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SHARE BASED COMPENSATION (Tables)
12 Months Ended
Dec. 31, 2017
Share Based Compensation Tables  
Stock and stock option-based compensation expense
In Thousands of US Dollars
Functional Expense Category   2017     2016     2015  
General and administrative expense   $ 3,708     $ 5,002     $ 10,107  
Research and development expense     2,589       4,072       5,677  
Total   $ 6,297     $ 9,074     $ 15,784