost </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> Gross Unrealized Gains </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> Gross Unrealized Losses </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> Fair Value </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="text-align: left; font-style: italic;">Security type</td> <td> </td> <td style="text-align: left;"> </td> <td style="text-align: right;"> </td> <td style="text-align: left;"> </td> <td> </td> <td style="text-align: left;"> </td> <td style="text-align: right;"> </td> <td style="text-align: left;"> </td> <td> </td> <td style="text-align: left;"> </td> <td style="text-align: right;"> </td> <td style="text-align: left;"> </td> <td> </td> <td style="text-align: left;"> </td> <td style="text-align: right;"> </td> <td style="text-align: left;"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="width: 660.58px; text-align: left; text-indent: -8.65pt; padding-bottom: 2px; padding-left: 17.3pt;">Corporate debt securities-short term</td> <td style="width: 14.54px; padding-bottom: 2px;"> </td> <td style="width: 14.54px; text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">$</td> <td style="width: 142.72px; text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">25,629</td> <td style="width: 14.54px; text-align: left; padding-bottom: 2px;"> </td> <td style="width: 14.54px; padding-bottom: 2px;"> </td> <td style="width: 14.54px; text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">$</td> <td style="width: 142.72px; text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">34</td> <td style="width: 14.54px; text-align: left; padding-bottom: 2px;"> </td> <td style="width: 14.54px; padding-bottom: 2px;"> </td> <td style="width: 13.63px; text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">$</td> <td style="width: 141.81px; text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">(2</td> <td style="width: 13.63px; text-align: left; padding-bottom: 2px;">)</td> <td style="width: 13.63px; padding-bottom: 2px;"> </td> <td style="width: 13.63px; text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">$</td> <td style="width: 141.81px; text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">25,661</td> <td style="width: 13.63px; text-align: left; padding-bottom: 2px;"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="text-align: left; padding-bottom: 4px;">Total available-for-sale marketable securities</td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">$</td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">25,629</td> <td style="text-align: left; padding-bottom: 4px;"> </td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">$</td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">34</td> <td style="text-align: left; padding-bottom: 4px;"> </td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">$</td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">(2</td> <td style="text-align: left; padding-bottom: 4px;">)</td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">$</td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">25,661</td> <td style="text-align: left; padding-bottom: 4px;"> </td> </tr> </table> <p style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px; color: #000000; text-transform: none; text-indent: 0px; letter-spacing: normal; word-spacing: 0px; white-space: normal; widows: 1; font-stretch: normal; -webkit-text-stroke-width: 0px;">  <table align="center" style="font: 10pt/normal 'times new roman', times, serif; width: 100%; text-transform: none; text-indent: 0px; letter-spacing: normal; word-spacing: 0px; border-collapse: collapse; widows: 1; font-size-adjust: none; font-stretch: normal; -webkit-text-stroke-width: 0px;" border="0" cellspacing="0" cellpadding="0"> <tr style="vertical-align: bottom;"> <td style="font-weight: bold; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" nowrap="nowrap">December 31, 2015</td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> Amortized <div style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px; text-align: center; font-stretch: normal;">Cost</div> </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> Gross Unrealized Gains </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> Gross Unrealized Losses </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> Fair Value </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="text-align: left; font-style: italic;">Security type</td> <td> </td> <td style="text-align: left;"> </td> <td style="text-align: right;"> </td> <td style="text-align: left;"> </td> <td> </td> <td style="text-align: left;"> </td> <td style="text-align: right;"> </td> <td style="text-align: left;"> </td> <td> </td> <td style="text-align: left;"> </td> <td style="text-align: right;"> </td> <td style="text-align: left;"> </td> <td> </td> <td style="text-align: left;"> </td> <td style="text-align: right;"> </td> <td style="text-align: left;"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="width: 660.58px; text-align: left; text-indent: -8.65pt; padding-bottom: 2px; padding-left: 17.3pt;">Corporate debt securities-short term</td> <td style="width: 14.54px; padding-bottom: 2px;"> </td> <td style="width: 14.54px; text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">$</td> <td style="width: 142.72px; text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">24,786</td> <td style="width: 14.54px; text-align: left; padding-bottom: 2px;"> </td> <td style="width: 14.54px; padding-bottom: 2px;"> </td> <td style="width: 14.54px; text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">$</td> <td style="width: 142.72px; text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">13</td> <td style="width: 14.54px; text-align: left; padding-bottom: 2px;"> </td> <td style="width: 14.54px; padding-bottom: 2px;"> </td> <td style="width: 13.63px; text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">$</td> <td style="width: 141.81px; text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">(10</td> <td style="width: 13.63px; text-align: left; padding-bottom: 2px;">)</td> <td style="width: 13.63px; padding-bottom: 2px;"> </td> <td style="width: 13.63px; text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">$</td> <td style="width: 141.81px; text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">24,789</td> <td style="width: 13.63px; text-align: left; padding-bottom: 2px;"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="text-align: left; padding-bottom: 4px;">Total available-for-sale marketable securities</td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">$</td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">24,786</td> <td style="text-align: left; padding-bottom: 4px;"> </td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">$</td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">13</td> <td style="text-align: left; padding-bottom: 4px;"> </td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">$</td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">(10</td> <td style="text-align: left; padding-bottom: 4px;">)</td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">$</td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">24,789</td> <td style="text-align: left; padding-bottom: 4px;"> </td> </tr> </table>

<table align="center" style="font: 10pt/normal 'times new roman', times, serif; width: 100%; text-transform: none; text-indent: 0px; letter-spacing: normal; word-spacing: 0px; border-collapse: collapse; widows: 1; font-size-adjust: none; font-stretch: normal; -webkit-text-stroke-width: 0px;" border="0" cellspacing="0" cellpadding="0"> <tr style="vertical-align: bottom;"> <td nowrap="nowrap"> </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> June 30, 2016 </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> Quoted Prices in Active Markets (Level 1) </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> Significant Other Observable Inputs (Level 2) </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> Significant Unobservable Inputs (Level 3) </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="width: 683.63px; text-align: left;">Cash equivalents</td> <td style="width: 14.54px;"> </td> <td style="width: 14.54px; text-align: left;">$</td> <td style="width: 142.72px; text-align: right;">15,051</td> <td style="width: 14.54px; text-align: left;"> </td> <td style="width: 14.54px;"> </td> <td style="width: 14.54px; text-align: left;">$</td> <td style="width: 142.72px; text-align: right;">15,051</td> <td style="width: 14.54px; text-align: left;"> </td> <td style="width: 14.54px;"> </td> <td style="width: 13.63px; text-align: left;">$</td> <td style="width: 141.81px; text-align: right;">—</td> <td style="width: 13.63px; text-align: left;"> </td> <td style="width: 13.63px;"> </td> <td style="width: 13.63px; text-align: left;">$</td> <td style="width: 141.81px; text-align: right;">—</td> <td style="width: 13.63px; text-align: left;"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="text-align: left; padding-bottom: 2px;">Corporate debt securities-short term</td> <td style="padding-bottom: 2px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;"> </td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">25,661</td> <td style="text-align: left; padding-bottom: 2px;"> </td> <td style="padding-bottom: 2px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;"> </td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">—</td> <td style="text-align: left; padding-bottom: 2px;"> </td> <td style="padding-bottom: 2px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;"> </td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">25,661</td> <td style="text-align: left; padding-bottom: 2px;"> </td> <td style="padding-bottom: 2px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;"> </td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">—</td> <td style="text-align: left; padding-bottom: 2px;"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="text-indent: -8.65pt; padding-bottom: 4px; padding-left: 34.55pt;">Total</td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">$</td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">40,712</td> <td style="text-align: left; padding-bottom: 4px;"> </td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">$</td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">15,051</td> <td style="text-align: left; padding-bottom: 4px;"> </td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">$</td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">25,661</td> <td style="text-align: left; padding-bottom: 4px;"> </td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">$</td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">—</td> <td style="text-align: left; padding-bottom: 4px;"> </td> </tr> </table> <p style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px; color: #000000; text-transform: none; text-indent: 0px; letter-spacing: normal; word-spacing: 0px; white-space: normal; widows: 1; font-stretch: normal; -webkit-text-stroke-width: 0px;">  <table align="center" style="font: 10pt/normal 'times new roman', times, serif; width: 100%; text-transform: none; text-indent: 0px; letter-spacing: normal; word-spacing: 0px; border-collapse: collapse; widows: 1; font-size-adjust: none; font-stretch: normal; -webkit-text-stroke-width: 0px;" border="0" cellspacing="0" cellpadding="0"> <tr style="vertical-align: bottom;"> <td nowrap="nowrap"> </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> <div style="font: 10pt/normal 'times new roman', times, serif; margin: 0pt 0px; text-align: center; font-stretch: normal;">December 31,</div> 2015 </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> Quoted Prices in Active Markets (Level 1) </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> Significant Other Observable Inputs (Level 2) </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> Significant Unobservable Inputs (Level 3) </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="width: 683.63px; text-align: left;">Cash equivalents</td> <td style="width: 14.54px;"> </td> <td style="width: 14.54px; text-align: left;">$</td> <td style="width: 142.72px; text-align: right;">11,800</td> <td style="width: 14.54px; text-align: left;"> </td> <td style="width: 14.54px;"> </td> <td style="width: 14.54px; text-align: left;">$</td> <td style="width: 142.72px; text-align: right;">11,800</td> <td style="width: 14.54px; text-align: left;"> </td> <td style="width: 14.54px;"> </td> <td style="width: 13.63px; text-align: left;">$</td> <td style="width: 141.81px; text-align: right;">—</td> <td style="width: 13.63px; text-align: left;"> </td> <td style="width: 13.63px;"> </td> <td style="width: 13.63px; text-align: left;">$</td> <td style="width: 141.81px; text-align: right;">—</td> <td style="width: 13.63px; text-align: left;"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="text-align: left; padding-bottom: 2px;">Corporate debt securities-short term</td> <td style="padding-bottom: 2px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;"> </td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">24,789</td> <td style="text-align: left; padding-bottom: 2px;"> </td> <td style="padding-bottom: 2px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;"> </td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">—</td> <td style="text-align: left; padding-bottom: 2px;"> </td> <td style="padding-bottom: 2px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;"> </td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">24,789</td> <td style="text-align: left; padding-bottom: 2px;"> </td> <td style="padding-bottom: 2px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;"> </td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">—</td> <td style="text-align: left; padding-bottom: 2px;"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="text-indent: -8.65pt; padding-bottom: 4px; padding-left: 34.55pt;">Total</td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">$</td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">36,589</td> <td style="text-align: left; padding-bottom: 4px;"> </td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">$</td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">11,800</td> <td style="text-align: left; padding-bottom: 4px;"> </td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">$</td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">24,789</td> <td style="text-align: left; padding-bottom: 4px;"> </td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">$</td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">—</td> <td style="text-align: left; padding-bottom: 4px;"> </td> </tr> </table>

<table align="center" style="font: 10pt/normal 'times new roman', times, serif; width: 100%; text-transform: none; text-indent: 0px; letter-spacing: normal; margin-left: 0in; word-spacing: 0px; border-collapse: collapse; widows: 1; font-size-adjust: none; font-stretch: normal; -webkit-text-stroke-width: 0px;" border="0" cellspacing="0" cellpadding="0"> <tr style="vertical-align: bottom;"> <td style="font-weight: bold; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" nowrap="nowrap">Stock Options</td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> Number of Shares </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> <td style="text-align: center; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;" colspan="2" nowrap="nowrap"> Weighted Average Exercise Price </td> <td style="padding-bottom: 2px;" nowrap="nowrap"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="width: 797.27px;">Outstanding as of December 31, 2015</td> <td style="width: 11.81px;"> </td> <td style="width: 11.81px; text-align: left;"> </td> <td style="width: 137.27px; text-align: right;">8,305,950</td> <td style="width: 10.9px; text-align: left;"> </td> <td style="width: 10.9px;"> </td> <td style="width: 10.9px; text-align: left;">$</td> <td style="width: 136.36px; text-align: right;">4.24</td> <td style="width: 10.9px; text-align: left;"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td>Granted</td> <td> </td> <td style="text-align: left;"> </td> <td style="text-align: right;">1,609,000</td> <td style="text-align: left;"> </td> <td> </td> <td style="text-align: left;"> </td> <td style="text-align: right;">1.78</td> <td style="text-align: left;"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td>Exercised</td> <td> </td> <td style="text-align: left;"> </td> <td style="text-align: right;">(97,498</td> <td style="text-align: left;">)</td> <td> </td> <td style="text-align: left;"> </td> <td style="text-align: right;">1.16</td> <td style="text-align: left;"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="padding-bottom: 2px;">Cancelled</td> <td style="padding-bottom: 2px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;"> </td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">(628,254</td> <td style="text-align: left; padding-bottom: 2px;">)</td> <td style="padding-bottom: 2px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;"> </td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;">5.31</td> <td style="text-align: left; padding-bottom: 2px;"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="padding-bottom: 4px;">Outstanding as of June 30, 2016</td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;"> </td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">9,189,198</td> <td style="text-align: left; padding-bottom: 4px;"> </td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">$</td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">3.77</td> <td style="text-align: left; padding-bottom: 4px;"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="padding-bottom: 2px;"> </td> <td style="padding-bottom: 2px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;"> </td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;"> </td> <td style="text-align: left; padding-bottom: 2px;"> </td> <td style="padding-bottom: 2px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;"> </td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 2px; border-bottom-style: solid;"> </td> <td style="text-align: left; padding-bottom: 2px;"> </td> </tr> <tr style="vertical-align: bottom; background-color: white;"> <td style="padding-bottom: 4px;">Exercisable as of June 30, 2016</td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;"> </td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">6,103,542</td> <td style="text-align: left; padding-bottom: 4px;"> </td> <td style="padding-bottom: 4px;"> </td> <td style="text-align: left; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">$</td> <td style="text-align: right; border-bottom-color: black; border-bottom-width: 4px; border-bottom-style: double;">4.78</td> <td style="text-align: left; padding-bottom: 4px;"> </td> </tr> </table>

3000000

5000000

25000000

10000000

15000000

100000000

48000000

3000000

27000000

60000000

123000000 560000000 55000000 100000000 155000000 64700000 104700000 P90D P180D

900000

1400000

30000000 mid-teen percent low-twenty percent P90D

24786000

25629000

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Ltd It represents partners of the company. Kyowa Hakko Kirin Company Ltd Member Kyowa Hakko Kirin Co. Ltd. This element represents information of Kyowa Hakko Kirin Company Ltd. Research and Development Arrangement, Contract to Perform for Others [Line Items] Research and Development Arrangement, Contract to Perform for Others [Line Items] Revenue Recognition, Milestone Method, Revenue Recognized Milestone payment received Milestone Payment For First Patient Trial Milestone payments related to first patient enrolled in METIV-HCC trial Represents Milestone payment for first patient trial. 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Collaborative Arrangements and Non-Collaborative Arrangement Transactions [Line Items] Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] Research and Development Arrangement, Contract to Perform for Others, Compensation Earned Upfront fee on ARQ 092 Agreement Upfront payment received Revenue From Potential Future Milestones and Royalties Additional potential development and sales milestone payments Upfront and potential development milestone payments The sum of potential development and sales milestone payment received. Milestone Payments For Official Acceptance Of Drug Approval Applications Milestone payments for official acceptance of drug approval applications Represents milestone payments for official acceptance of drug approval applications. Milestone Payments To Be Received Upon Regulatory Approvals And First Commercial Sales Milestone payments to be received upon regulatory approvals and first commercial sales Represents milestone payments to be received upon regulatory approvals and first commercial sales. Milestone Partially Offset Total milestone partially offset Represents milestone partially offset. Cumulative Phase Costs Attributable To Collaboration Agreements In Excess Of Milestone Payments and Royalties Cumulative share of phase 3 collaboration costs in excess of milestones amounts received The amount received in excess. Baseline Contractual Rate Represents baseline contractual rate. Cumulative Phase Costs Attributable To Collaboration Agreements Cumulative share of phase 3 collaboration costs The amount of cumulative share of costs since inception. Notice Period For Termination Of Contract Prior To Start Of Specified Phase Notice period for termination of contract prior to start of specified period The number of years under agreement payment for research supported. Notice Period For Termination Of Contract Post Start Of Phase Notice period for termination of contract post start of Phase 3 clinical trials The number of years under agreement payment for research supported. Deferred Revenue Deferred revenue Kyowa Hakko Kirin Licensing Agreement [Member] Kyowa Hakko Kirin Licensing Agreement Contractual agreement of the company. Lease Arrangement, Type [Axis] Lease Arrangement, Type [Domain] Kyowa Hakko Kirin [Member] Kyowa Hakko Kirin Represents party of the contractual agreement. Phases [Axis] Information by phases. Phases [Domain] Information by phases. Phase Two Trial Kyowa Hakko Kirin [Member] Phase Two trial Kyowa Hakko Kirin Contractual agreement of the company. Phase Three Attention Trial Asia [Member] Phase Three Attention Trial Asia Contractual agreement of the company. Upfront Licensing Payments, Cash Cash upfront licensing payments Upfront licensing payments paid for the development, manufacturing and marketing on a worldwide basis. Percentage Of Royalties Expected To Be Received From Collaboration Lower Range Percentage of royalties expected to be received - lower range The percentage of royalties expected to be received from collaboration. Percentage Of Royalties Expected To Be Received From Collaboration Upper Range Percentage of royalties expected to be received - upper range The percentage of royalties expected to be received from collaboration. Notice Period For Termination Of Contract Notice period for termination of contract Represents notice period for termination of contract. 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Document and Entity Information - shares	6 Months Ended
Document and Entity Information - shares	Jun. 30, 2016	Jul. 20, 2016
Document and Entity Information [Abstract]
Entity Registrant Name	ARQULE INC
Entity Central Index Key	0001019695
Trading Symbol	arql
Current Fiscal Year End Date	--12-31
Entity Filer Category	Accelerated Filer
Entity Common Stock, Shares Outstanding		71,106,954
Document Type	10-Q
Document Period End Date	Jun. 30, 2016
Amendment Flag	false
Document Fiscal Year Focus	2016
Document Fiscal Period Focus	Q2

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CONDENSED BALANCE SHEETS (Unaudited) - USD ($) $ in Thousands	Jun. 30, 2016	Dec. 31, 2015
Current assets:
Cash and cash equivalents	$ 17,454	$ 13,983
Marketable securities-short term	25,661	24,789
Prepaid expenses and other current assets	420	714
Total current assets	43,535	39,486
Property and equipment, net	228	266
Other assets	252	252
Total assets	44,015	40,004
Current liabilities:
Accounts payable and accrued expenses	6,235	6,234
Deferred revenue	2,301	4,591
Total current liabilities	8,536	10,825
Commitments and contingencies
Stockholders' equity:
Preferred stock, $0.01 par value; 1,000,000 shares authorized; no shares issued or outstanding
Common stock, $0.01 par value; 100,000,000 shares authorized; 71,106,224 and 62,939,780 shares issued and outstanding at June 30, 2016 and December 31, 2015, respectively	711	629
Additional paid-in capital	526,934	510,664
Accumulated other comprehensive income	32	3
Accumulated deficit	(492,198)	(482,117)
Total stockholders' equity	35,479	29,179
Total liabilities and stockholders' equity	$ 44,015	$ 40,004

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CONDENSED BALANCE SHEETS (Unaudited) (Parentheticals) - $ / shares	Jun. 30, 2016	Dec. 31, 2015
Statement Of Financial Position [Abstract]
Preferred stock, par value (in dollars per share)	$ 0.01	$ 0.01
Preferred stock, shares authorized	1,000,000	1,000,000
Preferred stock, shares issued	0	0
Preferred stock, shares outstanding	0	0
Common stock, par value (in dollars per share)	$ 0.01	$ 0.01
Common stock, shares authorized	100,000,000	100,000,000
Common stock, shares issued	71,106,224	62,939,780
Common stock, shares outstanding	71,106,224	62,939,780

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CONDENSED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2016	Jun. 30, 2015	Jun. 30, 2016	Jun. 30, 2015
Revenue
Research and development revenue	$ 1,072	$ 3,004	$ 2,299	$ 5,789
Costs and expenses:
Research and development	4,337	4,327	8,535	8,740
General and administrative	1,887	2,776	3,931	5,963
Total costs and expenses	6,224	7,103	12,466	14,703
Loss from operations	(5,152)	(4,099)	(10,167)	(8,914)
Interest income	52	28	86	64
Other income		54		282
Net loss	(5,100)	(4,017)	(10,081)	(8,568)
Unrealized gain (loss) on marketable securities		(8)	29	3
Comprehensive loss	$ (5,100)	$ (4,025)	$ (10,052)	$ (8,565)
Basic and diluted net loss per share:
Net loss per share (in dollars per share)	$ (0.07)	$ (0.06)	$ (0.15)	$ (0.14)
Weighted average basic and diluted common shares outstanding (in shares)	71,062	62,754	68,275	62,747

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CONDENSED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2016	Jun. 30, 2015
Cash flows from operating activities:
Net loss	$ (10,081)	$ (8,568)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	53	91
Amortization of premium on marketable securities	40	322
Amortization of deferred gain on sale leaseback		(232)
Non-cash stock compensation	1,015	1,240
Gain on sale of property and equipment		(282)
Changes in operating assets and liabilities:
Prepaid expenses and other assets	294	1,196
Accounts payable and accrued expenses	1	(1,210)
Deferred revenue	(2,290)	(5,513)
Net cash used in operating activities	(10,968)	(12,956)
Cash flows from investing activities:
Purchases of marketable securities	(21,648)	(11,807)
Proceeds from sale or maturity of marketable securities	20,765	26,339
Additions to property and equipment	(15)	(280)
Proceeds from sale of property and equipment		228
Net cash provided by (used in) investing activities	(898)	14,480
Cash flows from financing activities:
Proceeds from stock offering, net	15,174
Proceeds from employee stock option exercises and employee stock purchase plan purchases	163	62
Net cash provided by financing activities	15,337	62
Net increase in cash and cash equivalents	3,471	1,586
Cash and cash equivalents, beginning of period	13,983	12,525
Cash and cash equivalents, end of period	$ 17,454	$ 14,111

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NATURE OF OPERATIONS AND BASIS OF PRESENTATION

6 Months Ended

Jun. 30, 2016

Organization and Nature Of Operations [Abstract]

NATURE OF OPERATIONS AND BASIS OF PRESENTATION

1. NATURE OF OPERATIONS AND BASIS OF PRESENTATION

XML 17 R7.htm IDEA: XBRL DOCUMENT

COLLABORATIONS AND ALLIANCES

6 Months Ended

Jun. 30, 2016

Organization, Consolidation and Presentation Of Financial Statements [Abstract]

COLLABORATIONS AND ALLIANCES

2. COLLABORATIONS AND ALLIANCES

Daiichi Sankyo Tivantinib Agreement

Kyowa Hakko Kirin Licensing Agreement

Beryllium Discovery Corp. Agreement

XML 18 R8.htm IDEA: XBRL DOCUMENT

MARKETABLE SECURITIES AND FAIR VALUE MEASUREMENTS

6 Months Ended

Jun. 30, 2016

Marketable Securities and Fair Value Measurements [Abstract]

MARKETABLE SECURITIES AND FAIR VALUE MEASUREMENTS

3. MARKETABLE SECURITIES AND FAIR VALUE MEASUREMENTS

The following is a summary of the fair value of available-for-sale marketable securities we held at June 30, 2016 and December 31, 2015:

June 30, 2016	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Fair Value
Security type
Corporate debt securities-short term	$	25,629	$	34	$	(2	)	$	25,661
Total available-for-sale marketable securities	$	25,629	$	34	$	(2	)	$	25,661

December 31, 2015	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Fair Value
Security type
Corporate debt securities-short term	$	24,786	$	13	$	(10	)	$	24,789
Total available-for-sale marketable securities	$	24,786	$	13	$	(10	)	$	24,789

Our available-for-sale marketable securities in a loss position at June 30, 2016, and December 31, 2015 were in a continuous unrealized loss position for less than 12 months.

	June 30, 2016		Quoted Prices in Active Markets (Level 1)		Significant Other Observable Inputs (Level 2)		Significant Unobservable Inputs (Level 3)
Cash equivalents	$	15,051	$	15,051	$	—	$	—
Corporate debt securities-short term		25,661		—		25,661		—
Total	$	40,712	$	15,051	$	25,661	$	—

	December 31, 2015		Quoted Prices in Active Markets (Level 1)		Significant Other Observable Inputs (Level 2)		Significant Unobservable Inputs (Level 3)
Cash equivalents	$	11,800	$	11,800	$	—	$	—
Corporate debt securities-short term		24,789		—		24,789		—
Total	$	36,589	$	11,800	$	24,789	$	—

XML 19 R9.htm IDEA: XBRL DOCUMENT

ACCOUNTS PAYABLE AND ACCRUED EXPENSES

6 Months Ended

Jun. 30, 2016

Payables and Accruals [Abstract]

Accounts payable and accrued expenses

4. ACCOUNTS PAYABLE AND ACCRUED EXPENSES

Accounts payable and accrued expenses include the following at June 30, 2016 and December 31, 2015:

	June 30, 2016		December 31, 2015
Accounts payable	$	313	$	186
Accrued payroll		1,288		1,956
Accrued outsourced pre-clinical and clinical fees		4,098		3,273
Accrued professional fees		307		516
Other accrued expenses		229		303
	$	6,235	$	6,234

XML 20 R10.htm IDEA: XBRL DOCUMENT

NET LOSS PER SHARE

6 Months Ended

Jun. 30, 2016

Earnings Per Share [Abstract]

NET LOSS PER SHARE

5. NET LOSS PER SHARE

XML 21 R11.htm IDEA: XBRL DOCUMENT

STOCK-BASED COMPENSATION AND STOCK PLANS

6 Months Ended

Jun. 30, 2016

Compensation and Retirement Disclosure [Abstract]

STOCK-BASED COMPENSATION AND STOCK PLANS

6. STOCK-BASED COMPENSATION AND STOCK PLANS

The following table presents stock-based compensation expense included in our Condensed Statements of Operations and Comprehensive Loss:

	Three Months Ended June 30,				Six Months Ended June 30,
	2016		2015		2016		2015
Research and development	$	109	$	124	$	299	$	396
General and administrative		312		298		716		844
Total stock-based compensation expense	$	421	$	422	$	1,015	$	1,240

Option activity under our stock plans for the six months ended June 30, 2016 was as follows:

Stock Options	Number of Shares			Weighted Average Exercise Price
Outstanding as of December 31, 2015		8,305,950		$	4.24
Granted		1,609,000			1.78
Exercised		(97,498	)		1.16
Cancelled		(628,254	)		5.31
Outstanding as of June 30, 2016		9,189,198		$	3.77

Exercisable as of June 30, 2016		6,103,542		$	4.78

Shares vested, expected to vest and exercisable at June 30, 2016 are as follows:

Weighted-Average

Exercise Price

Weighted-Average

Remaining

Contractual

Term (in years)

Aggregate

Intrinsic

Value

Vested and unvested expected to vest at June 30, 2016

9,020,805

3.77

5.8

979

Exercisable at June 30, 2016

6,103,542

4.78

4.2

203

Restricted stock activity under the Plan for the six months ended June 30, 2016 was as follows:

Restricted Stock	Number of Shares			Weighted Average Grant Date Fair Value
Unvested as of December 31, 2015		58,635		$	2.51
Vested		(29,306	)		2.51
Cancelled		(53	)		2.51
Unvested as of June 30, 2016		29,276		$	2.51

The fair value of restricted stock vested in the six months ended June 30, 2016 and 2015 was $56 and $58, respectively.

Through June 30, 2016, no expense has been recorded for any performance-based stock units granted to the CEO, COO, or CMO.

- Definition

The entire disclosure for compensation-related costs for equity-based compensation, which may include disclosure of policies, compensation plan details, allocation of equity compensation, incentive distributions, equity-based arrangements to obtain goods and services, deferred compensation arrangements, employee stock ownership plan details and employee stock purchase plan details.

+ References + Details

XML 22 R12.htm IDEA: XBRL DOCUMENT

STOCK OFFERING

6 Months Ended

Jun. 30, 2016

Stockholders' Equity Note [Abstract]

STOCK OFFERING

7. STOCK OFFERING

- Definition

The entire disclosure for shareholders' equity comprised of portions attributable to the parent entity and noncontrolling interest, including other comprehensive income. Includes, but is not limited to, balances of common stock, preferred stock, additional paid-in capital, other capital and retained earnings, accumulated balance for each classification of other comprehensive income and amount of comprehensive income.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 310
-SubTopic 10
-Section S99
-Paragraph 4
-Subparagraph (SAB Topic 4.E)
-URI http://asc.fasb.org/extlink&oid=27010918&loc=d3e74567-122707

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
-SubTopic 10
-Section 50
-Paragraph 4
-URI http://asc.fasb.org/extlink&oid=6928386&loc=d3e21484-112644

Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 210
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.5-02(29))
-URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682

Reference 4: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
-SubTopic 10
-Section 50
-Paragraph 5
-URI http://asc.fasb.org/extlink&oid=6928386&loc=d3e21488-112644

Reference 5: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 235
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08(e))
-URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690

Reference 6: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 210
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.5-02(31))
-URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682

Reference 7: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
-SubTopic 10
-Section S99
-Paragraph 4
-Subparagraph (SAB Topic 4.C)
-URI http://asc.fasb.org/extlink&oid=27012166&loc=d3e187143-122770

Reference 8: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 210
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.5-02(30))
-URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682

Reference 9: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
-SubTopic 10
-Section 50
-Paragraph 6
-URI http://asc.fasb.org/extlink&oid=6928386&loc=d3e21506-112644

Reference 10: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 235
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08(d))
-URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690

Reference 11: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.3-04)
-URI http://asc.fasb.org/extlink&oid=27012166&loc=d3e187085-122770

Reference 12: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
-SubTopic 30
-Section 50
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=6405834&loc=d3e23285-112656

Reference 13: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
-SubTopic 10
-Section 50
-Paragraph 3
-URI http://asc.fasb.org/extlink&oid=6928386&loc=d3e21475-112644

Reference 14: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Glossary Preferred Stock
-URI http://asc.fasb.org/extlink&oid=6521494

Reference 15: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
-SubTopic 10
-Section 50
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=6928386&loc=d3e21463-112644

Reference 16: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
-SubTopic 10
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-Paragraph 11
-URI http://asc.fasb.org/extlink&oid=6928386&loc=d3e21564-112644

+ Details

XML 23 R13.htm IDEA: XBRL DOCUMENT

RECENT ACCOUNTING PRONOUNCEMENTS

6 Months Ended

Jun. 30, 2016

New Accounting Pronouncements and Changes in Accounting Principles [Abstract]

RECENT ACCOUNTING PRONOUNCEMENTS

8. RECENT ACCOUNTING PRONOUNCEMENTS

- Definition

The entire disclosure of changes in accounting principles, including adoption of new accounting pronouncements, that describes the new methods, amount and effects on financial statement line items.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Glossary Change in Accounting Principle
-URI http://asc.fasb.org/extlink&oid=6507316

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Glossary Direct Effects of a Change in Accounting Principle
-URI http://asc.fasb.org/extlink&oid=66092750

Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 250
-SubTopic 10
-Section 50
-Paragraph 3
-URI http://asc.fasb.org/extlink&oid=64853466&loc=d3e22583-107794

Reference 4: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Glossary Indirect Effects of a Change in Accounting Principle
-URI http://asc.fasb.org/extlink&oid=6515603

Reference 5: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 250
-SubTopic 10
-Section 50
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=64853466&loc=d3e22580-107794

Reference 6: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 270
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.10-01.(b)(6))
-URI http://asc.fasb.org/extlink&oid=27015980&loc=d3e46468-122699

Reference 7: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Glossary Accounting Change
-URI http://asc.fasb.org/extlink&oid=6503790

Reference 8: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 250
-SubTopic 10
-Section 50
-Paragraph 1
-URI http://asc.fasb.org/extlink&oid=64853466&loc=d3e22499-107794

Reference 9: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Glossary Retrospective Application
-URI http://asc.fasb.org/extlink&oid=6523989

Reference 10: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 270
-SubTopic 10
-Section 45
-Paragraph 13
-URI http://asc.fasb.org/extlink&oid=68064558&loc=d3e765-108305

Reference 11: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 270
-SubTopic 10
-Section 45
-Paragraph 12
-URI http://asc.fasb.org/extlink&oid=68064558&loc=d3e725-108305

+ Details

XML 24 R14.htm IDEA: XBRL DOCUMENT

INCOME TAXES

6 Months Ended

Jun. 30, 2016

Income Tax Disclosure [Abstract]

INCOME TAXES

9. INCOME TAXES

XML 25 R15.htm IDEA: XBRL DOCUMENT

Significant Accounting Policies (Policies)

6 Months Ended

Jun. 30, 2016

Accounting Policies [Abstract]

BASIS OF PRESENTATION

XML 26 R16.htm IDEA: XBRL DOCUMENT

MARKETABLE SECURITIES AND FAIR VALUE MEASUREMENTS (Tables)

6 Months Ended

Jun. 30, 2016

Marketable Securities and Fair Value Measurements [Abstract]

Schedule of fair value of available-for-sale marketable securities

June 30, 2016	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Fair Value
Security type
Corporate debt securities-short term	$	25,629	$	34	$	(2	)	$	25,661
Total available-for-sale marketable securities	$	25,629	$	34	$	(2	)	$	25,661

December 31, 2015	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Fair Value
Security type
Corporate debt securities-short term	$	24,786	$	13	$	(10	)	$	24,789
Total available-for-sale marketable securities	$	24,786	$	13	$	(10	)	$	24,789

Schedule of assets measured at fair value on a recurring basis

	June 30, 2016		Quoted Prices in Active Markets (Level 1)		Significant Other Observable Inputs (Level 2)		Significant Unobservable Inputs (Level 3)
Cash equivalents	$	15,051	$	15,051	$	—	$	—
Corporate debt securities-short term		25,661		—		25,661		—
Total	$	40,712	$	15,051	$	25,661	$	—

	December 31, 2015		Quoted Prices in Active Markets (Level 1)		Significant Other Observable Inputs (Level 2)		Significant Unobservable Inputs (Level 3)
Cash equivalents	$	11,800	$	11,800	$	—	$	—
Corporate debt securities-short term		24,789		—		24,789		—
Total	$	36,589	$	11,800	$	24,789	$	—

- Definition

Tabular disclosure of available-for-sale securities which includes, but is not limited to, changes in the cost basis and fair value, fair value and gross unrealized gain (loss), fair values by type of security, contractual maturity and classification, amortized cost basis, contracts to acquire securities to be accounted for as available-for-sale, debt maturities, transfers to trading, change in net unrealized holding gain (loss) net of tax, continuous unrealized loss position fair value, aggregate losses qualitative disclosures, other than temporary impairment (OTTI) losses or other disclosures related to available for sale securities.

+ References + Details

XML 27 R17.htm IDEA: XBRL DOCUMENT

ACCOUNTS PAYABLE AND ACCRUED EXPENSES (Tables)

6 Months Ended

Jun. 30, 2016

Payables and Accruals [Abstract]

Schedule of accounts payable and accrued expense

	June 30, 2016		December 31, 2015
Accounts payable	$	313	$	186
Accrued payroll		1,288		1,956
Accrued outsourced pre-clinical and clinical fees		4,098		3,273
Accrued professional fees		307		516
Other accrued expenses		229		303
	$	6,235	$	6,234

XML 28 R18.htm IDEA: XBRL DOCUMENT

STOCK-BASED COMPENSATION AND STOCK PLANS (Tables)

6 Months Ended

Jun. 30, 2016

Compensation and Retirement Disclosure [Abstract]

Schedule of stock-based compensation expense

	Three Months Ended June 30,				Six Months Ended June 30,
	2016		2015		2016		2015
Research and development	$	109	$	124	$	299	$	396
General and administrative		312		298		716		844
Total stock-based compensation expense	$	421	$	422	$	1,015	$	1,240

Schedule of activity of options under stock plans

Stock Options	Number of Shares			Weighted Average Exercise Price
Outstanding as of December 31, 2015		8,305,950		$	4.24
Granted		1,609,000			1.78
Exercised		(97,498	)		1.16
Cancelled		(628,254	)		5.31
Outstanding as of June 30, 2016		9,189,198		$	3.77

Exercisable as of June 30, 2016		6,103,542		$	4.78

Schedule of shares vested, expected to vest and exercisable

Weighted-Average

Exercise Price

Weighted-Average

Remaining

Contractual

Term (in years)

Aggregate

Intrinsic

Value

Vested and unvested expected to vest at June 30, 2016

9,020,805

3.77

5.8

979

Exercisable at June 30, 2016

6,103,542

4.78

4.2

203

Schedule of restricted stock activity

Restricted Stock	Number of Shares			Weighted Average Grant Date Fair Value
Unvested as of December 31, 2015		58,635		$	2.51
Vested		(29,306	)		2.51
Cancelled		(53	)		2.51
Unvested as of June 30, 2016		29,276		$	2.51

XML 29 R19.htm IDEA: XBRL DOCUMENT

NATURE OF OPERATIONS AND BASIS OF PRESENTATION (Detail Textuals) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2016	Jun. 30, 2015
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Net use of cash	$ (10,968)	$ (12,956)
License agreement \| Daiichi Sankyo Co. Ltd
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Milestone payment received	100,000
Net use of cash	15,000
License agreement \| Kyowa Hakko Kirin Co. Ltd.
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Milestone payments related to first patient enrolled in METIV-HCC trial	$ 48,000

XML 30 R20.htm IDEA: XBRL DOCUMENT

COLLABORATIONS AND ALLIANCES (Detail Textuals) - USD ($) $ in Thousands		1 Months Ended			3 Months Ended		6 Months Ended
	Nov. 03, 2015	Jan. 31, 2013	Feb. 28, 2011	Dec. 31, 2008	Jun. 30, 2016	Jun. 30, 2015	Jun. 30, 2016	Jun. 30, 2015
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Baseline Contractual Rate							20.00%
Notice period for termination of contract prior to start of specified period							90 days
Notice period for termination of contract post start of Phase 3 clinical trials							180 days
Net revenues					$ 1,072	$ 3,004	$ 2,299	$ 5,789
Phase 3 collaboration costs
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total milestone partially offset	$ 155,000
Cumulative share of phase 3 collaboration costs in excess of milestones amounts received							64,700
Cumulative share of phase 3 collaboration costs							104,700
Milestone payment received		$ 15,000	$ 25,000
Non-Phase 3 tivantinib collaboration costs
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Contra revenue from non-phase 3 cost less than collaboration partner's share					78
Revenue from non-phase 3 in excess of collaboration partner's share						229
Net revenues								240
Daiichi Sankyo Tivantinib Agreement
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Upfront payment received				$ 60,000
Additional potential development and sales milestone payments				$ 560,000
Milestone payments for official acceptance of drug approval applications	55,000
Milestone payments to be received upon regulatory approvals and first commercial sales	$ 100,000
Net revenues					600	$ 1,600	1,400	$ 2,900
Deferred revenue					$ 1,400		$ 1,400

XML 31 R21.htm IDEA: XBRL DOCUMENT

COLLABORATIONS AND ALLIANCES (Detail Textuals 1) - USD ($) $ in Thousands		1 Months Ended				3 Months Ended		6 Months Ended
	May 07, 2007	Aug. 31, 2011	Sep. 30, 2010	Feb. 29, 2008	Apr. 27, 2007	Jun. 30, 2016	Jun. 30, 2015	Jun. 30, 2016	Jun. 30, 2015
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Research and development revenue						$ 1,072	$ 3,004	$ 2,299	$ 5,789
Kyowa Hakko Kirin Licensing Agreement
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Upfront payment received	$ 27,000				$ 3,000
Upfront and potential development milestone payments					123,000
Cash upfront licensing payments					$ 30,000
Notice period for termination of contract								90 days
Research and development revenue						500	$ 1,400	$ 900	$ 2,800
Deferred revenue						$ 900		$ 900
Kyowa Hakko Kirin Licensing Agreement \| Phase Two trial Kyowa Hakko Kirin
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Milestone payment received			$ 5,000
Kyowa Hakko Kirin Licensing Agreement \| Phase Three Attention Trial Asia
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Milestone payment received		$ 10,000
Kyowa Hakko Kirin Licensing Agreement \| Kyowa Hakko Kirin
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Milestone payment received				$ 3,000
Percentage of royalties expected to be received - lower range				mid-teen percent
Percentage of royalties expected to be received - upper range				low-twenty percent

XML 32 R22.htm IDEA: XBRL DOCUMENT

MARKETABLE SECURITIES AND FAIR VALUE MEASUREMENTS - Summary of fair value of available-for-sale securities (Details) - USD ($) $ in Thousands	Jun. 30, 2016	Dec. 31, 2015
Schedule of Available-for-sale Securities [Line Items]
Amortized Cost	$ 25,629	$ 24,786
Gross Unrealized Gains	34	13
Gross Unrealized Losses	(2)	(10)
Fair Value	25,661	24,789
Corporate debt securities \| Short term
Schedule of Available-for-sale Securities [Line Items]
Amortized Cost	25,629	24,786
Gross Unrealized Gains	34	13
Gross Unrealized Losses	(2)	(10)
Fair Value	$ 25,661	$ 24,789

XML 33 R23.htm IDEA: XBRL DOCUMENT

MARKETABLE SECURITIES AND FAIR VALUE MEASUREMENTS - Assets measured at fair value on a recurring basis (Details 1) - USD ($) $ in Thousands	Jun. 30, 2016	Dec. 31, 2015
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Corporate debt securities-short term	$ 25,661	$ 24,789
Fair Value, Measurements, Recurring
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Cash equivalents	15,051	11,800
Corporate debt securities-short term	25,661	24,789
Total	40,712	36,589
Fair Value, Measurements, Recurring \| Quoted Prices in Active Markets (Level 1)
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Cash equivalents	15,051	11,800
Total	15,051	11,800
Fair Value, Measurements, Recurring \| Quoted Prices in Active Markets (Level 1) \| Corporate debt securities \| Short term
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Corporate debt securities-short term
Fair Value, Measurements, Recurring \| Significant Other Observable Inputs (Level 2)
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Cash equivalents
Total	25,661	24,789
Fair Value, Measurements, Recurring \| Significant Other Observable Inputs (Level 2) \| Corporate debt securities \| Short term
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Corporate debt securities-short term	25,661	24,789
Fair Value, Measurements, Recurring \| Significant Unobservable Inputs (Level 3)
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Cash equivalents
Total
Fair Value, Measurements, Recurring \| Significant Unobservable Inputs (Level 3) \| Corporate debt securities \| Short term
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Corporate debt securities-short term

XML 34 R24.htm IDEA: XBRL DOCUMENT

ACCOUNTS PAYABLE AND ACCRUED EXPENSES - Summary of accounts payable and accrued expenses (Details) - USD ($) $ in Thousands	Jun. 30, 2016	Dec. 31, 2015
Payables and Accruals [Abstract]
Accounts payable	$ 313	$ 186
Accrued payroll	1,288	1,956
Accrued outsourced pre-clinical and clinical fees	4,098	3,273
Accrued professional fees	307	516
Other accrued expenses	229	303
Accounts payable and accrued expenses, Total	$ 6,235	$ 6,234

XML 35 R25.htm IDEA: XBRL DOCUMENT

NET LOSS PER SHARE (Detail Textuals) - shares	1 Months Ended	3 Months Ended		6 Months Ended
NET LOSS PER SHARE (Detail Textuals) - shares	Feb. 26, 2016	Jun. 30, 2016	Jun. 30, 2015	Jun. 30, 2016	Jun. 30, 2015
Earnings Per Share [Abstract]
Potential common shares issued upon exercise of outstanding stock options	3,567,956	9,189,198	8,791,732	9,189,198	8,791,732

XML 36 R26.htm IDEA: XBRL DOCUMENT

STOCK-BASED COMPENSATION AND STOCK PLANS - Stock-based compensation expense (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2016	Jun. 30, 2015	Jun. 30, 2016	Jun. 30, 2015
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Total stock-based compensation expense	$ 421	$ 422	$ 1,015	$ 1,240
Research and development
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Total stock-based compensation expense	109	124	299	396
General and administrative
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Total stock-based compensation expense	$ 312	$ 298	$ 716	$ 844

XML 37 R27.htm IDEA: XBRL DOCUMENT

STOCK-BASED COMPENSATION AND STOCK PLANS - Option activity (Details 1) - Stock Options	6 Months Ended
	Jun. 30, 2016 $ / shares shares
Number of Shares
Outstanding as of December 31, 2015 \| shares	8,305,950
Granted \| shares	1,609,000
Exercised \| shares	(97,498)
Cancelled \| shares	(628,254)
Outstanding as of March 31, 2016 \| shares	9,189,198
Exercisable as of March 31, 2016 \| shares	6,103,542
Weighted Average Exercise Price
Outstanding as of December 31, 2014 \| $ / shares	$ 4.24
Granted \| $ / shares	1.78
Exercised \| $ / shares	1.16
Cancelled \| $ / shares	5.31
Outstanding as of March 31, 2016 \| $ / shares	3.77
Exercisable as of March 31, 2016 \| $ / shares	$ 4.78

XML 38 R28.htm IDEA: XBRL DOCUMENT

STOCK-BASED COMPENSATION AND STOCK PLANS - Shares vested, expected to vest and exercisable (Details 2) - Stock Options $ / shares in Units, $ in Thousands	6 Months Ended
	Jun. 30, 2016 USD ($) $ / shares shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vested and unvested expected to vest shares \| shares	9,020,805
Vested and unvested expected to vest, weighted-average exercise price \| $ / shares	$ 3.77
Vested and unvested expected to vest, weighted-average remaining contractual term (in years)	5 years 9 months 18 days
Vested and unvested expected to vest, aggregate intrinsic value \| $	$ 979
Exercisable shares \| shares	6,103,542
Exercisable, weighted-average exercise price \| $ / shares	$ 4.78
Exercisable, weighted-average remaining contractual term (in years)	4 years 2 months 12 days
Exercisable, aggregate intrinsic value \| $	$ 203

XML 39 R29.htm IDEA: XBRL DOCUMENT

STOCK-BASED COMPENSATION AND STOCK PLANS - Restricted stock activity (Details 3) - Restricted Stock	6 Months Ended
	Jun. 30, 2016 $ / shares shares
Number of Shares
Unvested as of December 31, 2015 \| shares	58,635
Vested \| shares	(29,306)
Cancelled \| shares	(53)
Unvested as of June 30, 2016 \| shares	29,276
Weighted Average Grant Date Fair Value
Unvested as of December 31, 2015 \| $ / shares	$ 2.51
Vested \| $ / shares	2.51
Cancelled \| $ / shares	2.51
Unvested as of June 30, 2016 \| $ / shares	$ 2.51

XML 40 R30.htm IDEA: XBRL DOCUMENT

STOCK-BASED COMPENSATION AND STOCK PLANS (Detail Textuals) - Stock Options - USD ($) $ / shares in Units, $ in Thousands	6 Months Ended
	Jun. 30, 2016	Jun. 30, 2015
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Aggregate intrinsic value of options outstanding	$ 1,023
Aggregate intrinsic value of options exercisable	$ 203
Weighted average grant date fair value of options granted (in dollars per share)	$ 1.10	$ 0.77
Intrinsic value of options exercised	$ 60
Employee Service Share-Based Compensation, Nonvested Awards, Total Compensation Cost Not Yet Recognized, Stock Options	$ 3,400
Compensation cost related to non-vested option awards recognition period	2 years 8 months 12 days
Number of the non-vested options shares expired during the period	551,036
Number of options forfeited during the period	2,218
Weighted average remaining contractual life for options exercisable	4 years 2 months 12 days

XML 41 R31.htm IDEA: XBRL DOCUMENT

STOCK-BASED COMPENSATION AND STOCK PLANS (Detail Textuals 1) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended		6 Months Ended		12 Months Ended
	Jun. 30, 2016	Jun. 30, 2015	Jun. 30, 2016	Jun. 30, 2015	Dec. 31, 2013
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based compensation expense	$ 421	$ 422	$ 1,015	$ 1,240
Restricted Stock
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of shares granted					242,697
Award vesting period					4 years
Weighted average grant date fair value for the options granted during the period (in dollars per share)					$ 2.51
Number of shares forfeited			82,617
Number of shares vested during the period			130,804
Share-based compensation expense			$ 39	42
Fair value of stock vested during period			$ 56	$ 58

XML 42 R32.htm IDEA: XBRL DOCUMENT

STOCK-BASED COMPENSATION AND STOCK PLANS (Detail Textuals 2) - shares	1 Months Ended			6 Months Ended
	Mar. 31, 2013	Feb. 29, 2012	Jul. 31, 2010	Jun. 30, 2016
Stock Options
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Granted				1,609,000
Chief executive officer employment agreement \| Chief executive officer (CEO) \| Stock Options
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Granted			100,000
Chief executive officer employment agreement \| Chief executive officer (CEO) \| Stock Options \| Vested upon grant
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Percentage of options vested			25.00%
Chief executive officer employment agreement \| Chief executive officer (CEO) \| Stock Options \| Vest annually
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Percentage of options vested			25.00%
Award vesting period			3 years
Chief executive officer employment agreement \| Chief executive officer (CEO) \| Performance-based stock units
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of stocks vested during the period			390,000
Chief medical officer employment agreement \| Chief medical officer (CMO) \| Performance-based stock units
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of stocks vested during the period	120,000	50,000
Chief operating officer employment agreement \| Chief operating officer (COO) \| Performance-based stock units
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of stocks vested during the period	125,000

XML 43 R33.htm IDEA: XBRL DOCUMENT

STOCK OFFERING (Detail Textuals) - USD ($) $ / shares in Units, $ in Thousands	1 Months Ended	6 Months Ended
	Feb. 26, 2016	Jun. 30, 2016	Jun. 30, 2015
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Additional proceeds if optios exercised		$ 163	$ 62
Definitive stock purchase agreements
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of common stock issued under agreement	8,027,900
Number of non transferable options issued	3,567,956
Aggregate net proceeds	$ 15,200
Stock option exercise price	$ 2.50
Additional proceeds if optios exercised	$ 8,900

XML 44 R34.htm IDEA: XBRL DOCUMENT

INCOME TAXES (Detail Textuals) - USD ($) $ in Thousands	6 Months Ended	12 Months Ended
INCOME TAXES (Detail Textuals) - USD ($) $ in Thousands	Jun. 30, 2016	Dec. 31, 2015
Operating Loss Carryforwards [Line Items]
Increase in ownership percentage of certain stockholders or public groups	more than 50 percentage points
Ownership change, increase in ownership percentage, term	3 years
Federal income tax
Operating Loss Carryforwards [Line Items]
Net operating loss		$ 357,122
Net operating loss generated from excess tax deduction from share based awards		15,020
State income tax
Operating Loss Carryforwards [Line Items]
Net operating loss		176,712
Net operating loss generated from excess tax deduction from share based awards		868
Research and development credit carryforwards
Operating Loss Carryforwards [Line Items]
Net operating loss		$ 27,750

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