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Property and Equipment, net (Tables)
12 Months Ended
Dec. 31, 2015
Property, Plant and Equipment [Abstract]  
Property, Plant and Equipment [Table Text Block]
The principal categories of property and equipment, net at December 31, 2015 and 2014 are as follows:  
 
 
 
2015
 
2014
 
Laboratory equipment
 
$
9,963
 
$
9,801
 
Office and computer equipment
 
 
2,968
 
 
3,288
 
Furniture, fixtures and fittings
 
 
4,315
 
 
4,544
 
Less - accumulated depreciation
 
 
(14,630)
 
 
(15,857)
 
Total
 
$
2,616
 
$
1,776