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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (USD $)
In Thousands
6 Months Ended
Jun. 30, 2011
Jun. 30, 2010
Cash flows from operating activities:    
Net loss $ (12,270) $ (17,979)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 598 744
Amortization of premium/discount on marketable securities 570 522
Amortization of deferred gain on sale leaseback (277) (277)
Non-cash stock compensation 2,301 1,906
Loss on auction rate securities put option   5,074
Gain on auction rate securities (47) (4,459)
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets (4,497) 993
Other long-term assets (24) (5)
Accounts payable and accrued expenses 9,362 2,107
Deferred revenue (1,103) (9,622)
Net cash used in operating activities (5,387) (20,996)
Cash flows from investing activities:    
Purchases of marketable securities (95,131) (36,821)
Proceeds from sale or maturity of marketable securities 57,660 76,998
Purchases of property and equipment (324) (144)
Net cash provided by (used in) investing activities (37,795) 40,033
Cash flows from financing activities:    
Payment of notes payable   (29,900)
Proceeds from stock offering, net 46,761  
Proceeds from stock option exercises 3,808 460
Net cash provided by (used in) financing activities 50,569 (29,440)
Net increase (decrease) in cash and cash equivalents 7,387 (10,403)
Cash and cash equivalents, beginning of period 20,457 36,551
Cash and cash equivalents, end of period $ 27,844 $ 26,148