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Income Taxes - Additional Information (Detail) - USD ($)
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Operating Loss Carryforwards [Line Items]        
U.S. federal statutory tax rate   34.00% 34.00% 34.00%
Provisional estimate of reduction in deferred tax assets   $ 24,196,000    
Provisional estimate of reduction in valuation allowance   $ 24,196,000    
Period of incurred losses for both book and tax purposes   3 years    
Valuation allowance for deferred tax assets   $ 52,038,000 $ 67,758,000  
Increased and decreased total valuation allowance   15,720,000 8,864,000  
Deferred tax assets, net of valuation allowances   0 0  
Net operating loss carry forward unused amount   428,000    
Unrecognized tax benefits   0 0  
Interest or penalties charged in relation to unrecognized tax benefits   0 0  
Interest or penalties accrued in relation to unrecognized tax benefits   $ 0 $ 0  
Total unrecognized tax benefits changing period   12 months    
U.S Federal Tax [Member]        
Operating Loss Carryforwards [Line Items]        
Net operating loss carry forward   $ 176,069,000    
Research credit carryforward   5,617,000    
Foreign Tax Authority [Member]        
Operating Loss Carryforwards [Line Items]        
Net operating loss carry forward   $ 454,000    
Tax credit carryforward expiration year   2018    
Maximum [Member]        
Operating Loss Carryforwards [Line Items]        
U.S. federal statutory tax rate   35.00%    
Maximum [Member] | U.S Federal Tax [Member]        
Operating Loss Carryforwards [Line Items]        
Net operating loss carryforward expiration year   2037    
Tax credit carryforward expiration year   2037    
Minimum [Member] | U.S Federal Tax [Member]        
Operating Loss Carryforwards [Line Items]        
Net operating loss carryforward expiration year   2018    
Tax credit carryforward expiration year   2018    
Scenario, Plan [Member]        
Operating Loss Carryforwards [Line Items]        
U.S. federal statutory tax rate 21.00%