Exhibit

We hereby consent to the incorporation by reference in this Registration Statement of our reports dated March 9, 2016, relating to the consolidated financial statements and the effectiveness of Apricus Biosciences, Inc.’s (the “Company”) internal control over financial reporting appearing in the Company’s Annual Report on Form 10-K for the year ended December 31, 2015. Our report contains an explanatory paragraph regarding the Company’s ability to continue as a going concern.