CONDENSED CONSOLIDATED STATEMENTS OF SHAREHOLDERS’ EQUITY - USD ($) shares in Thousands, $ in Thousands	Total	Ordinary shares	Preferred shares	Additional paid-in capital	Accumulated deficit	Accumulated other comprehensive loss
Beginning balance (in shares) at Dec. 31, 2022		62,878	488
Beginning balance at Dec. 31, 2022	$ (21,145)	$ 628	$ 5	$ 589,783	$ (585,220)	$ (26,341)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net loss	(30,784)				(30,784)
Other comprehensive (loss) income	315					315
Issuance of common stock under at-the-market offering program, net of issuance costs (in shares)		1,564
Issuance of common stock under at-the-market offering program, net of issuance costs	11,913	$ 16		11,897
Amortization of deferred issuance costs	(16)			(16)
Vesting of restricted shares (in shares)		22
Employee share purchase plan share issuance (in shares)		14
Employee share purchase plan share issuance	29			29
Share-based compensation expense	1,522			1,522
Ending balance (in shares) at Mar. 31, 2023		64,478	488
Ending balance at Mar. 31, 2023	(38,166)	$ 644	$ 5	603,215	(616,004)	(26,026)
Beginning balance (in shares) at Dec. 31, 2023		89,825	5,194
Beginning balance at Dec. 31, 2023	87,739	$ 898	$ 52	855,452	(745,496)	(23,167)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net loss	(27,342)				(27,342)
Other comprehensive (loss) income	(589)					(589)
Issuance of common stock under at-the-market offering program, net of issuance costs (in shares)		640
Issuance of common stock under at-the-market offering program, net of issuance costs	9,250	$ 6		9,244
Amortization of deferred issuance costs	(3)			(3)
Conversion of preferred stock into ordinary shares (in shares)		5,194	(5,194)
Conversion of preferred stock into ordinary shares		$ 52	$ (52)
Exercise of stock options (in shares)		390
Exercise of stock options	3,356	$ 3		3,353
Employee share purchase plan share issuance (in shares)		48
Employee share purchase plan share issuance	584	$ 1		583
Share-based compensation expense	5,389			5,389
Ending balance (in shares) at Mar. 31, 2024		96,097	0
Ending balance at Mar. 31, 2024	$ 78,384	$ 960	$ 0	$ 874,018	$ (772,838)	$ (23,756)