8-K

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

Date of report (Date of earliest event reported):  January 15, 2009

CALIPER LIFE SCIENCES, INC.

(Exact Name of Registrant as Specified in Charter)

Delaware	0-28229	33-0675808
(State or other jurisdiction of incorporation)	(Commission File Number)	(IRS Employer Identification No.)
68 Elm Street, Hopkinton, Massachusetts		01748
(Address of Principal Executive Offices)		(Zip Code)

(508) 435-9500

(Registrant’s telephone number, including area code)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):

oWritten communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

oSoliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

oPre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

oPre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

ITEM 2.02.  Results of Operations and Financial Condition.

On January 15, 2009, Caliper Life Sciences, Inc issued a press release announcing preliminary revenue results for its fourth quarter and full year ended December 31, 2008. The press release is attached to this report as Exhibit 99.1.

The information in this report, including Exhibit 99.1 attached hereto, shall not be deemed to be “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, or otherwise subject to the liabilities of that Section or Sections 11 and 12(a)(2) of the Securities Act of 1933, as amended.  The information contained herein and in the accompanying exhibit shall not be incorporated by reference into any filing with the U.S. Securities and Exchange Commission made by Caliper, whether made before or after the date hereof, regardless of any general incorporation language in such filing.

ITEM 9.01.  Financial Statements and Exhibits.

Exhibit No.	Exhibit
99.1	Press Release entitled “Caliper Life Sciences Announces Preliminary 2008 Fourth Quarter and Full Year Revenue Results”.

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SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

	CALIPER LIFE SCIENCES, INC.
Date: January 15, 2009	By:	/s/ Peter F. McAree
		Peter F. McAree
		Senior Vice President  & Chief Financial Officer

EX-99.1

EXHIBIT 99.1

For Immediate Release

Caliper Life Sciences Announces Preliminary 2008 Fourth Quarter and Full Year Revenue Results

HOPKINTON, Mass., January 15, 2009 — Caliper Life Sciences, Inc. (NASDAQ: CALP) today announced preliminary revenue results for its 2008 fourth quarter and full year ended December 31, 2008.

Based on the company’s preliminary financial results, total revenue is expected to be approximately $36.5 million for the fourth quarter of 2008 and approximately $133.9 million for the full year, which is at the upper end of the company’s previous revenue guidance for the fourth quarter of $34 million to $37 million.

Earlier in the fourth quarter, Caliper announced the sale of its Pharmaceutical Development & Quality and AutoTrace product lines in transactions valued in the aggregate at approximately $21.0 million.  2008 pro forma revenue, reflecting the divestiture of these two product lines, for the fourth quarter and full year is expected to be approximately $34.6 million and $122.8 million, respectively.

Fourth quarter and full year preliminary revenue results are pending finalization of the company’s financial results for the quarter and year ended December 31, 2008 and accordingly are subject to change.

2009 Revenue Guidance

For 2009, Caliper currently expects total revenue to increase by approximately 4% to 7% compared with 2008 pro forma revenue, with the growth primarily occurring in the second half of the year.  The company cited currency headwinds as a key factor influencing its estimates.

Presentation at Today’s J.P. Morgan Conference

As announced in a separate press release issued by the company on December 23, 2008, Caliper will today make a presentation at the J.P. Morgan Healthcare Conference in San Francisco, California.  A live webcast of the company’s presentation can be accessed at http://metameetings.com/webcasts/jpmorgan/healthcare09/directlink?ticker=CALP.  An archived edition of the presentation will be available for 90 days.

About Caliper Life Sciences

Caliper Life Sciences is a premier provider of leading-edge technologies enabling researchers in the life sciences industry to create life-saving and enhancing medicines

and diagnostic tests more quickly and efficiently. Caliper is aggressively innovating new technology to bridge the gap between in vitro assays and in vivo results and then translating those results into cures for human disease. Caliper’s portfolio of offerings includes state-of-the-art microfluidics, lab automation & liquid handling, optical imaging technologies, and discovery & development outsourcing solutions. For more information please visit www.caliperLS.com.

The statements in this press release regarding Caliper’s anticipated total revenue for the fourth quarter of 2008 and for 2008 and its expected revenue results for 2009 are “forward-looking statements” within the meaning of Section 21E of the Securities Exchange Act of 1934.  These statements are subject to risks and uncertainties that could cause actual results to differ materially from those Caliper expects or projects, including the risks that unexpected information may be received, or adjustments may be made, in the course of finalizing and analyzing the financial results, which could cause the final results to differ from these preliminary results.  Finalization of the company’s financial results for 2008 could lead to revisions in the company’s current expectations regarding revenue for the quarter and year ended December 31, 2008 and the year ending December 31, 2009.  Further information on risks faced by Caliper is included in risks discussed under the caption “Risk Factors” in Caliper’s annual report on Form 10-K for the year ended December 31, 2007, filed with the Securities and Exchange Commission on March 14, 2008, and in our other SEC reports and filings. These SEC reports and filings are available on a web site maintained by the SEC at http://www.sec.gov. Caliper expressly disclaims any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in Caliper’s expectations with regard thereto or any change in events, conditions, or circumstances on which any such statements are based.

Caliper is a registered trademark of Caliper Life Sciences, Inc.

Contact:

Peter McAree

SVP and CFO

Caliper Life Sciences

508.497.2215

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