EXHIBIT 32.2

                            CERTIFICATION PURSUANT TO
                             18 U.S.C. SECTION 1350,
                             AS ADOPTED PURSUANT TO
                  SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the Quarterly Report of Caliper Life Sciences, Inc. (the
"Company") on Form 10-Q for the period ending September 30, 2004 as filed with
the Securities and Exchange Commission on the date hereof (the "Report"), I,
Peter F. McAree, Vice President, Finance and Principal Accounting Officer of the
Company, certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to
Section 906 of the Sarbanes-Oxley Act of 2002, that, to the best of my
knowledge:

(1) The Report fully complies with the requirements of section 13(a) or section
15(d) of the Securities Exchange Act of 1934; and

(2) The information contained in the Report fairly presents, in all material
respects, the financial condition and results of operations of Caliper.

November 9, 2004

                                                             /s/ Peter F. McAree
                                                  ------------------------------
                                                                 Peter F. McAree
                                                     Principal Financial Officer


This certification accompanies the Form 10-Q to which it relates, is not deemed
filed with the SEC and is not to be incorporated by reference into any filing of
Caliper's under the Securities Act of 1933, as amended, or the Securities
Exchange Act of 1934, as amended, irrespective of any general incorporation
language contained in such filing.


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