Unassociated Document

We hereby consent to the incorporation by reference in the Registration Statements on Form S-8 (File Nos. 333-178228, 333-178227, 333-178226, and 333-130159) of ArQule, Inc., of our report dated March 14, 2013 relating to the financial statements and the effectiveness of internal control over financial reporting, which appears in this Form 10-K.