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Stockholders' Equity (Tables)
12 Months Ended
Dec. 31, 2017
Equity [Abstract]  
Summary of Warrant Activity
A summary of warrant activity during the year ended December 31, 2017 is as follows (share amounts in thousands):
 
Common Shares
Issuable upon
Exercise
 
Weighted
Average
Exercise
Price
Outstanding at December 31, 2016
2,318

 
$
15.19

Issued
5,199

 
$
1.60

Exercised
(186
)
 
$
1.55

Cancelled
(247
)
 
52.50

Outstanding as of December 31, 2017
7,084

 
$
3.91

Exercisable as of December 31, 2017
7,084

 
$
3.91

The following table shows the number of outstanding warrants by exercise price and date of expiration as of December 31, 2017 (share amounts in thousands):
Shares Issuable Upon Exercise
 
Exercise Price
 
Expiration Date
300

 
$
34.00

 
May 2018
1,068

 
$
1.67

 
March 2020
107

 
$
2.16

 
March 2020
252

 
$
1.75

 
April 2022
4,452

 
$
1.55

 
May 2022
429

 
$
8.80

 
January 2023
442

 
$
8.80

 
March 2023
19

 
$
12.90

 
October 2024
15

 
$
16.40

 
July 2025
7,084