S-8

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, DC 20549

FORM S-8

REGISTRATION STATEMENT UNDER THE

SECURITIES ACT OF 1933

AMARILLO BIOSCIENCES, INC.

(Exact Name of Registrant as Specified in Its Charter)

TEXAS	75-1974352
(State or other jurisdiction of	(IRS Employer Identification No.)
incorporation or organization)

4134 Business Park Drive, Amarillo, Texas	79110
(Address of principal executive offices)	(Zip Code)

806-376-1741	FAX 806-376-9301
(Issuer's telephone number, including area code)

2008 Executive Officers Compensatory Stock Plan

(Full Title of the Plan)

Joseph M. Cummins

Chief Executive Officer

4134 Business Park Drive

Amarillo, Texas 79110

(Name and Address of Agent For Service)

(806) 376-1741

(Telephone Number, Including Area Code, of Agent For Service)

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated file, a non-accelerated filer, or a smaller reporting company. See the definitions of “large accelerated filer,” “accelerated filer,” and “smaller reporting company” in Rule 12b-2 of the Exchange Act. (Check one):

Large Accelerated filer                                                                                      Accelerated filer   

Non-accelerated filer                                                                                         Smaller reporting company X

(do not check if a smaller reporting company)

CALCULATION OF REGISTRATION FEE

Title of Each Class of Securities To Be Registered	Amount To Be Registered	Proposed Maximum Offering Price Per Unit	Proposed Maximum Aggregate Offering Price	Amount Of Registration Fee
Common Stock, $0.01  par value	200,000 (1)	$.21 (2)	$42,000	$1.66

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Notes to Calculation of Registration Fee Chart

(1) The number of shares of common stock set forth to be registered is the number of shares authorized to be issued under the Company’s 2008 Executive Officers Compensatory Stock Plan (the “Plan”).  This Registration Statement shall also cover any additional shares of common stock which become issuable under the Plan by reason of any stock dividend, stock split, recapitalization, or other similar transaction effected without the receipt of consideration which results in an increase in the number of outstanding shares of common stock of Amarillo Biosciences, Inc.

(2) Calculated on the basis of the average of the over-the-counter high and low prices on August 4, 2008, pursuant to Rule 457(c) of the Securities Act of 1933, as amended.

PART I.

INFORMATION REQUIRED IN THE SECTION 10 (a) PROSPECTUS

The documents constituting Part I of this Registration Statement will be sent or given to consultants of Amarillo Biosciences, Inc. (the “Registrant”) as specified by Rule 428(b)(1) of the Securities Act of 1933, as amended (the “Securities Act”) and the Note to Part I of Form S-8.

Item 1. Plan Information

Pursuant to Rule 428(b)(1) of the Securities Act and the Note to Part I of Form S-8, the information required by this item has been omitted from this Registration Statement.

Item 2. Registrant Information and Employee Plan Annual Information

Pursuant to Rule 428(b)(1) of the Securities Act and the Note to Part I of Form S-8, the information required by this item has been omitted from this Registration Statement.

PART II.

INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 3. Incorporation of Documents by Reference

The following documents, previously filed with the Securities and Exchange Commission are incorporated by reference in this Registration Statement:

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(a)   Registrant’s annual report for the year ended December 31, 2007, dated March 17, 2008, filed pursuant to Section 13(a) or 15(d) of the Securities Exchange Act of 1934 (the “Exchange Act”).

(c)   All other reports filed pursuant to Section 13(a) or 15(d) of the Exchange Act since the end of the fiscal year covered by the Registrant document referred to in (a) above.

(c)   The class of securities to be offered is registered under Section 12(g) of the Exchange Act.  The description of the class of securities contained in the Form 8-A Registration Statement is as follows:

“This Registration Statement relates to the Common Stock, par value $.01 per share  (the Common Stock), of Amarillo Biosciences, Inc., a Texas corporation (the “Registrant”).  A Registration Statement on Form SB-2 (Registration No. 333-04413) relating to an offering of up to 2,300,000 shares of Common Stock (the Registration Statement) was filed with the Securities and Exchange Commission on May 23, 1996, pursuant to the Securities Act of 1933, as amended (the Securities Act).  The description of the Common Stock to be contained in the final Prospectus to be filed by the Registrant pursuant to Rule 424(b) under the Securities Act shall be deemed incorporated by reference.”

The description of the Common Stock is as follows:

The company is authorized to issue 100,000,000 shares of Common Stock, par value $.01 per share. As of the date of this Registration Statement, there are 30,261,477 shares outstanding which are held by 398 holders of record.

The holders of the Common Stock are entitled to one vote for each share held of record on all matters to be voted on by the shareholders.  There is no cumulative voting with respect to the election of directors, with the result that the holders of more than 50% of the shares voting for the election of directors can elect all of the directors.  The holders of Common Stock are entitled to receive dividends when, as and if declared by the Board of Directors in its discretion, out of funds legally available therefor.  In the event of liquidation, dissolution or winding up of the Company, the holders of Common Stock are entitled to share ratably in the assets of the Company, if any, legally available for distribution to them after payment of debts and liabilities of the Company and after provision has been made for each class of stock, if any, having liquidation preference over the Common Stock.  Holders of shares of Common Stock have no conversion, preemptive or other subscription rights, and there are no redemption or sinking fund provisions applicable to the Common Stock.

All documents subsequently filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a post-effective amendment which indicates that all

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securities offered have been sold or which de-registers all securities then remaining unsold, shall be deemed to by incorporated by reference in the Registration Statement and to be part thereof from the date of filing of such documents.

Item 4. Description of Securities.

Not Applicable.

Item 5. Interests of Named Experts and Counsel.

The opinion of counsel as to the legality of the securities, attached as Exhibit 5, has been rendered by the law firm of SandersBaker, P.C.  Mr. Edward L. Morris, a shareholder and principal of that firm and the attorney signing said opinion, is the corporate secretary of the Registrant.  Mr. Morris is not a director, executive officer, or employee of the Registrant.

Item 6. Indemnification of Directors and Officers.

Texas Law

Article 2.02-1 of the Texas Business Corporation Act allows a Texas corporation to indemnify a person who was, is, or is threatened to be made a defendant or respondent in a proceeding because the person is or was a director if it is determined that the person (1) conducted himself in good faith, (2) reasonably believed that his conduct in his official capacity as director was in the best interest of the corporation and in all other cases was at least not opposed to the corporation’s best interest, and (3) in the case of any criminal proceeding, had no reasonable cause to believe his conduct was unlawful.  Indemnification under Article 2.02-1 may be made for judgments, penalties, fines, settlements, and reasonable expenses actually incurred by the person in connection with the proceeding, subject to limitations provided therein.  Article 2.02-1 (H) requires indemnification of a defendant / respondent director against reasonable expenses incurred by him in connection with a proceeding in which he has been wholly successful, on the merits or otherwise, in the defense of the proceeding.

To the same extent as a director, Article 2.02-1 (O) of the Texas Business Corporation Act provides that an officer of the corporation shall be indemnified against reasonable expenses incurred by him in connection with a proceeding in which he is a named defendant or respondent because he is or was an officer if he was wholly successful, on the merits or otherwise, in the defense of the proceeding.

Pursuant to Article 2.02-1 (J) of the Texas Business Corporation Act, upon application, a court may order the equitable indemnification of a director or officer if it determines the person is fairly and reasonably entitled to indemnification in view of all the relevant circumstances, regardless of other requirements of indemnification.  However, if the person is adjudicated liable to the corporation or it is found that personal benefit was improperly received by the person, the indemnification shall be limited to reasonable expenses actually incurred in connection with the proceeding.

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By-laws and Indemnification Provisions

The Registrant’s By-laws provide for the Registrant to indemnify each director and officer of the Registrant against liabilities imposed upon him (including reasonable amounts paid in settlement) and expenses incurred by him in connection with any claim made against him or any action, suit or proceeding to which he may be a party by reason of his being or having been a director or officer of the Registrant.  The Registrant has also entered into Indemnification Agreements with each officer and director pursuant to which the Registrant will, in general, indemnify such persons to the maximum extent permitted by the Registrant’s By-laws and the laws of the State of Texas against any expenses (including attorney’s fees), judgments, fines and amounts paid in settlement incurred in connection with any actual or threatened action or proceeding to which such director or officer is made or threatened to be made a party by reason of the fact that such person is or was a director or officer of the Registrant.  The foregoing provisions may reduce the likelihood of derivative litigation against directors and may discourage or deter shareholders or management from suing directors for breaches of their duty of care, even though such an action, if successful, might otherwise benefit the Registrant and its shareholders.

Insurance

The Registrant is insured under a Directors, Officers and Company Liability Policy that obligates the Insurer to pay for claims against the directors and officers for wrongful acts during the effective period of the Policy. The current policy expires May 30, 2009.

Item 7. Exemption from Registration Claimed.

Not applicable.

Item 8. Exhibits.

Exhibit Index

Exhibit Number

  5  Opinion Regarding Legality  Page 10

10	2008 Executive Officers Compensatory Stock Plan	Pages 11-12
23	Consent of LBB & Associates Ltd., LLP	Page13

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Item 9. Undertakings.

The undersigned Registrant hereby undertakes:

(1) To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement: (i) to include any prospectus required by section 10(a)(3) of the Securities Act of 1933; (ii) to reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement.  Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20% change in the maximum aggregate offering price set forth in the “Calculation of Registration Fee” table in the effective registration statement; and (iii) to include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration statement.

Provided, however, that paragraphs (1)(i) and (1)(ii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in periodic reports filed by the registrant pursuant to section 13 or section 15(d) of the Securities Exchange Act of 1934 that are incorporated by reference in the registration statement.

(2) That, for the purpose of determining any liability under the Securities Act of 1933, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

(3) To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.

The undersigned registrant hereby undertakes that, for the purposes of determining any liability under the Securities Act of 1933, each filing of the registrant’s annual report pursuant to section 13(a) or section 15(d) of the Securities Exchange Act of 1934 (and, where applicable, each filing of an employee benefit plan’s annual report pursuant to 15(d) of the Securities Exchange Act of 1934) that is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

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Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be permitted to directors, officers, and controlling persons of the registrant pursuant to the foregoing provisions, or otherwise, the registrant has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Act and is, therefore, unenforceable.  In the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director, officer, or controlling person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Act and will be governed by the final adjudication of such issue.

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SIGNATURES

The Registrant.  Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Amarillo, State of Texas, on August 5, 2008.

   AMARILLO BIOSCIENCES, INC.

   By:       /s/ Joseph M. Cummins

  Joseph M. Cummins, DVM, Ph.D.

     Chairman, President, CEO

Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities and on the dates indicated.

/s/ Joseph M. Cummins	Chief Executive Officer, President, and Chairman	August 5, 2008
Joseph M. Cummins
/s/ Peter Mueller	Chief Operating Officer	August 5, 2008
Peter Mueller
/s/ Gary Coy	Chief Financial Officer	August 5, 2008
Gary Coy
/s/ James Page	Director	August 5, 2008
James Page
/s/ Dennis Moore	Director	August 5, 2008
Dennis Moore
	Director	August 5, 2008
Stephen T. Chen
/s/ Thomas D'Alonzo	Director	August 5, 2008
Thomas D'Alonzo
	Director	August 5, 2008
Thomas Ulie

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Pursuant to the requirements of the Securities Act of 1933, these trustees (or other persons who administer the employee benefit plan) have duly caused the registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Amarillo, State of Texas, on August 5, 2008.

2008 EXECUTIVE OFFICERS COMPENSATORY STOCK PLAN

By:          /s/ Thomas D'Alonzo 

Thomas D’Alonzo

Plan Committee Member

By:          

Stephen Chen

Plan Committee Member

By:           /s/ James A. Page

James A. Page

Plan Committee Member

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EX-5

EXHIBIT 5

SandersBakerpc

Attorneys and counselors

ROBERT R. SANDERS         ONE MAXOR PLAZA        MAILING ADDRESS:

MITCH D. CARTHEL         320 S. POLK STREET, SUITE 700

ROGER S. COX                 AMARILLO, TEXAS 79101          P.O. BOX 2667

RUSS DeVORE*                   AMARILLO, TEXAS 79105-2667

EDWARD L. MORRIS         (806) 372-2020                  FAX (806) 372-3725

JUSTIN E. MYERS

JOHN B. ATKINS                sender’s email: emorris@sandersbaker.com

*Admitted in Texas, New Mexico & Colorado

August 5, 2008

Amarillo Biosciences, Inc.

4134 Business Park Dr.

Amarillo, Texas 79110

RE: Issuance of Stock Pursuant to S-8 Registration Statement

Gentlemen:

Pursuant to your request, we have examined the S-8 Registration Statement to be filed with the Securities and Exchange Commission, registering 200,000 shares of common stock of the company.  We have further examined the Certificate of Incorporation, Articles of Incorporation, Bylaws, any amendments thereto, and all such corporate records and documents that we believed were necessary or relevant to enable us to render an opinion in this matter.

Based solely on the foregoing examination, it is our opinion that, when sold or granted, and issued according the 2008 Executive Officers Compensatory Stock Plan, the shares of common stock covered by the Registration Statement will be legally issued, fully paid, and non assessable.

We consent to the filing of this opinion as an exhibit to the Registration Statement.

Very truly yours,

SandersBaker pc

/s/ Edward L. Morris

Edward L. Morris

ELM:ss

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EX-10

EXHIBIT 10

AMARILLO BIOSCIENCES, INC.

2008 EXECUTIVE OFFICERS COMPENSATORY STOCK PLAN

ARTICLE I.

PURPOSE AND ADOPTION OF THE PLAN

1.1Purpose. The purpose of the Amarillo Biosciences, Inc. (the “Company”) 2008 Executive Officers Compensatory Stock Plan (hereinafter referred to as the “Plan”) is to provide for issuance of shares of the Company’s Voting Stock to certain key employees to satisfy the Company’s payment (salary) obligations under the respective, written employment contracts with those key employees. The key employees, and the amount of salary compensation payable to each in the form of stock (rather than cash) are as follows:

Joseph M. Cummins	up to 50% of salary payable in stock at Company’s election, without employee’s consent, and up to 100% of salary payable in stock at Company’s election, with employee’s consent
Martin J. Cummins	up to 50% of salary payable in stock at Company’s election, without employee’s consent, and up to 100% of salary payable in stock at Company’s election, with employee’s consent
Gary Wayne Coy	up to 100% of salary payable in stock, at Company’s election, without employee’s consent

1.2Adoption and Term. The Plan has been approved by the Board of Directors (hereinafter referred to as the “Board”) of the “Company”, effective as of July 10, 2008. The Plan shall remain in effect until terminated by action of the Board.

ARTICLE II.

SHARES

2.1Number of Shares Issuable. The total number of shares initially authorized to be issued under the Plan shall be 200,000 shares of Common Stock of the Company, par value $0.01 per share (“Common Stock”).

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ARTICLE III.

PARTICIPATION

3.1 Eligible Participants. Participants in the Plan shall be the persons named in Section 1.1 above; and such other executive officers of the Company as may be designated by the Plan Committee to participate in the Plan.

ARTICLE IV.

PLAN COMMITTEE

4.1 Plan Committee. The Plan Committee shall consist of the following outside directors of the Board: Thomas D’Alonzo; Stephen Chen; James A. Page. The Board may add or remove Committee Members at any time, provided however, that each Plan Committee Member shall be an outside director currently sitting on the Board.

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EX-23

EXHIBIT 23

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

To the Board of Directors and Stockholders of

Amarillo Biosciences, Inc.

We consent to incorporation by reference in this Registration Statement of Amarillo Biosciences, Inc., on Form S-8 to be filed with the Commission on or about August 5, 2008 of our Report of Independent Registered Public Accounting Firm dated March 17, 2008 covering the balance sheet of Amarillo Biosciences, Inc. for the year ended December 31, 2007, and the related statements of operations, stockholders’ deficit, and cash flows for each of the years in the two year period then ended.

/s/ LBB & Associates Ltd., LLP

LBB & Associates Ltd., LLP

Houston, Texas

August 5, 2008

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