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SHARE BASED COMPENSATION (Tables)
12 Months Ended
Dec. 31, 2018
Share Based Compensation  
Stock and stock option-based compensation expense

In Thousands of US Dollars
Functional Expense Category   2018     2017     2016  
General and administrative expense   $ 2,064     $ 3,708     $ 5,002  
Research and development expense     1,819       2,589       4,072  
Total   $ 3,883     $ 6,297     $ 9,074