The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACCELERATE DIAGNOSTICS INC COM 00430H102 30,436 3,776,121 SH   SOLE   3,776,121 0 0
AGENUS INC COM NEW 00847G705 50,363 9,173,582 SH   SOLE   9,173,582 0 0
AMARIN CORP PLC SPONS ADR NEW 023111206 3,729 851,335 SH   SOLE   851,335 0 0
ANTARES PHARMA INC COM 036642106 8,284 1,900,000 SH   SOLE   1,900,000 0 0
ASPIRA WOMENS HEALTH INC COM 04537Y109 48,597 8,647,094 SH   SOLE   8,647,094 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 30,367 1,920,733 SH   SOLE   1,920,733 0 0
BIODESIX INC COM 09075X108 3,111 235,511 SH   SOLE   235,511 0 0
BIOGEN INC COM 09062X103 835 2,412 SH   SOLE   2,412 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 202,174 2,082,555 SH   SOLE   2,082,555 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 1,820 248,200 SH Put SOLE   248,200 0 0
CAPRICOR THERAPEUTICS INC COM NEW 14070B309 5,983 1,166,249 SH   SOLE   1,166,249 0 0
CODIAK BIOSCIENCES INC COM 192010106 12,576 678,700 SH   SOLE   678,700 0 0
CONTRAFECT CORP COM NEW 212326300 7,431 1,688,902 SH   SOLE   1,688,902 0 0
DERMTECH INC COM 24984K105 27,265 655,877 SH   SOLE   655,877 0 0
FORIAN INC COM 34630N106 10,915 868,342 SH   SOLE   868,342 0 0
IMMUTEP LTD SPONSORED ADS 45257L108 3,870 1,000,000 SH   SOLE   1,000,000 0 0
MOTUS GI HLDGS INC COM 62014P108 3,845 3,697,551 SH   SOLE   3,697,551 0 0
OPKO HEALTH INC COM 68375N103 51,917 12,819,073 SH   SOLE   12,819,073 0 0
OPKO HEALTH INC COM 68375N103 334 667,800 SH Put SOLE   667,800 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108 48,054 1,374,159 SH   SOLE   1,374,159 0 0
QUIDEL CORP COM 74838J101 107,250 837,109 SH   SOLE   837,109 0 0
SELECT MED HLDGS CORP COM 81619Q105 3,744 88,589 SH   SOLE   88,589 0 0
SOLENO THERAPEUTICS INC COM NEW 834203200 2,430 2,132,000 SH   SOLE   2,132,000 0 0
SPDR SER TR S&P BIOTECH 78464A870 10,317 76,200 SH   SOLE   76,200 0 0
SPDR SER TR S&P BIOTECH 78464A870 3,898 825,000 SH Put SOLE   825,000 0 0
VERTEX ENERGY INC COM 92534K107 1,191 90,000 SH   SOLE   90,000 0 0
VIR BIOTECHNOLOGY INC COM 92764N102 33,355 705,486 SH   SOLE   705,486 0 0
VIR BIOTECHNOLOGY INC COM 92764N102 1,313 196,700 SH Put SOLE   196,700 0 0
Y-MABS THERAPEUTICS INC COM 984241109 10,162 300,642 SH   SOLE   300,642 0 0