EXHIBIT 32.2

                           CALIPER LIFE SCIENCES, INC.

                            CERTIFICATION PURSUANT TO
                             18 U.S.C. SECTION 1350,
                             AS ADOPTED PURSUANT TO
                  SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

         In connection with the Annual Report of Caliper Life Sciences, Inc.
(the "Company") on Form 10-K for the year ended December 31, 2004 as filed with
the Securities and Exchange Commission on the date hereof (the "Report"), I,
Thomas T. Higgins, Vice President and Chief Financial Officer of the Company
certify, pursuant to the requirement set forth in Rule 13a-14(b) of the
Securities Exchange Act of 1934, as amended (the "Exchange Act") and 18 U.S.C.
Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of
2002, to the best of my knowledge that:

                  (1) The Report fully complies with the requirements of section
         13(a) or 15(d) of the Exchange Act; and

                  (2) The information contained in the Report fairly presents,
         in all material respects, the financial condition and result of
         operations of the Company.

                                           /s/ THOMAS T. HIGGINS
                                      -----------------------------------
                                      Thomas T. Higgins
                                      Vice President and
                                      Chief Financial Officer

Date: March 16, 2005