EXHIBIT 31.3

CERTIFICATION

I, E. Kevin Hrusovsky, certify that:

1.I have reviewed this amendment to the Annual Report on Form 10-K of Caliper Life Sciences, Inc.;

2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report.

Date: April 28, 2006

/s/ E. KEVIN HRUSOVSKY

E. Kevin Hrusovsky

President and Chief Executive Officer
(Principal Executive Officer)