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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 KnwwAR7LDivbtV1mT2UjVP4alLvYrs5oQtkMhiEM2BG96ulsjaPc0KgYnBYoBNkY
 Y2ORfl3PMVKPyIomupiZ0g==

<SEC-DOCUMENT>0001019695-06-000020.txt : 20060905
<SEC-HEADER>0001019695-06-000020.hdr.sgml : 20060904
<ACCEPTANCE-DATETIME>20060905162505
ACCESSION NUMBER:		0001019695-06-000020
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20060901
FILED AS OF DATE:		20060905
DATE AS OF CHANGE:		20060905

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ARQULE INC
		CENTRAL INDEX KEY:			0001019695
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				043221586
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		19 PRESIDENTIAL WAY
		CITY:			WOBURN
		STATE:			MA
		ZIP:			01801
		BUSINESS PHONE:		781-994-0300

	MAIL ADDRESS:	
		STREET 1:		19 PRESIDENTIAL WAY
		CITY:			WOBURN
		STATE:			MA
		ZIP:			01801

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Woodrich Richard H
		CENTRAL INDEX KEY:			0001374392

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-21429
		FILM NUMBER:		061074293

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		781-994-0300

	MAIL ADDRESS:	
		STREET 1:		C/O ARQULE, INC.
		STREET 2:		19 PRESIDENTIAL WAY
		CITY:			WOBURN
		STATE:			MA
		ZIP:			01801
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>primary_doc.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2006-09-01</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001019695</issuerCik>
        <issuerName>ARQULE INC</issuerName>
        <issuerTradingSymbol>ARQL</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001374392</rptOwnerCik>
            <rptOwnerName>Woodrich Richard H</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O ARQULE, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>19 PRESIDENTIAL WAY</rptOwnerStreet2>
            <rptOwnerCity>WOBURN</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>01801</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Acting Chief Financial Officer</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>100</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <ownerSignature>
        <signatureName>Robert J. Connaughton by Power of Attorney for Richard H. Woodrich</signatureName>
        <signatureDate>2006-09-05</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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